Click here to switch to the map view.

The map label for this gene is uvrD

Identifier: 15618681

GI number: 15618681

Start: 870466

End: 872385

Strand: Reverse

Name: uvrD

Synonym: CPn0772

Alternate gene names: 15618681

Gene position: 872385-870466 (Counterclockwise)

Preceding gene: 15618684

Following gene: 15618680

Centisome position: 70.91

GC content: 40.26

Gene sequence:

>1920_bases
ATGACATGTATCTCAGAACTTAACGAAGCACAACGCAAAGCTGTAACAGCTCCTCTCAATCCTGTACTCGTTCTAGCAGG
AGCAGGAGCAGGTAAAACTCGTGTGGTTACCTATAGAATCTTACACCTAATTAACCAAGGCATCGCGCCTCGAGAAATTC
TGGCTGTAACTTTTACGAATAAAGCAGCGCGAGAACTTAAAGAACGTATTGTCAATCAGTGTGCTTCCACTAATGAATTT
GATGTTCCGATGGTGTGTACATTTCATAGTTTAGGAGTTTTTATTCTCCGACGTTCTATAAATCTGCTAAATCGTGAAAA
TAATTTTACTATTTATGATCAAAGTGACGCGGAAAAGCTCATCAAGCATGCCTTGCAACAACACAACCTCAAACCTAATC
TTGCGAGCAAAATACAAGCTCACGTCTCACAAGCAAAGAACCGTTTACTCTTTCCCGAAGACTTGGATCCCAATGACTAT
ATCGATCCTGTAGTCTCGATATACCAAGAATACCAAAAGAAACTTATCGAAGCGAATGCTCTGGATTTCGATGATCTTCT
CTTTTTAACCGTAAGACTTCTTAGAGAAAGTCCCGAAGCACAGGAATTATATAACCAATTATGGAAAGCATTGCTCATCG
ATGAGTATCAAGATACCAACCATGCACAATATACTTTAATGCAGCTCCTCTCAAAGCAACATCGCAATGTCTTTGCTGTT
GGGGATCCTGATCAGTCTATCTACTCCTGGCGAGGAGCAAATATTCACAATATCTTAAATTTTGAAAACGATTACCCTAA
TGCTAAAGTCTTATGCCTCGAAGAAAACTACCGCAGTTATGGCAATATTCTAAATGCCGCTAATGCTCTGATTAAAAATA
ACGCATCAAGGTTAGAAAAAGAATTGCGTAGCGTCAAAGGACCTGGAGAAAAGATTCGTCTTTTCCTAGGAAGCACAGAT
CGCGAAGAAGCAGACTTTGTCGCTGCAGAAATTCTTCAATTACATAGAGTCGGGAATATAAAACTACGTGACATCTGTAT
TTTCTATAGAACGAACTCCCAATCTCGGACATTTGAAGACGCTCTACTTCGCAGGCGCATTCCCTATGAAATTATCGGGG
GTCTCTCCTTCTACAAGCGTAAGGAAATCCAAGATATCCTAGCCTTTCTCCGTATCTTTATTTCCAAAAGCGACATCGTT
GCTTTTGATAGAACTGTAAATCTACCCAAACGAGGGATCGGTTCAACAACGATATTTGCACTCACGCAATATGCAATTGC
TCAAGGTCTCCCTATCCTCAAAGCATGCCAACAAGCCTTGGATACTAAAGACGTCAAATTATCTAAAAAACAACAAGAAG
GCCTTCAAGAGTATCTTGCACTTTTCCCTCAAATTGAACATGCCTACAATACTCTTTCCCTTAGAGATTTTATAGAGTCT
GTAGTTAGGATCACGGGTTACCTTGAGATCTTAAAAGAAGATGCGGATACCTTCAAAGATCGGAAAAGCAATTTAGAGGA
ACTCTATCATAAAGCTTTGGAATCCGAACAACAAAATCCAAAGACACATTTGGAACTTTTCCTTGATGATCTTGCCTTAA
AAGGCTCTGATGATGATCTAAATTTAACTGCGGATCGCGTGAATTTGATGACCCTTCATAATGGAAAAGGGTTGGAGTTC
CGTGTATCATTTCTTGTAGGTCTAGAAGAACAATTGCTTCCACATGCGAACTCTCTGGGCGGCACTTATGAAAATATTGA
AGAAGAACGACGGTTATGCTACGTAGGAATTACTCGAGCTCAAGATCTCCTCTATCTTACTGCCGCACAAGTTCGCAGCC
TCTGGGGAACCGTACGGATGATGAAGCCCAGTAGATTTTTAAAGGAAATTCCAAAAGATTATATGATTCAAGTGCGTTAG

Upstream 100 bases:

>100_bases
ATCACCTTTCTATAATTGTGATGAAAGTATACTCGCTTTTTATTTTAGCTCGACAGAGATTGTCAGTCTCGAGGTGTAAA
GCTAAAAATTAGGACTTATT

Downstream 100 bases:

>100_bases
ACATGTTTCAGCAAAAGCAGAAGTTGTCTCTAAAGTATCTACCCTCACTAAGGATGCAACAAGGCCTGCAGATGCTGCAA
TCGCCACTTACTGAGTTATC

Product: DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MTCISELNEAQRKAVTAPLNPVLVLAGAGAGKTRVVTYRILHLINQGIAPREILAVTFTNKAARELKERIVNQCASTNEF
DVPMVCTFHSLGVFILRRSINLLNRENNFTIYDQSDAEKLIKHALQQHNLKPNLASKIQAHVSQAKNRLLFPEDLDPNDY
IDPVVSIYQEYQKKLIEANALDFDDLLFLTVRLLRESPEAQELYNQLWKALLIDEYQDTNHAQYTLMQLLSKQHRNVFAV
GDPDQSIYSWRGANIHNILNFENDYPNAKVLCLEENYRSYGNILNAANALIKNNASRLEKELRSVKGPGEKIRLFLGSTD
REEADFVAAEILQLHRVGNIKLRDICIFYRTNSQSRTFEDALLRRRIPYEIIGGLSFYKRKEIQDILAFLRIFISKSDIV
AFDRTVNLPKRGIGSTTIFALTQYAIAQGLPILKACQQALDTKDVKLSKKQQEGLQEYLALFPQIEHAYNTLSLRDFIES
VVRITGYLEILKEDADTFKDRKSNLEELYHKALESEQQNPKTHLELFLDDLALKGSDDDLNLTADRVNLMTLHNGKGLEF
RVSFLVGLEEQLLPHANSLGGTYENIEEERRLCYVGITRAQDLLYLTAAQVRSLWGTVRMMKPSRFLKEIPKDYMIQVR

Sequences:

>Translated_639_residues
MTCISELNEAQRKAVTAPLNPVLVLAGAGAGKTRVVTYRILHLINQGIAPREILAVTFTNKAARELKERIVNQCASTNEF
DVPMVCTFHSLGVFILRRSINLLNRENNFTIYDQSDAEKLIKHALQQHNLKPNLASKIQAHVSQAKNRLLFPEDLDPNDY
IDPVVSIYQEYQKKLIEANALDFDDLLFLTVRLLRESPEAQELYNQLWKALLIDEYQDTNHAQYTLMQLLSKQHRNVFAV
GDPDQSIYSWRGANIHNILNFENDYPNAKVLCLEENYRSYGNILNAANALIKNNASRLEKELRSVKGPGEKIRLFLGSTD
REEADFVAAEILQLHRVGNIKLRDICIFYRTNSQSRTFEDALLRRRIPYEIIGGLSFYKRKEIQDILAFLRIFISKSDIV
AFDRTVNLPKRGIGSTTIFALTQYAIAQGLPILKACQQALDTKDVKLSKKQQEGLQEYLALFPQIEHAYNTLSLRDFIES
VVRITGYLEILKEDADTFKDRKSNLEELYHKALESEQQNPKTHLELFLDDLALKGSDDDLNLTADRVNLMTLHNGKGLEF
RVSFLVGLEEQLLPHANSLGGTYENIEEERRLCYVGITRAQDLLYLTAAQVRSLWGTVRMMKPSRFLKEIPKDYMIQVR
>Mature_638_residues
TCISELNEAQRKAVTAPLNPVLVLAGAGAGKTRVVTYRILHLINQGIAPREILAVTFTNKAARELKERIVNQCASTNEFD
VPMVCTFHSLGVFILRRSINLLNRENNFTIYDQSDAEKLIKHALQQHNLKPNLASKIQAHVSQAKNRLLFPEDLDPNDYI
DPVVSIYQEYQKKLIEANALDFDDLLFLTVRLLRESPEAQELYNQLWKALLIDEYQDTNHAQYTLMQLLSKQHRNVFAVG
DPDQSIYSWRGANIHNILNFENDYPNAKVLCLEENYRSYGNILNAANALIKNNASRLEKELRSVKGPGEKIRLFLGSTDR
EEADFVAAEILQLHRVGNIKLRDICIFYRTNSQSRTFEDALLRRRIPYEIIGGLSFYKRKEIQDILAFLRIFISKSDIVA
FDRTVNLPKRGIGSTTIFALTQYAIAQGLPILKACQQALDTKDVKLSKKQQEGLQEYLALFPQIEHAYNTLSLRDFIESV
VRITGYLEILKEDADTFKDRKSNLEELYHKALESEQQNPKTHLELFLDDLALKGSDDDLNLTADRVNLMTLHNGKGLEFR
VSFLVGLEEQLLPHANSLGGTYENIEEERRLCYVGITRAQDLLYLTAAQVRSLWGTVRMMKPSRFLKEIPKDYMIQVR

Specific function: DNA helicase used for plasmid rolling-circle replication and also involved in UV repair [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=649, Percent_Identity=38.366718027735, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI48994965, Length=653, Percent_Identity=39.6630934150077, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1787196, Length=345, Percent_Identity=27.8260869565217, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=744, Percent_Identity=28.494623655914, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324477, Length=669, Percent_Identity=25.7100149476831, Blast_Score=116, Evalue=8e-27,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 73209; Mature: 73078

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCISELNEAQRKAVTAPLNPVLVLAGAGAGKTRVVTYRILHLINQGIAPREILAVTFTN
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHEEEEEECC
KAARELKERIVNQCASTNEFDVPMVCTFHSLGVFILRRSINLLNRENNFTIYDQSDAEKL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
IKHALQQHNLKPNLASKIQAHVSQAKNRLLFPEDLDPNDYIDPVVSIYQEYQKKLIEANA
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LDFDDLLFLTVRLLRESPEAQELYNQLWKALLIDEYQDTNHAQYTLMQLLSKQHRNVFAV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEE
GDPDQSIYSWRGANIHNILNFENDYPNAKVLCLEENYRSYGNILNAANALIKNNASRLEK
CCCCHHHHHCCCCCHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHH
ELRSVKGPGEKIRLFLGSTDREEADFVAAEILQLHRVGNIKLRDICIFYRTNSQSRTFED
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHH
ALLRRRIPYEIIGGLSFYKRKEIQDILAFLRIFISKSDIVAFDRTVNLPKRGIGSTTIFA
HHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHH
LTQYAIAQGLPILKACQQALDTKDVKLSKKQQEGLQEYLALFPQIEHAYNTLSLRDFIES
HHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRITGYLEILKEDADTFKDRKSNLEELYHKALESEQQNPKTHLELFLDDLALKGSDDDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
NLTADRVNLMTLHNGKGLEFRVSFLVGLEEQLLPHANSLGGTYENIEEERRLCYVGITRA
EEEECEEEEEEEECCCCCEEEEHHHHCCHHHHCCCCHHCCCCHHHHHHHCCEEEEECHHH
QDLLYLTAAQVRSLWGTVRMMKPSRFLKEIPKDYMIQVR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHEEECC
>Mature Secondary Structure 
TCISELNEAQRKAVTAPLNPVLVLAGAGAGKTRVVTYRILHLINQGIAPREILAVTFTN
CCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHEEEEEECC
KAARELKERIVNQCASTNEFDVPMVCTFHSLGVFILRRSINLLNRENNFTIYDQSDAEKL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
IKHALQQHNLKPNLASKIQAHVSQAKNRLLFPEDLDPNDYIDPVVSIYQEYQKKLIEANA
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LDFDDLLFLTVRLLRESPEAQELYNQLWKALLIDEYQDTNHAQYTLMQLLSKQHRNVFAV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEE
GDPDQSIYSWRGANIHNILNFENDYPNAKVLCLEENYRSYGNILNAANALIKNNASRLEK
CCCCHHHHHCCCCCHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHH
ELRSVKGPGEKIRLFLGSTDREEADFVAAEILQLHRVGNIKLRDICIFYRTNSQSRTFED
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHH
ALLRRRIPYEIIGGLSFYKRKEIQDILAFLRIFISKSDIVAFDRTVNLPKRGIGSTTIFA
HHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHH
LTQYAIAQGLPILKACQQALDTKDVKLSKKQQEGLQEYLALFPQIEHAYNTLSLRDFIES
HHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRITGYLEILKEDADTFKDRKSNLEELYHKALESEQQNPKTHLELFLDDLALKGSDDDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
NLTADRVNLMTLHNGKGLEFRVSFLVGLEEQLLPHANSLGGTYENIEEERRLCYVGITRA
EEEECEEEEEEEECCCCCEEEEHHHHCCHHHHCCCCHHCCCCHHHHHHHCCEEEEECHHH
QDLLYLTAAQVRSLWGTVRMMKPSRFLKEIPKDYMIQVR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9701819; 9384377 [H]