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The map label for this gene is ispA

Identifier: 15618657

GI number: 15618657

Start: 844118

End: 844987

Strand: Reverse

Name: ispA

Synonym: CPn0748

Alternate gene names: 15618657

Gene position: 844987-844118 (Counterclockwise)

Preceding gene: 15618658

Following gene: 15618655

Centisome position: 68.69

GC content: 40.57

Gene sequence:

>870_bases
GTGTTACATGCTTTAGATACGTATCGACCTTCTATAGAAAGTGCTATAGAAAAGGCTTTGGAAGGATTTGGTCCTATAGG
TCACCCGATTCGCTCTCCTGTAGAATACGCTTTACAGGGCGGTGGAAAGCGTTTAAGACCTGGTTTAGTCTGCATGATGG
CTCAAGGTTTGGGCTTAAATCATGACGTTATGGACTCAGCTTTAGCTGTAGAGTTTGTCCACACTTCCACCCTAATTGCG
GACGATCTTCCTTGCATGGACAACGACGATGAGCGTAGGGGACGCCCGACGGTACATAAAGCTTTCGATGAAGCAACCGC
CTTACTCGCATCTTACGCCCTAATTCCTGCTGCTTACTCCCACCTTCGCTTAAACGCAAAGAAGTTAAAAGAACAGGGCT
GTGATCCTAGAGAAATAGATATCGCTTACAACATTATCGGAGATATTACAGACAAAAATATTGGATGTTCTGGGGTATTA
GGAGGGCAGTATGATGATATGTTCTTTTCTAACCGAGGTCAAGAACACGTACAATCTATTATGATCAAAAAAACGGGTTC
TCTATTTGAGATTGCATGTATTTCTGGTTGGTTATTTGGTGGCGGAGACCCACAATTTGCACCTATAATTACAAGTTTCT
CAAATAATTTTGGCTTACTTTTTCAAATAAAAGATGATTTTTCAGATTTACAAAAAGACTCCCAACAAATTGGGCTAAAT
TATGCTTTACTATTTGGAGAAAAGGCCGCTCTAGAGCTATTAGCAAGATCTCAAAACAATTGCTTAGAGCTCTTGGATCG
TCTCAGTGCTGGTGGATTAAAGAATAGTTCTGAATTCGAAACGATTATCTCGAGTTTAGGATCTTTTTAA

Upstream 100 bases:

>100_bases
GGTTGCTATAGGATGCAATGTTGTCATCAATCCAGGCCAACATATTCTCCCTCATACTAGAATTCGTCCTGGTCAAGTCA
TTTAAAAATAGGGGACTCTT

Downstream 100 bases:

>100_bases
ATCTTCAAGGATATTCTAAGGTGCTATTTTAAACTTACAGCCACCTTGGCTTCTATCTTTACTAACAAAATTTCTTATAA
AAAAGGGATGAAGATAAAAT

Product: geranyl transtransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MLHALDTYRPSIESAIEKALEGFGPIGHPIRSPVEYALQGGGKRLRPGLVCMMAQGLGLNHDVMDSALAVEFVHTSTLIA
DDLPCMDNDDERRGRPTVHKAFDEATALLASYALIPAAYSHLRLNAKKLKEQGCDPREIDIAYNIIGDITDKNIGCSGVL
GGQYDDMFFSNRGQEHVQSIMIKKTGSLFEIACISGWLFGGGDPQFAPIITSFSNNFGLLFQIKDDFSDLQKDSQQIGLN
YALLFGEKAALELLARSQNNCLELLDRLSAGGLKNSSEFETIISSLGSF

Sequences:

>Translated_289_residues
MLHALDTYRPSIESAIEKALEGFGPIGHPIRSPVEYALQGGGKRLRPGLVCMMAQGLGLNHDVMDSALAVEFVHTSTLIA
DDLPCMDNDDERRGRPTVHKAFDEATALLASYALIPAAYSHLRLNAKKLKEQGCDPREIDIAYNIIGDITDKNIGCSGVL
GGQYDDMFFSNRGQEHVQSIMIKKTGSLFEIACISGWLFGGGDPQFAPIITSFSNNFGLLFQIKDDFSDLQKDSQQIGLN
YALLFGEKAALELLARSQNNCLELLDRLSAGGLKNSSEFETIISSLGSF
>Mature_289_residues
MLHALDTYRPSIESAIEKALEGFGPIGHPIRSPVEYALQGGGKRLRPGLVCMMAQGLGLNHDVMDSALAVEFVHTSTLIA
DDLPCMDNDDERRGRPTVHKAFDEATALLASYALIPAAYSHLRLNAKKLKEQGCDPREIDIAYNIIGDITDKNIGCSGVL
GGQYDDMFFSNRGQEHVQSIMIKKTGSLFEIACISGWLFGGGDPQFAPIITSFSNNFGLLFQIKDDFSDLQKDSQQIGLN
YALLFGEKAALELLARSQNNCLELLDRLSAGGLKNSSEFETIISSLGSF

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=213, Percent_Identity=30.5164319248826, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786623, Length=214, Percent_Identity=34.5794392523364, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789578, Length=208, Percent_Identity=29.3269230769231, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31509; Mature: 31509

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHALDTYRPSIESAIEKALEGFGPIGHPIRSPVEYALQGGGKRLRPGLVCMMAQGLGLN
CCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
HDVMDSALAVEFVHTSTLIADDLPCMDNDDERRGRPTVHKAFDEATALLASYALIPAAYS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HLRLNAKKLKEQGCDPREIDIAYNIIGDITDKNIGCSGVLGGQYDDMFFSNRGQEHVQSI
HHHCCHHHHHHCCCCCCEEEEHEEHHHCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHH
MIKKTGSLFEIACISGWLFGGGDPQFAPIITSFSNNFGLLFQIKDDFSDLQKDSQQIGLN
HHHCCCCEEEEHHHHCEEECCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCE
YALLFGEKAALELLARSQNNCLELLDRLSAGGLKNSSEFETIISSLGSF
EEEEECCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLHALDTYRPSIESAIEKALEGFGPIGHPIRSPVEYALQGGGKRLRPGLVCMMAQGLGLN
CCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCC
HDVMDSALAVEFVHTSTLIADDLPCMDNDDERRGRPTVHKAFDEATALLASYALIPAAYS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HLRLNAKKLKEQGCDPREIDIAYNIIGDITDKNIGCSGVLGGQYDDMFFSNRGQEHVQSI
HHHCCHHHHHHCCCCCCEEEEHEEHHHCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHH
MIKKTGSLFEIACISGWLFGGGDPQFAPIITSFSNNFGLLFQIKDDFSDLQKDSQQIGLN
HHHCCCCEEEEHHHHCEEECCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCE
YALLFGEKAALELLARSQNNCLELLDRLSAGGLKNSSEFETIISSLGSF
EEEEECCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]