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The map label for this gene is gcsP1

Identifier: 15606927

GI number: 15606927

Start: 1339276

End: 1340724

Strand: Direct

Name: gcsP1

Synonym: aq_1903

Alternate gene names: 15606927

Gene position: 1339276-1340724 (Clockwise)

Preceding gene: 15606926

Following gene: 15606928

Centisome position: 86.33

GC content: 45.96

Gene sequence:

>1449_bases
ATGGAACTCATCTTTGAAAAATCCAAAAAGGGAAGGAAAGGTTATAAACTTCCAGAGCTGGACGTTGAAGAGGTAAATAT
AAAAGAATACCTTCCGGAAGAGTACTTAAGGGAAGAGCTTGACTTTCCAGAGGTTTCGGAGCTCGACGTTGTCCGCCATT
ACACTAACCTATCACACCTGAACTACGCCGTTGACACGACTATGGTTCCTCTCGGCTCCTGCACTATGAAGTACAACCCG
AGAATAAACGAGGAACTCGTAAATAAAAAGGAATTCTTAAACGTCCACCCGTTAACCCCAGAGGAGTACATACAGCCCCT
TTTAAAGCTCGTGTACGAGTTAAAGGAACTTTTAAAGGAACTTGGAGGTTTTGCAGAAGTTTCCCTCCAGCCTGCAGCGG
GAGCACACGGTGAACTCCTCGGACTTCTGCTCATTCACGCATACCATCAGGATAGGGGAAATAAAGAGAAGAAAGTGGTT
TTAATCCCCGACTCCGCTCACGGAACCAACCCAGCGAGTGCTGCTATATGCGGATTTGATATAAAGGTAGTAAAGAGCGA
CAAGAAGGGAGAACTTGATTTCGAAGACTTTATAAAGAAACTGGATGAGAGAGTTGCCGCTTTAATGATAACGAACCCGA
ATACTTTGGGGATTTTCGAGAGGAAAATAAAAGAGATAGCTGAGGAGCTTCACAAAAGGGACGCTCTCCTTTACATGGAC
GGGGCAAACTTCAATGCCTTGGTTGGTAGGTTCAAACCAGGAGAGTGGGGAGTTGACGTTATGCACTTTAACCTTCACAA
AACCTTCTCAACACCCCACGGAGGGGGAGGACCCGGAGCAGGACCCGTGGGCGTATCGGAGAGGTTAAAACCCTACCTCC
CCGTTCCACAGATTGAGTACGACGGGAAAAAATACTACCTTAACTGGAATATAGAAAAGAGCGTAGGGAAGATCCTCGCC
TTTCACGGACACTTCCTCGTCTGGCTGAAAGCCCTCGCTTACATACTCACCTACGGAAAAGACATAAAGAAAGTTTCCGA
GTACGCAGTCCTGAATGCGAGGTATTTAAAGCACCTGCTTAAAGGCGTGTTTAAGGACCCTTACCCTGAATCTCCCTGCA
TGCACGAGTTTGTTCTCTCGGCTACTAACCTTACAAAGTACGGCGTCAGGGCTTCCGACGTTGCAAAGAGAATACTAGAC
TACGGCTTTTACGCTCCCACCATGTACTTCCCCTTAATAGTCAGAGAAGCCTTAATGATAGAACCCACGGAAACGGAAAA
TCCCGACACTTTGAAAAAGTTCGCCCTAATTTTAAGGAAAATCGTTAAGGAAGCCAAGGAAAAGCCCGAAATTCTTAAGA
AAGCTCCCCACAGGACACCCGTGAGGAGGATAAAGGAGGCAGAAGCCAACAGGAACTTAATCTTGAAGTTTAAAGATATA
AAGGAATAG

Upstream 100 bases:

>100_bases
AAGATGGGAATTAAGGAAGTGGTTTCCTTCGGGAGGAGGTTTAAAAAGCTCGGCTTCAAAACTGTAAACCCTTACGAGGA
GAGTTAAAATTATTACTTCC

Downstream 100 bases:

>100_bases
AATTTAAATTTCTCGGAGGTAAAGACCTTGTACAAGGTACTGATTACTGACCCGATAGCTCCCGAAGGGATTGAACTGCT
TCAAAAGGACCCGGAAGTTG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MELIFEKSKKGRKGYKLPELDVEEVNIKEYLPEEYLREELDFPEVSELDVVRHYTNLSHLNYAVDTTMVPLGSCTMKYNP
RINEELVNKKEFLNVHPLTPEEYIQPLLKLVYELKELLKELGGFAEVSLQPAAGAHGELLGLLLIHAYHQDRGNKEKKVV
LIPDSAHGTNPASAAICGFDIKVVKSDKKGELDFEDFIKKLDERVAALMITNPNTLGIFERKIKEIAEELHKRDALLYMD
GANFNALVGRFKPGEWGVDVMHFNLHKTFSTPHGGGGPGAGPVGVSERLKPYLPVPQIEYDGKKYYLNWNIEKSVGKILA
FHGHFLVWLKALAYILTYGKDIKKVSEYAVLNARYLKHLLKGVFKDPYPESPCMHEFVLSATNLTKYGVRASDVAKRILD
YGFYAPTMYFPLIVREALMIEPTETENPDTLKKFALILRKIVKEAKEKPEILKKAPHRTPVRRIKEAEANRNLILKFKDI
KE

Sequences:

>Translated_482_residues
MELIFEKSKKGRKGYKLPELDVEEVNIKEYLPEEYLREELDFPEVSELDVVRHYTNLSHLNYAVDTTMVPLGSCTMKYNP
RINEELVNKKEFLNVHPLTPEEYIQPLLKLVYELKELLKELGGFAEVSLQPAAGAHGELLGLLLIHAYHQDRGNKEKKVV
LIPDSAHGTNPASAAICGFDIKVVKSDKKGELDFEDFIKKLDERVAALMITNPNTLGIFERKIKEIAEELHKRDALLYMD
GANFNALVGRFKPGEWGVDVMHFNLHKTFSTPHGGGGPGAGPVGVSERLKPYLPVPQIEYDGKKYYLNWNIEKSVGKILA
FHGHFLVWLKALAYILTYGKDIKKVSEYAVLNARYLKHLLKGVFKDPYPESPCMHEFVLSATNLTKYGVRASDVAKRILD
YGFYAPTMYFPLIVREALMIEPTETENPDTLKKFALILRKIVKEAKEKPEILKKAPHRTPVRRIKEAEANRNLILKFKDI
KE
>Mature_482_residues
MELIFEKSKKGRKGYKLPELDVEEVNIKEYLPEEYLREELDFPEVSELDVVRHYTNLSHLNYAVDTTMVPLGSCTMKYNP
RINEELVNKKEFLNVHPLTPEEYIQPLLKLVYELKELLKELGGFAEVSLQPAAGAHGELLGLLLIHAYHQDRGNKEKKVV
LIPDSAHGTNPASAAICGFDIKVVKSDKKGELDFEDFIKKLDERVAALMITNPNTLGIFERKIKEIAEELHKRDALLYMD
GANFNALVGRFKPGEWGVDVMHFNLHKTFSTPHGGGGPGAGPVGVSERLKPYLPVPQIEYDGKKYYLNWNIEKSVGKILA
FHGHFLVWLKALAYILTYGKDIKKVSEYAVLNARYLKHLLKGVFKDPYPESPCMHEFVLSATNLTKYGVRASDVAKRILD
YGFYAPTMYFPLIVREALMIEPTETENPDTLKKFALILRKIVKEAKEKPEILKKAPHRTPVRRIKEAEANRNLILKFKDI
KE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=430, Percent_Identity=40.2325581395349, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1789269, Length=399, Percent_Identity=39.0977443609023, Blast_Score=244, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17535605, Length=409, Percent_Identity=37.4083129584352, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI32564013, Length=362, Percent_Identity=38.121546961326, Blast_Score=226, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323843, Length=441, Percent_Identity=39.0022675736961, Blast_Score=266, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=39.3203883495146, Blast_Score=249, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_AQUAE (O67740)

Other databases:

- EMBL:   AE000657
- PIR:   H70463
- RefSeq:   NP_214308.1
- ProteinModelPortal:   O67740
- SMR:   O67740
- GeneID:   1193545
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1903
- NMPDR:   fig|224324.1.peg.1323
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   AAEO224324:AQ_1903-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 54974; Mature: 54974

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIFEKSKKGRKGYKLPELDVEEVNIKEYLPEEYLREELDFPEVSELDVVRHYTNLSHL
CCCCCCCCCCCCCCCCCCCCCHHHCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NYAVDTTMVPLGSCTMKYNPRINEELVNKKEFLNVHPLTPEEYIQPLLKLVYELKELLKE
HEEHHHHEEECCCEEEEECCCCCHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGGFAEVSLQPAAGAHGELLGLLLIHAYHQDRGNKEKKVVLIPDSAHGTNPASAAICGFD
HCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHEEECCE
IKVVKSDKKGELDFEDFIKKLDERVAALMITNPNTLGIFERKIKEIAEELHKRDALLYMD
EEEEECCCCCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEC
GANFNALVGRFKPGEWGVDVMHFNLHKTFSTPHGGGGPGAGPVGVSERLKPYLPVPQIEY
CCCCHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEE
DGKKYYLNWNIEKSVGKILAFHGHFLVWLKALAYILTYGKDIKKVSEYAVLNARYLKHLL
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
KGVFKDPYPESPCMHEFVLSATNLTKYGVRASDVAKRILDYGFYAPTMYFPLIVREALMI
HHHHCCCCCCCCHHHHHHHHHHCHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEE
EPTETENPDTLKKFALILRKIVKEAKEKPEILKKAPHRTPVRRIKEAEANRNLILKFKDI
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCCCEEEEECCC
KE
CC
>Mature Secondary Structure
MELIFEKSKKGRKGYKLPELDVEEVNIKEYLPEEYLREELDFPEVSELDVVRHYTNLSHL
CCCCCCCCCCCCCCCCCCCCCHHHCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NYAVDTTMVPLGSCTMKYNPRINEELVNKKEFLNVHPLTPEEYIQPLLKLVYELKELLKE
HEEHHHHEEECCCEEEEECCCCCHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGGFAEVSLQPAAGAHGELLGLLLIHAYHQDRGNKEKKVVLIPDSAHGTNPASAAICGFD
HCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHEEECCE
IKVVKSDKKGELDFEDFIKKLDERVAALMITNPNTLGIFERKIKEIAEELHKRDALLYMD
EEEEECCCCCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEC
GANFNALVGRFKPGEWGVDVMHFNLHKTFSTPHGGGGPGAGPVGVSERLKPYLPVPQIEY
CCCCHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEE
DGKKYYLNWNIEKSVGKILAFHGHFLVWLKALAYILTYGKDIKKVSEYAVLNARYLKHLL
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
KGVFKDPYPESPCMHEFVLSATNLTKYGVRASDVAKRILDYGFYAPTMYFPLIVREALMI
HHHHCCCCCCCCHHHHHHHHHHCHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEE
EPTETENPDTLKKFALILRKIVKEAKEKPEILKKAPHRTPVRRIKEAEANRNLILKFKDI
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCCCEEEEECCC
KE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320