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The map label for this gene is uvrB

Identifier: 15606895

GI number: 15606895

Start: 1305589

End: 1307580

Strand: Direct

Name: uvrB

Synonym: aq_1856

Alternate gene names: 15606895

Gene position: 1305589-1307580 (Clockwise)

Preceding gene: 15606894

Following gene: 15606897

Centisome position: 84.16

GC content: 44.38

Gene sequence:

>1992_bases
ATGGGTGTATCTGAGCAAAGGTTTAAGCTAAAAACAAACCTGAAACCCGCAGGGGACCAGCCGAAAGCCATAAAAAAACT
CCTTGAAAACCTAAGGAAAGGCGTAAAAGAACAAACACTTCTCGGAGTCACGGGAAGCGGAAAGACTTTTACTCTAGCAA
ACGTAATAGCGAAGTACAACAAACCAACTCTTGTGGTAGTTCACAACAAAATTCTCGCGGCACAGCTATACAGGGAGTTT
AAAGAACTATTCCCTGAAAACGCTGTAGAGTACTTTGTCTCTTACTACGACTATTACCAACCTGAAGCCTACATTCCCGA
AAAAGATTTATACATAGAAAAGGACGCGAGTATAAACGAAACGCTGGAACGTTTCAGACACTCCGCCACGATATCCGTTC
TAGAAAGGAGGGACGTTATAGTAGTTGCTTCAGTTTCTTGCATATACGGACTCGGGAAACCTGAGCACTACGAAAACCTG
AGGATAAAACTCCAAAGGGGAATAAGACTGAACTTGAGTAAGCTCCTGAGGAAACTCGTTGAGCTAGGATATCAGAGAAA
TGACTTTGCCATAAAGAGGGCTACCTTCTCGGTTAGGGGAGACGTGGTTGAGATAGTCCCTTCTCACACGGAAGATTACC
TCGTGAGGGTAGAGTTCTGGGACGACGAAGTTGAAAGAATAGTCCTCATGGACGCTCTGAACAGACACGTTATAAAAGAA
GTGGAAGAGTATTCTGTATTTCCCGCCTCCCACTACATAGCCCCCAGACCCACCGTTGAACAGGCACTGAAAGAAATAGA
AAAGGATTTAATAGAGAGAGTAAAGTGGTTTAAAAGTCAGGGAAGGGAAGTGGAAGCCCAGAGGCTCTACCAGAGAACTA
TGTACGACATTGAGATGATAAGAGAACTTGGGCACTGCAAAGGGATAGAAAACTACTCCCGTTACTTTGACGGGAGAAAA
CCCGGAGAGCCACCCTTTACTCTCCTTGACTACTTCCCTGAAGACTTCCTGCTCATAATAGACGAGTCTCACATGACAAT
TCCTCAACTCAGGGCTATGTACAACGGGGACAGGAGCAGGAAGGAAAAACTCGTGGAGTATGGCTGGAGGCTTCCCTCAG
CACTCGACAACAGACCCCTCAAATTTGAAGAGTTTCTGGAAAGGATTAATCAGGTAATTTACGTTTCAGCAACACCCGGA
GACTGGGAACTTGAAAGGAGCGAGGCTGTAGTGGAACAAATAGTAAGACCTACGGGACTCCTGGACCCTGTTGTGGAAGT
AAGACCGAAGATGAACCAGCTTGAGAACTTAGTAAAGGAAATAAAGGAAGTCAAAAAGAGAAAGGAAAGGGCTTTAGTTC
TTACAACAACAAAAAGGCTTGCAGAAGAAATAGCTGACTACCTGACCGAAAGGAAGATAAGAGCCAAATATATGCACTCA
GAACTGGACGCAATAGAAAGGGCACAACTGATAAGGGAACTGAGGGAGGGAAGCATAGACGTTATAGTGGGTGTAAACCT
CTTGAGGGAAGGGCTCGACCTTCCCGAAGTTTCACTAGTTGCCATAATGGACGCGGACAAAGAGGGCTTTTTAAGGAGTT
ATCAGGCACTAATACAGACCATAGGAAGGGCTGCGAGAAATATACACGGAAAGGCTATACTCTACGCGGACAGGATAACT
AAAGCCATGGAAAAAGCGATTCAAGAGACCCAGAGGCGTAGAAAGATACAGGAAGAGTTCAACAAGAAACACGGCATAAC
TCCAAAATCCATAAAGAAGCCCGTAAAGGAACTCCTCGCAATAGAAGAGCTTGATTACGTGAGCGTTCCCGAAGAACTGC
CGAAGGGAGTTAAATCAGAAGAGGACATACTCAAGAAGATCGAAAAGCTTGAAAAGGAAATGTGGAAATACGCTCAAAAC
TGGGAGTTTGAAAAAGCTGCAAAAGTTAGGGATGAAATTAAGAAACTGAAAAAGTTATTAGGTTTGGATTAG

Upstream 100 bases:

>100_bases
TAAAGTCAAGGAATTGATGGAAGCTATGGAGGGTATGAAAAAACACATAAAGGATTTAGAAATCCTCGGAGAGACGGATG
AGGATTTAACTTTTTAAAGT

Downstream 100 bases:

>100_bases
AGAGGGGAAGCGGCCCATTAGCCGCAGGAGAAAGAACTTCCGCATCCGCAGCTTCCGGTTGCGTTGGGGTTCCTTATCGT
AAACCCACCGCCCATGAAGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MGVSEQRFKLKTNLKPAGDQPKAIKKLLENLRKGVKEQTLLGVTGSGKTFTLANVIAKYNKPTLVVVHNKILAAQLYREF
KELFPENAVEYFVSYYDYYQPEAYIPEKDLYIEKDASINETLERFRHSATISVLERRDVIVVASVSCIYGLGKPEHYENL
RIKLQRGIRLNLSKLLRKLVELGYQRNDFAIKRATFSVRGDVVEIVPSHTEDYLVRVEFWDDEVERIVLMDALNRHVIKE
VEEYSVFPASHYIAPRPTVEQALKEIEKDLIERVKWFKSQGREVEAQRLYQRTMYDIEMIRELGHCKGIENYSRYFDGRK
PGEPPFTLLDYFPEDFLLIIDESHMTIPQLRAMYNGDRSRKEKLVEYGWRLPSALDNRPLKFEEFLERINQVIYVSATPG
DWELERSEAVVEQIVRPTGLLDPVVEVRPKMNQLENLVKEIKEVKKRKERALVLTTTKRLAEEIADYLTERKIRAKYMHS
ELDAIERAQLIRELREGSIDVIVGVNLLREGLDLPEVSLVAIMDADKEGFLRSYQALIQTIGRAARNIHGKAILYADRIT
KAMEKAIQETQRRRKIQEEFNKKHGITPKSIKKPVKELLAIEELDYVSVPEELPKGVKSEEDILKKIEKLEKEMWKYAQN
WEFEKAAKVRDEIKKLKKLLGLD

Sequences:

>Translated_663_residues
MGVSEQRFKLKTNLKPAGDQPKAIKKLLENLRKGVKEQTLLGVTGSGKTFTLANVIAKYNKPTLVVVHNKILAAQLYREF
KELFPENAVEYFVSYYDYYQPEAYIPEKDLYIEKDASINETLERFRHSATISVLERRDVIVVASVSCIYGLGKPEHYENL
RIKLQRGIRLNLSKLLRKLVELGYQRNDFAIKRATFSVRGDVVEIVPSHTEDYLVRVEFWDDEVERIVLMDALNRHVIKE
VEEYSVFPASHYIAPRPTVEQALKEIEKDLIERVKWFKSQGREVEAQRLYQRTMYDIEMIRELGHCKGIENYSRYFDGRK
PGEPPFTLLDYFPEDFLLIIDESHMTIPQLRAMYNGDRSRKEKLVEYGWRLPSALDNRPLKFEEFLERINQVIYVSATPG
DWELERSEAVVEQIVRPTGLLDPVVEVRPKMNQLENLVKEIKEVKKRKERALVLTTTKRLAEEIADYLTERKIRAKYMHS
ELDAIERAQLIRELREGSIDVIVGVNLLREGLDLPEVSLVAIMDADKEGFLRSYQALIQTIGRAARNIHGKAILYADRIT
KAMEKAIQETQRRRKIQEEFNKKHGITPKSIKKPVKELLAIEELDYVSVPEELPKGVKSEEDILKKIEKLEKEMWKYAQN
WEFEKAAKVRDEIKKLKKLLGLD
>Mature_662_residues
GVSEQRFKLKTNLKPAGDQPKAIKKLLENLRKGVKEQTLLGVTGSGKTFTLANVIAKYNKPTLVVVHNKILAAQLYREFK
ELFPENAVEYFVSYYDYYQPEAYIPEKDLYIEKDASINETLERFRHSATISVLERRDVIVVASVSCIYGLGKPEHYENLR
IKLQRGIRLNLSKLLRKLVELGYQRNDFAIKRATFSVRGDVVEIVPSHTEDYLVRVEFWDDEVERIVLMDALNRHVIKEV
EEYSVFPASHYIAPRPTVEQALKEIEKDLIERVKWFKSQGREVEAQRLYQRTMYDIEMIRELGHCKGIENYSRYFDGRKP
GEPPFTLLDYFPEDFLLIIDESHMTIPQLRAMYNGDRSRKEKLVEYGWRLPSALDNRPLKFEEFLERINQVIYVSATPGD
WELERSEAVVEQIVRPTGLLDPVVEVRPKMNQLENLVKEIKEVKKRKERALVLTTTKRLAEEIADYLTERKIRAKYMHSE
LDAIERAQLIRELREGSIDVIVGVNLLREGLDLPEVSLVAIMDADKEGFLRSYQALIQTIGRAARNIHGKAILYADRITK
AMEKAIQETQRRRKIQEEFNKKHGITPKSIKKPVKELLAIEELDYVSVPEELPKGVKSEEDILKKIEKLEKEMWKYAQNW
EFEKAAKVRDEIKKLKKLLGLD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=55.4054054054054, Blast_Score=752, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_AQUAE (O67708)

Other databases:

- EMBL:   AE000657
- PIR:   B70460
- RefSeq:   NP_214276.1
- ProteinModelPortal:   O67708
- GeneID:   1193515
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1856
- NMPDR:   fig|224324.1.peg.1291
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- PhylomeDB:   O67708
- ProtClustDB:   PRK05298
- BioCyc:   AAEO224324:AQ_1856-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 77340; Mature: 77209

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVSEQRFKLKTNLKPAGDQPKAIKKLLENLRKGVKEQTLLGVTGSGKTFTLANVIAKYN
CCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHEEEECCCCCEEHHHHHHHHCC
KPTLVVVHNKILAAQLYREFKELFPENAVEYFVSYYDYYQPEAYIPEKDLYIEKDASINE
CCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHH
TLERFRHSATISVLERRDVIVVASVSCIYGLGKPEHYENLRIKLQRGIRLNLSKLLRKLV
HHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
ELGYQRNDFAIKRATFSVRGDVVEIVPSHTEDYLVRVEFWDDEVERIVLMDALNRHVIKE
HCCCCCCCCEEEHEEEECCCCEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
VEEYSVFPASHYIAPRPTVEQALKEIEKDLIERVKWFKSQGREVEAQRLYQRTMYDIEMI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RELGHCKGIENYSRYFDGRKPGEPPFTLLDYFPEDFLLIIDESHMTIPQLRAMYNGDRSR
HHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHH
KEKLVEYGWRLPSALDNRPLKFEEFLERINQVIYVSATPGDWELERSEAVVEQIVRPTGL
HHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCC
LDPVVEVRPKMNQLENLVKEIKEVKKRKERALVLTTTKRLAEEIADYLTERKIRAKYMHS
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
ELDAIERAQLIRELREGSIDVIVGVNLLREGLDLPEVSLVAIMDADKEGFLRSYQALIQT
HHHHHHHHHHHHHHHCCCEEEEECHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
IGRAARNIHGKAILYADRITKAMEKAIQETQRRRKIQEEFNKKHGITPKSIKKPVKELLA
HHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IEELDYVSVPEELPKGVKSEEDILKKIEKLEKEMWKYAQNWEFEKAAKVRDEIKKLKKLL
HHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GLD
CCC
>Mature Secondary Structure 
GVSEQRFKLKTNLKPAGDQPKAIKKLLENLRKGVKEQTLLGVTGSGKTFTLANVIAKYN
CCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHEEEECCCCCEEHHHHHHHHCC
KPTLVVVHNKILAAQLYREFKELFPENAVEYFVSYYDYYQPEAYIPEKDLYIEKDASINE
CCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHH
TLERFRHSATISVLERRDVIVVASVSCIYGLGKPEHYENLRIKLQRGIRLNLSKLLRKLV
HHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
ELGYQRNDFAIKRATFSVRGDVVEIVPSHTEDYLVRVEFWDDEVERIVLMDALNRHVIKE
HCCCCCCCCEEEHEEEECCCCEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
VEEYSVFPASHYIAPRPTVEQALKEIEKDLIERVKWFKSQGREVEAQRLYQRTMYDIEMI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RELGHCKGIENYSRYFDGRKPGEPPFTLLDYFPEDFLLIIDESHMTIPQLRAMYNGDRSR
HHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHH
KEKLVEYGWRLPSALDNRPLKFEEFLERINQVIYVSATPGDWELERSEAVVEQIVRPTGL
HHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCC
LDPVVEVRPKMNQLENLVKEIKEVKKRKERALVLTTTKRLAEEIADYLTERKIRAKYMHS
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
ELDAIERAQLIRELREGSIDVIVGVNLLREGLDLPEVSLVAIMDADKEGFLRSYQALIQT
HHHHHHHHHHHHHHHCCCEEEEECHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
IGRAARNIHGKAILYADRITKAMEKAIQETQRRRKIQEEFNKKHGITPKSIKKPVKELLA
HHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IEELDYVSVPEELPKGVKSEEDILKKIEKLEKEMWKYAQNWEFEKAAKVRDEIKKLKKLL
HHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GLD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320