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The map label for this gene is dnaX [H]

Identifier: 15606894

GI number: 15606894

Start: 1303882

End: 1305303

Strand: Direct

Name: dnaX [H]

Synonym: aq_1855

Alternate gene names: 15606894

Gene position: 1303882-1305303 (Clockwise)

Preceding gene: 15606892

Following gene: 15606895

Centisome position: 84.05

GC content: 44.3

Gene sequence:

>1422_bases
ATGAACTACGTTCCCTTCGCGAGAAAGTACAGACCGAAATTCTTCAGGGAAGTAATAGGACAGGAAGCTCCCGTAAGGAT
ACTCAAAAACGCTATAAAAAACGACAGAGTGGCTCACGCCTACCTCTTTGCCGGACCGAGGGGGGTTGGGAAGACGACTA
TTGCAAGAATTCTCGCAAAAGCTTTGAACTGTAAAAATCCCTCCAAAGGTGAGCCCTGCGGTGAGTGCGAAAACTGCAGG
GAGATAGACAGGGGTGTGTTCCCTGACTTAATTGAAATGGATGCCGCCTCAAACAGGGGTATAGACGACGTAAGGGCATT
AAAAGAAGCGGTCAATTACAAACCTATAAAAGGAAAGTACAAGGTTTACATAATAGACGAAGCTCACATGCTCACGAAAG
AAGCTTTCAACGCTCTCTTAAAAACCCTCGAAGAGCCCCCTCCCAGAACTGTTTTCGTCCTTTGTACCACGGAGTACGAC
AAAATTCTTCCCACGATACTCTCAAGGTGTCAGAGGATAATCTTCTCAAAGGTAAGAAAGGAAAAAGTAATAGAGTATCT
AAAAAAGATATGTGAAAAGGAAGGGATTGAGTGCGAAGAGGGAGCCCTTGAGGTTCTGGCTCATGCCTCTGAAGGGTGCA
TGAGGGATGCAGCCTCTCTCCTGGACCAGGCGAGCGTTTACGGGGAAGGCAGGGTAACAAAAGAAGTAGTGGAGAACTTC
CTCGGAATTCTCAGTCAGGAAAGCGTTAGGAGTTTTCTGAAATTGCTTCTGAACTCAGAAGTGGACGAAGCTATAAAGTT
CCTCAGAGAACTCTCAGAAAAGGGCTACAACCTGACCAAGTTTTGGGAGATGTTAGAAGAGGAAGTGAGAAACGCAATTT
TAGTAAAGAGCCTGAAAAATCCCGAAAGCGTGGTTCAGAACTGGCAGGATTACGAAGACTTCAAAGACTACCCTCTGGAA
GCCCTCCTCTACGTTGAGAACCTGATAAACAGGGGTAAAGTTGAAGCGAGAACGAGAGAACCCTTAAGAGCCTTTGAACT
CGCGGTAATAAAGAGCCTTATAGTCAAAGACATAATTCCCGTATCCCAGCTCGGAAGTGTGGTAAAGGAAACCAAAAAGG
AAGAAAAGAAAGTTGAAGTAAAAGAAGAGCCAAAAGTAAAAGAAGAAAAACCAAAGGAGCAGGAAGAGGACAGGTTCCAG
AAAGTTTTAAACGCTGTGGACGGCAAAATCCTTAAAAGAATACTTGAAGGGGCAAAAAGGGAAGAAAGAGACGGAAAAAT
CGTCCTAAAGATAGAAGCCTCTTATCTGAGAACCATGAAAAAGGAATTTGACTCACTAAAGGAGACTTTTCCTTTTTTAG
AGTTTGAACCCGTGGAGGATAAAAAAAAACCTCAGAAGTCCAGCGGGACGAGGCTGTTTTAA

Upstream 100 bases:

>100_bases
GGCGGGACAGGGTGAACTCCCCCAGGCCCGAAAGGGAGCAAGGGTAAGCCCGCCGTCCCGTGCGCAGGGTCCTAAAACAA
ATACCCTCCAGAGGTAATAA

Downstream 100 bases:

>100_bases
AGGTAAAGGAGCTCTTCAATGCAAAAATACTCAAAGTACGAAGTAAAAGCTAAGGTCATAAAGGTGAGAATGCCCGTGGA
AGAGATAGGGCTGTTTAACG

Product: DNA polymerase III gamma subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MNYVPFARKYRPKFFREVIGQEAPVRILKNAIKNDRVAHAYLFAGPRGVGKTTIARILAKALNCKNPSKGEPCGECENCR
EIDRGVFPDLIEMDAASNRGIDDVRALKEAVNYKPIKGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTVFVLCTTEYD
KILPTILSRCQRIIFSKVRKEKVIEYLKKICEKEGIECEEGALEVLAHASEGCMRDAASLLDQASVYGEGRVTKEVVENF
LGILSQESVRSFLKLLLNSEVDEAIKFLRELSEKGYNLTKFWEMLEEEVRNAILVKSLKNPESVVQNWQDYEDFKDYPLE
ALLYVENLINRGKVEARTREPLRAFELAVIKSLIVKDIIPVSQLGSVVKETKKEEKKVEVKEEPKVKEEKPKEQEEDRFQ
KVLNAVDGKILKRILEGAKREERDGKIVLKIEASYLRTMKKEFDSLKETFPFLEFEPVEDKKKPQKSSGTRLF

Sequences:

>Translated_473_residues
MNYVPFARKYRPKFFREVIGQEAPVRILKNAIKNDRVAHAYLFAGPRGVGKTTIARILAKALNCKNPSKGEPCGECENCR
EIDRGVFPDLIEMDAASNRGIDDVRALKEAVNYKPIKGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTVFVLCTTEYD
KILPTILSRCQRIIFSKVRKEKVIEYLKKICEKEGIECEEGALEVLAHASEGCMRDAASLLDQASVYGEGRVTKEVVENF
LGILSQESVRSFLKLLLNSEVDEAIKFLRELSEKGYNLTKFWEMLEEEVRNAILVKSLKNPESVVQNWQDYEDFKDYPLE
ALLYVENLINRGKVEARTREPLRAFELAVIKSLIVKDIIPVSQLGSVVKETKKEEKKVEVKEEPKVKEEKPKEQEEDRFQ
KVLNAVDGKILKRILEGAKREERDGKIVLKIEASYLRTMKKEFDSLKETFPFLEFEPVEDKKKPQKSSGTRLF
>Mature_473_residues
MNYVPFARKYRPKFFREVIGQEAPVRILKNAIKNDRVAHAYLFAGPRGVGKTTIARILAKALNCKNPSKGEPCGECENCR
EIDRGVFPDLIEMDAASNRGIDDVRALKEAVNYKPIKGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTVFVLCTTEYD
KILPTILSRCQRIIFSKVRKEKVIEYLKKICEKEGIECEEGALEVLAHASEGCMRDAASLLDQASVYGEGRVTKEVVENF
LGILSQESVRSFLKLLLNSEVDEAIKFLRELSEKGYNLTKFWEMLEEEVRNAILVKSLKNPESVVQNWQDYEDFKDYPLE
ALLYVENLINRGKVEARTREPLRAFELAVIKSLIVKDIIPVSQLGSVVKETKKEEKKVEVKEEPKVKEEKPKEQEEDRFQ
KVLNAVDGKILKRILEGAKREERDGKIVLKIEASYLRTMKKEFDSLKETFPFLEFEPVEDKKKPQKSSGTRLF

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=278, Percent_Identity=29.4964028776978, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI194306571, Length=273, Percent_Identity=30.4029304029304, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI194306567, Length=273, Percent_Identity=30.4029304029304, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI31563534, Length=277, Percent_Identity=29.2418772563177, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI4506491, Length=296, Percent_Identity=26.6891891891892, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI31881687, Length=296, Percent_Identity=26.6891891891892, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI194306569, Length=192, Percent_Identity=31.25, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786676, Length=285, Percent_Identity=44.9122807017544, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1787341, Length=192, Percent_Identity=30.7291666666667, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=300, Percent_Identity=28, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17541988, Length=279, Percent_Identity=29.0322580645161, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17554730, Length=303, Percent_Identity=24.7524752475248, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322528, Length=300, Percent_Identity=28, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324478, Length=278, Percent_Identity=29.136690647482, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324039, Length=310, Percent_Identity=26.4516129032258, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17647857, Length=279, Percent_Identity=28.3154121863799, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18859927, Length=312, Percent_Identity=27.2435897435897, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI19921076, Length=268, Percent_Identity=26.865671641791, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 54333; Mature: 54333

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYVPFARKYRPKFFREVIGQEAPVRILKNAIKNDRVAHAYLFAGPRGVGKTTIARILAK
CCCCCCHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHEEECCCCCCHHHHHHHHHH
ALNCKNPSKGEPCGECENCREIDRGVFPDLIEMDAASNRGIDDVRALKEAVNYKPIKGKY
HHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCE
KVYIIDEAHMLTKEAFNALLKTLEEPPPRTVFVLCTTEYDKILPTILSRCQRIIFSKVRK
EEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
EKVIEYLKKICEKEGIECEEGALEVLAHASEGCMRDAASLLDQASVYGEGRVTKEVVENF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LGILSQESVRSFLKLLLNSEVDEAIKFLRELSEKGYNLTKFWEMLEEEVRNAILVKSLKN
HHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PESVVQNWQDYEDFKDYPLEALLYVENLINRGKVEARTREPLRAFELAVIKSLIVKDIIP
HHHHHHCHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
VSQLGSVVKETKKEEKKVEVKEEPKVKEEKPKEQEEDRFQKVLNAVDGKILKRILEGAKR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EERDGKIVLKIEASYLRTMKKEFDSLKETFPFLEFEPVEDKKKPQKSSGTRLF
CCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MNYVPFARKYRPKFFREVIGQEAPVRILKNAIKNDRVAHAYLFAGPRGVGKTTIARILAK
CCCCCCHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHEEECCCCCCHHHHHHHHHH
ALNCKNPSKGEPCGECENCREIDRGVFPDLIEMDAASNRGIDDVRALKEAVNYKPIKGKY
HHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCE
KVYIIDEAHMLTKEAFNALLKTLEEPPPRTVFVLCTTEYDKILPTILSRCQRIIFSKVRK
EEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
EKVIEYLKKICEKEGIECEEGALEVLAHASEGCMRDAASLLDQASVYGEGRVTKEVVENF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LGILSQESVRSFLKLLLNSEVDEAIKFLRELSEKGYNLTKFWEMLEEEVRNAILVKSLKN
HHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PESVVQNWQDYEDFKDYPLEALLYVENLINRGKVEARTREPLRAFELAVIKSLIVKDIIP
HHHHHHCHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
VSQLGSVVKETKKEEKKVEVKEEPKVKEEKPKEQEEDRFQKVLNAVDGKILKRILEGAKR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EERDGKIVLKIEASYLRTMKKEFDSLKETFPFLEFEPVEDKKKPQKSSGTRLF
CCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]