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The map label for this gene is alr

Identifier: 15606873

GI number: 15606873

Start: 1285739

End: 1286755

Strand: Direct

Name: alr

Synonym: aq_1827

Alternate gene names: 15606873

Gene position: 1285739-1286755 (Clockwise)

Preceding gene: 15606872

Following gene: 15606878

Centisome position: 82.88

GC content: 43.46

Gene sequence:

>1017_bases
ATGCCCAGAGCTATTCTGGAGATAAACAGTGAAAGGATAAGACACAACGTCAAGAAGTTATCGGAGTTTTCCGGGAAAAA
GGTTATAGCGGTTATAAAGGCGGACGCCTACGGTATAGGTTCTATACAAATGGCAAAAATACTAGAGCCTATTGAAGAAG
TGGACGCTTTCGCGGTAGCCTGCGTTGAAGAGGGGGTTGAACTCAGGAAAATGGGAATAAAAAAGGAAATACTCATACTG
GGAGGAGTACTGAAGGATGAAGTCCCTTTAGTAGAGGAGTACTTCCTTACCCCCGTTGTTTCGGATATTGAGCACCTGAG
AGCTATAGGAAACAGGGATATAAAGTTTCACGTAAAGTACGACACGGGAATGGGAAGACTTGGGTTTTTGAACGAAGTTA
TACACGACCCGAGGGTGGAAGGGATAATGAGTCACCTCTCGAGCCCGGCGGACGAAGAATTTTCCAAACTCCAGATAAAG
AAGTTTGAGGAGATAGTTAAGAAGTACACAAAAGTTGAGAAAATCCACATGGAGAGTTCAGCAGGTGTTGTGTACAGAGT
GCCTTTTACCACTCACATAAGGGTAGGGCTTGCAATGTACGGCGAAAAACCCCTGAAGAATTACCCCGTTGATATAAAAC
CCGCACTCACTCTTAAAGCTAAGTTAATATCCGTAAAGGAACTTCCTGAAAATTATCCGGTATCTTACAGCAGGACGTAC
GTAACTAAGAAAAAAACGAAAACAGGTGTAGTTGCCTTCGGGTACGCGGACGGACTCATGAAAACACTGTCCAACAGGAG
TTATTTGCTTTATAAGGGAGAAAAGCTACCAATTTTCGGGAACATTACCATGGACATGACAATAGTGGACCTGAAAAATA
CGGACGCAAAGGTAGGGGATTGGGTTTACGTGGTAAACGAAGAAAGAACCTTTACGGAACTTGCAAGAGAAGCGGGAACG
ATACCCTATGAGCTCATGTGCAACTTATCAAAAAGGATTAAAAGAGTCGTAGTGTAG

Upstream 100 bases:

>100_bases
CTTCTCCGTTTTTAGATTTGATATTTTCCCACCTTTTCTTTATCAGGCTCACTTCTGTCTTTCTGATGTCCATAGGGAAA
ATTTTAAAATACTTGAGGTA

Downstream 100 bases:

>100_bases
ATTAAAGTAAATAGAGCCACAAATAAAAAGTAAATTTTTAGTTTCTTACTCCCGAATATAATCGCGTATCCAGACTTAAA
TAAATTGTTGGACATAACCG

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MPRAILEINSERIRHNVKKLSEFSGKKVIAVIKADAYGIGSIQMAKILEPIEEVDAFAVACVEEGVELRKMGIKKEILIL
GGVLKDEVPLVEEYFLTPVVSDIEHLRAIGNRDIKFHVKYDTGMGRLGFLNEVIHDPRVEGIMSHLSSPADEEFSKLQIK
KFEEIVKKYTKVEKIHMESSAGVVYRVPFTTHIRVGLAMYGEKPLKNYPVDIKPALTLKAKLISVKELPENYPVSYSRTY
VTKKKTKTGVVAFGYADGLMKTLSNRSYLLYKGEKLPIFGNITMDMTIVDLKNTDAKVGDWVYVVNEERTFTELAREAGT
IPYELMCNLSKRIKRVVV

Sequences:

>Translated_338_residues
MPRAILEINSERIRHNVKKLSEFSGKKVIAVIKADAYGIGSIQMAKILEPIEEVDAFAVACVEEGVELRKMGIKKEILIL
GGVLKDEVPLVEEYFLTPVVSDIEHLRAIGNRDIKFHVKYDTGMGRLGFLNEVIHDPRVEGIMSHLSSPADEEFSKLQIK
KFEEIVKKYTKVEKIHMESSAGVVYRVPFTTHIRVGLAMYGEKPLKNYPVDIKPALTLKAKLISVKELPENYPVSYSRTY
VTKKKTKTGVVAFGYADGLMKTLSNRSYLLYKGEKLPIFGNITMDMTIVDLKNTDAKVGDWVYVVNEERTFTELAREAGT
IPYELMCNLSKRIKRVVV
>Mature_337_residues
PRAILEINSERIRHNVKKLSEFSGKKVIAVIKADAYGIGSIQMAKILEPIEEVDAFAVACVEEGVELRKMGIKKEILILG
GVLKDEVPLVEEYFLTPVVSDIEHLRAIGNRDIKFHVKYDTGMGRLGFLNEVIHDPRVEGIMSHLSSPADEEFSKLQIKK
FEEIVKKYTKVEKIHMESSAGVVYRVPFTTHIRVGLAMYGEKPLKNYPVDIKPALTLKAKLISVKELPENYPVSYSRTYV
TKKKTKTGVVAFGYADGLMKTLSNRSYLLYKGEKLPIFGNITMDMTIVDLKNTDAKVGDWVYVVNEERTFTELAREAGTI
PYELMCNLSKRIKRVVV

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=359, Percent_Identity=30.3621169916435, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1787439, Length=332, Percent_Identity=28.0120481927711, Blast_Score=124, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_AQUAE (O67687)

Other databases:

- EMBL:   AE000657
- PIR:   E70457
- RefSeq:   NP_214253.1
- ProteinModelPortal:   O67687
- SMR:   O67687
- GeneID:   1193494
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1827
- NMPDR:   fig|224324.1.peg.1268
- HOGENOM:   HBG712172
- OMA:   SWISERD
- ProtClustDB:   CLSK2299837
- BioCyc:   AAEO224324:AQ_1827-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 38203; Mature: 38072

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 33-33 ACT_SITE 236-236

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRAILEINSERIRHNVKKLSEFSGKKVIAVIKADAYGIGSIQMAKILEPIEEVDAFAVA
CCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
CVEEGVELRKMGIKKEILILGGVLKDEVPLVEEYFLTPVVSDIEHLRAIGNRDIKFHVKY
HHHHCHHHHHCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
DTGMGRLGFLNEVIHDPRVEGIMSHLSSPADEEFSKLQIKKFEEIVKKYTKVEKIHMESS
CCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
AGVVYRVPFTTHIRVGLAMYGEKPLKNYPVDIKPALTLKAKLISVKELPENYPVSYSRTY
CCEEEECCCEEEEEEEHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEE
VTKKKTKTGVVAFGYADGLMKTLSNRSYLLYKGEKLPIFGNITMDMTIVDLKNTDAKVGD
EEECCCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCEEEECEEEEEEEEEECCCCCCCCC
WVYVVNEERTFTELAREAGTIPYELMCNLSKRIKRVVV
EEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRAILEINSERIRHNVKKLSEFSGKKVIAVIKADAYGIGSIQMAKILEPIEEVDAFAVA
CCEEEEECHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
CVEEGVELRKMGIKKEILILGGVLKDEVPLVEEYFLTPVVSDIEHLRAIGNRDIKFHVKY
HHHHCHHHHHCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
DTGMGRLGFLNEVIHDPRVEGIMSHLSSPADEEFSKLQIKKFEEIVKKYTKVEKIHMESS
CCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
AGVVYRVPFTTHIRVGLAMYGEKPLKNYPVDIKPALTLKAKLISVKELPENYPVSYSRTY
CCEEEECCCEEEEEEEHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEE
VTKKKTKTGVVAFGYADGLMKTLSNRSYLLYKGEKLPIFGNITMDMTIVDLKNTDAKVGD
EEECCCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCEEEECEEEEEEEEEECCCCCCCCC
WVYVVNEERTFTELAREAGTIPYELMCNLSKRIKRVVV
EEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320