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The map label for this gene is ndk

Identifier: 15606713

GI number: 15606713

Start: 1120638

End: 1121066

Strand: Direct

Name: ndk

Synonym: aq_1590

Alternate gene names: 15606713

Gene position: 1120638-1121066 (Clockwise)

Preceding gene: 15606712

Following gene: 15606714

Centisome position: 72.24

GC content: 49.18

Gene sequence:

>429_bases
ATGGCCGTAGAGAGGACACTCATAATAGTGAAACCCGACGCTATGGAAAAGGGAGCTCTCGGCAAGATCCTGGACCGCTT
CATTCAGGAGGGATTCCAGATAAAAGCTTTAAAGATGTTCAGGTTTACCCCCGAAAAGGCGGGAGAATTTTACTACGTCC
ACAGGGAAAGACCCTTCTTCCAGGAACTCGTTGAGTTCATGTCTTCTGGTCCCGTGGTTGCAGCTGTACTGGAAGGTGAA
GACGCAATAAAGAGAGTAAGGGAAATAATAGGTCCTACGGACAGCGAAGAGGCGAGAAAGGTAGCTCCCAACTCCATAAG
GGCTCAGTTCGGCACGGACAAGGGTAAAAACGCCATACACGCCTCAGACTCACCCGAGAGTGCACAGTACGAGATCTGTT
TCATATTCTCCGGTCTTGAGATAGTATGA

Upstream 100 bases:

>100_bases
TTCCCTTATAGGTGGTTTTGTCTTCAAGACGCAGGCTTTCGTTCTGGACACTTCTGTTAAAACCCAGCTTGAAAAACTCG
CAAGAGTTGGAGGTGTTTAA

Downstream 100 bases:

>100_bases
AGCTTTTTAACTTCAAAGGGGAAAGGGTATTCACGCCAGGTCCAGTAGAGATACCCGACAGAATAAGGGAAGTTTTAGGC
AGACAGATAATACACCACAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MAVERTLIIVKPDAMEKGALGKILDRFIQEGFQIKALKMFRFTPEKAGEFYYVHRERPFFQELVEFMSSGPVVAAVLEGE
DAIKRVREIIGPTDSEEARKVAPNSIRAQFGTDKGKNAIHASDSPESAQYEICFIFSGLEIV

Sequences:

>Translated_142_residues
MAVERTLIIVKPDAMEKGALGKILDRFIQEGFQIKALKMFRFTPEKAGEFYYVHRERPFFQELVEFMSSGPVVAAVLEGE
DAIKRVREIIGPTDSEEARKVAPNSIRAQFGTDKGKNAIHASDSPESAQYEICFIFSGLEIV
>Mature_141_residues
AVERTLIIVKPDAMEKGALGKILDRFIQEGFQIKALKMFRFTPEKAGEFYYVHRERPFFQELVEFMSSGPVVAAVLEGED
AIKRVREIIGPTDSEEARKVAPNSIRAQFGTDKGKNAIHASDSPESAQYEICFIFSGLEIV

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=43.1654676258993, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI37693993, Length=141, Percent_Identity=43.2624113475177, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI66392227, Length=140, Percent_Identity=41.4285714285714, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI66392205, Length=140, Percent_Identity=41.4285714285714, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI4505409, Length=140, Percent_Identity=41.4285714285714, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI66392192, Length=140, Percent_Identity=41.4285714285714, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI66392203, Length=140, Percent_Identity=41.4285714285714, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI38045913, Length=140, Percent_Identity=41.4285714285714, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4557797, Length=140, Percent_Identity=41.4285714285714, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=41.3533834586466, Blast_Score=105, Evalue=9e-24,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=41.3533834586466, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=39.5522388059701, Blast_Score=100, Evalue=3e-22,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=39.7058823529412, Blast_Score=96, Evalue=8e-21,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=32.6086956521739, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=35.2517985611511, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788866, Length=142, Percent_Identity=43.6619718309859, Blast_Score=122, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=39.568345323741, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=140, Percent_Identity=40, Blast_Score=114, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=42.4460431654676, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=35.0746268656716, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24645457, Length=136, Percent_Identity=31.6176470588235, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_AQUAE (O67528)

Other databases:

- EMBL:   AE000657
- PIR:   F70437
- RefSeq:   NP_214093.1
- ProteinModelPortal:   O67528
- SMR:   O67528
- GeneID:   1193151
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1590
- NMPDR:   fig|224324.1.peg.1108
- HOGENOM:   HBG445152
- OMA:   FHFAGRE
- ProtClustDB:   CLSK2299764
- BioCyc:   AAEO224324:AQ_1590-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15943; Mature: 15811

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 120-120 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 107-107 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVERTLIIVKPDAMEKGALGKILDRFIQEGFQIKALKMFRFTPEKAGEFYYVHRERPFF
CCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEHEEEECCCCCCCEEEEECCCCHH
QELVEFMSSGPVVAAVLEGEDAIKRVREIIGPTDSEEARKVAPNSIRAQFGTDKGKNAIH
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHCCCCHHEECCCCCCCCCCEE
ASDSPESAQYEICFIFSGLEIV
CCCCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
AVERTLIIVKPDAMEKGALGKILDRFIQEGFQIKALKMFRFTPEKAGEFYYVHRERPFF
CCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEHEEEECCCCCCCEEEEECCCCHH
QELVEFMSSGPVVAAVLEGEDAIKRVREIIGPTDSEEARKVAPNSIRAQFGTDKGKNAIH
HHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHCCCCHHEECCCCCCCCCCEE
ASDSPESAQYEICFIFSGLEIV
CCCCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320