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The map label for this gene is nuoH2 [H]

Identifier: 15606568

GI number: 15606568

Start: 977204

End: 977983

Strand: Direct

Name: nuoH2 [H]

Synonym: aq_1373

Alternate gene names: 15606568

Gene position: 977204-977983 (Clockwise)

Preceding gene: 15606567

Following gene: 15606569

Centisome position: 62.99

GC content: 47.69

Gene sequence:

>780_bases
ATGCACAGTTTCTGGATAAACCTTCTCTTTGCAGTGATAAAGATCGTCGTTATACTTCTTATCGCCCTTGGTATCGGAGC
TTTCCTGACATGGGTTGAGAGGAAAGTCGCGGCACACATCCAAAGAAGACCTGGTCCCATGGTTGTAGGATGGCACGGAC
TGCTTCAGCCCCTCGCAAACGGTTTAAAACTCCTGACTAAAGAAGATCTCTTCCCGAGGTACGGAGATAAATTCCTTTAT
CACCTCGCTATAATCCTCGCCCTCGTTCCGGCTACGCTCGTGTTTTCTGTGGTGCCCTTTGGTCCTGAATTTGAAGTCTT
CGGGTACAAGGTAAAACCGATACTTTCTGACGTAAACGTGGGCCTCCTCCTCGTTTTTGCTCTCGGTTCTATGGCAGTTT
ACGCTGTAGCCCTCGCAGGGTGGGCTTCCAATTCCAAGTACCCCCTCATAGCTTCTATGAGAAAAGCGGGAGTTTTAGTC
TCCTACGAAGTAGTAATTACCTTCGCCGTAATGGGTCCCATTATGCTTGCGGGTACTCTCTCAACTTACGAAATAGTCCA
GAAACAGATAGAGCAAAATTTATGGTACATATGGGTTCAGCCTATAGCCTTTGTGGTTTACATGTTCGCAGCCCTTGCGG
AAATGGGAAGAGTTCCCTTTGACGTTCAGGAAGCTGAGGCAGAACTGGTCACAGGATTTACCGTAGAGTACGGTGGTATG
AAGTTTGGACTCTTCCCCCTCGTTGAGTGGTACATAGAAGTCTTACCTTGTCTGCTATAG

Upstream 100 bases:

>100_bases
GGCGAAGGCAGAGGAAGGTTTATAAGCAGTTTTTATGGCTTTTCTTATTTACCCTCAATTAAATTTTTGTTAAACTTAAA
AATCACTTCGGGAGGAAGGT

Downstream 100 bases:

>100_bases
CTGTAGTTCTCTTTTTCGGTGGATGGTCTCCTATAAATATACCATTTGTAGGATTTGTGGATCCTTTATTTTTCTTGGGT
CCTCTATCACCCTTCGTGTG

Product: NADH dehydrogenase I chain H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MHSFWINLLFAVIKIVVILLIALGIGAFLTWVERKVAAHIQRRPGPMVVGWHGLLQPLANGLKLLTKEDLFPRYGDKFLY
HLAIILALVPATLVFSVVPFGPEFEVFGYKVKPILSDVNVGLLLVFALGSMAVYAVALAGWASNSKYPLIASMRKAGVLV
SYEVVITFAVMGPIMLAGTLSTYEIVQKQIEQNLWYIWVQPIAFVVYMFAALAEMGRVPFDVQEAEAELVTGFTVEYGGM
KFGLFPLVEWYIEVLPCLL

Sequences:

>Translated_259_residues
MHSFWINLLFAVIKIVVILLIALGIGAFLTWVERKVAAHIQRRPGPMVVGWHGLLQPLANGLKLLTKEDLFPRYGDKFLY
HLAIILALVPATLVFSVVPFGPEFEVFGYKVKPILSDVNVGLLLVFALGSMAVYAVALAGWASNSKYPLIASMRKAGVLV
SYEVVITFAVMGPIMLAGTLSTYEIVQKQIEQNLWYIWVQPIAFVVYMFAALAEMGRVPFDVQEAEAELVTGFTVEYGGM
KFGLFPLVEWYIEVLPCLL
>Mature_259_residues
MHSFWINLLFAVIKIVVILLIALGIGAFLTWVERKVAAHIQRRPGPMVVGWHGLLQPLANGLKLLTKEDLFPRYGDKFLY
HLAIILALVPATLVFSVVPFGPEFEVFGYKVKPILSDVNVGLLLVFALGSMAVYAVALAGWASNSKYPLIASMRKAGVLV
SYEVVITFAVMGPIMLAGTLSTYEIVQKQIEQNLWYIWVQPIAFVVYMFAALAEMGRVPFDVQEAEAELVTGFTVEYGGM
KFGLFPLVEWYIEVLPCLL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=224, Percent_Identity=37.0535714285714, Blast_Score=134, Evalue=9e-32,
Organism=Escherichia coli, GI1788618, Length=240, Percent_Identity=38.3333333333333, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 28786; Mature: 28786

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSFWINLLFAVIKIVVILLIALGIGAFLTWVERKVAAHIQRRPGPMVVGWHGLLQPLAN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
GLKLLTKEDLFPRYGDKFLYHLAIILALVPATLVFSVVPFGPEFEVFGYKVKPILSDVNV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEHHHHHHHCHH
GLLLVFALGSMAVYAVALAGWASNSKYPLIASMRKAGVLVSYEVVITFAVMGPIMLAGTL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCH
STYEIVQKQIEQNLWYIWVQPIAFVVYMFAALAEMGRVPFDVQEAEAELVTGFTVEYGGM
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEECCE
KFGLFPLVEWYIEVLPCLL
EEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHSFWINLLFAVIKIVVILLIALGIGAFLTWVERKVAAHIQRRPGPMVVGWHGLLQPLAN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
GLKLLTKEDLFPRYGDKFLYHLAIILALVPATLVFSVVPFGPEFEVFGYKVKPILSDVNV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEHHHHHHHCHH
GLLLVFALGSMAVYAVALAGWASNSKYPLIASMRKAGVLVSYEVVITFAVMGPIMLAGTL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCH
STYEIVQKQIEQNLWYIWVQPIAFVVYMFAALAEMGRVPFDVQEAEAELVTGFTVEYGGM
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEECCE
KFGLFPLVEWYIEVLPCLL
EEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]