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The map label for this gene is argH

Identifier: 15606567

GI number: 15606567

Start: 975755

End: 977128

Strand: Direct

Name: argH

Synonym: aq_1372

Alternate gene names: 15606567

Gene position: 975755-977128 (Clockwise)

Preceding gene: 15606566

Following gene: 15606568

Centisome position: 62.9

GC content: 46.0

Gene sequence:

>1374_bases
ATGGAAAAACCATGGTCGGGAAGGTTTAAAGAAGAAACGGATAAGTTTGTGGAAGATTTCACGGAAAGTGTATCCTTTGA
TAAAGAGCTCGCCTTTGAAGACATAGAGCAGGATATAGCCCACGTAAAAACACTTCAGAAAGCCGGCATCCTCACGGAAG
AGGAAGCGAGAGAACTCATCCAAGAACTCCTGAAGATTAAAGAGGAGATCAAAGAAGGGAAGTTCCAGTGGAAGAAGGAG
CTGGAAGACGTTCATATGAACATTGAGGCTGAATTAATAAACAGACTCGGTGATGTAGGGAGGAAACTCCACACCGCACG
CTCCAGAAACGACCAGGTGGCAACCGACGAAAAACTGTACCTGAAGAAAGAAATAAAAGAGGTACTCCAACTCCTGAAAG
AATTGAGAAAGACGCTCGTTGAGCTTGCGGAAACAACTGTGGACTTCGTCATGCCCTCCTACACGCACCTCCAGAGGGCA
CAGCCCATCAGAGTAGCCCATTACTTTCTGGCTTACCGGGAGATTCTTCTTAAAGACTCGGAGAGGTTGATGGACACGTA
CAGACGGGTTGACGAGCTTCCTCTGGGTAGCGGAGCTGTTGCCGGTGTAGACTTTCCCCTCGACAGGTTCTACACCGCCG
AACTTCTCGGTTTCAACAGGGTAACGAGGAACTCTATGTATGCCACTGCGGAAAGGGACTTTATAATTGAATTTCTTTCA
AATTGTGCACTCATAGCCCAGCATCTTTCAAGGCTGGCAGAAGACCTTATAATCTGGAACACGGAGGAGTTTAACTTCGT
GGAGCTTCCCGACAAACTCTGCACGGGCAGTTCCATTATGCCCCAGAAAAAAAACCCTGACGTTCTTGAGTTGATAAGAG
GGAAAACGGGAAGGATTTACGGAAACCTGATCGCCCTTTTGACCACCATGAAAGCCCTTCCCATGGCCTACAACAGGGAC
ATGCAGGAAGATAAAGAACCCCTATTTGACACACTTAAAAACCTTAAAAACATGATAAAGGGTATGACTTTAGTCCTTTC
AGATCTGAGGGTTAAAGAACAGAACATGAGAAAGGCTTCTGGAAACTTCCTGCTTATCACGGATATAGCGAACTACCTCG
TAGAAAAGGGTGTACCTTTCAGGACAGCTCACCACATAGCGGGAAGCATAGTTGCCTACCTACTTGAAAAAGGCAAGAAG
TTAGAAGAGATGACTTTAGAGGAGTTCAAGCAGTTCTCCGAAAAGTTTGAAGAAGACGTGTTTGATATTTTGAGCCCTGA
AAGGGCAGCGGACAGAAAGAGGGTTTACGGAGGAACTGCGAAAGAAGAAATCTTGAGGATTATTGAGGTGGCGAAGGCAG
AGGAAGGTTTATAA

Upstream 100 bases:

>100_bases
GTTCTTGTGATACCTTTAAAGTGTCTCGCACCTTCCACTCAAGTAAAGATTTACGAGGAAGTAGTAAAGGACATAATGAA
AACTTACTAAAATTTTCCTT

Downstream 100 bases:

>100_bases
GCAGTTTTTATGGCTTTTCTTATTTACCCTCAATTAAATTTTTGTTAAACTTAAAAATCACTTCGGGAGGAAGGTATGCA
CAGTTTCTGGATAAACCTTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MEKPWSGRFKEETDKFVEDFTESVSFDKELAFEDIEQDIAHVKTLQKAGILTEEEARELIQELLKIKEEIKEGKFQWKKE
LEDVHMNIEAELINRLGDVGRKLHTARSRNDQVATDEKLYLKKEIKEVLQLLKELRKTLVELAETTVDFVMPSYTHLQRA
QPIRVAHYFLAYREILLKDSERLMDTYRRVDELPLGSGAVAGVDFPLDRFYTAELLGFNRVTRNSMYATAERDFIIEFLS
NCALIAQHLSRLAEDLIIWNTEEFNFVELPDKLCTGSSIMPQKKNPDVLELIRGKTGRIYGNLIALLTTMKALPMAYNRD
MQEDKEPLFDTLKNLKNMIKGMTLVLSDLRVKEQNMRKASGNFLLITDIANYLVEKGVPFRTAHHIAGSIVAYLLEKGKK
LEEMTLEEFKQFSEKFEEDVFDILSPERAADRKRVYGGTAKEEILRIIEVAKAEEGL

Sequences:

>Translated_457_residues
MEKPWSGRFKEETDKFVEDFTESVSFDKELAFEDIEQDIAHVKTLQKAGILTEEEARELIQELLKIKEEIKEGKFQWKKE
LEDVHMNIEAELINRLGDVGRKLHTARSRNDQVATDEKLYLKKEIKEVLQLLKELRKTLVELAETTVDFVMPSYTHLQRA
QPIRVAHYFLAYREILLKDSERLMDTYRRVDELPLGSGAVAGVDFPLDRFYTAELLGFNRVTRNSMYATAERDFIIEFLS
NCALIAQHLSRLAEDLIIWNTEEFNFVELPDKLCTGSSIMPQKKNPDVLELIRGKTGRIYGNLIALLTTMKALPMAYNRD
MQEDKEPLFDTLKNLKNMIKGMTLVLSDLRVKEQNMRKASGNFLLITDIANYLVEKGVPFRTAHHIAGSIVAYLLEKGKK
LEEMTLEEFKQFSEKFEEDVFDILSPERAADRKRVYGGTAKEEILRIIEVAKAEEGL
>Mature_457_residues
MEKPWSGRFKEETDKFVEDFTESVSFDKELAFEDIEQDIAHVKTLQKAGILTEEEARELIQELLKIKEEIKEGKFQWKKE
LEDVHMNIEAELINRLGDVGRKLHTARSRNDQVATDEKLYLKKEIKEVLQLLKELRKTLVELAETTVDFVMPSYTHLQRA
QPIRVAHYFLAYREILLKDSERLMDTYRRVDELPLGSGAVAGVDFPLDRFYTAELLGFNRVTRNSMYATAERDFIIEFLS
NCALIAQHLSRLAEDLIIWNTEEFNFVELPDKLCTGSSIMPQKKNPDVLELIRGKTGRIYGNLIALLTTMKALPMAYNRD
MQEDKEPLFDTLKNLKNMIKGMTLVLSDLRVKEQNMRKASGNFLLITDIANYLVEKGVPFRTAHHIAGSIVAYLLEKGKK
LEEMTLEEFKQFSEKFEEDVFDILSPERAADRKRVYGGTAKEEILRIIEVAKAEEGL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=442, Percent_Identity=43.2126696832579, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI68303542, Length=442, Percent_Identity=43.2126696832579, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI68303547, Length=442, Percent_Identity=40.9502262443439, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI68303549, Length=442, Percent_Identity=40.7239819004525, Blast_Score=343, Evalue=2e-94,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=45.5947136563877, Blast_Score=414, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=42.3580786026201, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221473854, Length=450, Percent_Identity=40, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI78706858, Length=450, Percent_Identity=40, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_AQUAE (O67383)

Other databases:

- EMBL:   AE000657
- PIR:   D70419
- RefSeq:   NP_213947.1
- ProteinModelPortal:   O67383
- SMR:   O67383
- GeneID:   1192913
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_1372
- NMPDR:   fig|224324.1.peg.962
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   O67383
- ProtClustDB:   PRK00855
- BioCyc:   AAEO224324:AQ_1372-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52839; Mature: 52839

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPWSGRFKEETDKFVEDFTESVSFDKELAFEDIEQDIAHVKTLQKAGILTEEEARELI
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QELLKIKEEIKEGKFQWKKELEDVHMNIEAELINRLGDVGRKLHTARSRNDQVATDEKLY
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LKKEIKEVLQLLKELRKTLVELAETTVDFVMPSYTHLQRAQPIRVAHYFLAYREILLKDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERLMDTYRRVDELPLGSGAVAGVDFPLDRFYTAELLGFNRVTRNSMYATAERDFIIEFLS
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NCALIAQHLSRLAEDLIIWNTEEFNFVELPDKLCTGSSIMPQKKNPDVLELIRGKTGRIY
HHHHHHHHHHHHHHHHEEECCCCCCEEECCHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLIALLTTMKALPMAYNRDMQEDKEPLFDTLKNLKNMIKGMTLVLSDLRVKEQNMRKAS
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNFLLITDIANYLVEKGVPFRTAHHIAGSIVAYLLEKGKKLEEMTLEEFKQFSEKFEEDV
CCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FDILSPERAADRKRVYGGTAKEEILRIIEVAKAEEGL
HHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKPWSGRFKEETDKFVEDFTESVSFDKELAFEDIEQDIAHVKTLQKAGILTEEEARELI
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QELLKIKEEIKEGKFQWKKELEDVHMNIEAELINRLGDVGRKLHTARSRNDQVATDEKLY
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LKKEIKEVLQLLKELRKTLVELAETTVDFVMPSYTHLQRAQPIRVAHYFLAYREILLKDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERLMDTYRRVDELPLGSGAVAGVDFPLDRFYTAELLGFNRVTRNSMYATAERDFIIEFLS
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NCALIAQHLSRLAEDLIIWNTEEFNFVELPDKLCTGSSIMPQKKNPDVLELIRGKTGRIY
HHHHHHHHHHHHHHHHEEECCCCCCEEECCHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLIALLTTMKALPMAYNRDMQEDKEPLFDTLKNLKNMIKGMTLVLSDLRVKEQNMRKAS
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNFLLITDIANYLVEKGVPFRTAHHIAGSIVAYLLEKGKKLEEMTLEEFKQFSEKFEEDV
CCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FDILSPERAADRKRVYGGTAKEEILRIIEVAKAEEGL
HHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320