Click here to switch to the map view.

The map label for this gene is gmhA

Identifier: 15606238

GI number: 15606238

Start: 626498

End: 627073

Strand: Direct

Name: gmhA

Synonym: aq_908

Alternate gene names: 15606238

Gene position: 626498-627073 (Clockwise)

Preceding gene: 15606235

Following gene: 15606239

Centisome position: 40.38

GC content: 51.04

Gene sequence:

>576_bases
ATGTTGGAAAAGGTTAAGAAAATATTTAGGGAAAGTGCGGAGGTAAAACTCGCCTTCGTGGAGCTCTACGCCCAGCAAAT
TGTAGACGTTGCGGGAATAATAGCGACCGCCCTGAAAGACGGAAATAAAGTTCTCCTCTTCGGAAACGGAGGCAGTGCCG
CGGACGCCCAGCACATAGCGGCGGAACTAGTGGGAAGGTTCAAAAAGGAGAGGAGACCGCTTCCCGCCATAGCACTCACC
ACGGACACGTCTATCCTCACAGCTCTCGGGAACGATTACGGCTTTGAGACGATATTTGAAAGACAGGTGGAAGCCCTGTG
TATGCCCGGAGACGTGGCTATAGGGATAACGACTTCCGGGAACTCTGAAAACGTTATAAGGGGTTTAAAAAAAGCCCACG
ACCTCGGAGCAACCACGATAGCCTTCACGGGAAGGAACGGCGGAAAAGTAGCCCAGATAGCCCACTACACATTCATAGTT
CCCTCTTACGAGACTCAGAGGATTCAGGAGTGTCACATAACCCTCGGACACGTTCTCTGTGAACTCGTTGAAGAGATGGT
ATGCGAAAGGTCCTAG

Upstream 100 bases:

>100_bases
GTGGCTTTGTCTATGGCCTCCTGGACGAGTTTTGCCATTTTTATTACCTGTTCCTTTGTCTCTTCAAGTTCTTTGAAGAG
TTTCATAATAGTATTAATAT

Downstream 100 bases:

>100_bases
TCTTTTTAAAGAATTCCAAAAAGGCATTTGAGACTTTTAAAAGAGTTGAAAGAGTTTTAAAAGATTTAAACCTCAGCTAC
AAAAAGTTTATAAACAGGAA

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MLEKVKKIFRESAEVKLAFVELYAQQIVDVAGIIATALKDGNKVLLFGNGGSAADAQHIAAELVGRFKKERRPLPAIALT
TDTSILTALGNDYGFETIFERQVEALCMPGDVAIGITTSGNSENVIRGLKKAHDLGATTIAFTGRNGGKVAQIAHYTFIV
PSYETQRIQECHITLGHVLCELVEEMVCERS

Sequences:

>Translated_191_residues
MLEKVKKIFRESAEVKLAFVELYAQQIVDVAGIIATALKDGNKVLLFGNGGSAADAQHIAAELVGRFKKERRPLPAIALT
TDTSILTALGNDYGFETIFERQVEALCMPGDVAIGITTSGNSENVIRGLKKAHDLGATTIAFTGRNGGKVAQIAHYTFIV
PSYETQRIQECHITLGHVLCELVEEMVCERS
>Mature_191_residues
MLEKVKKIFRESAEVKLAFVELYAQQIVDVAGIIATALKDGNKVLLFGNGGSAADAQHIAAELVGRFKKERRPLPAIALT
TDTSILTALGNDYGFETIFERQVEALCMPGDVAIGITTSGNSENVIRGLKKAHDLGATTIAFTGRNGGKVAQIAHYTFIV
PSYETQRIQECHITLGHVLCELVEEMVCERS

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1789539, Length=188, Percent_Identity=38.8297872340425, Blast_Score=141, Evalue=2e-35,
Organism=Escherichia coli, GI1786416, Length=187, Percent_Identity=43.8502673796791, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_AQUAE (O67054)

Other databases:

- EMBL:   AE000657
- PIR:   C70378
- RefSeq:   NP_213616.1
- ProteinModelPortal:   O67054
- SMR:   O67054
- GeneID:   1193596
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_908
- NMPDR:   fig|224324.1.peg.631
- HOGENOM:   HBG671955
- OMA:   IIAHARD
- PhylomeDB:   O67054
- ProtClustDB:   PRK13937
- BioCyc:   AAEO224324:AQ_908-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR020620
- InterPro:   IPR001347

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20706; Mature: 20706

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS51464 SIS

Important sites: BINDING 62-62 BINDING 122-122 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKVKKIFRESAEVKLAFVELYAQQIVDVAGIIATALKDGNKVLLFGNGGSAADAQHIA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
AELVGRFKKERRPLPAIALTTDTSILTALGNDYGFETIFERQVEALCMPGDVAIGITTSG
HHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECC
NSENVIRGLKKAHDLGATTIAFTGRNGGKVAQIAHYTFIVPSYETQRIQECHITLGHVLC
CCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHH
ELVEEMVCERS
HHHHHHHHCCC
>Mature Secondary Structure
MLEKVKKIFRESAEVKLAFVELYAQQIVDVAGIIATALKDGNKVLLFGNGGSAADAQHIA
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
AELVGRFKKERRPLPAIALTTDTSILTALGNDYGFETIFERQVEALCMPGDVAIGITTSG
HHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECC
NSENVIRGLKKAHDLGATTIAFTGRNGGKVAQIAHYTFIVPSYETQRIQECHITLGHVLC
CCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHH
ELVEEMVCERS
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320