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The map label for this gene is purM [H]

Identifier: 15606152

GI number: 15606152

Start: 532826

End: 533821

Strand: Direct

Name: purM [H]

Synonym: aq_769

Alternate gene names: 15606152

Gene position: 532826-533821 (Clockwise)

Preceding gene: 15606151

Following gene: 15606153

Centisome position: 34.35

GC content: 44.68

Gene sequence:

>996_bases
ATGGTCACCTACAGGTCTGCGGGAGTTGACATAGACAAGGCGAACGAGTTCGTGAAGTTCATAAAAGAAAAGGTAAAAAA
AGAGTTTAATCTGGAAGAATTCGGAGGATTTGCGAGCGGTTTCCCGATAAAGGGTTATAAAAAACCCATTCTCTTTTCCA
CAACAGACGGCGTAGGAACGAAACTCAAAGTAGCACAGGCTGTGGGTGTTCACAATACCGTGGGAATAGATCTCGTTGCG
ATGAACGTAAACGACCTGATAACCACGGGGGCGGACCCCTTCATATTTCTGGACTACATAGCCACGGGAAAGCTGGATCT
TGAAGTTATGAAACAGGTAATGGAGGGGATTATAAAGGGCTGCAGGGAGGGAGAGGTAATTCTCGCAGGCGGTGAGACTG
CGGAGATGCCCGGATTTTACCCGGAAGGGGTTTACGACCTTGCAGGCTTTTGCGTTGGACTTTGTGAGGAAGATGAAGTA
ATTACGGGTAAAGAAATAAAGCCCGGGGACCTTCTTTTAGGACTTCCTTCTTCTGGATTTCACAGTAACGGATACTCTCT
CATAAGGAAAGTTCTTGAGATGAACAACGTTTCCTATGAGGATTACGTGGAAGAGCTCGGCAAAAAAGTGTGGGAAGTTT
TACTCGTCCCCACGAGGATATACGTAAAGGAAATTAAAAAACTTAAAAAGAATGTAAAAATTAAGGGGATAGCCCACATA
ACGGGCGGAGGAATTCCCGAAAACCTGATAAGGATACTTCCCGAGGGAACAAAGGCTGTAGTTTACAAAAAGAACATTCC
ACAAAACCCCGTGTTTTCCTGGATTCAAAGACTCGGAAATGTAGAGGAAAGGGAAATGTTCAGGACCTTTAACATGGGCG
TGGGAATGATAGTTATTCTGGACAAAGAAGAGTTTGATAAGGCAAGGGAGTTAATACCGGAGTCCTTTTACTTGGGTGAA
ATCCTTGCGGGAAGAAAGGAAGTGGAAATCCTGTAG

Upstream 100 bases:

>100_bases
GTGAAGACGAGGTAAACAAGATAGCCCTCATTTCCAGTACACTCACGTCCGTGGGACCCATATACACGGTGGTTGAGGAG
TTTTACCTCGGAGGGTGAAT

Downstream 100 bases:

>100_bases
CCCGTCTTTCTTTCGCTCTTTTGCTTTTGTTTAAAGTGGTAATAAGCGTAAGCCATAACTATAAAGAAAAAAATTAAGGT
TGCTATCCTTACCCACCTCT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVTYRSAGVDIDKANEFVKFIKEKVKKEFNLEEFGGFASGFPIKGYKKPILFSTTDGVGTKLKVAQAVGVHNTVGIDLVA
MNVNDLITTGADPFIFLDYIATGKLDLEVMKQVMEGIIKGCREGEVILAGGETAEMPGFYPEGVYDLAGFCVGLCEEDEV
ITGKEIKPGDLLLGLPSSGFHSNGYSLIRKVLEMNNVSYEDYVEELGKKVWEVLLVPTRIYVKEIKKLKKNVKIKGIAHI
TGGGIPENLIRILPEGTKAVVYKKNIPQNPVFSWIQRLGNVEEREMFRTFNMGVGMIVILDKEEFDKARELIPESFYLGE
ILAGRKEVEIL

Sequences:

>Translated_331_residues
MVTYRSAGVDIDKANEFVKFIKEKVKKEFNLEEFGGFASGFPIKGYKKPILFSTTDGVGTKLKVAQAVGVHNTVGIDLVA
MNVNDLITTGADPFIFLDYIATGKLDLEVMKQVMEGIIKGCREGEVILAGGETAEMPGFYPEGVYDLAGFCVGLCEEDEV
ITGKEIKPGDLLLGLPSSGFHSNGYSLIRKVLEMNNVSYEDYVEELGKKVWEVLLVPTRIYVKEIKKLKKNVKIKGIAHI
TGGGIPENLIRILPEGTKAVVYKKNIPQNPVFSWIQRLGNVEEREMFRTFNMGVGMIVILDKEEFDKARELIPESFYLGE
ILAGRKEVEIL
>Mature_331_residues
MVTYRSAGVDIDKANEFVKFIKEKVKKEFNLEEFGGFASGFPIKGYKKPILFSTTDGVGTKLKVAQAVGVHNTVGIDLVA
MNVNDLITTGADPFIFLDYIATGKLDLEVMKQVMEGIIKGCREGEVILAGGETAEMPGFYPEGVYDLAGFCVGLCEEDEV
ITGKEIKPGDLLLGLPSSGFHSNGYSLIRKVLEMNNVSYEDYVEELGKKVWEVLLVPTRIYVKEIKKLKKNVKIKGIAHI
TGGGIPENLIRILPEGTKAVVYKKNIPQNPVFSWIQRLGNVEEREMFRTFNMGVGMIVILDKEEFDKARELIPESFYLGE
ILAGRKEVEIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=336, Percent_Identity=44.047619047619, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI209869995, Length=336, Percent_Identity=44.047619047619, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI209869993, Length=336, Percent_Identity=44.047619047619, Blast_Score=265, Evalue=6e-71,
Organism=Escherichia coli, GI1788845, Length=316, Percent_Identity=50, Blast_Score=302, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17567511, Length=329, Percent_Identity=41.0334346504559, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6321203, Length=331, Percent_Identity=41.9939577039275, Blast_Score=252, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24582400, Length=288, Percent_Identity=42.0138888888889, Blast_Score=212, Evalue=3e-55,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36768; Mature: 36768

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTYRSAGVDIDKANEFVKFIKEKVKKEFNLEEFGGFASGFPIKGYKKPILFSTTDGVGT
CCEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
KLKVAQAVGVHNTVGIDLVAMNVNDLITTGADPFIFLDYIATGKLDLEVMKQVMEGIIKG
EEEHHHHHCCCCCCCEEEEEECHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHC
CREGEVILAGGETAEMPGFYPEGVYDLAGFCVGLCEEDEVITGKEIKPGDLLLGLPSSGF
CCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEECCCCCC
HSNGYSLIRKVLEMNNVSYEDYVEELGKKVWEVLLVPTRIYVKEIKKLKKNVKIKGIAHI
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEEEE
TGGGIPENLIRILPEGTKAVVYKKNIPQNPVFSWIQRLGNVEEREMFRTFNMGVGMIVIL
CCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEE
DKEEFDKARELIPESFYLGEILAGRKEVEIL
CCHHHHHHHHHCCCHHHHHHHHCCCCCEECC
>Mature Secondary Structure
MVTYRSAGVDIDKANEFVKFIKEKVKKEFNLEEFGGFASGFPIKGYKKPILFSTTDGVGT
CCEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
KLKVAQAVGVHNTVGIDLVAMNVNDLITTGADPFIFLDYIATGKLDLEVMKQVMEGIIKG
EEEHHHHHCCCCCCCEEEEEECHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHC
CREGEVILAGGETAEMPGFYPEGVYDLAGFCVGLCEEDEVITGKEIKPGDLLLGLPSSGF
CCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEECCCCCC
HSNGYSLIRKVLEMNNVSYEDYVEELGKKVWEVLLVPTRIYVKEIKKLKKNVKIKGIAHI
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEEEE
TGGGIPENLIRILPEGTKAVVYKKNIPQNPVFSWIQRLGNVEEREMFRTFNMGVGMIVIL
CCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEE
DKEEFDKARELIPESFYLGEILAGRKEVEIL
CCHHHHHHHHHCCCHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]