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The map label for this gene is murB1

Identifier: 15605988

GI number: 15605988

Start: 353194

End: 354087

Strand: Direct

Name: murB1

Synonym: aq_520

Alternate gene names: 15605988

Gene position: 353194-354087 (Clockwise)

Preceding gene: 15605987

Following gene: 15605989

Centisome position: 22.77

GC content: 37.7

Gene sequence:

>894_bases
ATGCTCTTCCTAAAGAACGTTCCCCTTCAGAACCTTACGACTATAAAAATAGGGGGAAGGGTATCCTTTTACGCAGAGCC
TTCCGATCTAAAGGAAATTTCCCTATGTATTGATTTTTCAAAATCCCGAGACATTCCTCTTTTTGTTTTGGGTAACGGTT
CTAATACTATTTTCGGTGACGTAAGAGGGCTCGTTGTAAATTTAAAAAACTTAAAAGGTTTTAAAGTAAAAGAAATTAAA
GGGAAATTTTTTGTAGAAGCTTTTTCCGGAACGCCTTTAAAGGATTTAATAAGGTTTAGTGTAAAGGAAAATGTAAAGAG
TTTTTACAAACTTCTCGGTTTTCCGGCAAGTGTCGGGGGAGCGGTTAGTATGAACGCCGGGGCTTTTGGGGTTGAGATAT
CGGATTTTTTAAAGGAAGTTTACTTCGTAGATTGGGAGGGGAAACTCCAAAAAGCAAAAAGGGATGAACTGAATTTTTCT
TACAGAAAATCGCCTTTTCCAAAACTTGGAATAGTTTTCAAAGTAGTTTTTGAGTTTGAAAGAAGTAAAGAAAATATACT
TCCCAAGTACGAAAAAATAAGAAGAATAAGGAAAGAAAAGCAACCTATAAACCTTCCAACCAGCGGTTCTACCTTCAAAA
ATCCGGAGGGTAATTTCGCGGGAAAGCTTCTGGAAAAAGCAGGTTTAAAAGGTTTTAGACTTAAAAACGTAGGATTTTCC
GAAAAACACGCTAACTTCCTTGTAAACTACGGAGGTGGAACTTTTTCGGAAGTGGTAGATTTAATAAATATTGCAAAGGA
AAGGGTTTACGAAAACTTCGGTATAGTATTGGAGGAGGAGGTAAAGCTGATTGAGAGTAGTGGTTCTGATGGGTGGAAGG
TCCTCGGAGCGTGA

Upstream 100 bases:

>100_bases
TATCTTGATGCTTTTCACATTTGCTTTCATAGTTTTTTATACATGGCTTTACTTCAGAATAGTCAAGTTTAAAACTCCGA
AAATCTTTAGAATTAAATAA

Downstream 100 bases:

>100_bases
AATATCCTTGAAAACGGGAAAGGCCGTTGCAAAGGCATTAAGAGAACTGGGGCACGAAGTTTACGAGCTTGACCTTGATA
AGGAACTTCCCTGTAAACTC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLFLKNVPLQNLTTIKIGGRVSFYAEPSDLKEISLCIDFSKSRDIPLFVLGNGSNTIFGDVRGLVVNLKNLKGFKVKEIK
GKFFVEAFSGTPLKDLIRFSVKENVKSFYKLLGFPASVGGAVSMNAGAFGVEISDFLKEVYFVDWEGKLQKAKRDELNFS
YRKSPFPKLGIVFKVVFEFERSKENILPKYEKIRRIRKEKQPINLPTSGSTFKNPEGNFAGKLLEKAGLKGFRLKNVGFS
EKHANFLVNYGGGTFSEVVDLINIAKERVYENFGIVLEEEVKLIESSGSDGWKVLGA

Sequences:

>Translated_297_residues
MLFLKNVPLQNLTTIKIGGRVSFYAEPSDLKEISLCIDFSKSRDIPLFVLGNGSNTIFGDVRGLVVNLKNLKGFKVKEIK
GKFFVEAFSGTPLKDLIRFSVKENVKSFYKLLGFPASVGGAVSMNAGAFGVEISDFLKEVYFVDWEGKLQKAKRDELNFS
YRKSPFPKLGIVFKVVFEFERSKENILPKYEKIRRIRKEKQPINLPTSGSTFKNPEGNFAGKLLEKAGLKGFRLKNVGFS
EKHANFLVNYGGGTFSEVVDLINIAKERVYENFGIVLEEEVKLIESSGSDGWKVLGA
>Mature_297_residues
MLFLKNVPLQNLTTIKIGGRVSFYAEPSDLKEISLCIDFSKSRDIPLFVLGNGSNTIFGDVRGLVVNLKNLKGFKVKEIK
GKFFVEAFSGTPLKDLIRFSVKENVKSFYKLLGFPASVGGAVSMNAGAFGVEISDFLKEVYFVDWEGKLQKAKRDELNFS
YRKSPFPKLGIVFKVVFEFERSKENILPKYEKIRRIRKEKQPINLPTSGSTFKNPEGNFAGKLLEKAGLKGFRLKNVGFS
EKHANFLVNYGGGTFSEVVDLINIAKERVYENFGIVLEEEVKLIESSGSDGWKVLGA

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_AQUAE (O66805)

Other databases:

- EMBL:   AE000657
- PIR:   A70347
- RefSeq:   NP_213365.1
- ProteinModelPortal:   O66805
- SMR:   O66805
- GeneID:   1193223
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_520
- NMPDR:   fig|224324.1.peg.380
- HOGENOM:   HBG686573
- OMA:   KITFIND
- PhylomeDB:   O66805
- ProtClustDB:   CLSK233254
- BioCyc:   AAEO224324:AQ_520-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33266; Mature: 33266

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 162-162 ACT_SITE 210-210 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLKNVPLQNLTTIKIGGRVSFYAEPSDLKEISLCIDFSKSRDIPLFVLGNGSNTIFGD
CEEECCCCCCCEEEEEECCEEEEEECCCCCCEEEEEEEECCCCCCEEEEEECCCCEEEEC
VRGLVVNLKNLKGFKVKEIKGKFFVEAFSGTPLKDLIRFSVKENVKSFYKLLGFPASVGG
CCEEEEEECCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AVSMNAGAFGVEISDFLKEVYFVDWEGKLQKAKRDELNFSYRKSPFPKLGIVFKVVFEFE
EEEECCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RSKENILPKYEKIRRIRKEKQPINLPTSGSTFKNPEGNFAGKLLEKAGLKGFRLKNVGFS
HCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCC
EKHANFLVNYGGGTFSEVVDLINIAKERVYENFGIVLEEEVKLIESSGSDGWKVLGA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCCEEECCC
>Mature Secondary Structure
MLFLKNVPLQNLTTIKIGGRVSFYAEPSDLKEISLCIDFSKSRDIPLFVLGNGSNTIFGD
CEEECCCCCCCEEEEEECCEEEEEECCCCCCEEEEEEEECCCCCCEEEEEECCCCEEEEC
VRGLVVNLKNLKGFKVKEIKGKFFVEAFSGTPLKDLIRFSVKENVKSFYKLLGFPASVGG
CCEEEEEECCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AVSMNAGAFGVEISDFLKEVYFVDWEGKLQKAKRDELNFSYRKSPFPKLGIVFKVVFEFE
EEEECCCCCCCCHHHHHHHHEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RSKENILPKYEKIRRIRKEKQPINLPTSGSTFKNPEGNFAGKLLEKAGLKGFRLKNVGFS
HCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCC
EKHANFLVNYGGGTFSEVVDLINIAKERVYENFGIVLEEEVKLIESSGSDGWKVLGA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320