Click here to switch to the map view.

The map label for this gene is gua [C]

Identifier: 15605936

GI number: 15605936

Start: 302447

End: 303136

Strand: Direct

Name: gua [C]

Synonym: aq_443

Alternate gene names: 15605936

Gene position: 302447-303136 (Clockwise)

Preceding gene: 15605934

Following gene: 15605937

Centisome position: 19.5

GC content: 44.35

Gene sequence:

>690_bases
ATGCTTCTGAACCTGGATGTGAGAATGCAACTAAAGGAGCTGGCACAAAAGGAATTCAAAGAACCTGTTAGTATAAAGCT
GTTTTCTCAGGCTATTGGATGTGAGTCCTGCCAAACCGCGGAAGAACTTCTGAAGGAAACCGTTGAGGTTATCGGAGAGG
CTGTGGGACAGGATAAGATAAAGCTCGACATATACTCTCCCTTTACTCATAAGGAAGAAACGGAAAAGTACGGAGTTGAC
AGGGTTCCGACAATAGTTATAGAAGGAGACAAGGATTACGGAATAAGGTATATAGGACTTCCCGCGGGACTGGAGTTTAC
CACACTCATAAACGGTATATTCCACGTTTCTCAAAGAAAGCCTCAACTTTCTGAAAAAACTCTTGAACTCCTTCAGGTAG
TTGACATTCCAATAGAGATATGGGTTTTCGTTACGACTTCCTGCGGATACTGTCCTTCTGCAGCGGTAATGGCTTGGGAC
TTTGCGCTGGCAAACGACTACATAACTTCTAAGGTTATAGACGCTTCAGAGAATCAAGACCTTGCCGAACAATTCCAGGT
TGTAGGTGTCCCTAAGATAGTCATAAACAAGGGTGTGGCGGAATTCGTGGGAGCACAACCGGAGAACGCCTTCCTCGGTT
ATATAATGGCGGTTTACGAAAAACTCAAGAGGGAAAAAGAACAGGCTTAA

Upstream 100 bases:

>100_bases
TCTCCTGTCCCACCATGCGAAGGCTATGACACTCACGGTCAACATTTTAGATTAAACTCTTCGATTAAGATATACTCTAT
AACCTGAAGGAGGTTAGCAA

Downstream 100 bases:

>100_bases
TGCGTTTCTTAGATAGATTCTTCAAAAAGAAGAAGAAAGAGGAGGCTCTATGGACAAAGTGTCCGAACTGTAAAAGCCTC
CTCTACGTTCCCGACCTGGA

Product: glutaredoxin-like protein

Products: an alcohol; H2O; NAD [C]

Alternate protein names: Glutaredoxin-Like Domain-Containing Protein; Glutaredoxin-Like Protein; Thioredoxin Reductase; FAD-Dependent Pyridine Nucleotide-Disulphide Oxidoreductase; Glutaredoxin-Related Protein; Protein Disulfide Oxidoreductase; Protein-Disulfide Oxidoreductase; Alkyl Hydroperoxide Reductase Subunit F; NADH Dehydrogenase; Dehydrogenase Selenocysteine-Containing; Dehydrogenase Selenocysteine-Containing Protein; Alkyl Hydroperoxide Reductase F Subunit; Redoxin-Like Protein; Glutaredoxin Related Protein; Alkyl Hydroperoxide Reductase Subunit F Related Protein; Alkyl Hydroperoxide Reductase Large Subunit

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MLLNLDVRMQLKELAQKEFKEPVSIKLFSQAIGCESCQTAEELLKETVEVIGEAVGQDKIKLDIYSPFTHKEETEKYGVD
RVPTIVIEGDKDYGIRYIGLPAGLEFTTLINGIFHVSQRKPQLSEKTLELLQVVDIPIEIWVFVTTSCGYCPSAAVMAWD
FALANDYITSKVIDASENQDLAEQFQVVGVPKIVINKGVAEFVGAQPENAFLGYIMAVYEKLKREKEQA

Sequences:

>Translated_229_residues
MLLNLDVRMQLKELAQKEFKEPVSIKLFSQAIGCESCQTAEELLKETVEVIGEAVGQDKIKLDIYSPFTHKEETEKYGVD
RVPTIVIEGDKDYGIRYIGLPAGLEFTTLINGIFHVSQRKPQLSEKTLELLQVVDIPIEIWVFVTTSCGYCPSAAVMAWD
FALANDYITSKVIDASENQDLAEQFQVVGVPKIVINKGVAEFVGAQPENAFLGYIMAVYEKLKREKEQA
>Mature_229_residues
MLLNLDVRMQLKELAQKEFKEPVSIKLFSQAIGCESCQTAEELLKETVEVIGEAVGQDKIKLDIYSPFTHKEETEKYGVD
RVPTIVIEGDKDYGIRYIGLPAGLEFTTLINGIFHVSQRKPQLSEKTLELLQVVDIPIEIWVFVTTSCGYCPSAAVMAWD
FALANDYITSKVIDASENQDLAEQFQVVGVPKIVINKGVAEFVGAQPENAFLGYIMAVYEKLKREKEQA

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.6.4.- [C]

Molecular weight: Translated: 25641; Mature: 25641

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNLDVRMQLKELAQKEFKEPVSIKLFSQAIGCESCQTAEELLKETVEVIGEAVGQDKI
CEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEE
KLDIYSPFTHKEETEKYGVDRVPTIVIEGDKDYGIRYIGLPAGLEFTTLINGIFHVSQRK
EEEEECCCCCCHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
PQLSEKTLELLQVVDIPIEIWVFVTTSCGYCPSAAVMAWDFALANDYITSKVIDASENQD
CCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
LAEQFQVVGVPKIVINKGVAEFVGAQPENAFLGYIMAVYEKLKREKEQA
HHHHHHHCCCCHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLLNLDVRMQLKELAQKEFKEPVSIKLFSQAIGCESCQTAEELLKETVEVIGEAVGQDKI
CEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEE
KLDIYSPFTHKEETEKYGVDRVPTIVIEGDKDYGIRYIGLPAGLEFTTLINGIFHVSQRK
EEEEECCCCCCHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
PQLSEKTLELLQVVDIPIEIWVFVTTSCGYCPSAAVMAWDFALANDYITSKVIDASENQD
CCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
LAEQFQVVGVPKIVINKGVAEFVGAQPENAFLGYIMAVYEKLKREKEQA
HHHHHHHCCCCHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ROOH; Proton; NADH [C]

Specific reaction: ROOH + Proton + NADH = an alcohol + H2O + NAD [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA