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The map label for this gene is mutY1 [H]

Identifier: 15605819

GI number: 15605819

Start: 183890

End: 184531

Strand: Direct

Name: mutY1 [H]

Synonym: aq_282

Alternate gene names: 15605819

Gene position: 183890-184531 (Clockwise)

Preceding gene: 15605814

Following gene: 15605825

Centisome position: 11.85

GC content: 42.21

Gene sequence:

>642_bases
ATGAAAAGGGAAGACGTGCCTAAAGTTCTTGAAATTCTAAAAAGGGAATTTCCGAAATGGAATGCTCCCGTAGTTCACAT
GATAGCCCAGCACGATAAAGATCCCTTCAGGGTTCTGGTGTGTGCACTGCTTTCTACGAGAACAAAGGACGAACTCACTT
GGAGAGTTTGTAAAAGGTTTTTTGAAAAGGTAAAATCTCCCGAAGATCTTATAAAACTTTCCGAAAAAGAAATTGAAGAA
CTAATTTATCCTGTGGGTTTTTACAGGGTAAAGGCTAAACAATTAAAAGAGATTGGAAAAATCCTGATTGAGAAGTACGG
CGGGAAAGTCCCGGATACACTGGAAGAACTTCTGAAACTTCCGGGTGTGGGCAGAAAGGTGGCAAACCTCGTCCTTTCAA
AGGGATTTAATAAACCTGCTATAGTCGTTGACGTTCACGTCCACAGGATAGTGAACAGGTGGTGTCTGGTGAAGACGAAA
ACACCTGAAGAAACGGAGAGGAAATTAATGGAAATAGTTCCAAAAGAACTCTGGAGCGATATCAATTACCTTTTGGTTGC
CTTTGGGCAAACGATATGCCTTCCGAGAAAGCCGAAATGCGAGGAGTGCCCTGTAGAAAAGTACTGCGGAAAGTGCCTTT
AA

Upstream 100 bases:

>100_bases
TTATCACAAAAAGTTCTATGATATTAATCACAAAATCCTTTGCGCCAAAAACTTTCTTCTCATTAATGTCCATTCTACAA
ATCCCATAAAATCTTCCCTT

Downstream 100 bases:

>100_bases
CTCTTTTCACCGCCTATTTCAAAGTCTTCGGGTTTAATATTTTCGAGCCACTCCCTTAACTTCTTCTTCTCTTCGTCCTC
TTCGGGTTCCGGCAGTTTTG

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKREDVPKVLEILKREFPKWNAPVVHMIAQHDKDPFRVLVCALLSTRTKDELTWRVCKRFFEKVKSPEDLIKLSEKEIEE
LIYPVGFYRVKAKQLKEIGKILIEKYGGKVPDTLEELLKLPGVGRKVANLVLSKGFNKPAIVVDVHVHRIVNRWCLVKTK
TPEETERKLMEIVPKELWSDINYLLVAFGQTICLPRKPKCEECPVEKYCGKCL

Sequences:

>Translated_213_residues
MKREDVPKVLEILKREFPKWNAPVVHMIAQHDKDPFRVLVCALLSTRTKDELTWRVCKRFFEKVKSPEDLIKLSEKEIEE
LIYPVGFYRVKAKQLKEIGKILIEKYGGKVPDTLEELLKLPGVGRKVANLVLSKGFNKPAIVVDVHVHRIVNRWCLVKTK
TPEETERKLMEIVPKELWSDINYLLVAFGQTICLPRKPKCEECPVEKYCGKCL
>Mature_213_residues
MKREDVPKVLEILKREFPKWNAPVVHMIAQHDKDPFRVLVCALLSTRTKDELTWRVCKRFFEKVKSPEDLIKLSEKEIEE
LIYPVGFYRVKAKQLKEIGKILIEKYGGKVPDTLEELLKLPGVGRKVANLVLSKGFNKPAIVVDVHVHRIVNRWCLVKTK
TPEETERKLMEIVPKELWSDINYLLVAFGQTICLPRKPKCEECPVEKYCGKCL

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=200, Percent_Identity=40, Blast_Score=158, Evalue=3e-39,
Organism=Homo sapiens, GI115298648, Length=191, Percent_Identity=27.7486910994764, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI6912520, Length=191, Percent_Identity=27.7486910994764, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI115298650, Length=193, Percent_Identity=28.4974093264249, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI190358497, Length=191, Percent_Identity=27.7486910994764, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI115298654, Length=193, Percent_Identity=28.4974093264249, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI115298652, Length=193, Percent_Identity=28.4974093264249, Blast_Score=88, Evalue=7e-18,
Organism=Escherichia coli, GI1787920, Length=202, Percent_Identity=33.1683168316832, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789331, Length=186, Percent_Identity=29.5698924731183, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17554540, Length=191, Percent_Identity=41.3612565445026, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319304, Length=175, Percent_Identity=41.1428571428571, Blast_Score=115, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324530, Length=194, Percent_Identity=35.0515463917526, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45550361, Length=177, Percent_Identity=43.5028248587571, Blast_Score=152, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 24766; Mature: 24766

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREDVPKVLEILKREFPKWNAPVVHMIAQHDKDPFRVLVCALLSTRTKDELTWRVCKRF
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
FEKVKSPEDLIKLSEKEIEELIYPVGFYRVKAKQLKEIGKILIEKYGGKVPDTLEELLKL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
PGVGRKVANLVLSKGFNKPAIVVDVHVHRIVNRWCLVKTKTPEETERKLMEIVPKELWSD
CCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
INYLLVAFGQTICLPRKPKCEECPVEKYCGKCL
HHHHHHHHCCHHCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MKREDVPKVLEILKREFPKWNAPVVHMIAQHDKDPFRVLVCALLSTRTKDELTWRVCKRF
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
FEKVKSPEDLIKLSEKEIEELIYPVGFYRVKAKQLKEIGKILIEKYGGKVPDTLEELLKL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
PGVGRKVANLVLSKGFNKPAIVVDVHVHRIVNRWCLVKTKTPEETERKLMEIVPKELWSD
CCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
INYLLVAFGQTICLPRKPKCEECPVEKYCGKCL
HHHHHHHHCCHHCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]