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The map label for this gene is speH

Identifier: 15605798

GI number: 15605798

Start: 162752

End: 163159

Strand: Direct

Name: speH

Synonym: aq_254

Alternate gene names: 15605798

Gene position: 162752-163159 (Clockwise)

Preceding gene: 15605791

Following gene: 15605799

Centisome position: 10.49

GC content: 49.75

Gene sequence:

>408_bases
ATGGCAAAGACCCTCGGACTGCATATCCTAGCGGACCTTTACGGTGTGGACGCGGATAAGATTGACCGCGTCGAAGATAT
CAGAGAGCTCCTTGAAGGAGCTGTAAAGTACGCCAACCTCACCAAAATTTCCTCCCATTACTACCAGTTCCAGCCCCACG
GTGCCACAGGAGTTGTACTCTTAGCGGAATCCCACATATCAATCCACACGTGGCCCGAACACGGACTCGCAACCGTAGAC
GTTTACACCTGCGGTGACCCCTCCAAAGCCTACAGGGCAATGGACTACATAATCACCCAGCTCAATCCCAAGAGGATTGA
CAAACAAGTTCATGAAAGGGGAATAGTTGAAGAGGAAAGTAATCAGAGCGAGGCTGAAAAACTCCGAAGTATACTCCTTC
AGGTTTAA

Upstream 100 bases:

>100_bases
CAATTGTTGTATTATACTTTTATTTTGCCGAAGGAGGCAAAGTTATGCGACATGTAATTTTTGAGAAGCTTTTCAAAAAC
TTTTCAAGGGAGGATAGGAA

Downstream 100 bases:

>100_bases
ACACCTCCTTCTCCTCCCTTAAAATAAATCCCGATGAAAGTGCTCATAGTCTTTTACAAGGATCTGGAAAAAAATAAAGA
GGAAATTCTTAACTTAATGA

Product: S-adenosylmethionine decarboxylase proenzyme

Products: NA

Alternate protein names: AdoMetDC; SAMDC

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MAKTLGLHILADLYGVDADKIDRVEDIRELLEGAVKYANLTKISSHYYQFQPHGATGVVLLAESHISIHTWPEHGLATVD
VYTCGDPSKAYRAMDYIITQLNPKRIDKQVHERGIVEEESNQSEAEKLRSILLQV

Sequences:

>Translated_135_residues
MAKTLGLHILADLYGVDADKIDRVEDIRELLEGAVKYANLTKISSHYYQFQPHGATGVVLLAESHISIHTWPEHGLATVD
VYTCGDPSKAYRAMDYIITQLNPKRIDKQVHERGIVEEESNQSEAEKLRSILLQV
>Mature_134_residues
AKTLGLHILADLYGVDADKIDRVEDIRELLEGAVKYANLTKISSHYYQFQPHGATGVVLLAESHISIHTWPEHGLATVDV
YTCGDPSKAYRAMDYIITQLNPKRIDKQVHERGIVEEESNQSEAEKLRSILLQV

Specific function: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine

COG id: COG1586

COG function: function code E; S-adenosylmethionine decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEH_AQUAE (O66615)

Other databases:

- EMBL:   AE000657
- PIR:   C70323
- RefSeq:   NP_213175.1
- PDB:   2III
- PDBsum:   2III
- ProteinModelPortal:   O66615
- SMR:   O66615
- GeneID:   1192849
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_254
- NMPDR:   fig|224324.1.peg.190
- HOGENOM:   HBG485559
- OMA:   KPNEMHI
- ProtClustDB:   PRK01236
- BioCyc:   AAEO224324:AQ_254-MONOMER
- BRENDA:   4.1.1.50
- HAMAP:   MF_00464
- InterPro:   IPR003826
- InterPro:   IPR016067
- InterPro:   IPR017716
- Gene3D:   G3DSA:3.60.90.10
- TIGRFAMs:   TIGR03330

Pfam domain/function: PF02675 AdoMet_dc; SSF56276 S-AdenosylMet_decarbase_core

EC number: =4.1.1.50

Molecular weight: Translated: 15200; Mature: 15069

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: ACT_SITE 64-64 ACT_SITE 69-69 ACT_SITE 84-84

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTLGLHILADLYGVDADKIDRVEDIRELLEGAVKYANLTKISSHYYQFQPHGATGVVL
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEE
LAESHISIHTWPEHGLATVDVYTCGDPSKAYRAMDYIITQLNPKRIDKQVHERGIVEEES
EECCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
NQSEAEKLRSILLQV
CHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKTLGLHILADLYGVDADKIDRVEDIRELLEGAVKYANLTKISSHYYQFQPHGATGVVL
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEE
LAESHISIHTWPEHGLATVDVYTCGDPSKAYRAMDYIITQLNPKRIDKQVHERGIVEEES
EECCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
NQSEAEKLRSILLQV
CHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320