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The map label for this gene is trpD

Identifier: 15605759

GI number: 15605759

Start: 117938

End: 118960

Strand: Direct

Name: trpD

Synonym: aq_196

Alternate gene names: 15605759

Gene position: 117938-118960 (Clockwise)

Preceding gene: 15605750

Following gene: 15605760

Centisome position: 7.6

GC content: 46.82

Gene sequence:

>1023_bases
ATGGAACTGGTAAGGGAACTGCTAAGGAAAATAGCTGAATTTGAAAACCTAACTGCGGAAGAAATGTACAACTTGATGAA
AGAAGTGGCGGAGGGAAGGGCAACGGACGCCCAGATCGGAGCACTCGTAATGGGAACAAAGATGAAGGGGGAAACTCCTG
AGGAAATAGAGGGTGCAGTAAAGCTCTTCAGGGAAAAAGTCGTAAGGGTTCCCGTAAAAGATCCTGAAGAGCTCGTGGAC
GTAGTAGGAACGGGAGGAGATAAAAGTTCTACTTTTAACGTTTCCACTGTTACTGGGTTTGTTCTCGCTGGTGCAGGAGT
AAAAGTGGCAAAACATGGGAACCGCTCCGTCTCTTCAAAAAGCGGTAGTGCGGATTTTCTGGAAGCCCTCGGAGCAAAAG
TAGAACTTCTCCCTGAAAAGGTGGCGAGACTTATTGAAGAAGTGGGATTCGGATTTATGTTCGCTCCGCTCTTCCACCCC
GCCATGAAAAGGGTCGTTTCTCCGAGAAGGGAGGTGGGAGTCCGATCCATTTTTAATTTGATAGGACCACTTACAAACCC
CGCGGGTGTAAAGAGGTATCTCCTCGGTGTTTTTTCAAAGGAATACGTTGATAAATTCGCAAAAGCCCTTAAAAACCTCG
GCGTTAAAAAGGCATTCGTCGTGCACGGGGAAGGTGGTATTGACGAGGTGAGCGTAGAAGGGGAAACCTACGTTACGGAA
GTTTCAGAAGAAGGGATAAGGAGTTTTACCTTTTCTCCTGAAGAACTCGGTGTAAAGAGAAAGTCTCTGAGTGAAGTTAG
GGTAAACTCCCCGGAAGAGAGCGTAAAAGTTGCACTTTCAGTTTTGAGAGGAGAAGAGGGAACGCCGAGGGATATGGTTC
TCCTGAACGCAAGCTTCGGAATTCTCGTATCTGAAAGGGCAGGGGATATAAAGGAAGCCTTTGAAATGGCTAAGGAGTCC
ATAGACAGCGGAAAGGCTCTGGAGGTATTGGAGAAGTATGTGGAACTCTCAAATAAAATCTGA

Upstream 100 bases:

>100_bases
ACAAGTTCCCTGTCCGCGTAAACGTCTATAAAGAAGAAAAACTCCATCTTATTAATAATATTTCTACAAGCTTACTTTTT
AAAGGCTATTATAAAAGTGT

Downstream 100 bases:

>100_bases
TGAAGGAAGCCCTTATCCTTTTCTTTCTTATAGTTTCCTATAACTACCTCCTTTACTACATAACCGCCAAAGATTTAGCA
CTAATTCCCCTCTTTCCCGA

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MELVRELLRKIAEFENLTAEEMYNLMKEVAEGRATDAQIGALVMGTKMKGETPEEIEGAVKLFREKVVRVPVKDPEELVD
VVGTGGDKSSTFNVSTVTGFVLAGAGVKVAKHGNRSVSSKSGSADFLEALGAKVELLPEKVARLIEEVGFGFMFAPLFHP
AMKRVVSPRREVGVRSIFNLIGPLTNPAGVKRYLLGVFSKEYVDKFAKALKNLGVKKAFVVHGEGGIDEVSVEGETYVTE
VSEEGIRSFTFSPEELGVKRKSLSEVRVNSPEESVKVALSVLRGEEGTPRDMVLLNASFGILVSERAGDIKEAFEMAKES
IDSGKALEVLEKYVELSNKI

Sequences:

>Translated_340_residues
MELVRELLRKIAEFENLTAEEMYNLMKEVAEGRATDAQIGALVMGTKMKGETPEEIEGAVKLFREKVVRVPVKDPEELVD
VVGTGGDKSSTFNVSTVTGFVLAGAGVKVAKHGNRSVSSKSGSADFLEALGAKVELLPEKVARLIEEVGFGFMFAPLFHP
AMKRVVSPRREVGVRSIFNLIGPLTNPAGVKRYLLGVFSKEYVDKFAKALKNLGVKKAFVVHGEGGIDEVSVEGETYVTE
VSEEGIRSFTFSPEELGVKRKSLSEVRVNSPEESVKVALSVLRGEEGTPRDMVLLNASFGILVSERAGDIKEAFEMAKES
IDSGKALEVLEKYVELSNKI
>Mature_340_residues
MELVRELLRKIAEFENLTAEEMYNLMKEVAEGRATDAQIGALVMGTKMKGETPEEIEGAVKLFREKVVRVPVKDPEELVD
VVGTGGDKSSTFNVSTVTGFVLAGAGVKVAKHGNRSVSSKSGSADFLEALGAKVELLPEKVARLIEEVGFGFMFAPLFHP
AMKRVVSPRREVGVRSIFNLIGPLTNPAGVKRYLLGVFSKEYVDKFAKALKNLGVKKAFVVHGEGGIDEVSVEGETYVTE
VSEEGIRSFTFSPEELGVKRKSLSEVRVNSPEESVKVALSVLRGEEGTPRDMVLLNASFGILVSERAGDIKEAFEMAKES
IDSGKALEVLEKYVELSNKI

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=282, Percent_Identity=37.2340425531915, Blast_Score=188, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6320561, Length=287, Percent_Identity=35.191637630662, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_AQUAE (O66576)

Other databases:

- EMBL:   AE000657
- PIR:   D70318
- RefSeq:   NP_213136.1
- ProteinModelPortal:   O66576
- SMR:   O66576
- GeneID:   1192718
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_196
- NMPDR:   fig|224324.1.peg.151
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- PhylomeDB:   O66576
- ProtClustDB:   PRK00188
- BioCyc:   AAEO224324:AQ_196-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 36987; Mature: 36987

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVRELLRKIAEFENLTAEEMYNLMKEVAEGRATDAQIGALVMGTKMKGETPEEIEGAV
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHEEECCCCCCCHHHHHHHH
KLFREKVVRVPVKDPEELVDVVGTGGDKSSTFNVSTVTGFVLAGAGVKVAKHGNRSVSSK
HHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCEEEECCCCCCCCCC
SGSADFLEALGAKVELLPEKVARLIEEVGFGFMFAPLFHPAMKRVVSPRREVGVRSIFNL
CCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IGPLTNPAGVKRYLLGVFSKEYVDKFAKALKNLGVKKAFVVHGEGGIDEVSVEGETYVTE
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCHHHHH
VSEEGIRSFTFSPEELGVKRKSLSEVRVNSPEESVKVALSVLRGEEGTPRDMVLLNASFG
HHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCC
ILVSERAGDIKEAFEMAKESIDSGKALEVLEKYVELSNKI
EEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELVRELLRKIAEFENLTAEEMYNLMKEVAEGRATDAQIGALVMGTKMKGETPEEIEGAV
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHEEECCCCCCCHHHHHHHH
KLFREKVVRVPVKDPEELVDVVGTGGDKSSTFNVSTVTGFVLAGAGVKVAKHGNRSVSSK
HHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCEEEECCCCCCCCCC
SGSADFLEALGAKVELLPEKVARLIEEVGFGFMFAPLFHPAMKRVVSPRREVGVRSIFNL
CCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IGPLTNPAGVKRYLLGVFSKEYVDKFAKALKNLGVKKAFVVHGEGGIDEVSVEGETYVTE
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCHHHHH
VSEEGIRSFTFSPEELGVKRKSLSEVRVNSPEESVKVALSVLRGEEGTPRDMVLLNASFG
HHHHHHHHCCCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCC
ILVSERAGDIKEAFEMAKESIDSGKALEVLEKYVELSNKI
EEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320