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The map label for this gene is ctaB

Identifier: 15605727

GI number: 15605727

Start: 93768

End: 94646

Strand: Direct

Name: ctaB

Synonym: aq_154

Alternate gene names: 15605727

Gene position: 93768-94646 (Clockwise)

Preceding gene: 15605726

Following gene: 15605728

Centisome position: 6.04

GC content: 45.39

Gene sequence:

>879_bases
ATGAGTGAAAGGGTAGAGGCGGGACAGAACGTGATAAAGGAGTATTTGGTTCTCACAAAACCGGGAATAGTTTCCTTAGT
TCTTATTACCACTCTCGGCGGAATGTATTTAGGTTCAAGGGGTGAGCTTCAGCCCGAACTCGTTTTCTGGACCTTGCTCG
GTACGGGACTTGCCGCGGCAGGTTCCGCGGTTCTCAATATGGTAATTGATAAAGACATAGATAAATTGATGGTAAGAACT
TCCGAGAGACCGCTTCCAAAGGGAACGGTTGACCCTACAAAAGCTTTCATCTTCGGTATAACTCTTCAGGTTTTCTCACT
CGTTATAATGCTCACTTTTGTGGGAGTCCTTCCAGCGCTGCTCGTAGCGCTCGCTTCCTTTTCTTACGTGATACTTTACT
CTTTGCTTCTCAAGAGAAAGAGTCCCGTTGCAACTGAAATAGGCGGGATATCGGGGGCACTTCCGCCCGTTATAGGTTAT
GTTGCGGCTTCAGGAAGCGTAGATATAAACGCCATAGCCCTCTTCCTTTTAATGTTCATGTGGCAACCTCCTCACTTCTG
GGTTTTAGCCCTCAAGTACGCGGACGACTATAAGAGGGCGGGAATTCCGACACTTCCCGTAGCCAGAGGTGTATTCATCA
CCAAACTAAAGACACTCCTTTACACAGCTTCACTCTTTCCCGTATCCTTAATCCCTTACCTGACGGGACTTGTAGAAAAC
CTTTACTTTGTCGTTGCGGTTGTTATGAATCTGATTTATCTGGGGCTCACTTTAAAGTTCTTCTTCTCAAAGAAAGAGGA
AAGTATGAAACTCTTTTTCTTCTCAATCATTTACCTTGCGGTTCTTTTCGGAACAATGATAGTGGACATGGTGAAGTGA

Upstream 100 bases:

>100_bases
TTCTTCACATAGCAATAGGATTCTTTATAGTCCTTTGGGTATCCTACCTTGTAGCACCTTCCGTTTTAAAGACTTATACT
GAGTTTAGAGGAGAGCTGGC

Downstream 100 bases:

>100_bases
TATGCTCTGGTTTTCCCTCTTTATTTTATCCATAGCAATCGGTGGTTCTTTTGCCCTCCTCGTTGCAATAGCAAGGACTC
CGGGACTTGCGGATCTCTTT

Product: cytochrome C oxidase assembly factor

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSERVEAGQNVIKEYLVLTKPGIVSLVLITTLGGMYLGSRGELQPELVFWTLLGTGLAAAGSAVLNMVIDKDIDKLMVRT
SERPLPKGTVDPTKAFIFGITLQVFSLVIMLTFVGVLPALLVALASFSYVILYSLLLKRKSPVATEIGGISGALPPVIGY
VAASGSVDINAIALFLLMFMWQPPHFWVLALKYADDYKRAGIPTLPVARGVFITKLKTLLYTASLFPVSLIPYLTGLVEN
LYFVVAVVMNLIYLGLTLKFFFSKKEESMKLFFFSIIYLAVLFGTMIVDMVK

Sequences:

>Translated_292_residues
MSERVEAGQNVIKEYLVLTKPGIVSLVLITTLGGMYLGSRGELQPELVFWTLLGTGLAAAGSAVLNMVIDKDIDKLMVRT
SERPLPKGTVDPTKAFIFGITLQVFSLVIMLTFVGVLPALLVALASFSYVILYSLLLKRKSPVATEIGGISGALPPVIGY
VAASGSVDINAIALFLLMFMWQPPHFWVLALKYADDYKRAGIPTLPVARGVFITKLKTLLYTASLFPVSLIPYLTGLVEN
LYFVVAVVMNLIYLGLTLKFFFSKKEESMKLFFFSIIYLAVLFGTMIVDMVK
>Mature_291_residues
SERVEAGQNVIKEYLVLTKPGIVSLVLITTLGGMYLGSRGELQPELVFWTLLGTGLAAAGSAVLNMVIDKDIDKLMVRTS
ERPLPKGTVDPTKAFIFGITLQVFSLVIMLTFVGVLPALLVALASFSYVILYSLLLKRKSPVATEIGGISGALPPVIGYV
AASGSVDINAIALFLLMFMWQPPHFWVLALKYADDYKRAGIPTLPVARGVFITKLKTLLYTASLFPVSLIPYLTGLVENL
YFVVAVVMNLIYLGLTLKFFFSKKEESMKLFFFSIIYLAVLFGTMIVDMVK

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=264, Percent_Identity=31.0606060606061, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=36.5591397849462, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71998235, Length=269, Percent_Identity=28.2527881040892, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=260, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19921064, Length=275, Percent_Identity=32, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_AQUAE (O66544)

Other databases:

- EMBL:   AE000657
- PIR:   E70314
- RefSeq:   NP_213104.1
- GeneID:   1192687
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_154
- NMPDR:   fig|224324.1.peg.119
- HOGENOM:   HBG656003
- OMA:   IPHFMAL
- PhylomeDB:   O66544
- ProtClustDB:   CLSK2748250
- BioCyc:   AAEO224324:AQ_154-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32009; Mature: 31878

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc1377f8)-; HASH(0xbd44d94)-; HASH(0xaf42bfc)-; HASH(0xba469e8)-; HASH(0xbab83ec)-; HASH(0xbb0d74c)-; HASH(0x97698dc)-; HASH(0xbc1ccb4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERVEAGQNVIKEYLVLTKPGIVSLVLITTLGGMYLGSRGELQPELVFWTLLGTGLAAA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
GSAVLNMVIDKDIDKLMVRTSERPLPKGTVDPTKAFIFGITLQVFSLVIMLTFVGVLPAL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVALASFSYVILYSLLLKRKSPVATEIGGISGALPPVIGYVAASGSVDINAIALFLLMFM
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
WQPPHFWVLALKYADDYKRAGIPTLPVARGVFITKLKTLLYTASLFPVSLIPYLTGLVEN
CCCCCCEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYFVVAVVMNLIYLGLTLKFFFSKKEESMKLFFFSIIYLAVLFGTMIVDMVK
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SERVEAGQNVIKEYLVLTKPGIVSLVLITTLGGMYLGSRGELQPELVFWTLLGTGLAAA
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
GSAVLNMVIDKDIDKLMVRTSERPLPKGTVDPTKAFIFGITLQVFSLVIMLTFVGVLPAL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVALASFSYVILYSLLLKRKSPVATEIGGISGALPPVIGYVAASGSVDINAIALFLLMFM
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
WQPPHFWVLALKYADDYKRAGIPTLPVARGVFITKLKTLLYTASLFPVSLIPYLTGLVEN
CCCCCCEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYFVVAVVMNLIYLGLTLKFFFSKKEESMKLFFFSIIYLAVLFGTMIVDMVK
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320