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The map label for this gene is tlpA [H]

Identifier: 15605725

GI number: 15605725

Start: 91861

End: 92301

Strand: Direct

Name: tlpA [H]

Synonym: aq_152

Alternate gene names: 15605725

Gene position: 91861-92301 (Clockwise)

Preceding gene: 15605724

Following gene: 15605726

Centisome position: 5.92

GC content: 42.63

Gene sequence:

>441_bases
ATGAAAAGGCTTCTCCCCGTCTTCCTCGCCCTTATACTCTTCGGTTTGTTAGTTTACATAGGACTAAATCAGGATAAACA
CGATCACTACACAATCACAACCCAGAAAGGTCAGAAAATCCCAAACGTTACCTTAACAACACCTGACGGAAAGAAGGTAA
GTATAGAGGAATTTAAAGGGAAGGTTTTGCTCATAAACTTTTGGGCCACTTGGTGTCCTCCCTGTAAAGAAGAAATCCCG
ATGTTTAAAGAGATATACGAAAAGTACAGGGACAGAGGTTTTGAAATACTCGCCATAAACATGGATCCCGAAAACCTCAC
AGGCTTCCTGAAAAATAACCCCCTTCCATTCCCGGTATTCGTGATAAACGAGAAGTGGAAAGAGCCTTTAACATTCCAGG
GCTTCCAACGTCGTACTTGGTTGACAGAGGAGGAACTATAG

Upstream 100 bases:

>100_bases
AATTAACGCAGGAGAAACCCTTCTCCAAGAGACTTTCCGAAGAGGAGTATGAATACACCGGAGTTGAACCGAGGGAACTC
CCGCCCGAAAGGAAGAAGGT

Downstream 100 bases:

>100_bases
TAAAGGTTCGCTTGGGAATTTACAGGGAGCTGGAAAAGGATTTGAACGATCTTCTGGAAAAGTAATTAGGTCTTTATAAT
TTAAAAAGGTTATGAGCAGT

Product: thiol disulfide interchange protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKRLLPVFLALILFGLLVYIGLNQDKHDHYTITTQKGQKIPNVTLTTPDGKKVSIEEFKGKVLLINFWATWCPPCKEEIP
MFKEIYEKYRDRGFEILAINMDPENLTGFLKNNPLPFPVFVINEKWKEPLTFQGFQRRTWLTEEEL

Sequences:

>Translated_146_residues
MKRLLPVFLALILFGLLVYIGLNQDKHDHYTITTQKGQKIPNVTLTTPDGKKVSIEEFKGKVLLINFWATWCPPCKEEIP
MFKEIYEKYRDRGFEILAINMDPENLTGFLKNNPLPFPVFVINEKWKEPLTFQGFQRRTWLTEEEL
>Mature_146_residues
MKRLLPVFLALILFGLLVYIGLNQDKHDHYTITTQKGQKIPNVTLTTPDGKKVSIEEFKGKVLLINFWATWCPPCKEEIP
MFKEIYEKYRDRGFEILAINMDPENLTGFLKNNPLPFPVFVINEKWKEPLTFQGFQRRTWLTEEEL

Specific function: Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalent

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: NA

Molecular weight: Translated: 17204; Mature: 17204

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLLPVFLALILFGLLVYIGLNQDKHDHYTITTQKGQKIPNVTLTTPDGKKVSIEEFKG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCCEEEHHHHCC
KVLLINFWATWCPPCKEEIPMFKEIYEKYRDRGFEILAINMDPENLTGFLKNNPLPFPVF
CEEEEEECCCCCCCCHHCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCEEE
VINEKWKEPLTFQGFQRRTWLTEEEL
EECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRLLPVFLALILFGLLVYIGLNQDKHDHYTITTQKGQKIPNVTLTTPDGKKVSIEEFKG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCCEEEHHHHCC
KVLLINFWATWCPPCKEEIPMFKEIYEKYRDRGFEILAINMDPENLTGFLKNNPLPFPVF
CEEEEEECCCCCCCCHHCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCEEE
VINEKWKEPLTFQGFQRRTWLTEEEL
EECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA