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The map label for this gene is fabD [H]

Identifier: 15603780

GI number: 15603780

Start: 2154233

End: 2155171

Strand: Direct

Name: fabD [H]

Synonym: PM1915

Alternate gene names: 15603780

Gene position: 2154233-2155171 (Clockwise)

Preceding gene: 15603779

Following gene: 15603781

Centisome position: 95.43

GC content: 45.58

Gene sequence:

>939_bases
ATGAAAAAATTTGCAATGGTTTTTCCAGGACAAGGCTCTCAAGCTGTAGGAATGTTAGCAGAATTAGCCACAGAATATCC
TGTGGTGGAAGAGACCTTTAAACAAGCTTCGGATGTGTTAGGTTATGACTTGTGGCAACTTGTGCAACAAGGACCTGCGG
AAGAACTGAATAAAACTTGGCAAACTCAACCAGCACTGTTAGCCGCATCTGTTGCTATTTATCGTGTATGGCAAGAGAAA
TATCCTCATTTGAAGCCAGACGTGATGGCTGGACATAGTTTAGGTGAATATTCTGCTTTAGTATGCGCGGGCGCACTTGA
TTTCCAAGATGCAGTCAAATTAGTGGAGCTGCGTGGTAAATTAATGCAACAAGCGGTTCCCGAAGGGACCGGTGCGATGT
ATGCGATTATTGGTTTAGATAATGAAGCCATCATCAGTGCCTGTGCCGACGCAGCGCAAGGCGAGGTGGTGTCTGCGGTG
AATTTTAACTCGCCGGGGCAAGTGGTGATCGCGGGAGCAAAAGCAGCGGTTGAACGTGCTGCAGCTGCTTGTAAAGACGC
CGGGGCAAAACGTGCCCTGCCTTTAGCGGTAAGTGTGCCTTCTCATTGTGCGTTAATGAAACCAGCAGCAGATCAATTAG
CCGTGTCTTTAGATAATATTGCGATTAGAACACCAACTACAGCGGTTATCAATAATGTGGATGTCGCGTGTGAAACGGAA
AATAGTGAAATTCGTCACGCACTTGTTCGTCAATTATATAGTCCAGTGCGTTGGACAGAAACCGTTGAACGTATGGCAAA
AGATGGCGTGCAGGTTTTAGTTGAAGTCGGTCCAAACAAAGTCTTGACGGGGTTAACAAAACGTATCGTCGCTGATTTAC
AAGCTACTGCGGTTAATGATCTGACATCATTAAATGCGGTTGATGAACTATTCGCTTAA

Upstream 100 bases:

>100_bases
GGTGGTCTGACTTGGGGATCGGCGTTAGTTAGGTTTTAATAGCCGGAATTGACTTAAAGTGCGGTCAGTTTTCAGTATTT
TTAAAAATAAGGAAAATAAC

Downstream 100 bases:

>100_bases
CTCATTAAAAAAGGGGAGATTCAATGCAGGGTAAAATTGCATTAGTAACAGGCGCAACGCGTGGTATTGGTCGTGCGATT
GCAGAAGAATTAAGTGCAAA

Product: acyl carrier protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKKFAMVFPGQGSQAVGMLAELATEYPVVEETFKQASDVLGYDLWQLVQQGPAEELNKTWQTQPALLAASVAIYRVWQEK
YPHLKPDVMAGHSLGEYSALVCAGALDFQDAVKLVELRGKLMQQAVPEGTGAMYAIIGLDNEAIISACADAAQGEVVSAV
NFNSPGQVVIAGAKAAVERAAAACKDAGAKRALPLAVSVPSHCALMKPAADQLAVSLDNIAIRTPTTAVINNVDVACETE
NSEIRHALVRQLYSPVRWTETVERMAKDGVQVLVEVGPNKVLTGLTKRIVADLQATAVNDLTSLNAVDELFA

Sequences:

>Translated_312_residues
MKKFAMVFPGQGSQAVGMLAELATEYPVVEETFKQASDVLGYDLWQLVQQGPAEELNKTWQTQPALLAASVAIYRVWQEK
YPHLKPDVMAGHSLGEYSALVCAGALDFQDAVKLVELRGKLMQQAVPEGTGAMYAIIGLDNEAIISACADAAQGEVVSAV
NFNSPGQVVIAGAKAAVERAAAACKDAGAKRALPLAVSVPSHCALMKPAADQLAVSLDNIAIRTPTTAVINNVDVACETE
NSEIRHALVRQLYSPVRWTETVERMAKDGVQVLVEVGPNKVLTGLTKRIVADLQATAVNDLTSLNAVDELFA
>Mature_312_residues
MKKFAMVFPGQGSQAVGMLAELATEYPVVEETFKQASDVLGYDLWQLVQQGPAEELNKTWQTQPALLAASVAIYRVWQEK
YPHLKPDVMAGHSLGEYSALVCAGALDFQDAVKLVELRGKLMQQAVPEGTGAMYAIIGLDNEAIISACADAAQGEVVSAV
NFNSPGQVVIAGAKAAVERAAAACKDAGAKRALPLAVSVPSHCALMKPAADQLAVSLDNIAIRTPTTAVINNVDVACETE
NSEIRHALVRQLYSPVRWTETVERMAKDGVQVLVEVGPNKVLTGLTKRIVADLQATAVNDLTSLNAVDELFA

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=325, Percent_Identity=34.1538461538462, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI27477045, Length=112, Percent_Identity=46.4285714285714, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787334, Length=310, Percent_Identity=70.9677419354839, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71984332, Length=298, Percent_Identity=28.5234899328859, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=296, Percent_Identity=28.3783783783784, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24665753, Length=308, Percent_Identity=32.7922077922078, Blast_Score=138, Evalue=4e-33,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33198; Mature: 33198

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFAMVFPGQGSQAVGMLAELATEYPVVEETFKQASDVLGYDLWQLVQQGPAEELNKTW
CCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QTQPALLAASVAIYRVWQEKYPHLKPDVMAGHSLGEYSALVCAGALDFQDAVKLVELRGK
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
LMQQAVPEGTGAMYAIIGLDNEAIISACADAAQGEVVSAVNFNSPGQVVIAGAKAAVERA
HHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECHHHHHHHH
AAACKDAGAKRALPLAVSVPSHCALMKPAADQLAVSLDNIAIRTPTTAVINNVDVACETE
HHHHHHCCCCCCCEEEEECCCCHHCCCCCHHHHHHHHCCEEEECCCHHHHCCCEEEEECC
NSEIRHALVRQLYSPVRWTETVERMAKDGVQVLVEVGPNKVLTGLTKRIVADLQATAVND
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LTSLNAVDELFA
HHHHHHHHHHHC
>Mature Secondary Structure
MKKFAMVFPGQGSQAVGMLAELATEYPVVEETFKQASDVLGYDLWQLVQQGPAEELNKTW
CCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QTQPALLAASVAIYRVWQEKYPHLKPDVMAGHSLGEYSALVCAGALDFQDAVKLVELRGK
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
LMQQAVPEGTGAMYAIIGLDNEAIISACADAAQGEVVSAVNFNSPGQVVIAGAKAAVERA
HHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECHHHHHHHH
AAACKDAGAKRALPLAVSVPSHCALMKPAADQLAVSLDNIAIRTPTTAVINNVDVACETE
HHHHHHCCCCCCCEEEEECCCCHHCCCCCHHHHHHHHCCEEEECCCHHHHCCCEEEEECC
NSEIRHALVRQLYSPVRWTETVERMAKDGVQVLVEVGPNKVLTGLTKRIVADLQATAVND
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LTSLNAVDELFA
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]