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The map label for this gene is fabH

Identifier: 15603779

GI number: 15603779

Start: 2153218

End: 2154171

Strand: Direct

Name: fabH

Synonym: PM1914

Alternate gene names: 15603779

Gene position: 2153218-2154171 (Clockwise)

Preceding gene: 15603778

Following gene: 15603780

Centisome position: 95.38

GC content: 45.18

Gene sequence:

>954_bases
ATGTATAGTAAAATCTTATCCACCGGGAGTTATTTACCCAAACATATCCGTACGAATGCCGATTTAGAAAAAATGGTGGA
CACCTCTGATGAATGGATTTCGGAACGTACTGGCATCAAAGAACGTCGCATTGCTGAAGCAAGCGAAACTGTGGCAACCA
TGGGATTTGAAGCTGCCCAGAATTGCTTAGCGGTATCGCCTATGGATGTCAATGAGATTGATCTTATTGTCGTCGCGACG
ACTAGCGCAACACATGCTTTTCCAAGTACGGCATGTCAAATTCAGAAAATGCTCGGCATAAAAGACGCGATTGCGTTTGA
TGTCGCAGCGGCCTGTTCGGGCTTTGTTTACGCCTTAACCGTTGCCGATCAATTTATCCGTACCGGAAAAGTAAAAAAAG
CCCTCGTGATTGGGGCGGATCTCTTTTCCCGCGCGTTAAATCCAGAGGATCGAGGCACGATTATTTTATTTGGTGATGGT
GCCGGTGCTGTGATTTTAGAAGCAAGTGAGCAAGCGGGGATCATTTCAACGCATTTACATGCAACAGGCGAAAGTGCTGA
AGTCTTAACCTTAGCTAATCAGGCGCGCGGTATTGAATCCGATCCTGCCTATTTAGAAATGCAGGGTAACGCAACTTTTA
AAATTGCAGTACGCGAATTAGCAAATGTGGTGGAAGAAACCTTAGAAGCCAACCAGTTAGATAAGAAAGATATTGATTGG
TTAGTTCCACATCAGGCGAACTTGCGGATTATTTCCGCTACCGCAAAAAAATTAGATATGGATATGTCACAAGTCGTGGT
TACACTTGATCGCCATGGCAATACGTCTGCAGGCAGTATTCCAAGTGCGCTTGATGAGGCAGTGCGTGATGGACGTATTC
AGCGTGGACAATTGTTGTTATTAGAAGCATTCGGCGGTGGTCTGACTTGGGGATCGGCGTTAGTTAGGTTTTAA

Upstream 100 bases:

>100_bases
GCTGGTTTAGAAAAGTACTAGCTGTATCAATATTAAAAAAATAATAGGTTAGAGCAACTTCAATTAGCCCATTTGGCTAC
GATTTTTAACGAGATTTCTT

Downstream 100 bases:

>100_bases
TAGCCGGAATTGACTTAAAGTGCGGTCAGTTTTCAGTATTTTTAAAAATAAGGAAAATAACATGAAAAAATTTGCAATGG
TTTTTCCAGGACAAGGCTCT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MYSKILSTGSYLPKHIRTNADLEKMVDTSDEWISERTGIKERRIAEASETVATMGFEAAQNCLAVSPMDVNEIDLIVVAT
TSATHAFPSTACQIQKMLGIKDAIAFDVAAACSGFVYALTVADQFIRTGKVKKALVIGADLFSRALNPEDRGTIILFGDG
AGAVILEASEQAGIISTHLHATGESAEVLTLANQARGIESDPAYLEMQGNATFKIAVRELANVVEETLEANQLDKKDIDW
LVPHQANLRIISATAKKLDMDMSQVVVTLDRHGNTSAGSIPSALDEAVRDGRIQRGQLLLLEAFGGGLTWGSALVRF

Sequences:

>Translated_317_residues
MYSKILSTGSYLPKHIRTNADLEKMVDTSDEWISERTGIKERRIAEASETVATMGFEAAQNCLAVSPMDVNEIDLIVVAT
TSATHAFPSTACQIQKMLGIKDAIAFDVAAACSGFVYALTVADQFIRTGKVKKALVIGADLFSRALNPEDRGTIILFGDG
AGAVILEASEQAGIISTHLHATGESAEVLTLANQARGIESDPAYLEMQGNATFKIAVRELANVVEETLEANQLDKKDIDW
LVPHQANLRIISATAKKLDMDMSQVVVTLDRHGNTSAGSIPSALDEAVRDGRIQRGQLLLLEAFGGGLTWGSALVRF
>Mature_317_residues
MYSKILSTGSYLPKHIRTNADLEKMVDTSDEWISERTGIKERRIAEASETVATMGFEAAQNCLAVSPMDVNEIDLIVVAT
TSATHAFPSTACQIQKMLGIKDAIAFDVAAACSGFVYALTVADQFIRTGKVKKALVIGADLFSRALNPEDRGTIILFGDG
AGAVILEASEQAGIISTHLHATGESAEVLTLANQARGIESDPAYLEMQGNATFKIAVRELANVVEETLEANQLDKKDIDW
LVPHQANLRIISATAKKLDMDMSQVVVTLDRHGNTSAGSIPSALDEAVRDGRIQRGQLLLLEAFGGGLTWGSALVRF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=68.7697160883281, Blast_Score=456, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_PASMU (Q9CJS8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246853.1
- ProteinModelPortal:   Q9CJS8
- SMR:   Q9CJS8
- GeneID:   1245261
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1914
- NMPDR:   fig|272843.1.peg.1915
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- ProtClustDB:   PRK09352
- BioCyc:   PMUL272843:PM1914-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34034; Mature: 34034

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 244-244 ACT_SITE 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKILSTGSYLPKHIRTNADLEKMVDTSDEWISERTGIKERRIAEASETVATMGFEAAQ
CCHHHHCCCCCCHHHHCCCCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHC
NCLAVSPMDVNEIDLIVVATTSATHAFPSTACQIQKMLGIKDAIAFDVAAACSGFVYALT
CCEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHH
VADQFIRTGKVKKALVIGADLFSRALNPEDRGTIILFGDGAGAVILEASEQAGIISTHLH
HHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEE
ATGESAEVLTLANQARGIESDPAYLEMQGNATFKIAVRELANVVEETLEANQLDKKDIDW
CCCCCCEEEEEHHHHCCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCE
LVPHQANLRIISATAKKLDMDMSQVVVTLDRHGNTSAGSIPSALDEAVRDGRIQRGQLLL
ECCCCCCEEEEEEHHHHHCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEE
LEAFGGGLTWGSALVRF
EEECCCCCHHHHHHHCC
>Mature Secondary Structure
MYSKILSTGSYLPKHIRTNADLEKMVDTSDEWISERTGIKERRIAEASETVATMGFEAAQ
CCHHHHCCCCCCHHHHCCCCCHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHC
NCLAVSPMDVNEIDLIVVATTSATHAFPSTACQIQKMLGIKDAIAFDVAAACSGFVYALT
CCEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHH
VADQFIRTGKVKKALVIGADLFSRALNPEDRGTIILFGDGAGAVILEASEQAGIISTHLH
HHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEE
ATGESAEVLTLANQARGIESDPAYLEMQGNATFKIAVRELANVVEETLEANQLDKKDIDW
CCCCCCEEEEEHHHHCCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCE
LVPHQANLRIISATAKKLDMDMSQVVVTLDRHGNTSAGSIPSALDEAVRDGRIQRGQLLL
ECCCCCCEEEEEEHHHHHCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEE
LEAFGGGLTWGSALVRF
EEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100