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The map label for this gene is cah [H]

Identifier: 15603770

GI number: 15603770

Start: 2144620

End: 2145378

Strand: Direct

Name: cah [H]

Synonym: PM1905

Alternate gene names: 15603770

Gene position: 2144620-2145378 (Clockwise)

Preceding gene: 15603769

Following gene: 15603776

Centisome position: 95.0

GC content: 42.16

Gene sequence:

>759_bases
ATGAAAAAATCAAACCTTTTTGTGCTTACGTTAGGTGCATTAGCATTGACAGCGTGTACAAGCCCCCTTAAGAAAGAAGA
AACGCACACGCATTGGGGATACACCGGACACGAATCGCCAGAACATTGGGCTGAACTTTCACCCAAATTCCGTATTTGTG
GCGAAGGTAAAAACCAAACACCAATAGATATCAAGCATACGATTGATGGTAAGTTAGCGCCGATTAAGCTGGATTATCGA
CCTTCCAATGTGGAGATTGTCAATAATGGGCATACTATTCAAGTGGATTTCAAAGAGGCAAGTAATCGAATGCAGCTTAA
TGGAAAGACCTTTACCCTTAAACAATTCCATTTCCATGTGCCGAGTGAAAACTTAATTCGAGGCAAATCCTTCCCGATGG
AAGCACATTTTGTACACGCAGACAATGAAGGGAATCTTGCTGTGCTTGGCGTGCTCTATGTATTATCCAGTGAAAACCAA
CGGTTAGCCCCAATTTGGCAAAACTTCCCGCAAAAAGCAGGGGAGAAATATACGCTTAGTACCGCTTTTGACCCAGCAAC
ATTAATTCCGAAAAAACGCGATTACTATCGTTTCAGCGGGTCATTAACTACACCACCTTGTTCTGAAGGTGTAAATTGGT
TAGTGTTAAAACACTATGACAACATTAGCCAATCTCAAGTTGAGGCGTTTGCGACCTTGATGAAAGGACACAATAATCGT
CCAGTGCAACCGATCAATGCACGTGTGATTGTTGAATAA

Upstream 100 bases:

>100_bases
ATGGAGTGTTGTTTTGCCTAAGATGAAAGCGTCTCGGATTAAGACATCATTGAGTTTAGGTTGTCTCATCAATTCATCTC
TTTTAATCAGGAGCTAGGCT

Downstream 100 bases:

>100_bases
CTTCTCTGTATCGTAATCCCTATCTCAGAGCGAAAGTATCACGAAAGTTTGACTGTGAATAGTCGCAAAAAAACAACCGC
ACTTTTTTGTGCGGTTGTGT

Product: hypothetical protein

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKKSNLFVLTLGALALTACTSPLKKEETHTHWGYTGHESPEHWAELSPKFRICGEGKNQTPIDIKHTIDGKLAPIKLDYR
PSNVEIVNNGHTIQVDFKEASNRMQLNGKTFTLKQFHFHVPSENLIRGKSFPMEAHFVHADNEGNLAVLGVLYVLSSENQ
RLAPIWQNFPQKAGEKYTLSTAFDPATLIPKKRDYYRFSGSLTTPPCSEGVNWLVLKHYDNISQSQVEAFATLMKGHNNR
PVQPINARVIVE

Sequences:

>Translated_252_residues
MKKSNLFVLTLGALALTACTSPLKKEETHTHWGYTGHESPEHWAELSPKFRICGEGKNQTPIDIKHTIDGKLAPIKLDYR
PSNVEIVNNGHTIQVDFKEASNRMQLNGKTFTLKQFHFHVPSENLIRGKSFPMEAHFVHADNEGNLAVLGVLYVLSSENQ
RLAPIWQNFPQKAGEKYTLSTAFDPATLIPKKRDYYRFSGSLTTPPCSEGVNWLVLKHYDNISQSQVEAFATLMKGHNNR
PVQPINARVIVE
>Mature_252_residues
MKKSNLFVLTLGALALTACTSPLKKEETHTHWGYTGHESPEHWAELSPKFRICGEGKNQTPIDIKHTIDGKLAPIKLDYR
PSNVEIVNNGHTIQVDFKEASNRMQLNGKTFTLKQFHFHVPSENLIRGKSFPMEAHFVHADNEGNLAVLGVLYVLSSENQ
RLAPIWQNFPQKAGEKYTLSTAFDPATLIPKKRDYYRFSGSLTTPPCSEGVNWLVLKHYDNISQSQVEAFATLMKGHNNR
PVQPINARVIVE

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=256, Percent_Identity=33.59375, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI192447434, Length=256, Percent_Identity=33.59375, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI192447432, Length=256, Percent_Identity=33.59375, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI192447430, Length=256, Percent_Identity=33.59375, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4502517, Length=256, Percent_Identity=33.59375, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4885101, Length=260, Percent_Identity=34.2307692307692, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38348436, Length=256, Percent_Identity=34.375, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI4885099, Length=257, Percent_Identity=32.6848249027237, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4557395, Length=258, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4502521, Length=232, Percent_Identity=32.7586206896552, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI6005723, Length=232, Percent_Identity=32.3275862068966, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI62240989, Length=202, Percent_Identity=35.1485148514851, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI22027500, Length=243, Percent_Identity=31.2757201646091, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI70167127, Length=267, Percent_Identity=28.4644194756554, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI169636420, Length=261, Percent_Identity=28.3524904214559, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI4502515, Length=238, Percent_Identity=29.8319327731092, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI45935383, Length=238, Percent_Identity=29.8319327731092, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI6912284, Length=262, Percent_Identity=29.7709923664122, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI194097398, Length=271, Percent_Identity=28.0442804428044, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI4502519, Length=268, Percent_Identity=26.865671641791, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI91208428, Length=243, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568715, Length=260, Percent_Identity=30, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71995280, Length=257, Percent_Identity=28.0155642023346, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32564019, Length=256, Percent_Identity=25.390625, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17737413, Length=251, Percent_Identity=32.2709163346614, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24645604, Length=274, Percent_Identity=28.8321167883212, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21358169, Length=259, Percent_Identity=28.1853281853282, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28573346, Length=227, Percent_Identity=26.8722466960352, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18858185, Length=250, Percent_Identity=24, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161079350, Length=276, Percent_Identity=26.4492753623188, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650523, Length=241, Percent_Identity=27.8008298755187, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 28420; Mature: 28420

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSNLFVLTLGALALTACTSPLKKEETHTHWGYTGHESPEHWAELSPKFRICGEGKNQT
CCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCC
PIDIKHTIDGKLAPIKLDYRPSNVEIVNNGHTIQVDFKEASNRMQLNGKTFTLKQFHFHV
CEEEEEECCCEEEEEEEEECCCCEEEEECCCEEEEEHHHCCCEEEECCCEEEEEEEEEEC
PSENLIRGKSFPMEAHFVHADNEGNLAVLGVLYVLSSENQRLAPIWQNFPQKAGEKYTLS
CCCHHCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCEECHHHHHHHHHCCCEEEEE
TAFDPATLIPKKRDYYRFSGSLTTPPCSEGVNWLVLKHYDNISQSQVEAFATLMKGHNNR
ECCCCHHCCCCCCCEEEEECCCCCCCHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCC
PVQPINARVIVE
CCCCCCCEEEEC
>Mature Secondary Structure
MKKSNLFVLTLGALALTACTSPLKKEETHTHWGYTGHESPEHWAELSPKFRICGEGKNQT
CCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCC
PIDIKHTIDGKLAPIKLDYRPSNVEIVNNGHTIQVDFKEASNRMQLNGKTFTLKQFHFHV
CEEEEEECCCEEEEEEEEECCCCEEEEECCCEEEEEHHHCCCEEEECCCEEEEEEEEEEC
PSENLIRGKSFPMEAHFVHADNEGNLAVLGVLYVLSSENQRLAPIWQNFPQKAGEKYTLS
CCCHHCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCEECHHHHHHHHHCCCEEEEE
TAFDPATLIPKKRDYYRFSGSLTTPPCSEGVNWLVLKHYDNISQSQVEAFATLMKGHNNR
ECCCCHHCCCCCCCEEEEECCCCCCCHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCC
PVQPINARVIVE
CCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9108244; 7721686; 9761692 [H]