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The map label for this gene is bioF [C]

Identifier: 15603766

GI number: 15603766

Start: 2141265

End: 2142428

Strand: Direct

Name: bioF [C]

Synonym: PM1901

Alternate gene names: 15603766

Gene position: 2141265-2142428 (Clockwise)

Preceding gene: 15603765

Following gene: 15603767

Centisome position: 94.85

GC content: 44.42

Gene sequence:

>1164_bases
ATGATCAGGTATTATCAGCAGCAGTTAGCTGATTTAAAGGCGCAGAATCAATTTCGCCAACTGCCCCAACTCATTCACCG
AGGGCGTTTTATTCAACGTGAGGACAATACGATGCTGAATATGTCCTCCAATGATTATTTAGGTTTAGCCAATAACGAAG
CCTTGCGTCAGGCGTTTTTCACGCAATACCAAGATCAACTCCCTGCATTGACGTCTTCTTCCTCCCGTTTATTAACAGGC
TCTTTTCCGATTTATGATGAGCTAGAAAGCTTAATGGCGCAGGCATTTGGACGAGAAACTGCCTTGCTATTTAATAGCGG
TTATCATGCTAATATTGGGATTTTGCCTGCTTTAGCGGACAAAAAAACGCTGATTGTGGCGGATAAACTGGTACATGCCA
GTATGATTGATGGCATTCGCTTGGCACAATGTGAGTTTGTGCGTTTTCGTCATCATGATTACGCCCACCTTGAACAAATT
TTGCAAAAAAATGACCGCACTTTTGAGCGGATTATCGTGGTCACGGAATCCGTGTTTAGTATGGATGGTGACTGTGCAGA
CCTCACCCAGTTGGTCGCATTAAAACAGCGCTATCCGCAAGTGATGTTATATGTAGATGAAGCCCATGCGATAGGCGTAT
TGGGTGAGAAGGGGCTAGGGTTAGCAGAACAACAAGGCTGTATCAACCAAATTGATATTTTGGTCGGCACGTTTGGCAAG
GCGTTGGGCTCTATGGGGGCTTATGTGATTTGCGATCAAGTGATCCGAGATTATTTGGTTAATAAAATGCGCCCATTGAT
TTTTTCCACGGCACTTCCGCCGTTTAATGTGGCATGGACACATTTTGTCTTTCAACAATTACCACATTTGCAAGCCGAGC
GCGCACATCTTGCTCAGCTTAGTCAACATTTACGCCAAGCGATTGTCGACATTTTTCAAGTCCCGATGCCAAGTGAAAGT
TGTATCGTACCTTATATTTTGGGCGACAACGAACTGACAGTAAGAACAGCGCAACGTTTGCAACAACAAGGTTATTATTG
CTTACCGATTCGCCCGCCGACAGTCCCAAAAGGTACCTCTCGTATTCGTTTTTCACTGACTGCAGATATGCAAGTGGCGG
AAGTGGAACAATTTATTGCTTGTTTACAGGAGCTTGCTGAATGA

Upstream 100 bases:

>100_bases
ATTTGATGCCACCGTATATCATCTCATCGGATCAATTGTCTCAATTAATTCATGGCACAATTCGCACCCTTCAAGAAGAG
TATGCACATAAGGAATCTCT

Downstream 100 bases:

>100_bases
AAACACAACATATTTCACAGCAAGGCGACAATCTGATCGTCTATTTTGCAGGGTGGGGCACACCGCCGAGCGTGGTCGAG
CACCTGATTCTGCCGGAAAA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MIRYYQQQLADLKAQNQFRQLPQLIHRGRFIQREDNTMLNMSSNDYLGLANNEALRQAFFTQYQDQLPALTSSSSRLLTG
SFPIYDELESLMAQAFGRETALLFNSGYHANIGILPALADKKTLIVADKLVHASMIDGIRLAQCEFVRFRHHDYAHLEQI
LQKNDRTFERIIVVTESVFSMDGDCADLTQLVALKQRYPQVMLYVDEAHAIGVLGEKGLGLAEQQGCINQIDILVGTFGK
ALGSMGAYVICDQVIRDYLVNKMRPLIFSTALPPFNVAWTHFVFQQLPHLQAERAHLAQLSQHLRQAIVDIFQVPMPSES
CIVPYILGDNELTVRTAQRLQQQGYYCLPIRPPTVPKGTSRIRFSLTADMQVAEVEQFIACLQELAE

Sequences:

>Translated_387_residues
MIRYYQQQLADLKAQNQFRQLPQLIHRGRFIQREDNTMLNMSSNDYLGLANNEALRQAFFTQYQDQLPALTSSSSRLLTG
SFPIYDELESLMAQAFGRETALLFNSGYHANIGILPALADKKTLIVADKLVHASMIDGIRLAQCEFVRFRHHDYAHLEQI
LQKNDRTFERIIVVTESVFSMDGDCADLTQLVALKQRYPQVMLYVDEAHAIGVLGEKGLGLAEQQGCINQIDILVGTFGK
ALGSMGAYVICDQVIRDYLVNKMRPLIFSTALPPFNVAWTHFVFQQLPHLQAERAHLAQLSQHLRQAIVDIFQVPMPSES
CIVPYILGDNELTVRTAQRLQQQGYYCLPIRPPTVPKGTSRIRFSLTADMQVAEVEQFIACLQELAE
>Mature_387_residues
MIRYYQQQLADLKAQNQFRQLPQLIHRGRFIQREDNTMLNMSSNDYLGLANNEALRQAFFTQYQDQLPALTSSSSRLLTG
SFPIYDELESLMAQAFGRETALLFNSGYHANIGILPALADKKTLIVADKLVHASMIDGIRLAQCEFVRFRHHDYAHLEQI
LQKNDRTFERIIVVTESVFSMDGDCADLTQLVALKQRYPQVMLYVDEAHAIGVLGEKGLGLAEQQGCINQIDILVGTFGK
ALGSMGAYVICDQVIRDYLVNKMRPLIFSTALPPFNVAWTHFVFQQLPHLQAERAHLAQLSQHLRQAIVDIFQVPMPSES
CIVPYILGDNELTVRTAQRLQQQGYYCLPIRPPTVPKGTSRIRFSLTADMQVAEVEQFIACLQELAE

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=352, Percent_Identity=32.9545454545455, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=33.4277620396601, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI83977440, Length=346, Percent_Identity=32.0809248554913, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI83977442, Length=346, Percent_Identity=32.0809248554913, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI83977444, Length=346, Percent_Identity=32.0809248554913, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI119220554, Length=383, Percent_Identity=27.4151436031332, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=28.4552845528455, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4502025, Length=380, Percent_Identity=27.8947368421053, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI40316939, Length=380, Percent_Identity=27.8947368421053, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI5454084, Length=246, Percent_Identity=26.0162601626016, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1786993, Length=357, Percent_Identity=36.1344537815126, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1790046, Length=372, Percent_Identity=30.6451612903226, Blast_Score=177, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=31.6326530612245, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=351, Percent_Identity=28.7749287749288, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17560912, Length=350, Percent_Identity=28.8571428571429, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=25.5434782608696, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71982617, Length=256, Percent_Identity=25.78125, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=256, Percent_Identity=25.78125, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=29.3150684931507, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6320438, Length=375, Percent_Identity=29.8666666666667, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=334, Percent_Identity=27.5449101796407, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24662918, Length=360, Percent_Identity=34.4444444444444, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI17137420, Length=388, Percent_Identity=28.8659793814433, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=27.3712737127371, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24653280, Length=260, Percent_Identity=27.3076923076923, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653276, Length=260, Percent_Identity=27.3076923076923, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653278, Length=260, Percent_Identity=27.3076923076923, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_PASMU (Q9CJU0)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246840.1
- HSSP:   P12998
- ProteinModelPortal:   Q9CJU0
- GeneID:   1245248
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1901
- NMPDR:   fig|272843.1.peg.1902
- HOGENOM:   HBG649839
- OMA:   HLERILR
- ProtClustDB:   PRK05958
- BioCyc:   PMUL272843:PM1901-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 43838; Mature: 43838

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 19-19 BINDING 132-132 BINDING 180-180 BINDING 354-354

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRYYQQQLADLKAQNQFRQLPQLIHRGRFIQREDNTMLNMSSNDYLGLANNEALRQAFF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCEECCCCHHHHHHHH
TQYQDQLPALTSSSSRLLTGSFPIYDELESLMAQAFGRETALLFNSGYHANIGILPALAD
HHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCC
KKTLIVADKLVHASMIDGIRLAQCEFVRFRHHDYAHLEQILQKNDRTFERIIVVTESVFS
CCEEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHC
MDGDCADLTQLVALKQRYPQVMLYVDEAHAIGVLGEKGLGLAEQQGCINQIDILVGTFGK
CCCCHHHHHHHHHHHHHCCEEEEEEECCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHH
ALGSMGAYVICDQVIRDYLVNKMRPLIFSTALPPFNVAWTHFVFQQLPHLQAERAHLAQL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
SQHLRQAIVDIFQVPMPSESCIVPYILGDNELTVRTAQRLQQQGYYCLPIRPPTVPKGTS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCEEEECCCCCCCCCCC
RIRFSLTADMQVAEVEQFIACLQELAE
EEEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRYYQQQLADLKAQNQFRQLPQLIHRGRFIQREDNTMLNMSSNDYLGLANNEALRQAFF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCEECCCCHHHHHHHH
TQYQDQLPALTSSSSRLLTGSFPIYDELESLMAQAFGRETALLFNSGYHANIGILPALAD
HHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCC
KKTLIVADKLVHASMIDGIRLAQCEFVRFRHHDYAHLEQILQKNDRTFERIIVVTESVFS
CCEEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHC
MDGDCADLTQLVALKQRYPQVMLYVDEAHAIGVLGEKGLGLAEQQGCINQIDILVGTFGK
CCCCHHHHHHHHHHHHHCCEEEEEEECCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHH
ALGSMGAYVICDQVIRDYLVNKMRPLIFSTALPPFNVAWTHFVFQQLPHLQAERAHLAQL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
SQHLRQAIVDIFQVPMPSESCIVPYILGDNELTVRTAQRLQQQGYYCLPIRPPTVPKGTS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCEEEECCCCCCCCCCC
RIRFSLTADMQVAEVEQFIACLQELAE
EEEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100