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The map label for this gene is bioA [H]

Identifier: 15603765

GI number: 15603765

Start: 2139862

End: 2141268

Strand: Direct

Name: bioA [H]

Synonym: PM1900

Alternate gene names: 15603765

Gene position: 2139862-2141268 (Clockwise)

Preceding gene: 15603762

Following gene: 15603766

Centisome position: 94.79

GC content: 45.27

Gene sequence:

>1407_bases
TTGAAAAGCCGAATGCTTGGCGATTATAACAAGTTATTCCGTTTATGTAAGTATTTGCGTGAATTTACGCCAGTTGAAAG
GGCGATTCACAACCGAGGTGAAACGATGAATGAGCAGCAACTTTTAGAATGTGATCGACAACATATTTGGCACCCTTATG
CGGCGTTAAATGCGGATTTTCCCTTATTTGTAGTAGAACGTGCCGAAGGCGTGTATATCCAGTTAAAAAACGGTCAGCAA
TTGATTGATGGCATGTCATCGTGGTGGTCAGCGATTCATGGCTATAATCACCCCCGTTTAAACCACGCTGCCACGCAACA
ACTGAGTCAAATGAGTCATGTGATGTTTGGTGGATTAACGCACCAACCAGCAGTAGAACTGGCGCAGCAACTGGTCAACA
TCTTGCCGGAAAGTTTGGATAAAATTTTCTTTGCCGACAGTGGTTCGGTCGCCGTGGAAGTGGCGATGAAAATGGCGGTG
CAATATCAACATGCTAAAGGTGAAACACAGCGCTGTAAATTTGCTACGATTCGTTCGGGCTATCATGGTGATACCTGGCA
TGCAATGTCCGTGTGTGATCCCGTGACCGGCATGCACAGCTTGTTTGCCAAAGGGCTACCCGTGCAATATTTTTTACCGC
AACCCCCGGTAAAATTTGGGCAAGCTTGGCAACCCGAAGCGATGCAACCGTTACAGGATTTATTGGCACAACATGGTGAT
GAGATTGCGGGCTTAATTTTAGAACCGGTAGTGCAAGGGGCGGGCGGTATGTATTTTTATTCCCCTGAGTATTTGGTGCA
AGCAAAAGCCTTGTGCGAACAGTACGGCATTTTGCTGATTTTTGATGAAATTGCCACAGGATTTGGGCGTACAGGCAAAT
TATTTGCTTGTGAACATGCCAATGTCGTACCGGATGTGATGTGTATCGGTAAAGCTTTAACAGGGGGGTATTTAACCCTA
TCCGCTACCATTACCAACCAAACAGTAGCAGACGTGATTTGTTCTGGCGAGGCAAAATGTTTTATGCACGGTCCGACGTT
TATGGCAAATCCACTGGCGTGTGCGGTAGCAGCAGAAAGTATCAAATTGTTATTGGCAAGCCCTTGGCAACAACGTATTC
AACAGATTGAACAGCAATTACGTCAAGAATTGCGCCAAGCGGAAGCCTTAGATTGTGTTGCTGAAGTGAGAGTACTTGGG
GCGATTGGGGTGATTGAAATGAAAGCGCCTGTCAATATGGCAAGTTTACAACCACGCTTTGTGCAAAATGGCGTTTGGGT
GCGTCCATTTGGAAAATTAGTGTATTTGATGCCACCGTATATCATCTCATCGGATCAATTGTCTCAATTAATTCATGGCA
CAATTCGCACCCTTCAAGAAGAGTATGCACATAAGGAATCTCTATGA

Upstream 100 bases:

>100_bases
ATTGAAAGGCAATTTTAATCCGTTGCCAGTAACTCAGTTGTGCTTTTTTTTCTAATATATTCATAGTGATAAATCATCTT
TTTAAGTTAGAATAATGGGC

Downstream 100 bases:

>100_bases
TCAGGTATTATCAGCAGCAGTTAGCTGATTTAAAGGCGCAGAATCAATTTCGCCAACTGCCCCAACTCATTCACCGAGGG
CGTTTTATTCAACGTGAGGA

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKSRMLGDYNKLFRLCKYLREFTPVERAIHNRGETMNEQQLLECDRQHIWHPYAALNADFPLFVVERAEGVYIQLKNGQQ
LIDGMSSWWSAIHGYNHPRLNHAATQQLSQMSHVMFGGLTHQPAVELAQQLVNILPESLDKIFFADSGSVAVEVAMKMAV
QYQHAKGETQRCKFATIRSGYHGDTWHAMSVCDPVTGMHSLFAKGLPVQYFLPQPPVKFGQAWQPEAMQPLQDLLAQHGD
EIAGLILEPVVQGAGGMYFYSPEYLVQAKALCEQYGILLIFDEIATGFGRTGKLFACEHANVVPDVMCIGKALTGGYLTL
SATITNQTVADVICSGEAKCFMHGPTFMANPLACAVAAESIKLLLASPWQQRIQQIEQQLRQELRQAEALDCVAEVRVLG
AIGVIEMKAPVNMASLQPRFVQNGVWVRPFGKLVYLMPPYIISSDQLSQLIHGTIRTLQEEYAHKESL

Sequences:

>Translated_468_residues
MKSRMLGDYNKLFRLCKYLREFTPVERAIHNRGETMNEQQLLECDRQHIWHPYAALNADFPLFVVERAEGVYIQLKNGQQ
LIDGMSSWWSAIHGYNHPRLNHAATQQLSQMSHVMFGGLTHQPAVELAQQLVNILPESLDKIFFADSGSVAVEVAMKMAV
QYQHAKGETQRCKFATIRSGYHGDTWHAMSVCDPVTGMHSLFAKGLPVQYFLPQPPVKFGQAWQPEAMQPLQDLLAQHGD
EIAGLILEPVVQGAGGMYFYSPEYLVQAKALCEQYGILLIFDEIATGFGRTGKLFACEHANVVPDVMCIGKALTGGYLTL
SATITNQTVADVICSGEAKCFMHGPTFMANPLACAVAAESIKLLLASPWQQRIQQIEQQLRQELRQAEALDCVAEVRVLG
AIGVIEMKAPVNMASLQPRFVQNGVWVRPFGKLVYLMPPYIISSDQLSQLIHGTIRTLQEEYAHKESL
>Mature_468_residues
MKSRMLGDYNKLFRLCKYLREFTPVERAIHNRGETMNEQQLLECDRQHIWHPYAALNADFPLFVVERAEGVYIQLKNGQQ
LIDGMSSWWSAIHGYNHPRLNHAATQQLSQMSHVMFGGLTHQPAVELAQQLVNILPESLDKIFFADSGSVAVEVAMKMAV
QYQHAKGETQRCKFATIRSGYHGDTWHAMSVCDPVTGMHSLFAKGLPVQYFLPQPPVKFGQAWQPEAMQPLQDLLAQHGD
EIAGLILEPVVQGAGGMYFYSPEYLVQAKALCEQYGILLIFDEIATGFGRTGKLFACEHANVVPDVMCIGKALTGGYLTL
SATITNQTVADVICSGEAKCFMHGPTFMANPLACAVAAESIKLLLASPWQQRIQQIEQQLRQELRQAEALDCVAEVRVLG
AIGVIEMKAPVNMASLQPRFVQNGVWVRPFGKLVYLMPPYIISSDQLSQLIHGTIRTLQEEYAHKESL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=420, Percent_Identity=26.9047619047619, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=28.5266457680251, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI13994255, Length=407, Percent_Identity=26.044226044226, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI37574042, Length=385, Percent_Identity=24.4155844155844, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI226442705, Length=385, Percent_Identity=24.1558441558442, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI226442709, Length=325, Percent_Identity=24.6153846153846, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=57.6190476190476, Blast_Score=497, Evalue=1e-142,
Organism=Escherichia coli, GI145693181, Length=395, Percent_Identity=32.6582278481013, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1789016, Length=354, Percent_Identity=29.3785310734463, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1787560, Length=352, Percent_Identity=30.1136363636364, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788044, Length=341, Percent_Identity=29.9120234604106, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789759, Length=350, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786349, Length=329, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=447, Percent_Identity=25.0559284116331, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI25144274, Length=221, Percent_Identity=31.2217194570136, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=375, Percent_Identity=25.0666666666667, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=408, Percent_Identity=23.5294117647059, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324386, Length=465, Percent_Identity=42.5806451612903, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323470, Length=428, Percent_Identity=27.5700934579439, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=320, Percent_Identity=27.1875, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357415, Length=414, Percent_Identity=26.0869565217391, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356575, Length=388, Percent_Identity=25.7731958762887, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281366494, Length=304, Percent_Identity=28.6184210526316, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24667139, Length=304, Percent_Identity=28.6184210526316, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24667143, Length=304, Percent_Identity=28.6184210526316, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 52234; Mature: 52234

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRMLGDYNKLFRLCKYLREFTPVERAIHNRGETMNEQQLLECDRQHIWHPYAALNADF
CCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHCCCC
PLFVVERAEGVYIQLKNGQQLIDGMSSWWSAIHGYNHPRLNHAATQQLSQMSHVMFGGLT
CEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
HQPAVELAQQLVNILPESLDKIFFADSGSVAVEVAMKMAVQYQHAKGETQRCKFATIRSG
CCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHHCC
YHGDTWHAMSVCDPVTGMHSLFAKGLPVQYFLPQPPVKFGQAWQPEAMQPLQDLLAQHGD
CCCCCCHHHHHHCHHHHHHHHHHCCCCEEEECCCCCHHCCCCCCCHHHHHHHHHHHHCCC
EIAGLILEPVVQGAGGMYFYSPEYLVQAKALCEQYGILLIFDEIATGFGRTGKLFACEHA
HHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCC
NVVPDVMCIGKALTGGYLTLSATITNQTVADVICSGEAKCFMHGPTFMANPLACAVAAES
CCCHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHCCCCEEEEECCCHHCCHHHHHHHHHH
IKLLLASPWQQRIQQIEQQLRQELRQAEALDCVAEVRVLGAIGVIEMKAPVNMASLQPRF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHCCCHH
VQNGVWVRPFGKLVYLMPPYIISSDQLSQLIHGTIRTLQEEYAHKESL
HHCCCEECCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSRMLGDYNKLFRLCKYLREFTPVERAIHNRGETMNEQQLLECDRQHIWHPYAALNADF
CCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHCCCC
PLFVVERAEGVYIQLKNGQQLIDGMSSWWSAIHGYNHPRLNHAATQQLSQMSHVMFGGLT
CEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
HQPAVELAQQLVNILPESLDKIFFADSGSVAVEVAMKMAVQYQHAKGETQRCKFATIRSG
CCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHHCC
YHGDTWHAMSVCDPVTGMHSLFAKGLPVQYFLPQPPVKFGQAWQPEAMQPLQDLLAQHGD
CCCCCCHHHHHHCHHHHHHHHHHCCCCEEEECCCCCHHCCCCCCCHHHHHHHHHHHHCCC
EIAGLILEPVVQGAGGMYFYSPEYLVQAKALCEQYGILLIFDEIATGFGRTGKLFACEHA
HHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCC
NVVPDVMCIGKALTGGYLTLSATITNQTVADVICSGEAKCFMHGPTFMANPLACAVAAES
CCCHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHCCCCEEEEECCCHHCCHHHHHHHHHH
IKLLLASPWQQRIQQIEQQLRQELRQAEALDCVAEVRVLGAIGVIEMKAPVNMASLQPRF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHCCCHH
VQNGVWVRPFGKLVYLMPPYIISSDQLSQLIHGTIRTLQEEYAHKESL
HHCCCEECCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]