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The map label for this gene is scrR [H]

Identifier: 15603712

GI number: 15603712

Start: 2087271

End: 2088290

Strand: Reverse

Name: scrR [H]

Synonym: PM1847

Alternate gene names: 15603712

Gene position: 2088290-2087271 (Counterclockwise)

Preceding gene: 15603713

Following gene: 15603711

Centisome position: 92.51

GC content: 39.31

Gene sequence:

>1020_bases
ATGAGCATTACCAATAAAAAACGTATCACCCTCAGCGATATTGCGAAATGTTGTGGTTTATCCACCACTACCGTCAGTAT
GATTTTAAATAATCGAGGTGAGGAATTTAAAATTAAAGCGGAGACGTGTCAACGCGTAAAAGCCATTGCGGAACAACAAG
GTTATCGAGCAAATGTCTACGCCAAATCACTCAAAATGCAACGCTCTAATGTAATAGGTTTCGTGATTCCAGATCTGACG
AACTACGGCTTTGCCTGTACAGCCAAAATATTAGAAAAGCAGTGTCGTGAAAATGGTTTACAACTTATTATTGCCTGTTC
AGATGACAATCCACAGCAAGAAAAATTAGCGATTGAGCGTTTATTGGATCGTCAAATTGATTTTTTAATTACGGCCCCTA
CTCATCAAGATCCGAGTTACTACCAGAAAATCGGTCAACACACTCCTATTTTACAATTGGATCGTTATGTACCAGACTTG
GCGCTGAACTATGTCATCAGTAATGATAGTGAACACATTACGGCTTTAATTTGCCGTCTATGTGACCAGTATCAGCTAAC
AGAATTCATGTACTTTGGCGGACAGCGTACCCTTTCTCCTAGCGAATCACGCTTAGCGGGCTTTTTACAAGGGCTTAAAC
AAGCCAATCTTAACCTAAAAAAAGAATGGATATTACACCGCACCTATCAACCAGAATCAGGTTATCAAATGTTAGCGGAG
ACAGAAGCTAAACTAGGTCGTTTACCTCAAGCGATCTTCACCGCTTCCTATACCTTGTTAGAGGGCGTGTTACGTTACTT
AACAGAGCAAAAAAAAATGGATTTATTACTTAATCGTCAGTTACATTTAGCTACTTTCGATGATCACGATATCTTAAATG
CCCTGCCATTCCACATACATTCTATTAAACAAAATCACCCCCAGCTTGCCCATCAGATTTTCCAACATATTATGCGTTAC
TTTGCAGGTAAAAAAAGCCCTAACCAAAAAATCGACTGTGACGTCATTTATCGTGATTAA

Upstream 100 bases:

>100_bases
GAAAATGCGTTAGATAGCTCTCGCCCGCTCTGTGTTTCTGTGGCAGAATTAAAACCCATTATCTTAACACCTTAAGTTTT
CATTTATTTCTCTTTACAGC

Downstream 100 bases:

>100_bases
GTTATCGCAACGCTGAAGACAAGGAGAATAAAGTAATTCTCCTTTGTTTTATTAAACGACGCTTTCTTCTTGTTCCATTC
AAACAATACATCGCTTCTTT

Product: ScrR

Products: NA

Alternate protein names: Scr operon regulatory protein [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSITNKKRITLSDIAKCCGLSTTTVSMILNNRGEEFKIKAETCQRVKAIAEQQGYRANVYAKSLKMQRSNVIGFVIPDLT
NYGFACTAKILEKQCRENGLQLIIACSDDNPQQEKLAIERLLDRQIDFLITAPTHQDPSYYQKIGQHTPILQLDRYVPDL
ALNYVISNDSEHITALICRLCDQYQLTEFMYFGGQRTLSPSESRLAGFLQGLKQANLNLKKEWILHRTYQPESGYQMLAE
TEAKLGRLPQAIFTASYTLLEGVLRYLTEQKKMDLLLNRQLHLATFDDHDILNALPFHIHSIKQNHPQLAHQIFQHIMRY
FAGKKSPNQKIDCDVIYRD

Sequences:

>Translated_339_residues
MSITNKKRITLSDIAKCCGLSTTTVSMILNNRGEEFKIKAETCQRVKAIAEQQGYRANVYAKSLKMQRSNVIGFVIPDLT
NYGFACTAKILEKQCRENGLQLIIACSDDNPQQEKLAIERLLDRQIDFLITAPTHQDPSYYQKIGQHTPILQLDRYVPDL
ALNYVISNDSEHITALICRLCDQYQLTEFMYFGGQRTLSPSESRLAGFLQGLKQANLNLKKEWILHRTYQPESGYQMLAE
TEAKLGRLPQAIFTASYTLLEGVLRYLTEQKKMDLLLNRQLHLATFDDHDILNALPFHIHSIKQNHPQLAHQIFQHIMRY
FAGKKSPNQKIDCDVIYRD
>Mature_338_residues
SITNKKRITLSDIAKCCGLSTTTVSMILNNRGEEFKIKAETCQRVKAIAEQQGYRANVYAKSLKMQRSNVIGFVIPDLTN
YGFACTAKILEKQCRENGLQLIIACSDDNPQQEKLAIERLLDRQIDFLITAPTHQDPSYYQKIGQHTPILQLDRYVPDLA
LNYVISNDSEHITALICRLCDQYQLTEFMYFGGQRTLSPSESRLAGFLQGLKQANLNLKKEWILHRTYQPESGYQMLAET
EAKLGRLPQAIFTASYTLLEGVLRYLTEQKKMDLLLNRQLHLATFDDHDILNALPFHIHSIKQNHPQLAHQIFQHIMRYF
AGKKSPNQKIDCDVIYRD

Specific function: Repressor for the scr operon. Binds D-fructose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786268, Length=323, Percent_Identity=30.030959752322, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790194, Length=320, Percent_Identity=25.625, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787948, Length=329, Percent_Identity=22.4924012158055, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789068, Length=338, Percent_Identity=23.9644970414201, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789202, Length=282, Percent_Identity=24.113475177305, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790369, Length=344, Percent_Identity=22.9651162790698, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788474, Length=284, Percent_Identity=26.056338028169, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787906, Length=230, Percent_Identity=22.6086956521739, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787580, Length=340, Percent_Identity=21.4705882352941, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012781
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38943; Mature: 38812

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITNKKRITLSDIAKCCGLSTTTVSMILNNRGEEFKIKAETCQRVKAIAEQQGYRANVY
CCCCCCCCEEHHHHHHHHCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCEEHHH
AKSLKMQRSNVIGFVIPDLTNYGFACTAKILEKQCRENGLQLIIACSDDNPQQEKLAIER
HHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LLDRQIDFLITAPTHQDPSYYQKIGQHTPILQLDRYVPDLALNYVISNDSEHITALICRL
HHHCCCCEEEECCCCCCHHHHHHHCCCCCCHHHHHHCHHHHHHEEECCCCHHHHHHHHHH
CDQYQLTEFMYFGGQRTLSPSESRLAGFLQGLKQANLNLKKEWILHRTYQPESGYQMLAE
HCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHEEECCCCCCCHHHHHH
TEAKLGRLPQAIFTASYTLLEGVLRYLTEQKKMDLLLNRQLHLATFDDHDILNALPFHIH
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
SIKQNHPQLAHQIFQHIMRYFAGKKSPNQKIDCDVIYRD
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
SITNKKRITLSDIAKCCGLSTTTVSMILNNRGEEFKIKAETCQRVKAIAEQQGYRANVY
CCCCCCCEEHHHHHHHHCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCEEHHH
AKSLKMQRSNVIGFVIPDLTNYGFACTAKILEKQCRENGLQLIIACSDDNPQQEKLAIER
HHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LLDRQIDFLITAPTHQDPSYYQKIGQHTPILQLDRYVPDLALNYVISNDSEHITALICRL
HHHCCCCEEEECCCCCCHHHHHHHCCCCCCHHHHHHCHHHHHHEEECCCCHHHHHHHHHH
CDQYQLTEFMYFGGQRTLSPSESRLAGFLQGLKQANLNLKKEWILHRTYQPESGYQMLAE
HCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHEEECCCCCCCHHHHHH
TEAKLGRLPQAIFTASYTLLEGVLRYLTEQKKMDLLLNRQLHLATFDDHDILNALPFHIH
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
SIKQNHPQLAHQIFQHIMRYFAGKKSPNQKIDCDVIYRD
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412665 [H]