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The map label for this gene is dmsA [H]

Identifier: 15603619

GI number: 15603619

Start: 1976957

End: 1979488

Strand: Direct

Name: dmsA [H]

Synonym: PM1754

Alternate gene names: 15603619

Gene position: 1976957-1979488 (Clockwise)

Preceding gene: 15603618

Following gene: 15603620

Centisome position: 87.57

GC content: 42.77

Gene sequence:

>2532_bases
TTGATCTATCTCATATTCCCTACCTCTTTTTGGTTGTTTAATAGAATAGATGTTTCTATGTCTGTTTATAGCATAACCAT
CGGGGGATACGTTATGGATAAATTGCTTGTCAATTCAAGATTGACCAGACGTTCTTTACTGCAAAGAACTTCAATTGGTG
CAGCGCTCGCTGCGACCAATCTGTCATTACCTTTCAAAGCCGTCGCTAATGAAAAAAAAGCGACATCCTCATCAACAGAA
AATCTGCAGGAAAAAGTGGTTTGGAGTGCTTGCACAGTGAACTGTGGTAGCCGTTGTCCACTGAGAATGCACGTGAAAGA
CAATAAAATTATCTATGTCGAAACTGACAACACGGGAACGGATACATATAACGTTGACCACCAAGTCAGAGCGTGTTTAC
GCGGACGTTCAATGCGCCGTCGTGTTTATAATCCAGACCGTTTGAAATACCCAATGAAGCGTGTGGGTAAACGCGGTGAA
GGTAAGTTTAAGCGTATCAGTTGGGATGAAGCACTAAATGAGATTGCTACTTCACTACGTAAGAATATTGCGCAATATGG
TAATGAATCGATTTATCTCAATTATGGTACGGGTACACTGGGTGGCACAATGACTAAGTCTTGGCCTCCGGGGTCAACTA
TGCTTGCCCGTTTTATGAACTGTTTAGGGGGTTATCTCAACCATTATGGTGATTACAGCACCGCACAAATTGCAGTCGGG
TTGGATTATACCTATGGCGGTGGTTGGGCATTAGGAAATGGCTTAGCTGATATCGAAAATACGAAGTTGGTTGTCCTTTT
TGGTAATAATCCAGCAGAAACACGCATGAGCGGTGGGGGATTGACGTATTGTATTGAACAAGCACGACAAAAATCGAATG
CGAAAATGATCATTATTGATCCTCGTTATACTGATACCGCGGCTGGACGTGAGGATGAATGGATTCCAATTCGTCCGGGT
ACTGATGCCGCCTTAGTTTCGGCTTTAGCTTATGTGATGATTACAGAAGATTTAGTCGATCAAGCGTTCTTAGATACGTA
TTGTGTTGGCTATGATGAAAAAACCTTGCCTGAAGGCGCACCAAAAAATGGGCATTATAAAGCCTATATTTTGGGGGAAG
GGGATGATGGAATTGTCAAAACACCGGAGTGGGCGGCGAAAATTACGGGAATTCCTGAACAACGTATTATTAAATTGGCT
CGAGAAATTGCCGGAACGAAACCTGCTTATATTTCGCAAGGTTGGGGACCACAACGTCGCAGTAATGGTGAGCTAATTTC
TCGTGCGATTGCTATGTTACCGATTCTGACCGGTAATGTGGGAATTAATGGGGGCAATACTGGAGCAAGGGAAAGCACTT
ATAAAGTCCCTTTTGTCCGTATGCCAACCTTAACAAACCCAGTGAAAGCCAGTATTCCGATGTTTTTATGGACAGATGCG
ATTTTTCGTGCGCACGAAATGACTGCATTAACGGATGGTATTCGTGGTGTGGAAAAACTCACCGCACCGATTAAAGTGAT
TTGGAATTATGCGAGTAACTGTTTGATTAACCAGCATTCCGACATCAATCGTACCCATGAAATTTTGCAAGATGAGACAC
AGTGTGAATTGATTATTACCATTGATAATCATATGACTTCAACCGCAAAATACAGTGATATTTTGTTACCAGATTGTACT
GCGTCAGAGCAAATGGATTTTTGTACCGATGCCTTTGTCGCCAATATGAACTATGTGATCTTTGCCGATCAAGTGATCCC
CCCTTCTTTTGAGTGCCGTAATATTTATGACATGTTAACGGATTTAGCCGAGAAAATGGGGGTTAAGCAAGCATTCACTG
AAGGGCGCACACAAGAAGAATGGCTCCGTCATATTTATCAACAATCCCGAGAAAACTTGCCAGAATTGCCGACCTTTGAA
GAATTCAGACAGCAAGGCATCTTTAAAAAAGTCGATCCAAATGGCTTTTATGTGGCTTATAAGGCTTTCCGTGAAGATCC
GCAAGCGAATCCTCTCAAAACACCATCCGGTAAAATTGAGATTTACTCTGAGCGCTTAGCGGAAATCGCCAAAACGTGGT
CGCTAAAAGACGATGAAGTGATTCACCCATTGCCTGTACATGCTGACAGTTTTGAACACTATGGCGATAAATTAATGGAA
AAATATCCGTTACAAATGACAGGTTTTCATTATAAAGCGCGTACACATTCAACCTACGGTAACGTGGACGTGATTAAGGC
GGCGACCCCGCAAGAAGTGTGGATTAATCCGATTGATGCACAAGCACGCAATATTAAAAATGGCGATATGATTCGTATCT
TTAATGATCGTGGTGAAGTACAGATTCATGCCAAAGTGACACCTCGTATTATCCCCGGTGTAGTCGCGTTAAGTGAGGGT
GCTTGGTATGCACCAGACAGTCAAGGTGTGGATCATTCAGGTTGTGTGAACGTATTGACAACACAACGTCCATCGCCTCT
CGCGAAGGGTAATCCACAGCATTCTAACTTAGTTCAAGTTGCGAAAGTGTAA

Upstream 100 bases:

>100_bases
TTTTACGCCTATTCTAATTGAATGCTAATTATTATCATTTTTATAAGTGATTGATTTATATCATATAATATGGCTTATTT
TTTGTCTTAAAAGATAAAAG

Downstream 100 bases:

>100_bases
GGAGTAAATGATGAGTGTTCAGTATGGCTTTTATTTTGACTCAGATCGTTGCACCGGCTGTAAGACTTGTGAATTAGCCT
GCAAAGACTATAAAGACCTC

Product: DmsA

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 843; Mature: 843

Protein sequence:

>843_residues
MIYLIFPTSFWLFNRIDVSMSVYSITIGGYVMDKLLVNSRLTRRSLLQRTSIGAALAATNLSLPFKAVANEKKATSSSTE
NLQEKVVWSACTVNCGSRCPLRMHVKDNKIIYVETDNTGTDTYNVDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGE
GKFKRISWDEALNEIATSLRKNIAQYGNESIYLNYGTGTLGGTMTKSWPPGSTMLARFMNCLGGYLNHYGDYSTAQIAVG
LDYTYGGGWALGNGLADIENTKLVVLFGNNPAETRMSGGGLTYCIEQARQKSNAKMIIIDPRYTDTAAGREDEWIPIRPG
TDAALVSALAYVMITEDLVDQAFLDTYCVGYDEKTLPEGAPKNGHYKAYILGEGDDGIVKTPEWAAKITGIPEQRIIKLA
REIAGTKPAYISQGWGPQRRSNGELISRAIAMLPILTGNVGINGGNTGARESTYKVPFVRMPTLTNPVKASIPMFLWTDA
IFRAHEMTALTDGIRGVEKLTAPIKVIWNYASNCLINQHSDINRTHEILQDETQCELIITIDNHMTSTAKYSDILLPDCT
ASEQMDFCTDAFVANMNYVIFADQVIPPSFECRNIYDMLTDLAEKMGVKQAFTEGRTQEEWLRHIYQQSRENLPELPTFE
EFRQQGIFKKVDPNGFYVAYKAFREDPQANPLKTPSGKIEIYSERLAEIAKTWSLKDDEVIHPLPVHADSFEHYGDKLME
KYPLQMTGFHYKARTHSTYGNVDVIKAATPQEVWINPIDAQARNIKNGDMIRIFNDRGEVQIHAKVTPRIIPGVVALSEG
AWYAPDSQGVDHSGCVNVLTTQRPSPLAKGNPQHSNLVQVAKV

Sequences:

>Translated_843_residues
MIYLIFPTSFWLFNRIDVSMSVYSITIGGYVMDKLLVNSRLTRRSLLQRTSIGAALAATNLSLPFKAVANEKKATSSSTE
NLQEKVVWSACTVNCGSRCPLRMHVKDNKIIYVETDNTGTDTYNVDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGE
GKFKRISWDEALNEIATSLRKNIAQYGNESIYLNYGTGTLGGTMTKSWPPGSTMLARFMNCLGGYLNHYGDYSTAQIAVG
LDYTYGGGWALGNGLADIENTKLVVLFGNNPAETRMSGGGLTYCIEQARQKSNAKMIIIDPRYTDTAAGREDEWIPIRPG
TDAALVSALAYVMITEDLVDQAFLDTYCVGYDEKTLPEGAPKNGHYKAYILGEGDDGIVKTPEWAAKITGIPEQRIIKLA
REIAGTKPAYISQGWGPQRRSNGELISRAIAMLPILTGNVGINGGNTGARESTYKVPFVRMPTLTNPVKASIPMFLWTDA
IFRAHEMTALTDGIRGVEKLTAPIKVIWNYASNCLINQHSDINRTHEILQDETQCELIITIDNHMTSTAKYSDILLPDCT
ASEQMDFCTDAFVANMNYVIFADQVIPPSFECRNIYDMLTDLAEKMGVKQAFTEGRTQEEWLRHIYQQSRENLPELPTFE
EFRQQGIFKKVDPNGFYVAYKAFREDPQANPLKTPSGKIEIYSERLAEIAKTWSLKDDEVIHPLPVHADSFEHYGDKLME
KYPLQMTGFHYKARTHSTYGNVDVIKAATPQEVWINPIDAQARNIKNGDMIRIFNDRGEVQIHAKVTPRIIPGVVALSEG
AWYAPDSQGVDHSGCVNVLTTQRPSPLAKGNPQHSNLVQVAKV
>Mature_843_residues
MIYLIFPTSFWLFNRIDVSMSVYSITIGGYVMDKLLVNSRLTRRSLLQRTSIGAALAATNLSLPFKAVANEKKATSSSTE
NLQEKVVWSACTVNCGSRCPLRMHVKDNKIIYVETDNTGTDTYNVDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGE
GKFKRISWDEALNEIATSLRKNIAQYGNESIYLNYGTGTLGGTMTKSWPPGSTMLARFMNCLGGYLNHYGDYSTAQIAVG
LDYTYGGGWALGNGLADIENTKLVVLFGNNPAETRMSGGGLTYCIEQARQKSNAKMIIIDPRYTDTAAGREDEWIPIRPG
TDAALVSALAYVMITEDLVDQAFLDTYCVGYDEKTLPEGAPKNGHYKAYILGEGDDGIVKTPEWAAKITGIPEQRIIKLA
REIAGTKPAYISQGWGPQRRSNGELISRAIAMLPILTGNVGINGGNTGARESTYKVPFVRMPTLTNPVKASIPMFLWTDA
IFRAHEMTALTDGIRGVEKLTAPIKVIWNYASNCLINQHSDINRTHEILQDETQCELIITIDNHMTSTAKYSDILLPDCT
ASEQMDFCTDAFVANMNYVIFADQVIPPSFECRNIYDMLTDLAEKMGVKQAFTEGRTQEEWLRHIYQQSRENLPELPTFE
EFRQQGIFKKVDPNGFYVAYKAFREDPQANPLKTPSGKIEIYSERLAEIAKTWSLKDDEVIHPLPVHADSFEHYGDKLME
KYPLQMTGFHYKARTHSTYGNVDVIKAATPQEVWINPIDAQARNIKNGDMIRIFNDRGEVQIHAKVTPRIIPGVVALSEG
AWYAPDSQGVDHSGCVNVLTTQRPSPLAKGNPQHSNLVQVAKV

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=809, Percent_Identity=73.4239802224969, Blast_Score=1251, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=808, Percent_Identity=64.480198019802, Blast_Score=1113, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=813, Percent_Identity=61.2546125461255, Blast_Score=1048, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=767, Percent_Identity=32.0730117340287, Blast_Score=309, Evalue=6e-85,
Organism=Escherichia coli, GI145693196, Length=741, Percent_Identity=32.1187584345479, Blast_Score=292, Evalue=5e-80,
Organism=Escherichia coli, GI87081994, Length=864, Percent_Identity=29.1666666666667, Blast_Score=285, Evalue=8e-78,
Organism=Escherichia coli, GI3868721, Length=789, Percent_Identity=24.4613434727503, Blast_Score=140, Evalue=5e-34,
Organism=Escherichia coli, GI3868720, Length=422, Percent_Identity=28.1990521327014, Blast_Score=98, Evalue=3e-21,
Organism=Escherichia coli, GI3868719, Length=465, Percent_Identity=24.9462365591398, Blast_Score=90, Evalue=7e-19,
Organism=Escherichia coli, GI1788534, Length=891, Percent_Identity=22.5589225589226, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 94229; Mature: 94229

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLIFPTSFWLFNRIDVSMSVYSITIGGYVMDKLLVNSRLTRRSLLQRTSIGAALAATN
CEEEEEECCEEEHEEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECC
LSLPFKAVANEKKATSSSTENLQEKVVWSACTVNCGSRCPLRMHVKDNKIIYVETDNTGT
CCCCHHHHCCCHHCCCCHHHHHHHHHHHHHEEECCCCCCCEEEEECCCEEEEEEECCCCC
DTYNVDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFKRISWDEALNEIATSLR
CCCCCHHHHHHHHHCHHHHHHCCCCHHHCCHHHHCCCCCCCCEEEECHHHHHHHHHHHHH
KNIAQYGNESIYLNYGTGTLGGTMTKSWPPGSTMLARFMNCLGGYLNHYGDYSTAQIAVG
HHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
LDYTYGGGWALGNGLADIENTKLVVLFGNNPAETRMSGGGLTYCIEQARQKSNAKMIIID
EEEECCCCEECCCCCCCCCCCEEEEEECCCCHHCEECCCCHHHHHHHHHHHCCCEEEEEC
PRYTDTAAGREDEWIPIRPGTDAALVSALAYVMITEDLVDQAFLDTYCVGYDEKTLPEGA
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PKNGHYKAYILGEGDDGIVKTPEWAAKITGIPEQRIIKLAREIAGTKPAYISQGWGPQRR
CCCCCEEEEEEECCCCCCEECCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SNGELISRAIAMLPILTGNVGINGGNTGARESTYKVPFVRMPTLTNPVKASIPMFLWTDA
CCHHHHHHHHHHHHHEECCEECCCCCCCCCCCEEECCEEECCCCCCCHHHCCCHHHHHHH
IFRAHEMTALTDGIRGVEKLTAPIKVIWNYASNCLINQHSDINRTHEILQDETQCELIIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHCCCCCEEEEEE
IDNHMTSTAKYSDILLPDCTASEQMDFCTDAFVANMNYVIFADQVIPPSFECRNIYDMLT
ECCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHH
DLAEKMGVKQAFTEGRTQEEWLRHIYQQSRENLPELPTFEEFRQQGIFKKVDPNGFYVAY
HHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEECCCCEEEEE
KAFREDPQANPLKTPSGKIEIYSERLAEIAKTWSLKDDEVIHPLPVHADSFEHYGDKLME
EEHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
KYPLQMTGFHYKARTHSTYGNVDVIKAATPQEVWINPIDAQARNIKNGDMIRIFNDRGEV
HCCCEEECEEEEEECCCCCCCEEEEECCCCHHHCCCCCCHHHCCCCCCCEEEEECCCCCE
QIHAKVTPRIIPGVVALSEGAWYAPDSQGVDHSGCVNVLTTQRPSPLAKGNPQHSNLVQV
EEEEEECCCHHCCEEEECCCCEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEE
AKV
ECC
>Mature Secondary Structure
MIYLIFPTSFWLFNRIDVSMSVYSITIGGYVMDKLLVNSRLTRRSLLQRTSIGAALAATN
CEEEEEECCEEEHEEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECC
LSLPFKAVANEKKATSSSTENLQEKVVWSACTVNCGSRCPLRMHVKDNKIIYVETDNTGT
CCCCHHHHCCCHHCCCCHHHHHHHHHHHHHEEECCCCCCCEEEEECCCEEEEEEECCCCC
DTYNVDHQVRACLRGRSMRRRVYNPDRLKYPMKRVGKRGEGKFKRISWDEALNEIATSLR
CCCCCHHHHHHHHHCHHHHHHCCCCHHHCCHHHHCCCCCCCCEEEECHHHHHHHHHHHHH
KNIAQYGNESIYLNYGTGTLGGTMTKSWPPGSTMLARFMNCLGGYLNHYGDYSTAQIAVG
HHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
LDYTYGGGWALGNGLADIENTKLVVLFGNNPAETRMSGGGLTYCIEQARQKSNAKMIIID
EEEECCCCEECCCCCCCCCCCEEEEEECCCCHHCEECCCCHHHHHHHHHHHCCCEEEEEC
PRYTDTAAGREDEWIPIRPGTDAALVSALAYVMITEDLVDQAFLDTYCVGYDEKTLPEGA
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PKNGHYKAYILGEGDDGIVKTPEWAAKITGIPEQRIIKLAREIAGTKPAYISQGWGPQRR
CCCCCEEEEEEECCCCCCEECCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SNGELISRAIAMLPILTGNVGINGGNTGARESTYKVPFVRMPTLTNPVKASIPMFLWTDA
CCHHHHHHHHHHHHHEECCEECCCCCCCCCCCEEECCEEECCCCCCCHHHCCCHHHHHHH
IFRAHEMTALTDGIRGVEKLTAPIKVIWNYASNCLINQHSDINRTHEILQDETQCELIIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHCCCCCEEEEEE
IDNHMTSTAKYSDILLPDCTASEQMDFCTDAFVANMNYVIFADQVIPPSFECRNIYDMLT
ECCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHH
DLAEKMGVKQAFTEGRTQEEWLRHIYQQSRENLPELPTFEEFRQQGIFKKVDPNGFYVAY
HHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEECCCCEEEEE
KAFREDPQANPLKTPSGKIEIYSERLAEIAKTWSLKDDEVIHPLPVHADSFEHYGDKLME
EEHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
KYPLQMTGFHYKARTHSTYGNVDVIKAATPQEVWINPIDAQARNIKNGDMIRIFNDRGEV
HCCCEEECEEEEEECCCCCCCEEEEECCCCHHHCCCCCCHHHCCCCCCCEEEEECCCCCE
QIHAKVTPRIIPGVVALSEGAWYAPDSQGVDHSGCVNVLTTQRPSPLAKGNPQHSNLVQV
EEEEEECCCHHCCEEEECCCCEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEE
AKV
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 8635740 [H]