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The map label for this gene is coaA

Identifier: 15603612

GI number: 15603612

Start: 1969367

End: 1970317

Strand: Direct

Name: coaA

Synonym: PM1747

Alternate gene names: 15603612

Gene position: 1969367-1970317 (Clockwise)

Preceding gene: 15603606

Following gene: 15603617

Centisome position: 87.24

GC content: 37.64

Gene sequence:

>951_bases
GTGGACTTAACAAATTCAACTTTTTTATCAAATCAATTAACCCCTTTTTTATCTTTTAGCCGCGAGCAGTGGGCTGAATT
AAGAAAGTCTGTACCGTTAACCTTAACTGAACAGGATTTAAAACCCCTGCTTGGGATTAATGAAGAACTTTCTTTAGATG
AAGTGCGAACTATTTATTTGCCGTTAGTACGTTTAATTAATTATTACATCGAAGAACGTATCCAGCGTCAGCAAGTGATG
AATCGCTTTTTAGGCGTCAACCCTGACAAAGTACCTTATATTATTAGTATTGCAGGGAGTGTTGCCGTTGGAAAAAGCAC
TTCAGCACGTATTCTGCAATCGTTACTTTCCCAATGGCCAGAACGTCGTAAAGTGGATTTGATCACGACAGATGGTTTTT
TATATCCGTTGGCTAAGTTGCAACAAGACAATCTTTTACATAAAAAAGGTTTTCCAGTTTCTTACGATACGGCGCGTTTA
GTGCGTTTTTTAGCTGATATTAAATCAGGTAAACCAAAGGTGAGTGCGCCTGTTTATTCCCATTTAATTTATGATATCGT
ACCGGATCAATTTGATGTGGTGGATCAACCTGATATTCTCATTTTAGAAGGCTTAAATGTCCTACAAACAGGCGATCGTT
CTAGTCAAACTTTCGTTTCTGATTTTGTTGATTTTTCTATTTATGTGGATGCAGATGAAGATCTCTTAAAAGCGTGGTAT
ATCAGCCGTTTTTTGAAATTCCGTCAAAGCGCATTTAGCGATCCGAATTCGTATTTTAAACATTATGCTACTTTATCAGA
ACCTGAAGCGATCAGTACGGCGGGGCGGATTTGGGATGAAATTAACGGGTTAAATTTAAGAGAAAATATTTTACCGACAA
GAGAACGTGCCAATTTAATTCTGACCAAAGGCACAGATCATGCCGTAGAGTTGGTGAAATTACGTAAATAG

Upstream 100 bases:

>100_bases
TTATAAAGTAGCCAGTTTTGTAAAATTTTTATCCTTTTTTACCTATTTATAGGGTATATTTCATACTCAATTTATTGCAA
CGTGACAACTTAAACAGATT

Downstream 100 bases:

>100_bases
TTCTGCTTTCTATTGAAATCATACAAAAACAAACCGCACTTTATTGATTCAAATAAAGTGCGGTTTTACGTTAAGCAAGA
TTATAAAATGAAACGGCTTA

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MDLTNSTFLSNQLTPFLSFSREQWAELRKSVPLTLTEQDLKPLLGINEELSLDEVRTIYLPLVRLINYYIEERIQRQQVM
NRFLGVNPDKVPYIISIAGSVAVGKSTSARILQSLLSQWPERRKVDLITTDGFLYPLAKLQQDNLLHKKGFPVSYDTARL
VRFLADIKSGKPKVSAPVYSHLIYDIVPDQFDVVDQPDILILEGLNVLQTGDRSSQTFVSDFVDFSIYVDADEDLLKAWY
ISRFLKFRQSAFSDPNSYFKHYATLSEPEAISTAGRIWDEINGLNLRENILPTRERANLILTKGTDHAVELVKLRK

Sequences:

>Translated_316_residues
MDLTNSTFLSNQLTPFLSFSREQWAELRKSVPLTLTEQDLKPLLGINEELSLDEVRTIYLPLVRLINYYIEERIQRQQVM
NRFLGVNPDKVPYIISIAGSVAVGKSTSARILQSLLSQWPERRKVDLITTDGFLYPLAKLQQDNLLHKKGFPVSYDTARL
VRFLADIKSGKPKVSAPVYSHLIYDIVPDQFDVVDQPDILILEGLNVLQTGDRSSQTFVSDFVDFSIYVDADEDLLKAWY
ISRFLKFRQSAFSDPNSYFKHYATLSEPEAISTAGRIWDEINGLNLRENILPTRERANLILTKGTDHAVELVKLRK
>Mature_316_residues
MDLTNSTFLSNQLTPFLSFSREQWAELRKSVPLTLTEQDLKPLLGINEELSLDEVRTIYLPLVRLINYYIEERIQRQQVM
NRFLGVNPDKVPYIISIAGSVAVGKSTSARILQSLLSQWPERRKVDLITTDGFLYPLAKLQQDNLLHKKGFPVSYDTARL
VRFLADIKSGKPKVSAPVYSHLIYDIVPDQFDVVDQPDILILEGLNVLQTGDRSSQTFVSDFVDFSIYVDADEDLLKAWY
ISRFLKFRQSAFSDPNSYFKHYATLSEPEAISTAGRIWDEINGLNLRENILPTRERANLILTKGTDHAVELVKLRK

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=308, Percent_Identity=64.6103896103896, Blast_Score=412, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_PASMU (P57967)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246686.1
- ProteinModelPortal:   P57967
- SMR:   P57967
- GeneID:   1245094
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1747
- NMPDR:   fig|272843.1.peg.1748
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- ProtClustDB:   PRK05439
- BioCyc:   PMUL272843:PM1747-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 36185; Mature: 36185

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTNSTFLSNQLTPFLSFSREQWAELRKSVPLTLTEQDLKPLLGINEELSLDEVRTIYL
CCCCCCCHHHHCCCHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHH
PLVRLINYYIEERIQRQQVMNRFLGVNPDKVPYIISIAGSVAVGKSTSARILQSLLSQWP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECCCHHHHHHHHHHHHCC
ERRKVDLITTDGFLYPLAKLQQDNLLHKKGFPVSYDTARLVRFLADIKSGKPKVSAPVYS
CCCCEEEEECCCHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
HLIYDIVPDQFDVVDQPDILILEGLNVLQTGDRSSQTFVSDFVDFSIYVDADEDLLKAWY
HHHHHHCCCCCCCCCCCCEEEECCCHHHHCCCCCHHHHHHHHHEEEEEECCCHHHHHHHH
ISRFLKFRQSAFSDPNSYFKHYATLSEPEAISTAGRIWDEINGLNLRENILPTRERANLI
HHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCHHHCCEE
LTKGTDHAVELVKLRK
EECCCHHHHHHHHHCC
>Mature Secondary Structure
MDLTNSTFLSNQLTPFLSFSREQWAELRKSVPLTLTEQDLKPLLGINEELSLDEVRTIYL
CCCCCCCHHHHCCCHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHH
PLVRLINYYIEERIQRQQVMNRFLGVNPDKVPYIISIAGSVAVGKSTSARILQSLLSQWP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECCCHHHHHHHHHHHHCC
ERRKVDLITTDGFLYPLAKLQQDNLLHKKGFPVSYDTARLVRFLADIKSGKPKVSAPVYS
CCCCEEEEECCCHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
HLIYDIVPDQFDVVDQPDILILEGLNVLQTGDRSSQTFVSDFVDFSIYVDADEDLLKAWY
HHHHHHCCCCCCCCCCCCEEEECCCHHHHCCCCCHHHHHHHHHEEEEEECCCHHHHHHHH
ISRFLKFRQSAFSDPNSYFKHYATLSEPEAISTAGRIWDEINGLNLRENILPTRERANLI
HHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCHHHCCEE
LTKGTDHAVELVKLRK
EECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100