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The map label for this gene is serA [H]

Identifier: 15603536

GI number: 15603536

Start: 1878008

End: 1879240

Strand: Direct

Name: serA [H]

Synonym: PM1671

Alternate gene names: 15603536

Gene position: 1878008-1879240 (Clockwise)

Preceding gene: 15603535

Following gene: 15603537

Centisome position: 83.19

GC content: 41.44

Gene sequence:

>1233_bases
ATGACGACCAAAGTGTCTTTAGATAAATCTAAAATTAAATTTCTCTTATTAGAAGGTGTCCATCAAACGGCATTGGAAGT
GCTACAAAATGCTGGCTATACCAACATTGAATACCATAAAAAAGCCTTAGATGATGATGAATTAAAAGAAGCCATTAAAG
ATGCGCACTTTGTGGGTATCCGCTCACGCACGTTCTTAACAGAAGAAGTACTTGCCCATGCACAAAAATTAATTGCGATT
GGTTGTTTCTGTATCGGTACTAACCAAGTCAATTTACAAGCGGCAAAATTACGTGGTATTCCAGTGTTTAATGCGCCGTT
TTCAAATACCCGTTCTGTAGCAGAATTAGTGTTAGGGGAAATTCTCTTGTTAATGCGTAACGTTCCCCAAGCCAATGCCG
AAGTACACCGTGGGATTTGGAATAAATCAGCCAATGGATCACATGAAGTACGTGGTAAAAAACTGGGTATCATTGGTTAC
GGGCATATCGGTTCACAGTTAAGTATTATTGCGGAGTCACTCGGGATGCGCGTATTCTTCTATGATATCGAGAATAAATT
GCCATTAGGCAATGCACAGCAATTACGCACATTAGAAGAACTTCTGTCTAGCTGTGATGTAGTGTCATTACATGTGCCTG
AAAATGCCTCAACTAAAAACCTCATCAGTGCAGAACGCATCGCACAATTAAAAGAAGGCGCCATCTTAATTAATGCGGCA
AGAGGCACAGTAGTAGATATTGATGCTTTAGCACAAGCCTTAGAGGCTGGCAAAATCCGTGGCGCAGCCTTAGATGTCTT
CCCAGAAGAACCCGCCTCCATTCAAGAGGAATTTGTTTCACCGTTACGTGCTTTTGATAATGTGATTCTTACGCCGCACA
TCGGTGGCTCCACGTCAGAAGCACAAGAAAACATTGGTGCAGAAGTATCCGGTAAATTTGTCAAATATTCAGATAATGGT
TCTACCCTTTCTGCTGTCAACTTCCCTGAAGTGTCACTCCCTGAACATGTTGGTACTAAACGCTTATTACATATTCACCA
CAATAAACAAGGGGTACTCAATAAGATTAACCAAGTGTTTGTGGATGCTAATGTGAATATCGCCGCACAATATTTACAAA
CAGACCCAGCGATCGGTTATGTCGTGATCGATGTTGAGACAGAAGACACACACAGCTTATTAACGCAATTAAAAGAGATT
GAAGGCACGATTCGCGCACGCGTCTTGTACTAG

Upstream 100 bases:

>100_bases
TGGTCACCAATGGCATTTTTGCTCTACGCGCAGCAGATATTATTATTGTCGGCACGCCTGAAGGTGCCAAAGTCATTGAA
TAACAAAAAGGAAAGCAAAC

Downstream 100 bases:

>100_bases
TGATAAACTTCATCTCATGCAAAGTGCGATCATTCAGATCGCATTTTGTCTTTTAGGGCTTATCAATTTCTGCCCAGCTT
TATGCTATAATCGCCAAACT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTTKVSLDKSKIKFLLLEGVHQTALEVLQNAGYTNIEYHKKALDDDELKEAIKDAHFVGIRSRTFLTEEVLAHAQKLIAI
GCFCIGTNQVNLQAAKLRGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGIWNKSANGSHEVRGKKLGIIGY
GHIGSQLSIIAESLGMRVFFYDIENKLPLGNAQQLRTLEELLSSCDVVSLHVPENASTKNLISAERIAQLKEGAILINAA
RGTVVDIDALAQALEAGKIRGAALDVFPEEPASIQEEFVSPLRAFDNVILTPHIGGSTSEAQENIGAEVSGKFVKYSDNG
STLSAVNFPEVSLPEHVGTKRLLHIHHNKQGVLNKINQVFVDANVNIAAQYLQTDPAIGYVVIDVETEDTHSLLTQLKEI
EGTIRARVLY

Sequences:

>Translated_410_residues
MTTKVSLDKSKIKFLLLEGVHQTALEVLQNAGYTNIEYHKKALDDDELKEAIKDAHFVGIRSRTFLTEEVLAHAQKLIAI
GCFCIGTNQVNLQAAKLRGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGIWNKSANGSHEVRGKKLGIIGY
GHIGSQLSIIAESLGMRVFFYDIENKLPLGNAQQLRTLEELLSSCDVVSLHVPENASTKNLISAERIAQLKEGAILINAA
RGTVVDIDALAQALEAGKIRGAALDVFPEEPASIQEEFVSPLRAFDNVILTPHIGGSTSEAQENIGAEVSGKFVKYSDNG
STLSAVNFPEVSLPEHVGTKRLLHIHHNKQGVLNKINQVFVDANVNIAAQYLQTDPAIGYVVIDVETEDTHSLLTQLKEI
EGTIRARVLY
>Mature_409_residues
TTKVSLDKSKIKFLLLEGVHQTALEVLQNAGYTNIEYHKKALDDDELKEAIKDAHFVGIRSRTFLTEEVLAHAQKLIAIG
CFCIGTNQVNLQAAKLRGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGIWNKSANGSHEVRGKKLGIIGYG
HIGSQLSIIAESLGMRVFFYDIENKLPLGNAQQLRTLEELLSSCDVVSLHVPENASTKNLISAERIAQLKEGAILINAAR
GTVVDIDALAQALEAGKIRGAALDVFPEEPASIQEEFVSPLRAFDNVILTPHIGGSTSEAQENIGAEVSGKFVKYSDNGS
TLSAVNFPEVSLPEHVGTKRLLHIHHNKQGVLNKINQVFVDANVNIAAQYLQTDPAIGYVVIDVETEDTHSLLTQLKEIE
GTIRARVLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=341, Percent_Identity=35.4838709677419, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=36.9477911646586, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=36.9477911646586, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=35.7429718875502, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=35.7429718875502, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=36.9477911646586, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI6912396, Length=266, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=68.9486552567237, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI87082289, Length=242, Percent_Identity=33.8842975206612, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787645, Length=253, Percent_Identity=30.4347826086957, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788660, Length=310, Percent_Identity=29.3548387096774, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081824, Length=155, Percent_Identity=34.8387096774194, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=327, Percent_Identity=34.8623853211009, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25147481, Length=230, Percent_Identity=29.5652173913043, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=49.5169082125604, Blast_Score=393, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=48.792270531401, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=32.6612903225806, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324964, Length=263, Percent_Identity=27.7566539923954, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=32.9032258064516, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=116, Percent_Identity=31.0344827586207, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=161, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=320, Percent_Identity=33.4375, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=35.0943396226415, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=35.0943396226415, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=35.0943396226415, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=35.0943396226415, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI62472511, Length=261, Percent_Identity=35.2490421455939, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=28.3018867924528, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571528, Length=296, Percent_Identity=27.7027027027027, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585514, Length=252, Percent_Identity=26.5873015873016, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574282, Length=252, Percent_Identity=26.5873015873016, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552429, Length=252, Percent_Identity=26.5873015873016, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45551003, Length=252, Percent_Identity=26.5873015873016, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574284, Length=252, Percent_Identity=26.5873015873016, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24585516, Length=293, Percent_Identity=23.5494880546075, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44760; Mature: 44629

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKVSLDKSKIKFLLLEGVHQTALEVLQNAGYTNIEYHKKALDDDELKEAIKDAHFVGI
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHEEEE
RSRTFLTEEVLAHAQKLIAIGCFCIGTNQVNLQAAKLRGIPVFNAPFSNTRSVAELVLGE
CCHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEHCCCCEEECCCCCCHHHHHHHHHHH
ILLLMRNVPQANAEVHRGIWNKSANGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMRVFF
HHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEE
YDIENKLPLGNAQQLRTLEELLSSCDVVSLHVPENASTKNLISAERIAQLKEGAILINAA
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEEC
RGTVVDIDALAQALEAGKIRGAALDVFPEEPASIQEEFVSPLRAFDNVILTPHIGGSTSE
CCCEEEHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCHH
AQENIGAEVSGKFVKYSDNGSTLSAVNFPEVSLPEHVGTKRLLHIHHNKQGVLNKINQVF
HHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHCCCCEEEEEECCCCHHHHHHHHEE
VDANVNIAAQYLQTDPAIGYVVIDVETEDTHSLLTQLKEIEGTIRARVLY
EECCCCEEEEEHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
TTKVSLDKSKIKFLLLEGVHQTALEVLQNAGYTNIEYHKKALDDDELKEAIKDAHFVGI
CCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHEEEE
RSRTFLTEEVLAHAQKLIAIGCFCIGTNQVNLQAAKLRGIPVFNAPFSNTRSVAELVLGE
CCHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEHCCCCEEECCCCCCHHHHHHHHHHH
ILLLMRNVPQANAEVHRGIWNKSANGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMRVFF
HHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEE
YDIENKLPLGNAQQLRTLEELLSSCDVVSLHVPENASTKNLISAERIAQLKEGAILINAA
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEEC
RGTVVDIDALAQALEAGKIRGAALDVFPEEPASIQEEFVSPLRAFDNVILTPHIGGSTSE
CCCEEEHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCHH
AQENIGAEVSGKFVKYSDNGSTLSAVNFPEVSLPEHVGTKRLLHIHHNKQGVLNKINQVF
HHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHCCCCEEEEEECCCCHHHHHHHHEE
VDANVNIAAQYLQTDPAIGYVVIDVETEDTHSLLTQLKEIEGTIRARVLY
EECCCCEEEEEHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]