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The map label for this gene is rpiA_2

Identifier: 15603535

GI number: 15603535

Start: 1877331

End: 1877990

Strand: Direct

Name: rpiA_2

Synonym: PM1670

Alternate gene names: 15603535

Gene position: 1877331-1877990 (Clockwise)

Preceding gene: 15603534

Following gene: 15603536

Centisome position: 83.16

GC content: 44.39

Gene sequence:

>660_bases
ATGGATCAACTTGAAATGAAAAAAATGGCTGCGGCAGCCGCACTGCAATACGTGAAACCCGATTCAATCATTGGGGTAGG
CAGTGGCTCAACAGTCAATTGTTTTATTGAAGCGCTAGGGAGTATGCGAGATCAAATTAAAGGGGCGGTGGCGGCCTCAA
AAGCCTCAGAAGCCTTATTAGCAAAACAAGGGATTGAAGTGTTTAGTGCCAATGAGGTTTCAAGCCTTGATATCTATGTC
GATGGTGCCGATGAGATTAACCCACAGAAAATGATGATCAAAGGCGGAGGTGCCGCACTAACCCGTGAAAAAATTGTGGC
AGCGTTGGCAAAAAAATTCATTTGTATCGTTGATACAAGCAAACAAGTTGATGTGCTCGGCTCAACTTTCGCCTTACCAG
TTGAGGTGATTCCAATGGCGCGCTCCCAAGTGGCGCGTAAATTAGTCGCCTTAGGTGGCTCACCAGAATACCGCGAAGGT
GTTGTTACAGATAATGGTAACGTGATTTTAGATGTCTATCATTTTGCTATTATGAATCCTGTTGAAATGGAAAAAGAATT
AAATAATGTGCCGGGCGTGGTCACCAATGGCATTTTTGCTCTACGCGCAGCAGATATTATTATTGTCGGCACGCCTGAAG
GTGCCAAAGTCATTGAATAA

Upstream 100 bases:

>100_bases
GCAAACGATTACGCAAGTTATATATCAATCAAAAGATGTCGTGCTACATTGCTTTTAGCACGACGTTAAACAGGATTATT
TGCAATTTAAAGGAATCAAC

Downstream 100 bases:

>100_bases
CAAAAAGGAAAGCAAACATGACGACCAAAGTGTCTTTAGATAAATCTAAAATTAAATTTCTCTTATTAGAAGGTGTCCAT
CAAACGGCATTGGAAGTGCT

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MDQLEMKKMAAAAALQYVKPDSIIGVGSGSTVNCFIEALGSMRDQIKGAVAASKASEALLAKQGIEVFSANEVSSLDIYV
DGADEINPQKMMIKGGGAALTREKIVAALAKKFICIVDTSKQVDVLGSTFALPVEVIPMARSQVARKLVALGGSPEYREG
VVTDNGNVILDVYHFAIMNPVEMEKELNNVPGVVTNGIFALRAADIIIVGTPEGAKVIE

Sequences:

>Translated_219_residues
MDQLEMKKMAAAAALQYVKPDSIIGVGSGSTVNCFIEALGSMRDQIKGAVAASKASEALLAKQGIEVFSANEVSSLDIYV
DGADEINPQKMMIKGGGAALTREKIVAALAKKFICIVDTSKQVDVLGSTFALPVEVIPMARSQVARKLVALGGSPEYREG
VVTDNGNVILDVYHFAIMNPVEMEKELNNVPGVVTNGIFALRAADIIIVGTPEGAKVIE
>Mature_219_residues
MDQLEMKKMAAAAALQYVKPDSIIGVGSGSTVNCFIEALGSMRDQIKGAVAASKASEALLAKQGIEVFSANEVSSLDIYV
DGADEINPQKMMIKGGGAALTREKIVAALAKKFICIVDTSKQVDVLGSTFALPVEVIPMARSQVARKLVALGGSPEYREG
VVTDNGNVILDVYHFAIMNPVEMEKELNNVPGVVTNGIFALRAADIIIVGTPEGAKVIE

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=227, Percent_Identity=33.920704845815, Blast_Score=113, Evalue=1e-25,
Organism=Escherichia coli, GI1789280, Length=218, Percent_Identity=64.6788990825688, Blast_Score=283, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI17551758, Length=211, Percent_Identity=36.9668246445498, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324669, Length=220, Percent_Identity=34.0909090909091, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281364072, Length=203, Percent_Identity=33.0049261083744, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_PASMU (P57961)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246609.1
- ProteinModelPortal:   P57961
- SMR:   P57961
- GeneID:   1245017
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1670
- NMPDR:   fig|272843.1.peg.1671
- HOGENOM:   HBG515603
- OMA:   VFDLNSV
- ProtClustDB:   PRK00702
- BioCyc:   PMUL272843:PM1670-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 23081; Mature: 23081

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQLEMKKMAAAAALQYVKPDSIIGVGSGSTVNCFIEALGSMRDQIKGAVAASKASEALL
CCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKQGIEVFSANEVSSLDIYVDGADEINPQKMMIKGGGAALTREKIVAALAKKFICIVDTS
HHHCCCEEECCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCEEEEEECC
KQVDVLGSTFALPVEVIPMARSQVARKLVALGGSPEYREGVVTDNGNVILDVYHFAIMNP
CCEEECCCCEECCHHEEHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEEEEHHHHCCH
VEMEKELNNVPGVVTNGIFALRAADIIIVGTPEGAKVIE
HHHHHHHHCCCCHHHCCEEEEEECCEEEEECCCCCCCCC
>Mature Secondary Structure
MDQLEMKKMAAAAALQYVKPDSIIGVGSGSTVNCFIEALGSMRDQIKGAVAASKASEALL
CCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKQGIEVFSANEVSSLDIYVDGADEINPQKMMIKGGGAALTREKIVAALAKKFICIVDTS
HHHCCCEEECCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCEEEEEECC
KQVDVLGSTFALPVEVIPMARSQVARKLVALGGSPEYREGVVTDNGNVILDVYHFAIMNP
CCEEECCCCEECCHHEEHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEEEEHHHHCCH
VEMEKELNNVPGVVTNGIFALRAADIIIVGTPEGAKVIE
HHHHHHHHCCCCHHHCCEEEEEECCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100