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The map label for this gene is pdxA

Identifier: 15603515

GI number: 15603515

Start: 1858391

End: 1859404

Strand: Reverse

Name: pdxA

Synonym: PM1650

Alternate gene names: 15603515

Gene position: 1859404-1858391 (Counterclockwise)

Preceding gene: 15603519

Following gene: 15603514

Centisome position: 82.37

GC content: 37.48

Gene sequence:

>1014_bases
ATGACGAAATCTACAGTGGCATTGACGTTAGGTGATCCTGCCGGTATTGGTCCAGAGTTAGTTGCTAAATTACTAGCAAA
ACAAAATATCAGAGAGAAAGCGAACATTGTGCTAGTGGCAGATAAAGATGAATTAGAAAAAGGGATGGAGATCGCTAAAG
CACAGTTTGTATATGAAGAAGTATCTTTTCATCAATTAGGTCAATATGAATTCAAAACAGGTGTACCCGTTTTAATTTCT
CATAAATCTTCACATCCCAAGCCTTTTGAGTACGGTAAAGTTACTGAACAAAGTGGTGTCTATATTTTAGAAACGCTAAA
AGTCGCATTAAATTTAGCAAAAATGGGGTATGTGCAAGCGATTTGTTTTGCACCATTAAATAAACAAGCGATGCATAAAG
GTGGACTGCGTTATCGAGATGAATTGCATTGGTTTGCTGAGCAAACAGATTTCAATGAATTTGTTTGTGAGTTAAATGTA
GTTGATGATATTTGGGCTGCACGAGTGACTTCTCATATTCCATTTAAAGATATTGTGCCTAATCTATCGATTAAGGGTGT
ATTTGATTGTATTCATCTTCTCTATCGCTCGTTAGTTCAAGCTGGTGTTGAAAATCCTAAAATCGCTGTTCAGGCATTAA
ATCCTCATGGCGGGGAAGGTGGTGTTTTTGGTGATGAAGAAATGACGATTATTCAACCAGGAATGGAACAAGCACGTAAA
GCAGGAATTGATGTTTATGGCCCATTTCCTGGTGATACCACAATGCGTGAAGTTGAACGTTTAAAAATTAATGGTGTTGT
TTCCATGTACCATGATCAATTTTCTACTGCGTTGAAGATTTTAGGTTTTGAACGTGGTGTGACAGTACAAGGTGGTATTC
CGATTCCTATCACAACAGCTAACCACGGTACCGCATTTGATTTACATGGTAAAAATATTGCTATTCCGACTGCATTTGAA
GCAGCGTTTAACATTGCAGTTAGAATGGGACAGGGTGTTTTAAATCAAAAGTAA

Upstream 100 bases:

>100_bases
ATCACACTATAAAGGTATGAAATTTGTTTTAATACATTTAACAAAAGTTAAAGCATTGATCTTTTGATCATTTCGTTTAT
TTGTTATTAGGAGAGTTATC

Downstream 100 bases:

>100_bases
TCTTTGCTGAGGACTCAAAAATGACTAGAAAACCAAAAAAACTCCTTAATCATCCAAATGATGTGCCTGCGGAGCAATTA
GAAGGGTTGCTCTATGCATG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTKSTVALTLGDPAGIGPELVAKLLAKQNIREKANIVLVADKDELEKGMEIAKAQFVYEEVSFHQLGQYEFKTGVPVLIS
HKSSHPKPFEYGKVTEQSGVYILETLKVALNLAKMGYVQAICFAPLNKQAMHKGGLRYRDELHWFAEQTDFNEFVCELNV
VDDIWAARVTSHIPFKDIVPNLSIKGVFDCIHLLYRSLVQAGVENPKIAVQALNPHGGEGGVFGDEEMTIIQPGMEQARK
AGIDVYGPFPGDTTMREVERLKINGVVSMYHDQFSTALKILGFERGVTVQGGIPIPITTANHGTAFDLHGKNIAIPTAFE
AAFNIAVRMGQGVLNQK

Sequences:

>Translated_337_residues
MTKSTVALTLGDPAGIGPELVAKLLAKQNIREKANIVLVADKDELEKGMEIAKAQFVYEEVSFHQLGQYEFKTGVPVLIS
HKSSHPKPFEYGKVTEQSGVYILETLKVALNLAKMGYVQAICFAPLNKQAMHKGGLRYRDELHWFAEQTDFNEFVCELNV
VDDIWAARVTSHIPFKDIVPNLSIKGVFDCIHLLYRSLVQAGVENPKIAVQALNPHGGEGGVFGDEEMTIIQPGMEQARK
AGIDVYGPFPGDTTMREVERLKINGVVSMYHDQFSTALKILGFERGVTVQGGIPIPITTANHGTAFDLHGKNIAIPTAFE
AAFNIAVRMGQGVLNQK
>Mature_336_residues
TKSTVALTLGDPAGIGPELVAKLLAKQNIREKANIVLVADKDELEKGMEIAKAQFVYEEVSFHQLGQYEFKTGVPVLISH
KSSHPKPFEYGKVTEQSGVYILETLKVALNLAKMGYVQAICFAPLNKQAMHKGGLRYRDELHWFAEQTDFNEFVCELNVV
DDIWAARVTSHIPFKDIVPNLSIKGVFDCIHLLYRSLVQAGVENPKIAVQALNPHGGEGGVFGDEEMTIIQPGMEQARKA
GIDVYGPFPGDTTMREVERLKINGVVSMYHDQFSTALKILGFERGVTVQGGIPIPITTANHGTAFDLHGKNIAIPTAFEA
AFNIAVRMGQGVLNQK

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=328, Percent_Identity=30.4878048780488, Blast_Score=151, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_PASMU (Q9CKG8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246589.1
- ProteinModelPortal:   Q9CKG8
- SMR:   Q9CKG8
- GeneID:   1244997
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1650
- NMPDR:   fig|272843.1.peg.1651
- HOGENOM:   HBG451136
- ProtClustDB:   PRK00232
- BioCyc:   PMUL272843:PM1650-MONOMER
- BRENDA:   1.1.1.262
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 37033; Mature: 36902

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: BINDING 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSTVALTLGDPAGIGPELVAKLLAKQNIREKANIVLVADKDELEKGMEIAKAQFVYEE
CCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
VSFHQLGQYEFKTGVPVLISHKSSHPKPFEYGKVTEQSGVYILETLKVALNLAKMGYVQA
HHHHHCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
ICFAPLNKQAMHKGGLRYRDELHWFAEQTDFNEFVCELNVVDDIWAARVTSHIPFKDIVP
HHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCCHHEEEECCHHHHHHHHHHCCCCHHHHCC
NLSIKGVFDCIHLLYRSLVQAGVENPKIAVQALNPHGGEGGVFGDEEMTIIQPGMEQARK
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCHHHHHH
AGIDVYGPFPGDTTMREVERLKINGVVSMYHDQFSTALKILGFERGVTVQGGIPIPITTA
CCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEC
NHGTAFDLHGKNIAIPTAFEAAFNIAVRMGQGVLNQK
CCCCEEEECCCEEECCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TKSTVALTLGDPAGIGPELVAKLLAKQNIREKANIVLVADKDELEKGMEIAKAQFVYEE
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
VSFHQLGQYEFKTGVPVLISHKSSHPKPFEYGKVTEQSGVYILETLKVALNLAKMGYVQA
HHHHHCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
ICFAPLNKQAMHKGGLRYRDELHWFAEQTDFNEFVCELNVVDDIWAARVTSHIPFKDIVP
HHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCCHHEEEECCHHHHHHHHHHCCCCHHHHCC
NLSIKGVFDCIHLLYRSLVQAGVENPKIAVQALNPHGGEGGVFGDEEMTIIQPGMEQARK
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEECCCHHHHHH
AGIDVYGPFPGDTTMREVERLKINGVVSMYHDQFSTALKILGFERGVTVQGGIPIPITTA
CCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEC
NHGTAFDLHGKNIAIPTAFEAAFNIAVRMGQGVLNQK
CCCCEEEECCCEEECCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100