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The map label for this gene is tkt_2 [H]

Identifier: 15603503

GI number: 15603503

Start: 1846682

End: 1848688

Strand: Reverse

Name: tkt_2 [H]

Synonym: PM1638

Alternate gene names: 15603503

Gene position: 1848688-1846682 (Counterclockwise)

Preceding gene: 15603504

Following gene: 15603497

Centisome position: 81.89

GC content: 44.79

Gene sequence:

>2007_bases
ATGGCAACACGTAGAGAACTGGCCAATGCCATTCGTTTTTTAAGTATGGATGCAGTGCAAAAAGCAAAATCAGGGCATCC
AGGTGCACCGATGGGGATGGCAGATATTGCAGAAGTCTTATGGCGTGACTTTTTAAAACATAACCCAAGCAATCCACACT
GGGCCGATCGCGACCGTTTCATTTTATCCAATGGTCATGGTTCAATGCTGATTTACAGTTTATTACATTTAAGTGGTTAT
GACCTTTCTATTGAAGATTTAAAACAATTCCGTCAATTACATTCCAAAACACCGGGACACCCAGAATACGGTTATGCGCC
GGGTGTTGAAACCACAACAGGACCATTAGGTCAAGGGATTACGAACGCAGTGGGTTTTGCGATTGCGGAGAAAACCCTTG
CCCATCAATTTAACCGTCCAGGTCATGAAATTGTTGACCACCACACCTATGTGTTCTTAGGCGATGGTTGTTTAATGGAA
GGGATTTCTCATGAAGCCTGTTCTTTAGCGGGTACTCTTGGGTTAGGTAAATTAATTGCTTTCTATGACGACAACAATAT
CTCAATTGATGGTCATGTGGACGGTTGGTTCACTGATGATACGCAAAAACGGTTTGAAGCTTATGGTTGGCATGTCATTC
CAGCGGTAGATGGTCATAATCCAGAACAAATTCTTGAGGCGGTGAAACAAGCCCAAGCGGAGACAACCAAACCAACCTTA
ATTATTTGTAAAACCATTATCGGTTATGGTTCACCGAATAAAGCCAACTCACACGATTGTCATGGTGCTCCATTAGGTGA
TGATGAAATTGCGGCAGCACGTGAATTCTTAAAATGGGAGCATGCCCCGTTTGAAATTCCTGCGGAGATTTATGCACAAT
GGGATGCGAAAGAAAAAGGTCAAGTTGCTGAAAAAGCGTGGGAAGAAAAATTGGCAGCTTATGCCAAAGCTTACCCAGAA
TTAGCGGCGGAATTTACTCGTCGTGTGAATGCGGAGCTACCGGCAAACTGGGCGGCAGAATCGCAAGCTTTTATTGAACA
TTTACAAGCGAATCCGGCGAACATTGCCAGCCGTAAAGCGTCACAAAATGCGATTGAAGCCTATGCTAAATTATTACCGG
AGTTTTTAGGTGGGTCAGCGGATTTAGCCAGCTCAAACTTAACCCTCTGGTCAGGTTCCAAACCAATCCGTGCGGTAGAA
AATGCCGATGGTAACTACATCAACTACGGTGTGCGTGAGTTTGGTATGTCGGCGATTATGAACGGTATTGCGTTACATGG
TGGTTTCATTCCTTATGGTGCCACTTTCTTGATGTTTATGGAATACGCACATAATGCGGTGCGTATGGCGGCGTTAATGA
AACAACGCTCATTGTTTGTTTATACTCACGACTCTATTGGGCTTGGTGAAGACGGTCCAACTCACCAACCGGTTGAACAA
ACGTCTGCTTTACGTTTAATTCCAAATTTGGAAACATGGCGCCCATGTGACCAAGTGGAATCGGCGGTGGCGTGGAAAGC
GGCAGTGGAACGTAAAGAGGGACCTAGTGCGTTAATTTTTACTCGTCAAAATCTTGCGCAAATGGACCGCACTGCTGAGC
AGTTAGCCAATGTGGCACGTGGTGGTTATGTATTACGTCATTGCTGTGAAAACCAAAACTGTCCAGATTTAATTTTGATT
GCGACCGGTTCTGAGGTGGAATTGGCGATGAAAGCGGCGGATGTTTTAGATGCAGAAGGGGTAAAAGTACGTGTTGTCTC
TATGCCGAGCACCAATGTGTTTGATAAACAAGATGCGGCTTACCGTGAAAGTGTGTTACCAAGCCACATAACAAAACGTG
TTGCGATTGAAGCGGGTATTGCGGACTTCTGGTACAAATATGTGGGCTTTGAGGGACGTGTTGTGGGAATGAACAGTTTT
GGTGAATCCGCACCAGCTGACCAATTGTTCAAACTCTTTGGTTTCACCGTTGAAAACGTGGTCGCGAAAGCCAAAGAAAT
TCTCTAA

Upstream 100 bases:

>100_bases
ATTAGCAGAAGGCATTTGTAAATTTGCAGAAGATCAAGAAAAACTAGAAAAAATGCTCTTGGAAAGACTATAACATGTTG
AATAAGAGGGAGTAATCACT

Downstream 100 bases:

>100_bases
TCTGTCTTTTAGCTCAACACACAATCTGCACATTAACATAGTTTAATGTGCAGATTTTTTTATATGTATCCAACCAAAGA
CAGTGCTCGTCTCTGACGAG

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRFILSNGHGSMLIYSLLHLSGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTL
IICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKGQVAEKAWEEKLAAYAKAYPE
LAAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKASQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVE
NADGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
TSALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVARGGYVLRHCCENQNCPDLILI
ATGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAAYRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSF
GESAPADQLFKLFGFTVENVVAKAKEIL

Sequences:

>Translated_668_residues
MATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRFILSNGHGSMLIYSLLHLSGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTL
IICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKGQVAEKAWEEKLAAYAKAYPE
LAAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKASQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVE
NADGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
TSALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVARGGYVLRHCCENQNCPDLILI
ATGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAAYRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSF
GESAPADQLFKLFGFTVENVVAKAKEIL
>Mature_667_residues
ATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRFILSNGHGSMLIYSLLHLSGYD
LSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLMEG
ISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTLI
ICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKGQVAEKAWEEKLAAYAKAYPEL
AAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKASQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVEN
ADGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQT
SALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVARGGYVLRHCCENQNCPDLILIA
TGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAAYRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSFG
ESAPADQLFKLFGFTVENVVAKAKEIL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=600, Percent_Identity=26.3333333333333, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI4507521, Length=600, Percent_Identity=26.3333333333333, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI133778974, Length=675, Percent_Identity=24.8888888888889, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI225637459, Length=689, Percent_Identity=21.3352685050798, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI225637461, Length=659, Percent_Identity=21.092564491654, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI225637463, Length=610, Percent_Identity=21.3114754098361, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI48994911, Length=668, Percent_Identity=76.3473053892216, Blast_Score=1078, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=666, Percent_Identity=69.3693693693694, Blast_Score=994, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=23.8872403560831, Blast_Score=165, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=47.6831091180867, Blast_Score=604, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=44.9404761904762, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI45551847, Length=269, Percent_Identity=33.8289962825279, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45550715, Length=269, Percent_Identity=33.8289962825279, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24666278, Length=262, Percent_Identity=29.7709923664122, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24645119, Length=235, Percent_Identity=33.1914893617021, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73356; Mature: 73224

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
ILSNGHGSMLIYSLLHLSGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTL
EEECCCEEECCCCCCEECCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
IICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKG
EEEHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCC
QVAEKAWEEKLAAYAKAYPELAAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
SQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVENADGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHCCCCCEEECCHHHHHHHHHH
NGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHH
TSALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVAR
HHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
GGYVLRHCCENQNCPDLILIATGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAA
CHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHH
YRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSFGESAPADQLFKLFGFTVENV
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
VAKAKEIL
HHHHHHCC
>Mature Secondary Structure 
ATRRELANAIRFLSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPSNPHWADRDRF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
ILSNGHGSMLIYSLLHLSGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGFAIAEKTLAHQFNRPGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFTDDTQKRFEAYGWHVIPAVDGHNPEQILEAVKQAQAETTKPTL
EEECCCEEECCCCCCEECCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
IICKTIIGYGSPNKANSHDCHGAPLGDDEIAAAREFLKWEHAPFEIPAEIYAQWDAKEKG
EEEHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCC
QVAEKAWEEKLAAYAKAYPELAAEFTRRVNAELPANWAAESQAFIEHLQANPANIASRKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
SQNAIEAYAKLLPEFLGGSADLASSNLTLWSGSKPIRAVENADGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHCCCCCEEECCHHHHHHHHHH
NGIALHGGFIPYGATFLMFMEYAHNAVRMAALMKQRSLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCHHH
TSALRLIPNLETWRPCDQVESAVAWKAAVERKEGPSALIFTRQNLAQMDRTAEQLANVAR
HHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
GGYVLRHCCENQNCPDLILIATGSEVELAMKAADVLDAEGVKVRVVSMPSTNVFDKQDAA
CHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHH
YRESVLPSHITKRVAIEAGIADFWYKYVGFEGRVVGMNSFGESAPADQLFKLFGFTVENV
HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
VAKAKEIL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]