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The map label for this gene is dtd

Identifier: 15603480

GI number: 15603480

Start: 1825027

End: 1825461

Strand: Reverse

Name: dtd

Synonym: PM1615

Alternate gene names: 15603480

Gene position: 1825461-1825027 (Counterclockwise)

Preceding gene: 15603481

Following gene: 15603470

Centisome position: 80.86

GC content: 42.76

Gene sequence:

>435_bases
ATGATTGCATTAATTCAACGTGTCAGCCAAGCGAAAGTGGACGTGGATAAGCAAACAGTAGGCGAAATTGGGCATGGCTT
ATTGGTGCTACTGGGTGTGCAAAAAGACGATGACCATGTCAAAGCAGATCGCTTGATTGAGAAAGTGCTGAATTATCGTG
TGTTTAGCGATGCAGAAGGCAAAATGAATTTAAATGTGCAACAAGTCAAGGGACAAGTATTAGTCGTTTCACAATTTACC
CTAGCTGCTGATACACAAAAAGGGTTGCGTCCAAGTTTTTCGCGTGGCGCAAGCCCTGATATGGCAGAAGCATTATACGA
CTATGTGGTCAAAAAGTGCGGTGAAAAAATCCCAACTTTCAGTGGGCAATTTGCCGCAGATATGCAAGTCAGTCTAACCA
ATGATGGTCCTGTCACATTCTGGTTAGAAATATAA

Upstream 100 bases:

>100_bases
CAGATACACACGAACCCGCGTTACAACAAAAAATGGAAAAAACAGAACAAACACTCAAAACAGAAATAACTCAGCAAAAA
CAACGATTGGAGAAACAAGG

Downstream 100 bases:

>100_bases
ATAAAAAAAACTGCATCGGATATCCGATGCAGTTCTTCACTGTTGTGACGTCAAAACGTCAGAGAATTAACGTTTTGGCA
AATAACGGGTTGGATCAACT

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MIALIQRVSQAKVDVDKQTVGEIGHGLLVLLGVQKDDDHVKADRLIEKVLNYRVFSDAEGKMNLNVQQVKGQVLVVSQFT
LAADTQKGLRPSFSRGASPDMAEALYDYVVKKCGEKIPTFSGQFAADMQVSLTNDGPVTFWLEI

Sequences:

>Translated_144_residues
MIALIQRVSQAKVDVDKQTVGEIGHGLLVLLGVQKDDDHVKADRLIEKVLNYRVFSDAEGKMNLNVQQVKGQVLVVSQFT
LAADTQKGLRPSFSRGASPDMAEALYDYVVKKCGEKIPTFSGQFAADMQVSLTNDGPVTFWLEI
>Mature_144_residues
MIALIQRVSQAKVDVDKQTVGEIGHGLLVLLGVQKDDDHVKADRLIEKVLNYRVFSDAEGKMNLNVQQVKGQVLVVSQFT
LAADTQKGLRPSFSRGASPDMAEALYDYVVKKCGEKIPTFSGQFAADMQVSLTNDGPVTFWLEI

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=147, Percent_Identity=37.4149659863946, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=71.7241379310345, Blast_Score=218, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI115533292, Length=143, Percent_Identity=39.8601398601399, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=39.1891891891892, Blast_Score=104, Evalue=6e-24,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=36.986301369863, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_PASMU (Q9CKK0)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246554.1
- ProteinModelPortal:   Q9CKK0
- SMR:   Q9CKK0
- GeneID:   1244962
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1615
- NMPDR:   fig|272843.1.peg.1616
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- ProtClustDB:   PRK05273
- BioCyc:   PMUL272843:PM1615-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15840; Mature: 15840

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALIQRVSQAKVDVDKQTVGEIGHGLLVLLGVQKDDDHVKADRLIEKVLNYRVFSDAEG
CHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEECCCCC
KMNLNVQQVKGQVLVVSQFTLAADTQKGLRPSFSRGASPDMAEALYDYVVKKCGEKIPTF
CCCCCHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
SGQFAADMQVSLTNDGPVTFWLEI
CCCEEEEEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MIALIQRVSQAKVDVDKQTVGEIGHGLLVLLGVQKDDDHVKADRLIEKVLNYRVFSDAEG
CHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCEEECCCCC
KMNLNVQQVKGQVLVVSQFTLAADTQKGLRPSFSRGASPDMAEALYDYVVKKCGEKIPTF
CCCCCHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
SGQFAADMQVSLTNDGPVTFWLEI
CCCEEEEEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100