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The map label for this gene is idp [H]

Identifier: 15603471

GI number: 15603471

Start: 1817479

End: 1818726

Strand: Direct

Name: idp [H]

Synonym: PM1606

Alternate gene names: 15603471

Gene position: 1817479-1818726 (Clockwise)

Preceding gene: 15603467

Following gene: 15603472

Centisome position: 80.51

GC content: 43.59

Gene sequence:

>1248_bases
ATGCAATCAAAAGTCGTTATCCCACAAGGTGAAAAAATTCAACTGGATGCCAAAGGAGCATTAATTGTACCTGATCATCC
GATTATCCCCTTTATTGAAGGCGATGGTATTGGTGTGGACGTTACCCCAGCGATGCGCACAGTCATTGATGCGGCGGTGG
AAAAAGCCTATGGCGGCAAACGTAAAATTTCGTGGATGGAAATCTATGCTGGTGGTAAAGCAAATGAGGTCTATGGCGAA
AATACTTGGTTACCCGATGAAACCATGACATTTATCCGTGATTATCATGTGGCGATTAAAGGACCGCTTATGACGCCAGT
CGGTGGTGGCATTCGTTCCTTGAATGTGGCGATGCGTCAAGGCTTAGATTTATATAATTGCTTACGTCCAATTCGTTATT
ATGACGGTACCCCAAGCCCTGTTAAACACCCTGAATTAGTGGACATGGTGATTTTCCGTGAAAACTCCGAAGATATTTAT
GCGGGTGTAGAATGGGTGGCAGGATCTGCCGAAGCGAATAAAGTGATTGCGTTTTTACAACAAGAAATGGGGGTGAAAAA
AATCCGTTTCACTGAAGATTGTGGCATTGGTATCAAACCAGTTTCTAAACAAGGTACCCAACGTTTAGTTCGTGCGGCAC
TACAATATGTGATTGATAATGATCGCAAATCGCTTACTCTAGTGCACAAAGGGAACATCATGAAATTTACCGAAGGCGCA
TTCAAAGAGTGGGGTTATCAAGTGGCGCAAGAGTTTGGTGCCGAATTGCTAGATGGTGGTCCATGGATGACATTAAAAAA
TCCAAAAACAGGCAGAGAAATCATCATTAAAGACAGCATTGCCGATGCGTTTTTACAAGAAATTCTGCTTCACCCAACGG
AGTACGATGTGATTGCGACTTTAAACCTAAACGGGGATTACATTTCTGACGCGTTAGCCGCGCAGGTGGGGGGTATCGGG
ATTTCACCGGGGGCGAATATTGGTGCAGAAGCTGCGATTTTTGAAGCCACCCACGGTACCGCACCAAAAATTGCAGGACA
AGATAAAGGTAATCCGGGTTCTTTGATTTTGAGTGGTGAAATGATGTTACGTCACTTAGGTTGGTTAGAAGCGGCGGATT
TAGTGGTCAAAGCAGTATCGAAAACCATTGCTGATAAAACCGTTACCTTTGATTTTGCTGAAATGTTAGAAGGCGCTAAA
TTACGTTCCACTTCGGAATTTGCTCAAGATATTGTAGCGAATATGTAA

Upstream 100 bases:

>100_bases
CGCCAGTTCCAATAGTTTTGTAAGGATAATCTCATGTCATCACGTAGATTACTGTCGAACAACTATCCTACCACAGGCAA
GAAAATAAGGAAGAAATGAT

Downstream 100 bases:

>100_bases
GTCTTACATTGATAAAATCTCCCCATGATTCTGCGGAATGATGGGGTTTTCTTTTCTTTACGGGGGAAAAATTTACCTTA
ATTTGCCTGATAAGTGCGGT

Product: Idp

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MQSKVVIPQGEKIQLDAKGALIVPDHPIIPFIEGDGIGVDVTPAMRTVIDAAVEKAYGGKRKISWMEIYAGGKANEVYGE
NTWLPDETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELVDMVIFRENSEDIY
AGVEWVAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSKQGTQRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGA
FKEWGYQVAQEFGAELLDGGPWMTLKNPKTGREIIIKDSIADAFLQEILLHPTEYDVIATLNLNGDYISDALAAQVGGIG
ISPGANIGAEAAIFEATHGTAPKIAGQDKGNPGSLILSGEMMLRHLGWLEAADLVVKAVSKTIADKTVTFDFAEMLEGAK
LRSTSEFAQDIVANM

Sequences:

>Translated_415_residues
MQSKVVIPQGEKIQLDAKGALIVPDHPIIPFIEGDGIGVDVTPAMRTVIDAAVEKAYGGKRKISWMEIYAGGKANEVYGE
NTWLPDETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELVDMVIFRENSEDIY
AGVEWVAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSKQGTQRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGA
FKEWGYQVAQEFGAELLDGGPWMTLKNPKTGREIIIKDSIADAFLQEILLHPTEYDVIATLNLNGDYISDALAAQVGGIG
ISPGANIGAEAAIFEATHGTAPKIAGQDKGNPGSLILSGEMMLRHLGWLEAADLVVKAVSKTIADKTVTFDFAEMLEGAK
LRSTSEFAQDIVANM
>Mature_415_residues
MQSKVVIPQGEKIQLDAKGALIVPDHPIIPFIEGDGIGVDVTPAMRTVIDAAVEKAYGGKRKISWMEIYAGGKANEVYGE
NTWLPDETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELVDMVIFRENSEDIY
AGVEWVAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSKQGTQRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGA
FKEWGYQVAQEFGAELLDGGPWMTLKNPKTGREIIIKDSIADAFLQEILLHPTEYDVIATLNLNGDYISDALAAQVGGIG
ISPGANIGAEAAIFEATHGTAPKIAGQDKGNPGSLILSGEMMLRHLGWLEAADLVVKAVSKTIADKTVTFDFAEMLEGAK
LRSTSEFAQDIVANM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=367, Percent_Identity=31.6076294277929, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI28178838, Length=367, Percent_Identity=27.5204359673025, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4758582, Length=393, Percent_Identity=27.2264631043257, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI28178816, Length=354, Percent_Identity=26.5536723163842, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI28178821, Length=354, Percent_Identity=27.1186440677966, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI28178819, Length=183, Percent_Identity=31.6939890710383, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=73.8609112709832, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=374, Percent_Identity=28.0748663101604, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081683, Length=400, Percent_Identity=24.25, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71986051, Length=359, Percent_Identity=32.5905292479109, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI25144293, Length=312, Percent_Identity=29.4871794871795, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=309, Percent_Identity=29.126213592233, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17550882, Length=384, Percent_Identity=26.0416666666667, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324709, Length=365, Percent_Identity=32.0547945205479, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322097, Length=367, Percent_Identity=29.700272479564, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6324291, Length=394, Percent_Identity=28.1725888324873, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24643268, Length=390, Percent_Identity=32.0512820512821, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24643270, Length=390, Percent_Identity=32.0512820512821, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24661184, Length=391, Percent_Identity=30.9462915601023, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI161078635, Length=307, Percent_Identity=29.9674267100977, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161078637, Length=307, Percent_Identity=29.9674267100977, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161078639, Length=307, Percent_Identity=29.9674267100977, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI161078633, Length=307, Percent_Identity=29.9674267100977, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24650122, Length=307, Percent_Identity=29.9674267100977, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI281362242, Length=393, Percent_Identity=26.4631043256997, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24648872, Length=393, Percent_Identity=26.4631043256997, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20130355, Length=360, Percent_Identity=24.1666666666667, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45167; Mature: 45167

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSKVVIPQGEKIQLDAKGALIVPDHPIIPFIEGDGIGVDVTPAMRTVIDAAVEKAYGGK
CCCCEECCCCCEEEEECCCEEECCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHHCCCC
RKISWMEIYAGGKANEVYGENTWLPDETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQ
CCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHC
GLDLYNCLRPIRYYDGTPSPVKHPELVDMVIFRENSEDIYAGVEWVAGSAEANKVIAFLQ
CCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEECHHHCCCCCHHHHHHHHHH
QEMGVKKIRFTEDCGIGIKPVSKQGTQRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGA
HHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCHH
FKEWGYQVAQEFGAELLDGGPWMTLKNPKTGREIIIKDSIADAFLQEILLHPTEYDVIAT
HHHHHHHHHHHHCHHHHCCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCEEEE
LNLNGDYISDALAAQVGGIGISPGANIGAEAAIFEATHGTAPKIAGQDKGNPGSLILSGE
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEHH
MMLRHLGWLEAADLVVKAVSKTIADKTVTFDFAEMLEGAKLRSTSEFAQDIVANM
HHHHHHCCHHHHHHHHHHHHHHHHHCEEEEEHHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQSKVVIPQGEKIQLDAKGALIVPDHPIIPFIEGDGIGVDVTPAMRTVIDAAVEKAYGGK
CCCCEECCCCCEEEEECCCEEECCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHHCCCC
RKISWMEIYAGGKANEVYGENTWLPDETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQ
CCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHC
GLDLYNCLRPIRYYDGTPSPVKHPELVDMVIFRENSEDIYAGVEWVAGSAEANKVIAFLQ
CCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEECHHHCCCCCHHHHHHHHHH
QEMGVKKIRFTEDCGIGIKPVSKQGTQRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGA
HHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCHH
FKEWGYQVAQEFGAELLDGGPWMTLKNPKTGREIIIKDSIADAFLQEILLHPTEYDVIAT
HHHHHHHHHHHHCHHHHCCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCEEEE
LNLNGDYISDALAAQVGGIGISPGANIGAEAAIFEATHGTAPKIAGQDKGNPGSLILSGE
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEHH
MMLRHLGWLEAADLVVKAVSKTIADKTVTFDFAEMLEGAKLRSTSEFAQDIVANM
HHHHHHCCHHHHHHHHHHHHHHHHHCEEEEEHHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112144; 8905232; 9278503; 9352899; 9298646; 2204109; 2682654; 10623532 [H]