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The map label for this gene is gnd [H]

Identifier: 15603419

GI number: 15603419

Start: 1756014

End: 1757468

Strand: Direct

Name: gnd [H]

Synonym: PM1554

Alternate gene names: 15603419

Gene position: 1756014-1757468 (Clockwise)

Preceding gene: 15603418

Following gene: 15603420

Centisome position: 77.79

GC content: 43.85

Gene sequence:

>1455_bases
ATGTCAGTAAAAGGTGACATCGGCGTTATCGGCTTAGCGGTAATGGGTCAAAACTTAATTTTAAATATGAATGATCACGG
CTTTAAAGTAGTTGCATTTAACCGTACGACTTCGAAAGTCGATGAGTTTTTGCAAGGTGCGGCAAAAGGCACGAATATTA
TTGGTGCGTATTCGTTGGAAGATCTTGCCAATAAATTGGAGAAACCGCGTAAAGTGATGCTGATGGTGCGTGCCGGTGAA
GTCGTGGATCAATTCATTGAGGCATTATTACCACACTTAGAAGAAGGCGACATCATTATTGATGGTGGTAACACGAATTA
CCCAGATACAAACCGCCGTGTCGCGTATTTACGTGAAAAAGGGATCCGTTTTATTGGAACGGGCGTATCTGGTGGTGAAG
AAGGGGCACGTTTCGGACCTTCTATTATGCCGGGCGGTGATGAATCTGCATGGGAACACGTGAAACCAATTTTACAAGCG
ATTTCAGCCAAAACAGATAAAGGCGAAGCTTGTTGTGATTGGGTTGGTCGTGATGGTGCTGGGCATTTCGTCAAAATGGT
GCATAACGGGATTGAATACGGCGATATGCAATTAATTTGCGAAGCGTATCAATTCTTAAAAGAAGGCGTAGGCTTATCTG
ATGACGAATTAGAAGCAACTTTCAAAGCGTGGCGTAACACCGAATTAGATAGCTATTTAATTGATATCACAGCGGATATT
CTTGGCTATAAAGATGAAGATGGCAGCCGTTTAGTCGACAAAATTTTGGATACCGCAGGTCAAAAAGGAACAGGTAAATG
GACGGGGATTAATGCCCTTGATTTCGGCATTCCATTGACTTTAATCACGGAATCTGTCTTTGCCCGTTGCGTCTCGTCTT
TCAAAGAACAGCGTGTGCAAGCCTCTCGCCTATTCAATAAAGTGGTCGGCAAAGTAGAAGGCGACAAAGCAGCTTGGGTT
GAAGCGGTGCGTAAAGCCTTATTAGCCTCCAAAATTATTTCTTATGCTCAAGGTTTTATGCTGATTCGTGAAGCGTCAGA
AAACTTTGGCTGGCACATTAACTACGGCGGTACAGCATTATTATGGCGTGAAGGTTGTATTATCCGTAGCCGTTTCTTAG
GTAATATCCGGGATGCTTATGAAGCCAATCCGGATCTGATTTTCTTAGGTTCAGATGCCTACTTCAAAGGTATCTTAGAA
AATAGCTTAGGCGAATGGCGTAAAGTGGTGGCGAAGTCGATCGAAGTGGGTATTCCAATGCCTTGTATGGCGTCTGCGAT
CACTTTCTTAGACAGCTATACGAGTGAACGTTTACCAGCGAACTTACTCCAAGCACAACGTGACTATTTCGGTGCACATA
CTTATGAACGTACGGATAAACCACGTGGTGAGTTCTTCCATACCAATTGGACAGGTCGTGGTGGTGATGCTGCATCGACC
ACTTATGATGTGTAA

Upstream 100 bases:

>100_bases
GACGAAAATATAGTCATATACAAACATTAGCGGTCTGCGTAATAAAATGTTTTAAAATCAGACCGCACTTTAATTATTCT
TATGGTTACAGGAGAACAAC

Downstream 100 bases:

>100_bases
GTAAATTTACCGATATCATACCGCACTTTTATGCTGAATCTTAAAAGTGCGGTGCTTTTTAAAAAAGTTTCATACTGTGA
ATAAACATCAGATGAACAAG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAFNRTTSKVDEFLQGAAKGTNIIGAYSLEDLANKLEKPRKVMLMVRAGE
VVDQFIEALLPHLEEGDIIIDGGNTNYPDTNRRVAYLREKGIRFIGTGVSGGEEGARFGPSIMPGGDESAWEHVKPILQA
ISAKTDKGEACCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGVGLSDDELEATFKAWRNTELDSYLIDITADI
LGYKDEDGSRLVDKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKEQRVQASRLFNKVVGKVEGDKAAWV
EAVRKALLASKIISYAQGFMLIREASENFGWHINYGGTALLWREGCIIRSRFLGNIRDAYEANPDLIFLGSDAYFKGILE
NSLGEWRKVVAKSIEVGIPMPCMASAITFLDSYTSERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGDAAST
TYDV

Sequences:

>Translated_484_residues
MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAFNRTTSKVDEFLQGAAKGTNIIGAYSLEDLANKLEKPRKVMLMVRAGE
VVDQFIEALLPHLEEGDIIIDGGNTNYPDTNRRVAYLREKGIRFIGTGVSGGEEGARFGPSIMPGGDESAWEHVKPILQA
ISAKTDKGEACCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGVGLSDDELEATFKAWRNTELDSYLIDITADI
LGYKDEDGSRLVDKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKEQRVQASRLFNKVVGKVEGDKAAWV
EAVRKALLASKIISYAQGFMLIREASENFGWHINYGGTALLWREGCIIRSRFLGNIRDAYEANPDLIFLGSDAYFKGILE
NSLGEWRKVVAKSIEVGIPMPCMASAITFLDSYTSERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGDAAST
TYDV
>Mature_483_residues
SVKGDIGVIGLAVMGQNLILNMNDHGFKVVAFNRTTSKVDEFLQGAAKGTNIIGAYSLEDLANKLEKPRKVMLMVRAGEV
VDQFIEALLPHLEEGDIIIDGGNTNYPDTNRRVAYLREKGIRFIGTGVSGGEEGARFGPSIMPGGDESAWEHVKPILQAI
SAKTDKGEACCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFLKEGVGLSDDELEATFKAWRNTELDSYLIDITADIL
GYKDEDGSRLVDKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKEQRVQASRLFNKVVGKVEGDKAAWVE
AVRKALLASKIISYAQGFMLIREASENFGWHINYGGTALLWREGCIIRSRFLGNIRDAYEANPDLIFLGSDAYFKGILEN
SLGEWRKVVAKSIEVGIPMPCMASAITFLDSYTSERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGDAASTT
YDV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=481, Percent_Identity=61.1226611226611, Blast_Score=614, Evalue=1e-176,
Organism=Escherichia coli, GI1788341, Length=467, Percent_Identity=54.1755888650964, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17542558, Length=483, Percent_Identity=58.3850931677019, Blast_Score=591, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6321695, Length=486, Percent_Identity=57.201646090535, Blast_Score=572, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6321977, Length=488, Percent_Identity=57.7868852459016, Blast_Score=558, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24639279, Length=483, Percent_Identity=57.9710144927536, Blast_Score=554, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53320; Mature: 53189

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAFNRTTSKVDEFLQGAAKGTNIIGAYSLE
CCCCCCCCCEEHEECCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCHH
DLANKLEKPRKVMLMVRAGEVVDQFIEALLPHLEEGDIIIDGGNTNYPDTNRRVAYLREK
HHHHHHCCCHHEEEEEHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHC
GIRFIGTGVSGGEEGARFGPSIMPGGDESAWEHVKPILQAISAKTDKGEACCDWVGRDGA
CCEEEECCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
GHFVKMVHNGIEYGDMQLICEAYQFLKEGVGLSDDELEATFKAWRNTELDSYLIDITADI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGYKDEDGSRLVDKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKEQRVQ
HCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ASRLFNKVVGKVEGDKAAWVEAVRKALLASKIISYAQGFMLIREASENFGWHINYGGTAL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEE
LWREGCIIRSRFLGNIRDAYEANPDLIFLGSDAYFKGILENSLGEWRKVVAKSIEVGIPM
EEECCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCMASAITFLDSYTSERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGDAAST
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
TYDV
CCCC
>Mature Secondary Structure 
SVKGDIGVIGLAVMGQNLILNMNDHGFKVVAFNRTTSKVDEFLQGAAKGTNIIGAYSLE
CCCCCCCCEEHEECCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCHH
DLANKLEKPRKVMLMVRAGEVVDQFIEALLPHLEEGDIIIDGGNTNYPDTNRRVAYLREK
HHHHHHCCCHHEEEEEHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHC
GIRFIGTGVSGGEEGARFGPSIMPGGDESAWEHVKPILQAISAKTDKGEACCDWVGRDGA
CCEEEECCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
GHFVKMVHNGIEYGDMQLICEAYQFLKEGVGLSDDELEATFKAWRNTELDSYLIDITADI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
LGYKDEDGSRLVDKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKEQRVQ
HCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ASRLFNKVVGKVEGDKAAWVEAVRKALLASKIISYAQGFMLIREASENFGWHINYGGTAL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEE
LWREGCIIRSRFLGNIRDAYEANPDLIFLGSDAYFKGILENSLGEWRKVVAKSIEVGIPM
EEECCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCMASAITFLDSYTSERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGDAAST
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
TYDV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]