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The map label for this gene is speA

Identifier: 15603247

GI number: 15603247

Start: 1576597

End: 1578531

Strand: Reverse

Name: speA

Synonym: PM1382

Alternate gene names: 15603247

Gene position: 1578531-1576597 (Counterclockwise)

Preceding gene: 15603248

Following gene: 15603246

Centisome position: 69.92

GC content: 41.96

Gene sequence:

>1935_bases
TTGGAACAGGTTACTTTAACGTCTGATGGCACTTCATCCGTGTTTGCTGAAAATACCGTACGTGAAGTGTGTAACATCAA
TTACTGGGGGATGCGTTATTATAACGTAGATGAAAAAGGGGACATTTTTGTTTGTCCTGATCCTGACAAACCACAAAATC
GTGTGTCTTTGGCGGCGTTAGCAGAAAAAGTGCAACGAGAACAAGGCGCACATTTACCAACACTCTTTTGCTTTCCGCAA
ATTATTCAACATCGTTTACGCTCGATTAATCAGGCGTTTAAACGTGCCCGTGAAGACTTTGGTTATGAAGGGAATTATTT
CCTCGTTTATCCAATCAAAGTGAATCAACATCGACGTATTGTGGAATCCTTAATTAGCTCAGGTCAACCGCTTGGCTTAG
AGGCCGGGTCAAAGGCGGAATTGATGGCTGTGCTAGCGCATGCAGGGATCACACAAACGGTGATTGTCTGTAATGGCTAT
AAAGATCGGGAATATGTTCGTTTTGCCCTGATGGGTGAAAAACTTGGACATAAAGTGTATTTAGTGATTGAAAAGCTCTC
TGAAATCCAGCTTGTTTTAGAGGAAGCAGCAAAACTGAATGTGAAGCCACGCTTAGGGGTACGTGCACGTTTAGCCTCAC
AGGGATCCGGTAAATGGCAATCTTCAGGCGGCGAAAAATCAAAATTTGGTTTATCTGCCTCACAAGTCTTGTCTTTAGTT
CAGATGTTAAAAGAACATGAGTGTCTCGATTGTTTACAGTTGCTACATTTCCACTTGGGATCACAGCTGGGCAACATTCG
TGATGTGGCGACAGGCGTGCGAGAAAGTGCTCGTTTTTATGTTGAATTGCATAAATTAGGCGTCAATATTCAGTGCTTTG
ATGTGGGTGGTGGCTTAGGTGTGGATTATGAAGGAAACCGTACACAATCCGATTGCTCAGTGAACTATGGTTTAAATGAA
TATGCCGATACTGTTGTGTGGGGTATTGGTCAAGCCTGCCGTGAGCATGGTTTACCACATCCTACCATTATCACCGAATC
GGGTCGTGGTGTGACTGCACACCATGCTGTTTTAGTCTCTAATGTGATTGGTGTAGAACGTTATAAATTTGAAACCTTAG
CGGCGCCAGCAAAAGACGCACCAAGTGTGTTACATAGTATGTGGGAAACTTGGGTGGATATTCAGTCTTCACGTGAAAAA
CGGTCGTTACGCAGTTGGATTCATGAAAGCCAATTTGATTTATCAGATGTACATAATCAATACAATGTCGGGTTGCTGAA
TTTAGAACAGCGTGCATGGGCTGAGCAACTTTATTTGAATATTTGTCATGAAGTGGGGCAATTATTTAATGAAAAGCACC
GTTCTCATCGTACAATTATTGATGAACTGCAAGAGCGCTTTGCGGATAAATTGTATGTGAACTTTTCTTTGTTCCAATCC
TTGCCTGATGCGTGGGGCATTGACCAGCTTTTCCCGGTCTGTCCAATTTCGAATTTAAATCAGCCGGTGAGCCGTCGTGC
AGTATTATTAGATATTACCTGTGATTCAGATGGCACGATTGATCATTATATTGATGGGGATGGTATTACGACCACCATGC
CGATGCCACATTATGAAGAAGACAATCCACCGTTATTAGGCTTCTTTATGGTTGGGGCGTATCAAGAAATTTTAGGTAAC
ATGCATAACTTATTTGGTGATACCAGTACAGTGGATGTTTTAGTTCATGAGCAGGATAAGGCTTATATTGTGGACTACGA
CGAAGGTAACACCGTAGCAGATATGTTGGAATATGTTTATCTTGATCCGAAAAAATTATTGGATCGCTATCGTGAACAAA
TTGAGCATTCAAACTTACCTGCGTCAGAAGCCATTCAGTTCTTAAATGAACTTGAGGTGGGCTTGAATGGTTATACCTAT
TTAGAAGACGAGTAA

Upstream 100 bases:

>100_bases
CTTGCAAACGTTTTTCTGTAATTGCGATGGGACAGAAAAAACAAAATATGGCGCGTTGGCGCTTGAATTTTTGACTCCTT
TTAAGAGGTAAACTAAGACA

Downstream 100 bases:

>100_bases
TTGGCAAAAGTGCGGTCTATTTTCTGTAAAAAGACCGCGCTTTAGGACAACAGGAATCACTATGTACAATACGTTAAACA
ATAAAGAAGATATTTCATTA

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MEQVTLTSDGTSSVFAENTVREVCNINYWGMRYYNVDEKGDIFVCPDPDKPQNRVSLAALAEKVQREQGAHLPTLFCFPQ
IIQHRLRSINQAFKRAREDFGYEGNYFLVYPIKVNQHRRIVESLISSGQPLGLEAGSKAELMAVLAHAGITQTVIVCNGY
KDREYVRFALMGEKLGHKVYLVIEKLSEIQLVLEEAAKLNVKPRLGVRARLASQGSGKWQSSGGEKSKFGLSASQVLSLV
QMLKEHECLDCLQLLHFHLGSQLGNIRDVATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGNRTQSDCSVNYGLNE
YADTVVWGIGQACREHGLPHPTIITESGRGVTAHHAVLVSNVIGVERYKFETLAAPAKDAPSVLHSMWETWVDIQSSREK
RSLRSWIHESQFDLSDVHNQYNVGLLNLEQRAWAEQLYLNICHEVGQLFNEKHRSHRTIIDELQERFADKLYVNFSLFQS
LPDAWGIDQLFPVCPISNLNQPVSRRAVLLDITCDSDGTIDHYIDGDGITTTMPMPHYEEDNPPLLGFFMVGAYQEILGN
MHNLFGDTSTVDVLVHEQDKAYIVDYDEGNTVADMLEYVYLDPKKLLDRYREQIEHSNLPASEAIQFLNELEVGLNGYTY
LEDE

Sequences:

>Translated_644_residues
MEQVTLTSDGTSSVFAENTVREVCNINYWGMRYYNVDEKGDIFVCPDPDKPQNRVSLAALAEKVQREQGAHLPTLFCFPQ
IIQHRLRSINQAFKRAREDFGYEGNYFLVYPIKVNQHRRIVESLISSGQPLGLEAGSKAELMAVLAHAGITQTVIVCNGY
KDREYVRFALMGEKLGHKVYLVIEKLSEIQLVLEEAAKLNVKPRLGVRARLASQGSGKWQSSGGEKSKFGLSASQVLSLV
QMLKEHECLDCLQLLHFHLGSQLGNIRDVATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGNRTQSDCSVNYGLNE
YADTVVWGIGQACREHGLPHPTIITESGRGVTAHHAVLVSNVIGVERYKFETLAAPAKDAPSVLHSMWETWVDIQSSREK
RSLRSWIHESQFDLSDVHNQYNVGLLNLEQRAWAEQLYLNICHEVGQLFNEKHRSHRTIIDELQERFADKLYVNFSLFQS
LPDAWGIDQLFPVCPISNLNQPVSRRAVLLDITCDSDGTIDHYIDGDGITTTMPMPHYEEDNPPLLGFFMVGAYQEILGN
MHNLFGDTSTVDVLVHEQDKAYIVDYDEGNTVADMLEYVYLDPKKLLDRYREQIEHSNLPASEAIQFLNELEVGLNGYTY
LEDE
>Mature_644_residues
MEQVTLTSDGTSSVFAENTVREVCNINYWGMRYYNVDEKGDIFVCPDPDKPQNRVSLAALAEKVQREQGAHLPTLFCFPQ
IIQHRLRSINQAFKRAREDFGYEGNYFLVYPIKVNQHRRIVESLISSGQPLGLEAGSKAELMAVLAHAGITQTVIVCNGY
KDREYVRFALMGEKLGHKVYLVIEKLSEIQLVLEEAAKLNVKPRLGVRARLASQGSGKWQSSGGEKSKFGLSASQVLSLV
QMLKEHECLDCLQLLHFHLGSQLGNIRDVATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGNRTQSDCSVNYGLNE
YADTVVWGIGQACREHGLPHPTIITESGRGVTAHHAVLVSNVIGVERYKFETLAAPAKDAPSVLHSMWETWVDIQSSREK
RSLRSWIHESQFDLSDVHNQYNVGLLNLEQRAWAEQLYLNICHEVGQLFNEKHRSHRTIIDELQERFADKLYVNFSLFQS
LPDAWGIDQLFPVCPISNLNQPVSRRAVLLDITCDSDGTIDHYIDGDGITTTMPMPHYEEDNPPLLGFFMVGAYQEILGN
MHNLFGDTSTVDVLVHEQDKAYIVDYDEGNTVADMLEYVYLDPKKLLDRYREQIEHSNLPASEAIQFLNELEVGLNGYTY
LEDE

Specific function: Catalyzes the biosynthesis of agmatine from arginine

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily

Homologues:

Organism=Escherichia coli, GI1789307, Length=644, Percent_Identity=69.7204968944099, Blast_Score=954, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEA_PASMU (Q9CL60)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246321.1
- ProteinModelPortal:   Q9CL60
- GeneID:   1244729
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1382
- NMPDR:   fig|272843.1.peg.1383
- HOGENOM:   HBG321436
- OMA:   TCDSDGE
- ProtClustDB:   PRK05354
- BioCyc:   PMUL272843:PM1382-MONOMER
- BRENDA:   4.1.1.19
- HAMAP:   MF_01417
- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PANTHER:   PTHR11482:SF3
- PIRSF:   PIRSF001336
- PRINTS:   PR01180
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01273

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.19

Molecular weight: Translated: 72708; Mature: 72708

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQVTLTSDGTSSVFAENTVREVCNINYWGMRYYNVDEKGDIFVCPDPDKPQNRVSLAAL
CCEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCCCCCCHHHHHHHHH
AEKVQREQGAHLPTLFCFPQIIQHRLRSINQAFKRAREDFGYEGNYFLVYPIKVNQHRRI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHH
VESLISSGQPLGLEAGSKAELMAVLAHAGITQTVIVCNGYKDREYVRFALMGEKLGHKVY
HHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEE
LVIEKLSEIQLVLEEAAKLNVKPRLGVRARLASQGSGKWQSSGGEKSKFGLSASQVLSLV
EHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
QMLKEHECLDCLQLLHFHLGSQLGNIRDVATGVRESARFYVELHKLGVNIQCFDVGGGLG
HHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEHHHHCCEEEEEECCCCCC
VDYEGNRTQSDCSVNYGLNEYADTVVWGIGQACREHGLPHPTIITESGRGVTAHHAVLVS
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHH
NVIGVERYKFETLAAPAKDAPSVLHSMWETWVDIQSSREKRSLRSWIHESQFDLSDVHNQ
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
YNVGLLNLEQRAWAEQLYLNICHEVGQLFNEKHRSHRTIIDELQERFADKLYVNFSLFQS
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHC
LPDAWGIDQLFPVCPISNLNQPVSRRAVLLDITCDSDGTIDHYIDGDGITTTMPMPHYEE
CCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCEECCCCCCCCC
DNPPLLGFFMVGAYQEILGNMHNLFGDTSTVDVLVHEQDKAYIVDYDEGNTVADMLEYVY
CCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCCHHHHHHHHHH
LDPKKLLDRYREQIEHSNLPASEAIQFLNELEVGLNGYTYLEDE
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCC
>Mature Secondary Structure
MEQVTLTSDGTSSVFAENTVREVCNINYWGMRYYNVDEKGDIFVCPDPDKPQNRVSLAAL
CCEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCCCCCCHHHHHHHHH
AEKVQREQGAHLPTLFCFPQIIQHRLRSINQAFKRAREDFGYEGNYFLVYPIKVNQHRRI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHH
VESLISSGQPLGLEAGSKAELMAVLAHAGITQTVIVCNGYKDREYVRFALMGEKLGHKVY
HHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEE
LVIEKLSEIQLVLEEAAKLNVKPRLGVRARLASQGSGKWQSSGGEKSKFGLSASQVLSLV
EHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
QMLKEHECLDCLQLLHFHLGSQLGNIRDVATGVRESARFYVELHKLGVNIQCFDVGGGLG
HHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEHHHHCCEEEEEECCCCCC
VDYEGNRTQSDCSVNYGLNEYADTVVWGIGQACREHGLPHPTIITESGRGVTAHHAVLVS
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHH
NVIGVERYKFETLAAPAKDAPSVLHSMWETWVDIQSSREKRSLRSWIHESQFDLSDVHNQ
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
YNVGLLNLEQRAWAEQLYLNICHEVGQLFNEKHRSHRTIIDELQERFADKLYVNFSLFQS
CCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHC
LPDAWGIDQLFPVCPISNLNQPVSRRAVLLDITCDSDGTIDHYIDGDGITTTMPMPHYEE
CCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCEECCCCCCCCC
DNPPLLGFFMVGAYQEILGNMHNLFGDTSTVDVLVHEQDKAYIVDYDEGNTVADMLEYVY
CCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCCHHHHHHHHHH
LDPKKLLDRYREQIEHSNLPASEAIQFLNELEVGLNGYTYLEDE
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100