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The map label for this gene is slyD [C]

Identifier: 15603214

GI number: 15603214

Start: 1540688

End: 1541404

Strand: Direct

Name: slyD [C]

Synonym: PM1349

Alternate gene names: 15603214

Gene position: 1540688-1541404 (Clockwise)

Preceding gene: 15603212

Following gene: 15603215

Centisome position: 68.25

GC content: 40.73

Gene sequence:

>717_bases
ATGTTTAAAATTCAAAAGCTTTCTCTTATTACCCTTGTGGTGAGTGCGGTTATTTCTGGCAATGCGTTAGCGAATACGGA
TGCTAAATTTAACGATGAAGCATCTTACGCAGTAGGGGTGTTATTAGGATCAAATGTTAAACAAATTGTAGAATCGCAAA
AAGGCATTATTGAATATGACAATACGCGTTTATTGGCAGGGGTGCAAGATGTATTAAATGGTAAGGTAGATCTTGATTCA
AATGAACAAATTGCACAAACATTACAACGCGTACAAGAGAAAATGCAACAAGCGCAAGCTCAGTTACTCGCCGATATTGC
AAAACAAGCAAAACAAGATGGCGACCAATATCGCCAAACATTTGAGAAAAAAGCGGGAGCGAAGAAAACCCAATCTGGTC
TGTTATATCGCATTGAACAAGCAGGGACAGGAAATACGATTAAGCCAACTGACACTGTTACCGTTAATTATACCGGCAAA
CTCCCTAATGGCGAGGTATTTGACAGTTCGCGTGGTAAACCGGTGTCCTTTAAATTGAACCAAGTGGTACCGGGTTGGAC
AGAAGGTTTACAACTTGTTAAAAAAGGTGGAAAAATCGAACTCGTTCTCCCACCAGAATTGGCGTATGGGGAGCAAGGGG
CTGGACAGATTCCACCAAATGCGACTTTACACTTTGATGTTGAAGTCATCGATGTGAAAGCGGATACACAAAAATAA

Upstream 100 bases:

>100_bases
ATTTTGCATCATTTAACTCCAAAAAAATAAATGTTGTGAAATTATTCATTCCGTTTTAACCTATCATAATTCATTTTTTC
ATTATAAAGGATTCAATCTT

Downstream 100 bases:

>100_bases
TGAAAAAACGACCGCACTTTGTCAGTAATCATCAAGTGCGGTCATGTCTTTGTGAATAAATGAGAGTAAGGCAATGTTAA
CGGATAAACAACCTTTTACA

Product: SlyD

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MFKIQKLSLITLVVSAVISGNALANTDAKFNDEASYAVGVLLGSNVKQIVESQKGIIEYDNTRLLAGVQDVLNGKVDLDS
NEQIAQTLQRVQEKMQQAQAQLLADIAKQAKQDGDQYRQTFEKKAGAKKTQSGLLYRIEQAGTGNTIKPTDTVTVNYTGK
LPNGEVFDSSRGKPVSFKLNQVVPGWTEGLQLVKKGGKIELVLPPELAYGEQGAGQIPPNATLHFDVEVIDVKADTQK

Sequences:

>Translated_238_residues
MFKIQKLSLITLVVSAVISGNALANTDAKFNDEASYAVGVLLGSNVKQIVESQKGIIEYDNTRLLAGVQDVLNGKVDLDS
NEQIAQTLQRVQEKMQQAQAQLLADIAKQAKQDGDQYRQTFEKKAGAKKTQSGLLYRIEQAGTGNTIKPTDTVTVNYTGK
LPNGEVFDSSRGKPVSFKLNQVVPGWTEGLQLVKKGGKIELVLPPELAYGEQGAGQIPPNATLHFDVEVIDVKADTQK
>Mature_238_residues
MFKIQKLSLITLVVSAVISGNALANTDAKFNDEASYAVGVLLGSNVKQIVESQKGIIEYDNTRLLAGVQDVLNGKVDLDS
NEQIAQTLQRVQEKMQQAQAQLLADIAKQAKQDGDQYRQTFEKKAGAKKTQSGLLYRIEQAGTGNTIKPTDTVTVNYTGK
LPNGEVFDSSRGKPVSFKLNQVVPGWTEGLQLVKKGGKIELVLPPELAYGEQGAGQIPPNATLHFDVEVIDVKADTQK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=113, Percent_Identity=41.5929203539823, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI224809327, Length=113, Percent_Identity=41.5929203539823, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4758384, Length=113, Percent_Identity=41.5929203539823, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI224809331, Length=113, Percent_Identity=41.5929203539823, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI206725530, Length=117, Percent_Identity=39.3162393162393, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI17149844, Length=117, Percent_Identity=39.3162393162393, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI17149842, Length=117, Percent_Identity=39.3162393162393, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503727, Length=101, Percent_Identity=41.5841584158416, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4758380, Length=98, Percent_Identity=43.8775510204082, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI17149836, Length=98, Percent_Identity=43.8775510204082, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4503725, Length=98, Percent_Identity=43.8775510204082, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI33469985, Length=101, Percent_Identity=40.5940594059406, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4503729, Length=114, Percent_Identity=39.4736842105263, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI8923659, Length=90, Percent_Identity=35.5555555555556, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=219, Percent_Identity=46.1187214611872, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI87082390, Length=203, Percent_Identity=38.9162561576355, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=40.8602150537634, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561782, Length=114, Percent_Identity=37.719298245614, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=108, Percent_Identity=45.3703703703704, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=99, Percent_Identity=45.4545454545455, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323482, Length=113, Percent_Identity=38.0530973451327, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323566, Length=113, Percent_Identity=36.283185840708, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=50, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=50, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24655568, Length=86, Percent_Identity=46.5116279069767, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=43.010752688172, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356629, Length=115, Percent_Identity=40, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25799; Mature: 25799

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKIQKLSLITLVVSAVISGNALANTDAKFNDEASYAVGVLLGSNVKQIVESQKGIIEYD
CCEEHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCEEEC
NTRLLAGVQDVLNGKVDLDSNEQIAQTLQRVQEKMQQAQAQLLADIAKQAKQDGDQYRQT
CCEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
FEKKAGAKKTQSGLLYRIEQAGTGNTIKPTDTVTVNYTGKLPNGEVFDSSRGKPVSFKLN
HHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCEECCCCCCEEEEECC
QVVPGWTEGLQLVKKGGKIELVLPPELAYGEQGAGQIPPNATLHFDVEVIDVKADTQK
CCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCC
>Mature Secondary Structure
MFKIQKLSLITLVVSAVISGNALANTDAKFNDEASYAVGVLLGSNVKQIVESQKGIIEYD
CCEEHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCEEEC
NTRLLAGVQDVLNGKVDLDSNEQIAQTLQRVQEKMQQAQAQLLADIAKQAKQDGDQYRQT
CCEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
FEKKAGAKKTQSGLLYRIEQAGTGNTIKPTDTVTVNYTGKLPNGEVFDSSRGKPVSFKLN
HHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCEECCCCCCEEEEECC
QVVPGWTEGLQLVKKGGKIELVLPPELAYGEQGAGQIPPNATLHFDVEVIDVKADTQK
CCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]