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The map label for this gene is apbE [H]

Identifier: 15603199

GI number: 15603199

Start: 1526384

End: 1527424

Strand: Direct

Name: apbE [H]

Synonym: PM1334

Alternate gene names: 15603199

Gene position: 1526384-1527424 (Clockwise)

Preceding gene: 15603198

Following gene: 15603200

Centisome position: 67.61

GC content: 39.39

Gene sequence:

>1041_bases
ATAAAACACATTCTTAATAGTATCATCATTGGCTTTTGTTCACTATGTTTATTGGCTTGTCATAAATCCCCTGAAGTTGT
GACGATCACGGGTAAGACCATGGGGACAACGTATAGTGTGAAATACATTGATGATGGTCAGATTAAGATTAAACCGATTG
AGATGCACGGGCAAATTGAAGAGATTTTGAAAGAAGTGAACAATAAAATGTCTACTTACCTTTCCACATCTGAATTGAGT
CAATTTAATCAAAATACACAAATTGATACGCCCGTTGAAATTTCGGCTGATTTAGCCTTTGTCTTAAAAGAAGCGATTCG
TTTACATGGCGTCACAGAAGGAGCATTGGATGTGACTGTGGGACCAATTGTGAATTTATGGGGGTTTGGACCTGAAAAGC
GTCAACCGAATGAAACCTTAGAAGAACAAGTGGAAAAACGTCGCGCTTGGGTCGGGATTGAAAAAATGAAATTAACCGAA
CAAGGCGATAAGTTTTATCTCGCTAAGACAGTTCCCCAGTTATATATTGACCTTTCTTCGATTGCCAAAGGGTTTGGTGT
CGATAAAGTGGCTGCACATTTAGCCACGAAAGGCATTGCTAATTATTTGGTGGAAATTGGTGGTGAGATTAACGCGAAAG
GAAAAAACATTGAAGGCAAAGATTGGCAAATCGCAATTGAAAAGCCGAATTTTGATGGGAGCCGTGCGGTATCACAAATT
ATTGGGCTGAAAGATTTTTCTATGGCAACATCGGGCAATTATCGTAACTATTTTGAAGAAAATGGTCGTCGTTTCTCTCA
TGAAATCGATCCTAAAACCGGCTACCCGATTGAACACCGATTGGCTTCAATCACTGTGTTAGCGGATTCCACCATGACCG
CAGATGGATTATCGACAGGTCTTTATGTGCTCGGAGAAGAGAAAGCCTTAGAAGTCGCGGAAAAATACAATTTATTGGTG
TATCTCATTAGCAAAACCGAAAAAGGATTTGAGGCAAAAATGTCCTCTGCATTTGAGAAATTATTAAATGAACAACATTA
G

Upstream 100 bases:

>100_bases
TCCATTTCAGAAAATTTGAAAATTTGGTTTTTATATTGCAATCCATATTGGAAAATCCAAACTTGCAAACTTTTTAAAAT
AGAAAGGATTTACAGTGAAA

Downstream 100 bases:

>100_bases
GATAAATCCATGCAACTTTTTTTAATCACGTTTGGCATCTTTTTATTGATTATTGCAGGAATGGCGATTGGTTATATTAT
TCAGCGTAAAACGATAGCTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKHILNSIIIGFCSLCLLACHKSPEVVTITGKTMGTTYSVKYIDDGQIKIKPIEMHGQIEEILKEVNNKMSTYLSTSELS
QFNQNTQIDTPVEISADLAFVLKEAIRLHGVTEGALDVTVGPIVNLWGFGPEKRQPNETLEEQVEKRRAWVGIEKMKLTE
QGDKFYLAKTVPQLYIDLSSIAKGFGVDKVAAHLATKGIANYLVEIGGEINAKGKNIEGKDWQIAIEKPNFDGSRAVSQI
IGLKDFSMATSGNYRNYFEENGRRFSHEIDPKTGYPIEHRLASITVLADSTMTADGLSTGLYVLGEEKALEVAEKYNLLV
YLISKTEKGFEAKMSSAFEKLLNEQH

Sequences:

>Translated_346_residues
MKHILNSIIIGFCSLCLLACHKSPEVVTITGKTMGTTYSVKYIDDGQIKIKPIEMHGQIEEILKEVNNKMSTYLSTSELS
QFNQNTQIDTPVEISADLAFVLKEAIRLHGVTEGALDVTVGPIVNLWGFGPEKRQPNETLEEQVEKRRAWVGIEKMKLTE
QGDKFYLAKTVPQLYIDLSSIAKGFGVDKVAAHLATKGIANYLVEIGGEINAKGKNIEGKDWQIAIEKPNFDGSRAVSQI
IGLKDFSMATSGNYRNYFEENGRRFSHEIDPKTGYPIEHRLASITVLADSTMTADGLSTGLYVLGEEKALEVAEKYNLLV
YLISKTEKGFEAKMSSAFEKLLNEQH
>Mature_346_residues
MKHILNSIIIGFCSLCLLACHKSPEVVTITGKTMGTTYSVKYIDDGQIKIKPIEMHGQIEEILKEVNNKMSTYLSTSELS
QFNQNTQIDTPVEISADLAFVLKEAIRLHGVTEGALDVTVGPIVNLWGFGPEKRQPNETLEEQVEKRRAWVGIEKMKLTE
QGDKFYLAKTVPQLYIDLSSIAKGFGVDKVAAHLATKGIANYLVEIGGEINAKGKNIEGKDWQIAIEKPNFDGSRAVSQI
IGLKDFSMATSGNYRNYFEENGRRFSHEIDPKTGYPIEHRLASITVLADSTMTADGLSTGLYVLGEEKALEVAEKYNLLV
YLISKTEKGFEAKMSSAFEKLLNEQH

Specific function: Involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2- methyl pyrimidine (HMP) moiety of thiamine [H]

COG id: COG1477

COG function: function code H; Membrane-associated lipoprotein involved in thiamine biosynthesis

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ApbE family [H]

Homologues:

Organism=Escherichia coli, GI1788543, Length=350, Percent_Identity=38.8571428571429, Blast_Score=254, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003374 [H]

Pfam domain/function: PF02424 ApbE [H]

EC number: NA

Molecular weight: Translated: 38442; Mature: 38442

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHILNSIIIGFCSLCLLACHKSPEVVTITGKTMGTTYSVKYIDDGQIKIKPIEMHGQIE
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCEEEEEEECCCCHHH
EILKEVNNKMSTYLSTSELSQFNQNTQIDTPVEISADLAFVLKEAIRLHGVTEGALDVTV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCEEEH
GPIVNLWGFGPEKRQPNETLEEQVEKRRAWVGIEKMKLTEQGDKFYLAKTVPQLYIDLSS
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEECCCCEEEEEHHHHHHHHHHHH
IAKGFGVDKVAAHLATKGIANYLVEIGGEINAKGKNIEGKDWQIAIEKPNFDGSRAVSQI
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
IGLKDFSMATSGNYRNYFEENGRRFSHEIDPKTGYPIEHRLASITVLADSTMTADGLSTG
HCCCCCCCCCCCCCHHHHHHCCCEECCCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCC
LYVLGEEKALEVAEKYNLLVYLISKTEKGFEAKMSSAFEKLLNEQH
EEEECCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKHILNSIIIGFCSLCLLACHKSPEVVTITGKTMGTTYSVKYIDDGQIKIKPIEMHGQIE
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCEEEEEEECCCCHHH
EILKEVNNKMSTYLSTSELSQFNQNTQIDTPVEISADLAFVLKEAIRLHGVTEGALDVTV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCEEEH
GPIVNLWGFGPEKRQPNETLEEQVEKRRAWVGIEKMKLTEQGDKFYLAKTVPQLYIDLSS
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEECCCCEEEEEHHHHHHHHHHHH
IAKGFGVDKVAAHLATKGIANYLVEIGGEINAKGKNIEGKDWQIAIEKPNFDGSRAVSQI
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
IGLKDFSMATSGNYRNYFEENGRRFSHEIDPKTGYPIEHRLASITVLADSTMTADGLSTG
HCCCCCCCCCCCCCHHHHHHCCCEECCCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCC
LYVLGEEKALEVAEKYNLLVYLISKTEKGFEAKMSSAFEKLLNEQH
EEEECCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]