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The map label for this gene is nqr6 [H]

Identifier: 15603198

GI number: 15603198

Start: 1524992

End: 1526215

Strand: Direct

Name: nqr6 [H]

Synonym: PM1333

Alternate gene names: 15603198

Gene position: 1524992-1526215 (Clockwise)

Preceding gene: 15603197

Following gene: 15603199

Centisome position: 67.55

GC content: 41.67

Gene sequence:

>1224_bases
ATGGAAATTACTCTTGGTATTGCAATGTTCACCGTTATCGTTTTGGCTTTAGCAGTCATTATCTTGTTTGCTAAATCAAA
ATTGGTTAATTCGGGTGATATTACAATTGAAATTAATGACGATCCAAGCAAAGCAATTCATTTGCCTGCGGGGGGCAAAT
TATTAGGTGCGCTGGCGAGTCAAGGCATCTTCGTTTCTTCCGCTTGTGGCGGTGGTGGTTCTTGTGGGCAATGTATCGTT
AAAGTCACCGAAGGGGGTGGCGATATTCTACCGACTGAACTTTCACACATTTCAAAACGTGAAGCAAAAGAAGGTTATCG
CCTTTCTTGCCAAGTGAATGTGAAAAACAGCATGAAGGTCGAATTGCCAGAAGAAGTCTTTGGGGTGAAAAAATGGGAAT
GTACCGTTATTTCTAATGATAATAAAGCGACTTTCATCAAAGAACTGAAATTAGCAATTCCTGAAGGGGAAGAAGTACCA
TTCCGTGCAGGTGGCTATATTCAGATTGAAGCAGAACCGCATACTGTCGCCTATAAAGACTTTGATATCCCAGAAGAATA
TCATGAAGATTGGGATAAATATAACTTATGGCGTTATGTGTCTAAAGTGGATGAGCATATTATTCGTGCATACTCCATGG
CTTCTTATCCGGAAGAAAAAGGCATCATCATGTTGAACGTGCGTATTGCAACGCCACCACCAAATAACCCAGACGCGCCT
CCTGGTCAAATGTCCTCATACATTTGGTCACTCAAAGCGGGTGATAAAGTGACTATTTCTGGTCCATTCGGTGAATTCTT
TGCGAAAGAAACCGATGCCGAGATGGTGTTCGTCGGCGGTGGTGCGGGTATGGCGCCAATGCGTTCACACATTTTTGACC
AATTAAAACGTTTGAAATCTAAACGTAAAATGTCATTCTGGTATGGTGCACGTTCTAAACGCGAAATGTTCTATGTGGAA
GATTTTGACACCTTACAAGCCGAAAATGATAACTTCGTATGGCATGTGGCACTTTCCGATCCACAACCGGGTGATAATTG
GGACGGCTACACCGGCTTTATTCATAATGTGCTTTATGAAAACTATCTGAAAGATCATGAAGCGCCAGAGGATTGTGAAT
ACTATATGTGTGGACCGCCAATCATGAATGCTTCCGTGATTAAGATGTTAAAAGATCTTGGTGTGGAAGATGAAAACATC
TTATTAGATGACTTTGGTGGTTAA

Upstream 100 bases:

>100_bases
AGGGTTACGTGGTTTAGGCATTACCTTTATCACTGTAGGTCTGATGGCACTTGGTTTTATGTCATTTTCAGGTATTCAGT
TGTAAGAAAGGGGATACAGA

Downstream 100 bases:

>100_bases
GCCAGCTTGCTCTTAGCATGATTAAAGTGCGGTCGGATTTTACGAATTTTGTAAAGGTTGACCGCACTTCCATTTCAGAA
AATTTGAAAATTTGGTTTTT

Product: Na(+)-translocating NADH-quinone reductase subunit F

Products: @TETR01txt*tetrahydropteridine!; NO3-; NAD(P); Proton [C]

Alternate protein names: Na(+)-NQR subunit F; Na(+)-translocating NQR subunit F; NQR complex subunit F; NQR-1 subunit F [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MEITLGIAMFTVIVLALAVIILFAKSKLVNSGDITIEINDDPSKAIHLPAGGKLLGALASQGIFVSSACGGGGSCGQCIV
KVTEGGGDILPTELSHISKREAKEGYRLSCQVNVKNSMKVELPEEVFGVKKWECTVISNDNKATFIKELKLAIPEGEEVP
FRAGGYIQIEAEPHTVAYKDFDIPEEYHEDWDKYNLWRYVSKVDEHIIRAYSMASYPEEKGIIMLNVRIATPPPNNPDAP
PGQMSSYIWSLKAGDKVTISGPFGEFFAKETDAEMVFVGGGAGMAPMRSHIFDQLKRLKSKRKMSFWYGARSKREMFYVE
DFDTLQAENDNFVWHVALSDPQPGDNWDGYTGFIHNVLYENYLKDHEAPEDCEYYMCGPPIMNASVIKMLKDLGVEDENI
LLDDFGG

Sequences:

>Translated_407_residues
MEITLGIAMFTVIVLALAVIILFAKSKLVNSGDITIEINDDPSKAIHLPAGGKLLGALASQGIFVSSACGGGGSCGQCIV
KVTEGGGDILPTELSHISKREAKEGYRLSCQVNVKNSMKVELPEEVFGVKKWECTVISNDNKATFIKELKLAIPEGEEVP
FRAGGYIQIEAEPHTVAYKDFDIPEEYHEDWDKYNLWRYVSKVDEHIIRAYSMASYPEEKGIIMLNVRIATPPPNNPDAP
PGQMSSYIWSLKAGDKVTISGPFGEFFAKETDAEMVFVGGGAGMAPMRSHIFDQLKRLKSKRKMSFWYGARSKREMFYVE
DFDTLQAENDNFVWHVALSDPQPGDNWDGYTGFIHNVLYENYLKDHEAPEDCEYYMCGPPIMNASVIKMLKDLGVEDENI
LLDDFGG
>Mature_407_residues
MEITLGIAMFTVIVLALAVIILFAKSKLVNSGDITIEINDDPSKAIHLPAGGKLLGALASQGIFVSSACGGGGSCGQCIV
KVTEGGGDILPTELSHISKREAKEGYRLSCQVNVKNSMKVELPEEVFGVKKWECTVISNDNKATFIKELKLAIPEGEEVP
FRAGGYIQIEAEPHTVAYKDFDIPEEYHEDWDKYNLWRYVSKVDEHIIRAYSMASYPEEKGIIMLNVRIATPPPNNPDAP
PGQMSSYIWSLKAGDKVTISGPFGEFFAKETDAEMVFVGGGAGMAPMRSHIFDQLKRLKSKRKMSFWYGARSKREMFYVE
DFDTLQAENDNFVWHVALSDPQPGDNWDGYTGFIHNVLYENYLKDHEAPEDCEYYMCGPPIMNASVIKMLKDLGVEDENI
LLDDFGG

Specific function: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by nqrF, which accepts electrons from NADH and reduces

COG id: COG2871

COG function: function code C; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323552, Length=202, Percent_Identity=24.7524752475248, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323510, Length=154, Percent_Identity=25.3246753246753, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR010205
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.5.1.34 [C]

Molecular weight: Translated: 45253; Mature: 45253

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITLGIAMFTVIVLALAVIILFAKSKLVNSGDITIEINDDPSKAIHLPAGGKLLGALAS
CEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCCHHHHHHHC
QGIFVSSACGGGGSCGQCIVKVTEGGGDILPTELSHISKREAKEGYRLSCQVNVKNSMKV
CCEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEE
ELPEEVFGVKKWECTVISNDNKATFIKELKLAIPEGEEVPFRAGGYIQIEAEPHTVAYKD
ECCHHHHCCCEEEEEEEECCCCCHHEEHHHHCCCCCCCCCEECCCEEEEECCCCEEEEEC
FDIPEEYHEDWDKYNLWRYVSKVDEHIIRAYSMASYPEEKGIIMLNVRIATPPPNNPDAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCC
PGQMSSYIWSLKAGDKVTISGPFGEFFAKETDAEMVFVGGGAGMAPMRSHIFDQLKRLKS
CCHHHHHEEEECCCCEEEEECCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
KRKMSFWYGARSKREMFYVEDFDTLQAENDNFVWHVALSDPQPGDNWDGYTGFIHNVLYE
HCCEEEEECCCCCCEEEEEECCCHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHH
NYLKDHEAPEDCEYYMCGPPIMNASVIKMLKDLGVEDENILLDDFGG
HHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCC
>Mature Secondary Structure
MEITLGIAMFTVIVLALAVIILFAKSKLVNSGDITIEINDDPSKAIHLPAGGKLLGALAS
CEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEECCCCCHHHHHHHC
QGIFVSSACGGGGSCGQCIVKVTEGGGDILPTELSHISKREAKEGYRLSCQVNVKNSMKV
CCEEEEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEE
ELPEEVFGVKKWECTVISNDNKATFIKELKLAIPEGEEVPFRAGGYIQIEAEPHTVAYKD
ECCHHHHCCCEEEEEEEECCCCCHHEEHHHHCCCCCCCCCEECCCEEEEECCCCEEEEEC
FDIPEEYHEDWDKYNLWRYVSKVDEHIIRAYSMASYPEEKGIIMLNVRIATPPPNNPDAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCC
PGQMSSYIWSLKAGDKVTISGPFGEFFAKETDAEMVFVGGGAGMAPMRSHIFDQLKRLKS
CCHHHHHEEEECCCCEEEEECCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
KRKMSFWYGARSKREMFYVEDFDTLQAENDNFVWHVALSDPQPGDNWDGYTGFIHNVLYE
HCCEEEEECCCCCCEEEEEECCCHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHH
NYLKDHEAPEDCEYYMCGPPIMNASVIKMLKDLGVEDENILLDDFGG
HHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dihydropteridine; 2 nitric oxide; O2; NAD(P)H [C]

Specific reaction: NAD(P)H + dihydropteridine = NAD(P)+ @TETR01.txt*tetrahydropteridine! 2 nitric oxide + 2 O2 + NAD(P)H = 2 NO3- + NAD(P) + Proton [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA