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The map label for this gene is mutY [H]

Identifier: 15603184

GI number: 15603184

Start: 1511105

End: 1512241

Strand: Direct

Name: mutY [H]

Synonym: PM1319

Alternate gene names: 15603184

Gene position: 1511105-1512241 (Clockwise)

Preceding gene: 15603183

Following gene: 15603185

Centisome position: 66.94

GC content: 43.1

Gene sequence:

>1137_bases
ATGATACTTGCTCAATCTTCTCCTCATGCCCCTTTTGCTCATGCCGTGTTAACTTGGTATGACAAATTTGGGCGTAAACA
TTTGCCTTGGCAACAGAATAAAACGTTATACGGGGTTTGGTTGTCCGAAGTGATGTTACAACAAACTCAAGTGGCGACGG
TGATTCCTTACTTTCAACGGTTTGTCGATAAATTTCCTAATATCTGTGCCTTGGCGAATGCACCATTAGATGAAGTGTTA
CATTTATGGACGGGGCTAGGTTACTATGCTCGTGCACGAAATTTACATAAAGCGGCACAAACCATTCGTGATCAATATGC
GGGTGAGTTTCCGACCGATTTTGAACAGGTGTGGGCGCTGACGGGCGTGGGGAAAAGCACTGCTGGTGCGGTACTTTCCT
CTTGTCTTGATGCGCCTTATCCGATTCTAGATGGTAATGTGAAACGCGTGCTTTCTCGTTATTTTGCTGTGTCTGGTTGG
GCGGGCGAGAAAAAAGTCGAAGAACAGTTATGGCAATATAGTGCACAGGTTACGCCGACTGAACAGGTCGCCAATTTTAA
TCAGGCGATGATGGATCTCGGGGCAATGGTATGCACTCGAACAAAGCCTAAATGTGATCTCTGTCCTTTACGTCATCATT
GCCAAGCATATTTACAACAAAACTGGCAGGCTTATCCGGGCAAAAAACCAAAAAAAGTTCTGCCAGAAAGAGAAAGTTAT
TTTTTGATTTTAAATGCCTATGGCAAAGTTGCGTTGGAGCAACGTGAAAATAACGGGCTTTGGGGCGGGCTCTATTGTTT
TCCTCAGTTTGAAAGCAAAGCAGCGCTGTTGGCATTTTTAGCGGCACAAGGGATTGGTTATTATCAAGAATGGACCGCAT
TTCGTCATACGTTTAGTCATTTCCATTTAGATATTTACCCCATTTATGTTGAGTTGCAACGGTCGCAACTCGATCAAAAT
CGCACCGATTGGAAAAAAGTCGCAGAAAAGACCGAACAGAGTGAATCAACTGTATTCAGTGCGGTCAAATATTGGTATGA
TCCGCAAAATCCAGAACAAATTGGACTGGCAACACCAGTAAAGAATTTATTAACACAATTTATAAGGAATTATTATGGCG
AGAACCGTATTCTGTGA

Upstream 100 bases:

>100_bases
AAAGAGTATGTCGCCACATTAACCTGTGCGAGAGAATTTTCAAAGTGCGGTCGGTTTTTTTAAATGCTTTGATCGTACCT
GTTTTCGGATTTTTTTATTG

Downstream 100 bases:

>100_bases
ATACCTTAAACAAGAGTCTGAAGGCTTGGACTTTCAGCTGTATCCAGGCGAGTTGGGTAAGCGTATTTTTGACTCAATCA
GTAAACAAGCATGGCGTGAA

Product: MutY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MILAQSSPHAPFAHAVLTWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFQRFVDKFPNICALANAPLDEVL
HLWTGLGYYARARNLHKAAQTIRDQYAGEFPTDFEQVWALTGVGKSTAGAVLSSCLDAPYPILDGNVKRVLSRYFAVSGW
AGEKKVEEQLWQYSAQVTPTEQVANFNQAMMDLGAMVCTRTKPKCDLCPLRHHCQAYLQQNWQAYPGKKPKKVLPERESY
FLILNAYGKVALEQRENNGLWGGLYCFPQFESKAALLAFLAAQGIGYYQEWTAFRHTFSHFHLDIYPIYVELQRSQLDQN
RTDWKKVAEKTEQSESTVFSAVKYWYDPQNPEQIGLATPVKNLLTQFIRNYYGENRIL

Sequences:

>Translated_378_residues
MILAQSSPHAPFAHAVLTWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFQRFVDKFPNICALANAPLDEVL
HLWTGLGYYARARNLHKAAQTIRDQYAGEFPTDFEQVWALTGVGKSTAGAVLSSCLDAPYPILDGNVKRVLSRYFAVSGW
AGEKKVEEQLWQYSAQVTPTEQVANFNQAMMDLGAMVCTRTKPKCDLCPLRHHCQAYLQQNWQAYPGKKPKKVLPERESY
FLILNAYGKVALEQRENNGLWGGLYCFPQFESKAALLAFLAAQGIGYYQEWTAFRHTFSHFHLDIYPIYVELQRSQLDQN
RTDWKKVAEKTEQSESTVFSAVKYWYDPQNPEQIGLATPVKNLLTQFIRNYYGENRIL
>Mature_378_residues
MILAQSSPHAPFAHAVLTWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFQRFVDKFPNICALANAPLDEVL
HLWTGLGYYARARNLHKAAQTIRDQYAGEFPTDFEQVWALTGVGKSTAGAVLSSCLDAPYPILDGNVKRVLSRYFAVSGW
AGEKKVEEQLWQYSAQVTPTEQVANFNQAMMDLGAMVCTRTKPKCDLCPLRHHCQAYLQQNWQAYPGKKPKKVLPERESY
FLILNAYGKVALEQRENNGLWGGLYCFPQFESKAALLAFLAAQGIGYYQEWTAFRHTFSHFHLDIYPIYVELQRSQLDQN
RTDWKKVAEKTEQSESTVFSAVKYWYDPQNPEQIGLATPVKNLLTQFIRNYYGENRIL

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=369, Percent_Identity=32.520325203252, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI115298650, Length=369, Percent_Identity=32.520325203252, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI6912520, Length=369, Percent_Identity=32.520325203252, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI115298654, Length=369, Percent_Identity=32.520325203252, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI115298652, Length=369, Percent_Identity=32.520325203252, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI190358497, Length=369, Percent_Identity=32.520325203252, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1789331, Length=358, Percent_Identity=58.1005586592179, Blast_Score=412, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43460; Mature: 43460

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILAQSSPHAPFAHAVLTWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFQR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
FVDKFPNICALANAPLDEVLHLWTGLGYYARARNLHKAAQTIRDQYAGEFPTDFEQVWAL
HHHHCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TGVGKSTAGAVLSSCLDAPYPILDGNVKRVLSRYFAVSGWAGEKKVEEQLWQYSAQVTPT
HCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCH
EQVANFNQAMMDLGAMVCTRTKPKCDLCPLRHHCQAYLQQNWQAYPGKKPKKVLPERESY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCE
FLILNAYGKVALEQRENNGLWGGLYCFPQFESKAALLAFLAAQGIGYYQEWTAFRHTFSH
EEEEECCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FHLDIYPIYVELQRSQLDQNRTDWKKVAEKTEQSESTVFSAVKYWYDPQNPEQIGLATPV
HEEEEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
KNLLTQFIRNYYGENRIL
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MILAQSSPHAPFAHAVLTWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFQR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
FVDKFPNICALANAPLDEVLHLWTGLGYYARARNLHKAAQTIRDQYAGEFPTDFEQVWAL
HHHHCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TGVGKSTAGAVLSSCLDAPYPILDGNVKRVLSRYFAVSGWAGEKKVEEQLWQYSAQVTPT
HCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCH
EQVANFNQAMMDLGAMVCTRTKPKCDLCPLRHHCQAYLQQNWQAYPGKKPKKVLPERESY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCE
FLILNAYGKVALEQRENNGLWGGLYCFPQFESKAALLAFLAAQGIGYYQEWTAFRHTFSH
EEEEECCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FHLDIYPIYVELQRSQLDQNRTDWKKVAEKTEQSESTVFSAVKYWYDPQNPEQIGLATPV
HEEEEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
KNLLTQFIRNYYGENRIL
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]