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The map label for this gene is lsrK [H]

Identifier: 15603137

GI number: 15603137

Start: 1464005

End: 1465573

Strand: Reverse

Name: lsrK [H]

Synonym: PM1272

Alternate gene names: 15603137

Gene position: 1465573-1464005 (Counterclockwise)

Preceding gene: 15603138

Following gene: 15603132

Centisome position: 64.92

GC content: 46.97

Gene sequence:

>1569_bases
ATGAGCAATCAATATCTTATGGCACTTGATGCTGGGACCGGGAGTGTACGTGCGGTCATTTTTGACTTAGACGGGAATCA
AATTGTCGCTGCCCAACGGGAATGGACGCACCTCGCTGATCCCAATATTCCCGGATCAATGGAATTTGATCTCAGCACAA
ACTGGCAACTTGCTTGTGACTGCATCCAACAAGCACTCCAAAAATCCCAGATTCCAGCACAACAGATTGCCGCCATCTCA
ACTTGTTCCATGCGTGAAGGCATTGTGTTATATGATGAAAATAAACAACCGATTTGGGCTTGTGGTAATGTGGATGCCCG
CGCCACAGAAGAAGTCAATGAATTAAAAGCACGTTGTGATCACCGCTTTGAAGAAAAATTGTATGCCATTTCAGGGCAAA
CTCTTGCCCTGAGTGCGGTCCCTCGTTTATTGTGGCTCGCCCACCATCGTCCTGATATTTATCAACAAACGAAAGCCATG
ACCATGATCAGTGACTGGCTTGGCTTTATGCTAAGTGGTGAACTTGCCGTAGAACCGTCCAATGCAGGTACCACCGGCAT
ACTCAATCTTAAAACACGACAGTGGGCACCTGAACTACTGGCTATGGCAGGGCTCAATAGCGATATTTTAACTCCAGTAA
AAGAGACCGGTGAGATCCTCGGCAACGTCAGCACGCTTGTCGCCCAACAAACTGGTTTACATGCTGGCACCCCTGTCGTA
GTAGGCGGCGGTGATGTGCAATTAGGCTGCATTGGGTTAGGCATTACAGAGCCATCTCAAGCGGCGGTCATTGGTGGAAC
ATTCTGGCAACAAGTTGTCAATTTACCTGAACCCGTCACGGATCCTGAGATGAATGTCCGGATTAACCCCCATGTTGTCG
CACCTTTAGTACAAGCAGAATCCATTAGTTTCTTTACTGGTTTAACTATGCGTTGGTTTAGAGATGCGTTTTGCCAAGAA
GAGAAAATCCTAGCGGAACGCTTAGGCATTGATACCTACACTTTATTAGAACAAATGGCAGAACGTGTGCCTGTCGGCGC
AAATGATGTCATTCCGATTTTCTCCGATGCCATGCACTTTAAATCTTGGTATCACGCGGCACCGTCTTTTGTGAATCTCT
CCATTGATCCAGAAAAATGTAATAAACCGGTCTTATTCCGTGCGTTAGAAGAAAATGCCGCCATAGTGTCTTCTTACAAC
TTAGATCAAGTAGAAAAATTCTCGGGGGTCAACCTCACTTCCATCGTCTTCGCTGGCGGTGGATCAAAAGGCAAACTTTG
GAGCCAAATTCTCGCCGATGTGACCGGCTTAGTAGTAAATATCCCGGTGGTCAAAGAAGCCACCGCACTGGGCTGTGCGA
TTGCTGCAGGTGTCGGGGTCGGACTCTACCCGTCACTCAGTGAAGCAGGCAAGAAATTAGTCAAATTTGAACGTCAACAC
CAACCGAATCCAGAGAATTATCAACTTTATCAGAAACATAAAGCAAAATGGGCTGATGTCTATGCCAAACAGTTACAGCT
GGTTGATAGCGGATTAACCACTTCGCTGTGGAAAGCGCCGGGTCTCTAA

Upstream 100 bases:

>100_bases
TCATTAGTAACGGAAGAAAAAACAGCTCGAATGATGTTAGCCGCCTTAGTGTGATGCGATAAGAGCTCCTTTTACTTCCT
TACAGCGAAAGGAGAAATCA

Downstream 100 bases:

>100_bases
TCCCCGCTTGGCAACAAAAAACCACCGCCTTTGTATAAAAGTGCGGTGTTTTTTGCAGTTTTTTTAAAGCCACTCTTGTT
CTAGCAACGCCTCAAATTCT

Product: autoinducer-2 (AI-2) kinase

Products: NA

Alternate protein names: AI-2 kinase [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSNQYLMALDAGTGSVRAVIFDLDGNQIVAAQREWTHLADPNIPGSMEFDLSTNWQLACDCIQQALQKSQIPAQQIAAIS
TCSMREGIVLYDENKQPIWACGNVDARATEEVNELKARCDHRFEEKLYAISGQTLALSAVPRLLWLAHHRPDIYQQTKAM
TMISDWLGFMLSGELAVEPSNAGTTGILNLKTRQWAPELLAMAGLNSDILTPVKETGEILGNVSTLVAQQTGLHAGTPVV
VGGGDVQLGCIGLGITEPSQAAVIGGTFWQQVVNLPEPVTDPEMNVRINPHVVAPLVQAESISFFTGLTMRWFRDAFCQE
EKILAERLGIDTYTLLEQMAERVPVGANDVIPIFSDAMHFKSWYHAAPSFVNLSIDPEKCNKPVLFRALEENAAIVSSYN
LDQVEKFSGVNLTSIVFAGGGSKGKLWSQILADVTGLVVNIPVVKEATALGCAIAAGVGVGLYPSLSEAGKKLVKFERQH
QPNPENYQLYQKHKAKWADVYAKQLQLVDSGLTTSLWKAPGL

Sequences:

>Translated_522_residues
MSNQYLMALDAGTGSVRAVIFDLDGNQIVAAQREWTHLADPNIPGSMEFDLSTNWQLACDCIQQALQKSQIPAQQIAAIS
TCSMREGIVLYDENKQPIWACGNVDARATEEVNELKARCDHRFEEKLYAISGQTLALSAVPRLLWLAHHRPDIYQQTKAM
TMISDWLGFMLSGELAVEPSNAGTTGILNLKTRQWAPELLAMAGLNSDILTPVKETGEILGNVSTLVAQQTGLHAGTPVV
VGGGDVQLGCIGLGITEPSQAAVIGGTFWQQVVNLPEPVTDPEMNVRINPHVVAPLVQAESISFFTGLTMRWFRDAFCQE
EKILAERLGIDTYTLLEQMAERVPVGANDVIPIFSDAMHFKSWYHAAPSFVNLSIDPEKCNKPVLFRALEENAAIVSSYN
LDQVEKFSGVNLTSIVFAGGGSKGKLWSQILADVTGLVVNIPVVKEATALGCAIAAGVGVGLYPSLSEAGKKLVKFERQH
QPNPENYQLYQKHKAKWADVYAKQLQLVDSGLTTSLWKAPGL
>Mature_521_residues
SNQYLMALDAGTGSVRAVIFDLDGNQIVAAQREWTHLADPNIPGSMEFDLSTNWQLACDCIQQALQKSQIPAQQIAAIST
CSMREGIVLYDENKQPIWACGNVDARATEEVNELKARCDHRFEEKLYAISGQTLALSAVPRLLWLAHHRPDIYQQTKAMT
MISDWLGFMLSGELAVEPSNAGTTGILNLKTRQWAPELLAMAGLNSDILTPVKETGEILGNVSTLVAQQTGLHAGTPVVV
GGGDVQLGCIGLGITEPSQAAVIGGTFWQQVVNLPEPVTDPEMNVRINPHVVAPLVQAESISFFTGLTMRWFRDAFCQEE
KILAERLGIDTYTLLEQMAERVPVGANDVIPIFSDAMHFKSWYHAAPSFVNLSIDPEKCNKPVLFRALEENAAIVSSYNL
DQVEKFSGVNLTSIVFAGGGSKGKLWSQILADVTGLVVNIPVVKEATALGCAIAAGVGVGLYPSLSEAGKKLVKFERQHQ
PNPENYQLYQKHKAKWADVYAKQLQLVDSGLTTSLWKAPGL

Specific function: Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787789, Length=521, Percent_Identity=71.2092130518234, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=513, Percent_Identity=27.4853801169591, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790361, Length=522, Percent_Identity=25.095785440613, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1789168, Length=503, Percent_Identity=23.4592445328032, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789987, Length=507, Percent_Identity=25.8382642998028, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1789138, Length=496, Percent_Identity=22.1774193548387, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17535599, Length=460, Percent_Identity=23.2608695652174, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: NA

Molecular weight: Translated: 56872; Mature: 56740

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQYLMALDAGTGSVRAVIFDLDGNQIVAAQREWTHLADPNIPGSMEFDLSTNWQLACD
CCCCEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHH
CIQQALQKSQIPAQQIAAISTCSMREGIVLYDENKQPIWACGNVDARATEEVNELKARCD
HHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHH
HRFEEKLYAISGQTLALSAVPRLLWLAHHRPDIYQQTKAMTMISDWLGFMLSGELAVEPS
HHHHHHHEEECCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCC
NAGTTGILNLKTRQWAPELLAMAGLNSDILTPVKETGEILGNVSTLVAQQTGLHAGTPVV
CCCCEEEEEECCHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VGGGDVQLGCIGLGITEPSQAAVIGGTFWQQVVNLPEPVTDPEMNVRINPHVVAPLVQAE
ECCCCEEEEEEEECCCCCCCCEEECHHHHHHHHCCCCCCCCCCCEEEECCEEEEHHHHHC
SISFFTGLTMRWFRDAFCQEEKILAERLGIDTYTLLEQMAERVPVGANDVIPIFSDAMHF
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
KSWYHAAPSFVNLSIDPEKCNKPVLFRALEENAAIVSSYNLDQVEKFSGVNLTSIVFAGG
HHHHHCCCCEEEEEECHHHCCCCCEEEEHHCCCEEEECCCHHHHHHHCCCCEEEEEEECC
GSKGKLWSQILADVTGLVVNIPVVKEATALGCAIAAGVGVGLYPSLSEAGKKLVKFERQH
CCCCHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
QPNPENYQLYQKHKAKWADVYAKQLQLVDSGLTTSLWKAPGL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
>Mature Secondary Structure 
SNQYLMALDAGTGSVRAVIFDLDGNQIVAAQREWTHLADPNIPGSMEFDLSTNWQLACD
CCCEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHH
CIQQALQKSQIPAQQIAAISTCSMREGIVLYDENKQPIWACGNVDARATEEVNELKARCD
HHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHH
HRFEEKLYAISGQTLALSAVPRLLWLAHHRPDIYQQTKAMTMISDWLGFMLSGELAVEPS
HHHHHHHEEECCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCC
NAGTTGILNLKTRQWAPELLAMAGLNSDILTPVKETGEILGNVSTLVAQQTGLHAGTPVV
CCCCEEEEEECCHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VGGGDVQLGCIGLGITEPSQAAVIGGTFWQQVVNLPEPVTDPEMNVRINPHVVAPLVQAE
ECCCCEEEEEEEECCCCCCCCEEECHHHHHHHHCCCCCCCCCCCEEEECCEEEEHHHHHC
SISFFTGLTMRWFRDAFCQEEKILAERLGIDTYTLLEQMAERVPVGANDVIPIFSDAMHF
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
KSWYHAAPSFVNLSIDPEKCNKPVLFRALEENAAIVSSYNLDQVEKFSGVNLTSIVFAGG
HHHHHCCCCEEEEEECHHHCCCCCEEEEHHCCCEEEECCCHHHHHHHCCCCEEEEEEECC
GSKGKLWSQILADVTGLVVNIPVVKEATALGCAIAAGVGVGLYPSLSEAGKKLVKFERQH
CCCCHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
QPNPENYQLYQKHKAKWADVYAKQLQLVDSGLTTSLWKAPGL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA