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The map label for this gene is tdk

Identifier: 15603101

GI number: 15603101

Start: 1428333

End: 1428911

Strand: Reverse

Name: tdk

Synonym: PM1236

Alternate gene names: 15603101

Gene position: 1428911-1428333 (Counterclockwise)

Preceding gene: 15603102

Following gene: 15603096

Centisome position: 63.3

GC content: 39.03

Gene sequence:

>579_bases
ATGGCAAAACTTTATTTTTATTATTCAACGATGAATGCGGGGAAATCCACCACCTTATTACAATCGTCCTATAACTACCA
AGAACGCGACATGAATACCTTAGTCTATACGGCAGCCATTGATGATCGGTTTGGTGTGGGAAAAGTAACCTCACGTATTG
GGATTAGCCAAGAGGCACAACTGTTTCATAAAGAAAGTGATCTTTTTGTTGAAATTGCACAACATCTTCAACAACAACCT
TTACATTGTATTTTAGTCGATGAGGCGCAATTTTTAACCAAAACACAAGTGTATCAGCTTAGCGAAGTGGTGGATAAATT
AAAGATTCCTGTGCTGTGTTACGGTTTACGCACAGATTTCCAAGCAGAATTGTTCGAGGGAAGTAAGTACCTTTTAGCGT
GGGCGGATCAATTAGAAGAGCTCAAAACCATTTGTTATTGCGGACGTAAAGCAAACTTTGTATTACGTTTAAATGACAAA
GGGGAAGTTGTACGTGACGGTGCGCAAATTCAAATCGGTGGGAATGACAGTTATCTGTCGGTTTGTCGTTTACATTACAA
AGAGAAGATTGCACTTTAA

Upstream 100 bases:

>100_bases
GTCGGTGGTGGAACCACTTTTGGTATTTTAATGTTGGCAGCCTTACCCCCTCTGACAGGCGCTATTTTTTATTATTTTTG
GAAATGGGTATTAAAGTAAG

Downstream 100 bases:

>100_bases
GCGTATTGACGCTGAAAAGTGCGGTCATTTTTAACGAAGTTTTGTCAGAGAAAAGGCGGAAAATCACTCCGCCTTTTGTT
GCACTGATTAACGCATCGTC

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MAKLYFYYSTMNAGKSTTLLQSSYNYQERDMNTLVYTAAIDDRFGVGKVTSRIGISQEAQLFHKESDLFVEIAQHLQQQP
LHCILVDEAQFLTKTQVYQLSEVVDKLKIPVLCYGLRTDFQAELFEGSKYLLAWADQLEELKTICYCGRKANFVLRLNDK
GEVVRDGAQIQIGGNDSYLSVCRLHYKEKIAL

Sequences:

>Translated_192_residues
MAKLYFYYSTMNAGKSTTLLQSSYNYQERDMNTLVYTAAIDDRFGVGKVTSRIGISQEAQLFHKESDLFVEIAQHLQQQP
LHCILVDEAQFLTKTQVYQLSEVVDKLKIPVLCYGLRTDFQAELFEGSKYLLAWADQLEELKTICYCGRKANFVLRLNDK
GEVVRDGAQIQIGGNDSYLSVCRLHYKEKIAL
>Mature_191_residues
AKLYFYYSTMNAGKSTTLLQSSYNYQERDMNTLVYTAAIDDRFGVGKVTSRIGISQEAQLFHKESDLFVEIAQHLQQQPL
HCILVDEAQFLTKTQVYQLSEVVDKLKIPVLCYGLRTDFQAELFEGSKYLLAWADQLEELKTICYCGRKANFVLRLNDKG
EVVRDGAQIQIGGNDSYLSVCRLHYKEKIAL

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=190, Percent_Identity=68.9473684210526, Blast_Score=279, Evalue=7e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_PASMU (P57926)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246173.1
- ProteinModelPortal:   P57926
- SMR:   P57926
- GeneID:   1244583
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1236
- NMPDR:   fig|272843.1.peg.1236
- HOGENOM:   HBG522108
- OMA:   FRYGAMN
- ProtClustDB:   PRK04296
- BioCyc:   PMUL272843:PM1236-MONOMER
- BRENDA:   2.7.1.21
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 21986; Mature: 21855

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 88-88

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLYFYYSTMNAGKSTTLLQSSYNYQERDMNTLVYTAAIDDRFGVGKVTSRIGISQEAQ
CCEEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCHHHHHCCCCHHHH
LFHKESDLFVEIAQHLQQQPLHCILVDEAQFLTKTQVYQLSEVVDKLKIPVLCYGLRTDF
HHHCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
QAELFEGSKYLLAWADQLEELKTICYCGRKANFVLRLNDKGEVVRDGAQIQIGGNDSYLS
HHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCEEEECCCCCHHH
VCRLHYKEKIAL
HHHHHHHHHCCC
>Mature Secondary Structure 
AKLYFYYSTMNAGKSTTLLQSSYNYQERDMNTLVYTAAIDDRFGVGKVTSRIGISQEAQ
CEEEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCHHHHHCCCCHHHH
LFHKESDLFVEIAQHLQQQPLHCILVDEAQFLTKTQVYQLSEVVDKLKIPVLCYGLRTDF
HHHCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
QAELFEGSKYLLAWADQLEELKTICYCGRKANFVLRLNDKGEVVRDGAQIQIGGNDSYLS
HHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCEEEECCCCCHHH
VCRLHYKEKIAL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100