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The map label for this gene is comE [H]

Identifier: 15603090

GI number: 15603090

Start: 1416502

End: 1417836

Strand: Reverse

Name: comE [H]

Synonym: PM1225

Alternate gene names: 15603090

Gene position: 1417836-1416502 (Counterclockwise)

Preceding gene: 15603091

Following gene: 15603089

Centisome position: 62.81

GC content: 38.65

Gene sequence:

>1335_bases
ATGTGGCGAGCATTCAGAAAAATATCTCTTGTGTACTTTTTATGTGGGGTTGCTTATGTTGGAAGTAGTCAAGCACAAGA
CGCAGAACATTTTTATTTACGTTTAAAACAAGCGCCTTTAGTCGAAATGTTACAGTATTTAGCATTGCAACAACATCAGG
ATTTGTTAATCGATGATCATTTAGAGGGCACATTATCACTACAGATGAAAAAGACAACCTTTGAGAAATGTTTACAGTCG
ATTGCAAGAATGAAACAACTTGAGTTACATCAAGAAGGAAAATCCTATTATTTAACTTCCCCTTCAGGTGTTGCAGCAAA
CGATACTCATCATCCTACGTCATTGATGACATCTTCAATAAAATTGCATTTTGCCAAAGCCGCAGAGGTGGTGAAATCTT
TAACTTCAGGGCAGGGAAGTTTACTTTCTGTCGGGGGGAGTTTGAGTTTTGATGAGCGGACTAATTTACTGCTGATTCAG
GATGAACCGCAATCAATACAGCGTATTAAAGCATTAGTAGCAGAAATGGATAAACCCATTGAACAAATTGCGATCGAAGC
TAGGATTGTGACGATGACAGACGAAAGTTTGCAGGAACTTGGTGTAAGATGGGGGCTATTTCAAGCAACAGAACAGGCAC
ATACTATTGCAGGGAGTTTAGCCGCGAACGGCTTTTCGAATATAGAAAACCAATTAAATGTGAATTTCTCGACCAATAGT
GCACCTGTTGGTTCCATCGCCTTACAGTTGGCGAAAATAAATGGTCGATTATTAGACTTGGAATTAACTGCCTTGGAGCG
AGAAAAGCATATTGAGATTATTGCGAGTCCTCGTTTATTAACAACGAATAAAAAAAGTGCCAGTATCAAACAAGGGACGG
AAATTCCTTATGTGATGAAACGGGGAAAAGATAAAAGCGAATCGGTGGAATTTCGAGAAGCTGTATTAGGTTTAGATGTG
ACACCGCATATCTCAAAAGACAACACGATTTTATTAGATTTATTGATTACACAAAATACATTAGGTGCACCGGTAGTGTA
TGATAAAGGTGAAATTGTTTCGATCGATAAACAGGAAATCAATACTCAAGTCGTCGCTCAAGATGGTGAAACCATCGTTT
TAGGTGGGGTGTTTCATGATACGATGACAAAGGGAGTCAATAAAGTACCACTACTAGGGGATTTGCCTTTGCTTAAACAT
GTGTTTAGCCAGAAAACTGAACGTCATCAAAAGCGGGAATTAGTGATTTTTGTCACTCCTCATATTATCAAACCTAGCCA
AGGTTCGCCTGAACAAAAAACAACAAGAGTTAAAAAATCTGCAAAATCGAGGTGA

Upstream 100 bases:

>100_bases
CAAACAGATAAGTCAATTTGGCGTTGAGTTATCTTATTGGAAGAATAAGCAAACTTGCACGGATGAAGGGATACTATCAC
TCAAATTTTAAGGAAAGATT

Downstream 100 bases:

>100_bases
CTTTTGTTCATATTAAGTAAATATCAGAAATAAATAAGCATTGAGGTTGAAAAAGAGGGCAATTTATTGCGATAATCTCA
ATTATTTTTTGGGTGATCTT

Product: ComE

Products: NA

Alternate protein names: DNA transformation protein ComE [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MWRAFRKISLVYFLCGVAYVGSSQAQDAEHFYLRLKQAPLVEMLQYLALQQHQDLLIDDHLEGTLSLQMKKTTFEKCLQS
IARMKQLELHQEGKSYYLTSPSGVAANDTHHPTSLMTSSIKLHFAKAAEVVKSLTSGQGSLLSVGGSLSFDERTNLLLIQ
DEPQSIQRIKALVAEMDKPIEQIAIEARIVTMTDESLQELGVRWGLFQATEQAHTIAGSLAANGFSNIENQLNVNFSTNS
APVGSIALQLAKINGRLLDLELTALEREKHIEIIASPRLLTTNKKSASIKQGTEIPYVMKRGKDKSESVEFREAVLGLDV
TPHISKDNTILLDLLITQNTLGAPVVYDKGEIVSIDKQEINTQVVAQDGETIVLGGVFHDTMTKGVNKVPLLGDLPLLKH
VFSQKTERHQKRELVIFVTPHIIKPSQGSPEQKTTRVKKSAKSR

Sequences:

>Translated_444_residues
MWRAFRKISLVYFLCGVAYVGSSQAQDAEHFYLRLKQAPLVEMLQYLALQQHQDLLIDDHLEGTLSLQMKKTTFEKCLQS
IARMKQLELHQEGKSYYLTSPSGVAANDTHHPTSLMTSSIKLHFAKAAEVVKSLTSGQGSLLSVGGSLSFDERTNLLLIQ
DEPQSIQRIKALVAEMDKPIEQIAIEARIVTMTDESLQELGVRWGLFQATEQAHTIAGSLAANGFSNIENQLNVNFSTNS
APVGSIALQLAKINGRLLDLELTALEREKHIEIIASPRLLTTNKKSASIKQGTEIPYVMKRGKDKSESVEFREAVLGLDV
TPHISKDNTILLDLLITQNTLGAPVVYDKGEIVSIDKQEINTQVVAQDGETIVLGGVFHDTMTKGVNKVPLLGDLPLLKH
VFSQKTERHQKRELVIFVTPHIIKPSQGSPEQKTTRVKKSAKSR
>Mature_444_residues
MWRAFRKISLVYFLCGVAYVGSSQAQDAEHFYLRLKQAPLVEMLQYLALQQHQDLLIDDHLEGTLSLQMKKTTFEKCLQS
IARMKQLELHQEGKSYYLTSPSGVAANDTHHPTSLMTSSIKLHFAKAAEVVKSLTSGQGSLLSVGGSLSFDERTNLLLIQ
DEPQSIQRIKALVAEMDKPIEQIAIEARIVTMTDESLQELGVRWGLFQATEQAHTIAGSLAANGFSNIENQLNVNFSTNS
APVGSIALQLAKINGRLLDLELTALEREKHIEIIASPRLLTTNKKSASIKQGTEIPYVMKRGKDKSESVEFREAVLGLDV
TPHISKDNTILLDLLITQNTLGAPVVYDKGEIVSIDKQEINTQVVAQDGETIVLGGVFHDTMTKGVNKVPLLGDLPLLKH
VFSQKTERHQKRELVIFVTPHIIKPSQGSPEQKTTRVKKSAKSR

Specific function: Involved in transformation (competence for DNA uptake) [H]

COG id: COG4796

COG function: function code U; Type II secretory pathway, component HofQ

Gene ontology:

Cell location: Cell outer membrane (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP D family [H]

Homologues:

Organism=Escherichia coli, GI1789793, Length=409, Percent_Identity=37.1638141809291, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI87082242, Length=359, Percent_Identity=26.1838440111421, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001775
- InterPro:   IPR005644
- InterPro:   IPR013355
- InterPro:   IPR004846
- InterPro:   IPR004845
- InterPro:   IPR001814 [H]

Pfam domain/function: PF00263 Secretin; PF03958 Secretin_N [H]

EC number: NA

Molecular weight: Translated: 49207; Mature: 49207

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS00875 T2SP_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRAFRKISLVYFLCGVAYVGSSQAQDAEHFYLRLKQAPLVEMLQYLALQQHQDLLIDDH
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHCCCCCEEECC
LEGTLSLQMKKTTFEKCLQSIARMKQLELHQEGKSYYLTSPSGVAANDTHHPTSLMTSSI
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHH
KLHFAKAAEVVKSLTSGQGSLLSVGGSLSFDERTNLLLIQDEPQSIQRIKALVAEMDKPI
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCH
EQIAIEARIVTMTDESLQELGVRWGLFQATEQAHTIAGSLAANGFSNIENQLNVNFSTNS
HHHEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCC
APVGSIALQLAKINGRLLDLELTALEREKHIEIIASPRLLTTNKKSASIKQGTEIPYVMK
CCHHHHHEEEEECCCEEEEEEEEECCCCCCEEEEECCEEEECCCCCCCCCCCCCCCHHHH
RGKDKSESVEFREAVLGLDVTPHISKDNTILLDLLITQNTLGAPVVYDKGEIVSIDKQEI
CCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCEEECCCCEEEECHHHC
NTQVVAQDGETIVLGGVFHDTMTKGVNKVPLLGDLPLLKHVFSQKTERHQKRELVIFVTP
CEEEEECCCCEEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECC
HIIKPSQGSPEQKTTRVKKSAKSR
CEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MWRAFRKISLVYFLCGVAYVGSSQAQDAEHFYLRLKQAPLVEMLQYLALQQHQDLLIDDH
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHCCCCCEEECC
LEGTLSLQMKKTTFEKCLQSIARMKQLELHQEGKSYYLTSPSGVAANDTHHPTSLMTSSI
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHH
KLHFAKAAEVVKSLTSGQGSLLSVGGSLSFDERTNLLLIQDEPQSIQRIKALVAEMDKPI
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCH
EQIAIEARIVTMTDESLQELGVRWGLFQATEQAHTIAGSLAANGFSNIENQLNVNFSTNS
HHHEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCC
APVGSIALQLAKINGRLLDLELTALEREKHIEIIASPRLLTTNKKSASIKQGTEIPYVMK
CCHHHHHEEEEECCCEEEEEEEEECCCCCCEEEEECCEEEECCCCCCCCCCCCCCCHHHH
RGKDKSESVEFREAVLGLDVTPHISKDNTILLDLLITQNTLGAPVVYDKGEIVSIDKQEI
CCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCEEECCCCEEEECHHHC
NTQVVAQDGETIVLGGVFHDTMTKGVNKVPLLGDLPLLKHVFSQKTERHQKRELVIFVTP
CEEEEECCCCEEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECC
HIIKPSQGSPEQKTTRVKKSAKSR
CEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1916268; 7542800; 1856167 [H]