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The map label for this gene is aroB

Identifier: 15603088

GI number: 15603088

Start: 1414687

End: 1415775

Strand: Reverse

Name: aroB

Synonym: PM1223

Alternate gene names: 15603088

Gene position: 1415775-1414687 (Counterclockwise)

Preceding gene: 15603089

Following gene: 15603087

Centisome position: 62.71

GC content: 42.61

Gene sequence:

>1089_bases
ATGTTGTGTGTAAATGTTGAGTTAAAAGAGCGCCGTTATCCAATTTATATTGGTTCGGGATTACTTTCGGATGAAAAATG
CTATCCTTTAAAATCTGGCGACAAAGTCATGATTGTGACGAACCCAACGATTGCACAATATTATCTTTCTCAAGTGACAG
ACACCTTGGTGAAAAAAGGCTGTTTGGTTGAACATGTAGTCTTATCAGATGGTGAACAATATAAAACACTAGACTCGTTA
AATCTTATTTTTACAGCACTGTTGCAAGGAAATCATGGCAGAGATACGACGATTATTGCTCTCGGTGGTGGTGTGATCGG
CGATGTTGCAGGTTATGCGGCGGCGAGTTATCAACGAGGTGTGCGTTTTATTCAAATTCCGACAACCTTATTAGCGCAAG
TTGATTCGTCCGTAGGGGGAAAAACCGCGGTCAATCATGCGCTTGGTAAAAATATGATCGGTGCGTTCTATCAACCTTGT
ACGGTGATCATCGATACATTAACCTTAAACAGTTTACCAAAACGAGAAATCAATGCAGGCTTAGCTGAAGTGATTAAGTA
TGGCGCGATTTTAGATCTACCATTCTTTACTTGGTTGGAACAAAATATTGATAGTCTAGTGGCACGAGATCCAGACAATT
TACAAACCTGTATTGCACGTTGTTGTCAAATTAAGGCAGATGTTGTCGCGCGCGATGAAACGGAAAAAGGCGATCGCGCT
TTATTAAATTTAGGGCATACATTTGGTCATGCGATTGAAACCCACTTAGGGTATGGGCATTGGTTACACGGTGAAGCGGT
GGCGGTTGGGATGCTAATGGCTGCGGTACTTTCAGAAAAACTGGGGAATTTGACGAAGACTGATGTGGCACGTCTTGAAA
GATTGCTAGCTCGAGCCAACTTACCGACAGTCTCACCAGATACTATGCAACCTGAAGACTATCTACCACATATGCTACGC
GATAAAAAAGTGCTCGCTGGAAAATTGCGTCTCGTCTTATTAGCGTCTTTAGGTCAGGCTTATGTCGCAACAGATACCGA
TCCAGCGTTAGTGCTAGATGCTATTCGTTGTTGCACGCAGGTTAATTGA

Upstream 100 bases:

>100_bases
GATATCACCTTACCTACTGATGAACAAAGCGCTAAGGTAATGGCAACGCAAATTGTCGATTTAATTGATAATCTTCACGG
TTAGATAAGTAGAGTAAAGC

Downstream 100 bases:

>100_bases
TTCATGCCACCTCGTCGAAAATGCCCGGTTAAGCGCCCCGCTATTGTTGGTAAGAAAAAAGCAAAATTAATCCCTATTAA
ACACCGCCCCTTTTTGAAGT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MLCVNVELKERRYPIYIGSGLLSDEKCYPLKSGDKVMIVTNPTIAQYYLSQVTDTLVKKGCLVEHVVLSDGEQYKTLDSL
NLIFTALLQGNHGRDTTIIALGGGVIGDVAGYAAASYQRGVRFIQIPTTLLAQVDSSVGGKTAVNHALGKNMIGAFYQPC
TVIIDTLTLNSLPKREINAGLAEVIKYGAILDLPFFTWLEQNIDSLVARDPDNLQTCIARCCQIKADVVARDETEKGDRA
LLNLGHTFGHAIETHLGYGHWLHGEAVAVGMLMAAVLSEKLGNLTKTDVARLERLLARANLPTVSPDTMQPEDYLPHMLR
DKKVLAGKLRLVLLASLGQAYVATDTDPALVLDAIRCCTQVN

Sequences:

>Translated_362_residues
MLCVNVELKERRYPIYIGSGLLSDEKCYPLKSGDKVMIVTNPTIAQYYLSQVTDTLVKKGCLVEHVVLSDGEQYKTLDSL
NLIFTALLQGNHGRDTTIIALGGGVIGDVAGYAAASYQRGVRFIQIPTTLLAQVDSSVGGKTAVNHALGKNMIGAFYQPC
TVIIDTLTLNSLPKREINAGLAEVIKYGAILDLPFFTWLEQNIDSLVARDPDNLQTCIARCCQIKADVVARDETEKGDRA
LLNLGHTFGHAIETHLGYGHWLHGEAVAVGMLMAAVLSEKLGNLTKTDVARLERLLARANLPTVSPDTMQPEDYLPHMLR
DKKVLAGKLRLVLLASLGQAYVATDTDPALVLDAIRCCTQVN
>Mature_362_residues
MLCVNVELKERRYPIYIGSGLLSDEKCYPLKSGDKVMIVTNPTIAQYYLSQVTDTLVKKGCLVEHVVLSDGEQYKTLDSL
NLIFTALLQGNHGRDTTIIALGGGVIGDVAGYAAASYQRGVRFIQIPTTLLAQVDSSVGGKTAVNHALGKNMIGAFYQPC
TVIIDTLTLNSLPKREINAGLAEVIKYGAILDLPFFTWLEQNIDSLVARDPDNLQTCIARCCQIKADVVARDETEKGDRA
LLNLGHTFGHAIETHLGYGHWLHGEAVAVGMLMAAVLSEKLGNLTKTDVARLERLLARANLPTVSPDTMQPEDYLPHMLR
DKKVLAGKLRLVLLASLGQAYVATDTDPALVLDAIRCCTQVN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=354, Percent_Identity=60.7344632768362, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6320332, Length=313, Percent_Identity=39.9361022364217, Blast_Score=195, Evalue=9e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_PASMU (P57924)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246160.1
- ProteinModelPortal:   P57924
- SMR:   P57924
- GeneID:   1244570
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1223
- NMPDR:   fig|272843.1.peg.1223
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- ProtClustDB:   PRK00002
- BioCyc:   PMUL272843:PM1223-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39376; Mature: 39376

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCVNVELKERRYPIYIGSGLLSDEKCYPLKSGDKVMIVTNPTIAQYYLSQVTDTLVKKG
CEEEEEEHHCCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCC
CLVEHVVLSDGEQYKTLDSLNLIFTALLQGNHGRDTTIIALGGGVIGDVAGYAAASYQRG
CHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCC
VRFIQIPTTLLAQVDSSVGGKTAVNHALGKNMIGAFYQPCTVIIDTLTLNSLPKREINAG
CEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHH
LAEVIKYGAILDLPFFTWLEQNIDSLVARDPDNLQTCIARCCQIKADVVARDETEKGDRA
HHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LLNLGHTFGHAIETHLGYGHWLHGEAVAVGMLMAAVLSEKLGNLTKTDVARLERLLARAN
HHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
LPTVSPDTMQPEDYLPHMLRDKKVLAGKLRLVLLASLGQAYVATDTDPALVLDAIRCCTQ
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHC
VN
CC
>Mature Secondary Structure
MLCVNVELKERRYPIYIGSGLLSDEKCYPLKSGDKVMIVTNPTIAQYYLSQVTDTLVKKG
CEEEEEEHHCCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCC
CLVEHVVLSDGEQYKTLDSLNLIFTALLQGNHGRDTTIIALGGGVIGDVAGYAAASYQRG
CHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCC
VRFIQIPTTLLAQVDSSVGGKTAVNHALGKNMIGAFYQPCTVIIDTLTLNSLPKREINAG
CEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHH
LAEVIKYGAILDLPFFTWLEQNIDSLVARDPDNLQTCIARCCQIKADVVARDETEKGDRA
HHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LLNLGHTFGHAIETHLGYGHWLHGEAVAVGMLMAAVLSEKLGNLTKTDVARLERLLARAN
HHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
LPTVSPDTMQPEDYLPHMLRDKKVLAGKLRLVLLASLGQAYVATDTDPALVLDAIRCCTQ
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHC
VN
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100