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The map label for this gene is mutT [H]

Identifier: 15603083

GI number: 15603083

Start: 1409757

End: 1410158

Strand: Reverse

Name: mutT [H]

Synonym: PM1218

Alternate gene names: 15603083

Gene position: 1410158-1409757 (Counterclockwise)

Preceding gene: 15603084

Following gene: 15603056

Centisome position: 62.47

GC content: 41.79

Gene sequence:

>402_bases
ATGACAAAACCTTTAGTTCACGTTGCAGCAGGCATTATTCGTAATGAGTTTGGTCAGATTTATGTTACGCAGCGTTTAGA
AGGGCAAGATTTTGCCCAAGCATTGGAGTTTCCCGGTGGAAAAGTGGACGATGGTGAAAGTCCGGAACAAGCGTTAAGAC
GTGAGTTAGAAGAGGAAATTGGCATACATATTTTAAATGCGACACTTTATGAGCGTTTTCAGTTTGAATATCCGACTAAA
ATGATTTCTTTTTATTTCTATCTCGTTGATGAATGGGTTGGTGAACCTTTTGGTCGTGAAGGACAAGCTGGATTTTGGGT
CGCACAAAACGAACTGGATGCCGGGCAATTTCCACCTGCGAATGTAAAATTAATCCAACGGTTACTGGCCGAGAATCGTT
AG

Upstream 100 bases:

>100_bases
AATATTAATCTTGTGTATAAGATGATTTAAGTAGATATAAAAGTGCGGTATGTTTTTAAAAAATTTTTAAAACTGACCGC
ACTTTTTTTAAGGATACATC

Downstream 100 bases:

>100_bases
TAATAGGTTGCCTTATATCAACAAAACCCCTGTATTAACAGGGGTTTTGTGTTTGCGTTGAGTAATTATTTTTTACCCAT
CATGCTTTGCATTTGTTTCA

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 133; Mature: 132

Protein sequence:

>133_residues
MTKPLVHVAAGIIRNEFGQIYVTQRLEGQDFAQALEFPGGKVDDGESPEQALRRELEEEIGIHILNATLYERFQFEYPTK
MISFYFYLVDEWVGEPFGREGQAGFWVAQNELDAGQFPPANVKLIQRLLAENR

Sequences:

>Translated_133_residues
MTKPLVHVAAGIIRNEFGQIYVTQRLEGQDFAQALEFPGGKVDDGESPEQALRRELEEEIGIHILNATLYERFQFEYPTK
MISFYFYLVDEWVGEPFGREGQAGFWVAQNELDAGQFPPANVKLIQRLLAENR
>Mature_132_residues
TKPLVHVAAGIIRNEFGQIYVTQRLEGQDFAQALEFPGGKVDDGESPEQALRRELEEEIGIHILNATLYERFQFEYPTKM
ISFYFYLVDEWVGEPFGREGQAGFWVAQNELDAGQFPPANVKLIQRLLAENR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=123, Percent_Identity=47.1544715447154, Blast_Score=128, Evalue=1e-31,
Organism=Escherichia coli, GI1788056, Length=128, Percent_Identity=35.15625, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15251; Mature: 15120

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPLVHVAAGIIRNEFGQIYVTQRLEGQDFAQALEFPGGKVDDGESPEQALRRELEEEI
CCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GIHILNATLYERFQFEYPTKMISFYFYLVDEWVGEPFGREGQAGFWVAQNELDAGQFPPA
CEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCC
NVKLIQRLLAENR
CHHHHHHHHHCCC
>Mature Secondary Structure 
TKPLVHVAAGIIRNEFGQIYVTQRLEGQDFAQALEFPGGKVDDGESPEQALRRELEEEI
CCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GIHILNATLYERFQFEYPTKMISFYFYLVDEWVGEPFGREGQAGFWVAQNELDAGQFPPA
CEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCC
NVKLIQRLLAENR
CHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]