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The map label for this gene is pyrR

Identifier: 15603072

GI number: 15603072

Start: 1399588

End: 1400133

Strand: Direct

Name: pyrR

Synonym: PM1207

Alternate gene names: 15603072

Gene position: 1399588-1400133 (Clockwise)

Preceding gene: 15603071

Following gene: 15603073

Centisome position: 62.0

GC content: 41.76

Gene sequence:

>546_bases
ATGGAAAAAATCATTATTGATGAAAACCAATTTCTTCGCACCATTTCCCGTATTTCACACGAGATTATCGAAAAACACCA
ACGTTTAGACAATATTGTCATTGTAGGCATTAAACGACGTGGTGCGGAAATTGCGGAGTTAATTAAGAAAAAAATTGCTG
ACCTCGCAAACGTTGAGTTACCCTCAATTGATCTGGACATCACCTTTTACCGTGATGATTTAGAATATGCTGAACCTGAC
TCCAAATCGCCTACCTATAGCGGTGCCTCCAGTTTTATTAGTATCCACAATAAAGAAGTGATTTTAGTCGATGACGTACT
TTATACCGGCAGAACCATTCGCGCAGCACTTGATGCATTAGTGGATTTCGGTCGTGCCGCGAAAATTGAGCTTGTTATTT
TTGTGGACAGAGGGCACCGTGAACTGCCAATTCGCGCGGATTATGTCGGTAAAAACGTTCCAACCAGTCGCAGTGAAGAA
GTGCAAGTACGCACCCTGAAGTTCGACAATTGTTATGAAGTTGCACTACTTTCGCCGACAAAATAA

Upstream 100 bases:

>100_bases
TTTATGAGGTTGTTTCCCGTATCTGATTTCACTCTAGGAGATTATTGGCTTTTATGCTATTTTAACGCCAACATTTCTTC
ACTATATGTAGGTCAATATT

Downstream 100 bases:

>100_bases
AGTTTGTGAACCTTTTGTAAAATTGATACTCTAACAAATGTAATTTTTAACCAACATAATGGAATAGATGATGAAAATGA
TTAATGTAAAATCTATTTTC

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MEKIIIDENQFLRTISRISHEIIEKHQRLDNIVIVGIKRRGAEIAELIKKKIADLANVELPSIDLDITFYRDDLEYAEPD
SKSPTYSGASSFISIHNKEVILVDDVLYTGRTIRAALDALVDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRSEE
VQVRTLKFDNCYEVALLSPTK

Sequences:

>Translated_181_residues
MEKIIIDENQFLRTISRISHEIIEKHQRLDNIVIVGIKRRGAEIAELIKKKIADLANVELPSIDLDITFYRDDLEYAEPD
SKSPTYSGASSFISIHNKEVILVDDVLYTGRTIRAALDALVDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRSEE
VQVRTLKFDNCYEVALLSPTK
>Mature_181_residues
MEKIIIDENQFLRTISRISHEIIEKHQRLDNIVIVGIKRRGAEIAELIKKKIADLANVELPSIDLDITFYRDDLEYAEPD
SKSPTYSGASSFISIHNKEVILVDDVLYTGRTIRAALDALVDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRSEE
VQVRTLKFDNCYEVALLSPTK

Specific function: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_PASMU (Q9CLL7)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246144.1
- ProteinModelPortal:   Q9CLL7
- SMR:   Q9CLL7
- GeneID:   1244554
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1207
- NMPDR:   fig|272843.1.peg.1207
- HOGENOM:   HBG641958
- OMA:   ELDITFF
- ProtClustDB:   PRK05205
- BioCyc:   PMUL272843:PM1207-MONOMER
- BRENDA:   2.4.2.9
- GO:   GO:0006350
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 20568; Mature: 20568

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 137-137 BINDING 161-161

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIIIDENQFLRTISRISHEIIEKHQRLDNIVIVGIKRRGAEIAELIKKKIADLANVEL
CCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCC
PSIDLDITFYRDDLEYAEPDSKSPTYSGASSFISIHNKEVILVDDVLYTGRTIRAALDAL
CCEEEEEEEEECCCCCCCCCCCCCCCCCCHHEEEECCCCEEEEECHHHCCHHHHHHHHHH
VDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRSEEVQVRTLKFDNCYEVALLSPT
HHCCCCCEEEEEEEEECCCCCCCEEHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCC
K
C
>Mature Secondary Structure
MEKIIIDENQFLRTISRISHEIIEKHQRLDNIVIVGIKRRGAEIAELIKKKIADLANVEL
CCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCC
PSIDLDITFYRDDLEYAEPDSKSPTYSGASSFISIHNKEVILVDDVLYTGRTIRAALDAL
CCEEEEEEEEECCCCCCCCCCCCCCCCCCHHEEEECCCCEEEEECHHHCCHHHHHHHHHH
VDFGRAAKIELVIFVDRGHRELPIRADYVGKNVPTSRSEEVQVRTLKFDNCYEVALLSPT
HHCCCCCEEEEEEEEECCCCCCCEEHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100