Click here to switch to the map view.

The map label for this gene is hisIE

Identifier: 15603071

GI number: 15603071

Start: 1398834

End: 1399439

Strand: Direct

Name: hisIE

Synonym: PM1206

Alternate gene names: 15603071

Gene position: 1398834-1399439 (Clockwise)

Preceding gene: 15603070

Following gene: 15603072

Centisome position: 61.96

GC content: 39.77

Gene sequence:

>606_bases
ATGAAGATCAACTGGCAAAAAGTCGATAATTTACTGCCCGTCATTATCCAAAACGTGGCAACTTGTGAAGTGTTAATGCT
TGGTTATATGAATCAAGAGGCATTAGAAAAAACGCTGGCGGAAAAACGAGTGACCTTTTTTTCTCGGACCAAAAACCGTT
TATGGACAAAAGGTGAAACTTCTGGACATTTTTTAAACGTAGTGGATATGAGTTTAGATTGTGATAACGATACCCTACTG
ATTCTAGTCAATCCGATTGGTGAAACCTGTCATACTGGGGCGGAAAGCTGTTTTTATCAATTTGAAAAGACAACACAGCC
GGATTGGATTTTTTTGAGCAAATTAGAACGTTTAATTGCCAGTCGTAAAGGTGCCGATCCTGAGAGTTCTTATACCGCAC
AACTGTATGCTAAAGGTACTAAACGCATTGCACAAAAAGTCGGTGAAGAAGGGGTGGAAACCGCTCTTGCCGCAACTGTG
AAAGACAAAGCAGAAACCATTTGTGAAGCTGCGGATCTCGTTTATCATTTAACGGTCTTGTTGCAAGATGCCGATTTAAG
CTGGTCAGATGTGATTCATAAATTAAAAGAACGTCACACAAAATAA

Upstream 100 bases:

>100_bases
TAAAAATCAATTAACTAAAGAAAGGTTGAATGATGCGTTTATACAACAAATAATGAGAGTTAAACGTAACTTAGAACTAC
GGAATTAATTTGAGGAATCT

Downstream 100 bases:

>100_bases
CAAAAAGCACCGCACTTTTTCTTCGCCTACAGAAAGTGCGGTTTATTTTTTATGAGGTTGTTTCCCGTATCTGATTTCAC
TCTAGGAGATTATTGGCTTT

Product: HisIE

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MKINWQKVDNLLPVIIQNVATCEVLMLGYMNQEALEKTLAEKRVTFFSRTKNRLWTKGETSGHFLNVVDMSLDCDNDTLL
ILVNPIGETCHTGAESCFYQFEKTTQPDWIFLSKLERLIASRKGADPESSYTAQLYAKGTKRIAQKVGEEGVETALAATV
KDKAETICEAADLVYHLTVLLQDADLSWSDVIHKLKERHTK

Sequences:

>Translated_201_residues
MKINWQKVDNLLPVIIQNVATCEVLMLGYMNQEALEKTLAEKRVTFFSRTKNRLWTKGETSGHFLNVVDMSLDCDNDTLL
ILVNPIGETCHTGAESCFYQFEKTTQPDWIFLSKLERLIASRKGADPESSYTAQLYAKGTKRIAQKVGEEGVETALAATV
KDKAETICEAADLVYHLTVLLQDADLSWSDVIHKLKERHTK
>Mature_201_residues
MKINWQKVDNLLPVIIQNVATCEVLMLGYMNQEALEKTLAEKRVTFFSRTKNRLWTKGETSGHFLNVVDMSLDCDNDTLL
ILVNPIGETCHTGAESCFYQFEKTTQPDWIFLSKLERLIASRKGADPESSYTAQLYAKGTKRIAQKVGEEGVETALAATV
KDKAETICEAADLVYHLTVLLQDADLSWSDVIHKLKERHTK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=198, Percent_Identity=65.1515151515152, Blast_Score=269, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319819, Length=179, Percent_Identity=34.6368715083799, Blast_Score=85, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_PASMU (Q9CLL8)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246143.1
- ProteinModelPortal:   Q9CLL8
- GeneID:   1244553
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1206
- NMPDR:   fig|272843.1.peg.1206
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- ProtClustDB:   CLSK2517342
- BioCyc:   PMUL272843:PM1206-MONOMER
- BRENDA:   3.5.4.19
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 22697; Mature: 22697

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINWQKVDNLLPVIIQNVATCEVLMLGYMNQEALEKTLAEKRVTFFSRTKNRLWTKGET
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGHFLNVVDMSLDCDNDTLLILVNPIGETCHTGAESCFYQFEKTTQPDWIFLSKLERLIA
CCCEEEEEEEEEECCCCEEEEEECCCCCHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
SRKGADPESSYTAQLYAKGTKRIAQKVGEEGVETALAATVKDKAETICEAADLVYHLTVL
HCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQDADLSWSDVIHKLKERHTK
HCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKINWQKVDNLLPVIIQNVATCEVLMLGYMNQEALEKTLAEKRVTFFSRTKNRLWTKGET
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGHFLNVVDMSLDCDNDTLLILVNPIGETCHTGAESCFYQFEKTTQPDWIFLSKLERLIA
CCCEEEEEEEEEECCCCEEEEEECCCCCHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
SRKGADPESSYTAQLYAKGTKRIAQKVGEEGVETALAATVKDKAETICEAADLVYHLTVL
HCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQDADLSWSDVIHKLKERHTK
HCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100