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The map label for this gene is argE [H]

Identifier: 15602982

GI number: 15602982

Start: 1315443

End: 1316663

Strand: Reverse

Name: argE [H]

Synonym: PM1117

Alternate gene names: 15602982

Gene position: 1316663-1315443 (Counterclockwise)

Preceding gene: 15602987

Following gene: 15602980

Centisome position: 58.32

GC content: 41.2

Gene sequence:

>1221_bases
ATGACTAATTATGCTATTATTATGCATAAATATTTAAAAGGCAATGTCTTTCTGTTTATCAAGGGAAAAACGATGAAAAA
AATTCCTTCTTTTTTGCAAATGTATTCCGCACTGATCGCTTCACCAACGATGAGTAGTATTGATCCACATTTTGATCAAT
CTAACCGCACCTTAATTGAATTATTAGCGAATTGGCTGAGTTCCCTTGGTTTTAGAACAGAGGTTATTCCTCTAGAGGGG
AGTCGTGATAAATTTAATTTATTAGCGACTTATGGTGAAGGGGAAGGCGGTTTACTCTTAGCGGGACATACAGATACTGT
GCCTTTTGATGAGGGGCGTTGGCAGTTTGATCCGTTTAAACTTACTGAAAAAGACGGTAAGTTTTATGGTTTAGGCACAG
CAGATATGAAAGGGTTTTTTGCTTTTGTCATTGATGCGGTAAGCCAGTTGGATTTAACGAGATTGACAAAACCCTTGCGC
ATTTTGGCGACGGCGGATGAAGAAACTACCATGTTAGGGGCAAGAACTTTTATTCAACATAGCCATATTCGTCCTGATTG
TGCGATTATCGGTGAGCCAACATCATTAAAGCCTATTCGTGCGCATAAAGGGCATGTAGGTGAAGCGTTACGAATTACAG
GAAAAAGTGGGCACTCGAGCGATCCTAGCAAGGGGATTAATGCGATTGAATTAATGCACGAGGCAACGGGTTATTTAATG
CAAATGCGGGATGAATTACGCCAGAAATATCATCATGCTGCATTTAATATCCCTTATCCAACGATGAATTTTGGCGCTAT
TTCAGGGGGAGATGCGGTGAATCGTATTTGTGCTTGCTGTGAATTGCATTTTGATATTCGCCCTTTGCCGAATTTACGTT
TAACGGATCTGAATGAAATGTTACAAGCAAAATTAGCCCCGATGTTTGAAAAATGGGGGGGGCGCATTTCGTTACAAGCT
TTACATGACCCTATTCCAGGCTATGAATGTGCGCATTCGGCACAAGTGGTGCAGGTAGTGGAAAAATTATTAGGTGAGCA
ATGTGAGACGGTGAACTATTGTACGGAGGCGCCTTTTATTCAACAGCTTTGTCCGACCTTGGTATTAGGTCCGGGATCCA
TTGAGCAGGCACATCAACCAGATGAATTTTTATCTGCTGAATTTATTGATCCAACTCGCGAGTTATTGAGCAAACTGATT
GGGCAGTTTTGTACAGGCTAA

Upstream 100 bases:

>100_bases
ATTAAAAGACGAGCAAGTTCAGCCCCCGTATAACCACTTGCACCAATGATAATCGCTTTTTGCATATTGTGTTGTGCCTT
ATAATAAGATAAATTTTTAA

Downstream 100 bases:

>100_bases
ATGCTAGGTCAAGATCGAAAAAGTGCGGTCTGTTTTAAAAAGTTTTCTCAAACAGACCGCACTTTGTATGCGTATTTTGA
GTAGTTATTTTAATAAATCT

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTNYAIIMHKYLKGNVFLFIKGKTMKKIPSFLQMYSALIASPTMSSIDPHFDQSNRTLIELLANWLSSLGFRTEVIPLEG
SRDKFNLLATYGEGEGGLLLAGHTDTVPFDEGRWQFDPFKLTEKDGKFYGLGTADMKGFFAFVIDAVSQLDLTRLTKPLR
ILATADEETTMLGARTFIQHSHIRPDCAIIGEPTSLKPIRAHKGHVGEALRITGKSGHSSDPSKGINAIELMHEATGYLM
QMRDELRQKYHHAAFNIPYPTMNFGAISGGDAVNRICACCELHFDIRPLPNLRLTDLNEMLQAKLAPMFEKWGGRISLQA
LHDPIPGYECAHSAQVVQVVEKLLGEQCETVNYCTEAPFIQQLCPTLVLGPGSIEQAHQPDEFLSAEFIDPTRELLSKLI
GQFCTG

Sequences:

>Translated_406_residues
MTNYAIIMHKYLKGNVFLFIKGKTMKKIPSFLQMYSALIASPTMSSIDPHFDQSNRTLIELLANWLSSLGFRTEVIPLEG
SRDKFNLLATYGEGEGGLLLAGHTDTVPFDEGRWQFDPFKLTEKDGKFYGLGTADMKGFFAFVIDAVSQLDLTRLTKPLR
ILATADEETTMLGARTFIQHSHIRPDCAIIGEPTSLKPIRAHKGHVGEALRITGKSGHSSDPSKGINAIELMHEATGYLM
QMRDELRQKYHHAAFNIPYPTMNFGAISGGDAVNRICACCELHFDIRPLPNLRLTDLNEMLQAKLAPMFEKWGGRISLQA
LHDPIPGYECAHSAQVVQVVEKLLGEQCETVNYCTEAPFIQQLCPTLVLGPGSIEQAHQPDEFLSAEFIDPTRELLSKLI
GQFCTG
>Mature_405_residues
TNYAIIMHKYLKGNVFLFIKGKTMKKIPSFLQMYSALIASPTMSSIDPHFDQSNRTLIELLANWLSSLGFRTEVIPLEGS
RDKFNLLATYGEGEGGLLLAGHTDTVPFDEGRWQFDPFKLTEKDGKFYGLGTADMKGFFAFVIDAVSQLDLTRLTKPLRI
LATADEETTMLGARTFIQHSHIRPDCAIIGEPTSLKPIRAHKGHVGEALRITGKSGHSSDPSKGINAIELMHEATGYLMQ
MRDELRQKYHHAAFNIPYPTMNFGAISGGDAVNRICACCELHFDIRPLPNLRLTDLNEMLQAKLAPMFEKWGGRISLQAL
HDPIPGYECAHSAQVVQVVEKLLGEQCETVNYCTEAPFIQQLCPTLVLGPGSIEQAHQPDEFLSAEFIDPTRELLSKLIG
QFCTG

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=379, Percent_Identity=64.6437994722955, Blast_Score=546, Evalue=1e-157,
Organism=Escherichia coli, GI1788816, Length=292, Percent_Identity=27.7397260273973, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789236, Length=356, Percent_Identity=24.1573033707865, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551016, Length=333, Percent_Identity=27.3273273273273, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 45147; Mature: 45015

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYAIIMHKYLKGNVFLFIKGKTMKKIPSFLQMYSALIASPTMSSIDPHFDQSNRTLIE
CCCEEEEEEHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHH
LLANWLSSLGFRTEVIPLEGSRDKFNLLATYGEGEGGLLLAGHTDTVPFDEGRWQFDPFK
HHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCCEECCCEE
LTEKDGKFYGLGTADMKGFFAFVIDAVSQLDLTRLTKPLRILATADEETTMLGARTFIQH
EECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHH
SHIRPDCAIIGEPTSLKPIRAHKGHVGEALRITGKSGHSSDPSKGINAIELMHEATGYLM
CCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
QMRDELRQKYHHAAFNIPYPTMNFGAISGGDAVNRICACCELHFDIRPLPNLRLTDLNEM
HHHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
LQAKLAPMFEKWGGRISLQALHDPIPGYECAHSAQVVQVVEKLLGEQCETVNYCTEAPFI
HHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
QQLCPTLVLGPGSIEQAHQPDEFLSAEFIDPTRELLSKLIGQFCTG
HHHHHHEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNYAIIMHKYLKGNVFLFIKGKTMKKIPSFLQMYSALIASPTMSSIDPHFDQSNRTLIE
CCEEEEEEHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHH
LLANWLSSLGFRTEVIPLEGSRDKFNLLATYGEGEGGLLLAGHTDTVPFDEGRWQFDPFK
HHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCCEECCCEE
LTEKDGKFYGLGTADMKGFFAFVIDAVSQLDLTRLTKPLRILATADEETTMLGARTFIQH
EECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHH
SHIRPDCAIIGEPTSLKPIRAHKGHVGEALRITGKSGHSSDPSKGINAIELMHEATGYLM
CCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
QMRDELRQKYHHAAFNIPYPTMNFGAISGGDAVNRICACCELHFDIRPLPNLRLTDLNEM
HHHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
LQAKLAPMFEKWGGRISLQALHDPIPGYECAHSAQVVQVVEKLLGEQCETVNYCTEAPFI
HHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
QQLCPTLVLGPGSIEQAHQPDEFLSAEFIDPTRELLSKLIGQFCTG
HHHHHHEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]