Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 15602549

GI number: 15602549

Start: 794093

End: 795397

Strand: Reverse

Name: hemA

Synonym: PM0684

Alternate gene names: 15602549

Gene position: 795397-794093 (Counterclockwise)

Preceding gene: 15602550

Following gene: 15602548

Centisome position: 35.23

GC content: 40.77

Gene sequence:

>1305_bases
ATGACGATTCTAGTTATTGGTATTAATCATAAGACAGCCTCTGTCGCTATCCGTGAGAAAGTGGCGTTTTCTGCTGAGAA
ACGGGTTGAGGCATTGGCGCAAATTCAGCAACAAGCATTGGCTGAAAGTGCGGTGATTTTATCTACTTGTAATCGTACTG
AAGTATATTTTCATCATAAAGCTATTCCGCCTCAAGAGGCAGAAAGTTGGACTGCGCGTTGTATGCAATGGTTTGCAGAA
ATACATCAGTTATCCTTAGATGCATTAGCAGGCTGCCTTTATTCGCAACAAAATCAACAAGCAGTTTTACATTTAATGCG
TGTTGCCTGTGGATTGGATTCGTTGGTATTGGGAGAACCGCAAATTTTAGGGCAAGTGAAAGACGCCTATCAATTGAGTA
AAATGTATTATCAAGGGCAAAATCAACCTCTTTCCAGTGAGTTTTCCCGTTTGTTTCAAAAAACGTTTTCTGTCGCAAAA
CGAGTTCGAACCGAAACGAACATTGGTGGCAATGCGGTGTCTGTAGCCTATGGTGCATGCAGTTTAGCGCGCCAAATTTT
TGATTCACTCAAAACATTAAATGTGCTTTTAGTCGGCGCAGGGGAGACCATCGAACTGACTTGTCGACATTTGTTACGCC
ATGGTGTACAACGAATTATGATTGCAAACCGGACATTTGAACGCGCGCAACATTTAGTGACTAAATTAGATGGTGCAGAA
AATGTGCAAGTTTTGGCGCTCACACAGTTACAAGAAGGCTTAAATCAAGCGGATATTGTGATCAGCTCAACAGGAAGTCC
GACAATCTTGATTACTCAAGATATGGTCAAGATTGCACAAAAAGCACGCTGTGACCTACCAATGCTGTTGGTGGACATTG
CGGTACCACGTGATATTGAAGAAAGTGTCGGTGAGCTAGACAGTATTTATCATTACACAGTAGATGATTTACAGACAATT
ATTCAACGCAATCTGGTAGAAAGAGAGAAAGCGTCGGCACAAGCGTGGGTGATTATTCAACAAGAATGCGCAGATTTCTT
TGAATGGTTAAAAGTGCATCAGTTTTCAAATTTAATCCGTTCTTACCGAGAAAATGCAGAAGATATTCGTCAAATACTAT
TAGAAAAGGCATTGCTTGCGTTACGTCAAGGTGAAGATAGTGAAGCCGTATTACAAGCACTGAGTTATAAATTGACAAAT
AAACTTTTACATTCACCTACACAAGTGATGAATGCGATGGTCAAAACAGGTAATTCAACGGGATTAGCACTGTTTTCTTC
AACTTTAAAGTCCGACGTGGAGTAG

Upstream 100 bases:

>100_bases
TGGCAGGACAATTGATTAAAATGGACCTTATTTCTTTTCTTTGTGGGTTCAACGTGGGTTCAACGCGCCGTGTCTTATCG
CGGTTCATGTAAAATAATGT

Downstream 100 bases:

>100_bases
CACAACAAATAAAAGTGATTTCTAATTCAGTCAATTCACTTTAGAATAATCAGGTTATTTTTTTATTGGGGTAAAATATG
CGAGAAAATCACCAAATAGC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTILVIGINHKTASVAIREKVAFSAEKRVEALAQIQQQALAESAVILSTCNRTEVYFHHKAIPPQEAESWTARCMQWFAE
IHQLSLDALAGCLYSQQNQQAVLHLMRVACGLDSLVLGEPQILGQVKDAYQLSKMYYQGQNQPLSSEFSRLFQKTFSVAK
RVRTETNIGGNAVSVAYGACSLARQIFDSLKTLNVLLVGAGETIELTCRHLLRHGVQRIMIANRTFERAQHLVTKLDGAE
NVQVLALTQLQEGLNQADIVISSTGSPTILITQDMVKIAQKARCDLPMLLVDIAVPRDIEESVGELDSIYHYTVDDLQTI
IQRNLVEREKASAQAWVIIQQECADFFEWLKVHQFSNLIRSYRENAEDIRQILLEKALLALRQGEDSEAVLQALSYKLTN
KLLHSPTQVMNAMVKTGNSTGLALFSSTLKSDVE

Sequences:

>Translated_434_residues
MTILVIGINHKTASVAIREKVAFSAEKRVEALAQIQQQALAESAVILSTCNRTEVYFHHKAIPPQEAESWTARCMQWFAE
IHQLSLDALAGCLYSQQNQQAVLHLMRVACGLDSLVLGEPQILGQVKDAYQLSKMYYQGQNQPLSSEFSRLFQKTFSVAK
RVRTETNIGGNAVSVAYGACSLARQIFDSLKTLNVLLVGAGETIELTCRHLLRHGVQRIMIANRTFERAQHLVTKLDGAE
NVQVLALTQLQEGLNQADIVISSTGSPTILITQDMVKIAQKARCDLPMLLVDIAVPRDIEESVGELDSIYHYTVDDLQTI
IQRNLVEREKASAQAWVIIQQECADFFEWLKVHQFSNLIRSYRENAEDIRQILLEKALLALRQGEDSEAVLQALSYKLTN
KLLHSPTQVMNAMVKTGNSTGLALFSSTLKSDVE
>Mature_433_residues
TILVIGINHKTASVAIREKVAFSAEKRVEALAQIQQQALAESAVILSTCNRTEVYFHHKAIPPQEAESWTARCMQWFAEI
HQLSLDALAGCLYSQQNQQAVLHLMRVACGLDSLVLGEPQILGQVKDAYQLSKMYYQGQNQPLSSEFSRLFQKTFSVAKR
VRTETNIGGNAVSVAYGACSLARQIFDSLKTLNVLLVGAGETIELTCRHLLRHGVQRIMIANRTFERAQHLVTKLDGAEN
VQVLALTQLQEGLNQADIVISSTGSPTILITQDMVKIAQKARCDLPMLLVDIAVPRDIEESVGELDSIYHYTVDDLQTII
QRNLVEREKASAQAWVIIQQECADFFEWLKVHQFSNLIRSYRENAEDIRQILLEKALLALRQGEDSEAVLQALSYKLTNK
LLHSPTQVMNAMVKTGNSTGLALFSSTLKSDVE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=429, Percent_Identity=50.8158508158508, Blast_Score=402, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PASMU (P95525)

Other databases:

- EMBL:   Y10430
- EMBL:   AE004439
- RefSeq:   NP_245621.1
- ProteinModelPortal:   P95525
- SMR:   P95525
- GeneID:   1244031
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0684
- NMPDR:   fig|272843.1.peg.684
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   PMUL272843:PM0684-MONOMER
- BRENDA:   1.2.1.70
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48408; Mature: 48277

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 114-114 BINDING 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVIGINHKTASVAIREKVAFSAEKRVEALAQIQQQALAESAVILSTCNRTEVYFHHK
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
AIPPQEAESWTARCMQWFAEIHQLSLDALAGCLYSQQNQQAVLHLMRVACGLDSLVLGEP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCCH
QILGQVKDAYQLSKMYYQGQNQPLSSEFSRLFQKTFSVAKRVRTETNIGGNAVSVAYGAC
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SLARQIFDSLKTLNVLLVGAGETIELTCRHLLRHGVQRIMIANRTFERAQHLVTKLDGAE
HHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NVQVLALTQLQEGLNQADIVISSTGSPTILITQDMVKIAQKARCDLPMLLVDIAVPRDIE
CEEEEEHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHCCCCHH
ESVGELDSIYHYTVDDLQTIIQRNLVEREKASAQAWVIIQQECADFFEWLKVHQFSNLIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
SYRENAEDIRQILLEKALLALRQGEDSEAVLQALSYKLTNKLLHSPTQVMNAMVKTGNST
HHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
GLALFSSTLKSDVE
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TILVIGINHKTASVAIREKVAFSAEKRVEALAQIQQQALAESAVILSTCNRTEVYFHHK
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
AIPPQEAESWTARCMQWFAEIHQLSLDALAGCLYSQQNQQAVLHLMRVACGLDSLVLGEP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCCH
QILGQVKDAYQLSKMYYQGQNQPLSSEFSRLFQKTFSVAKRVRTETNIGGNAVSVAYGAC
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SLARQIFDSLKTLNVLLVGAGETIELTCRHLLRHGVQRIMIANRTFERAQHLVTKLDGAE
HHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NVQVLALTQLQEGLNQADIVISSTGSPTILITQDMVKIAQKARCDLPMLLVDIAVPRDIE
CEEEEEHHHHHHCCCCEEEEEECCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHCCCCHH
ESVGELDSIYHYTVDDLQTIIQRNLVEREKASAQAWVIIQQECADFFEWLKVHQFSNLIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
SYRENAEDIRQILLEKALLALRQGEDSEAVLQALSYKLTNKLLHSPTQVMNAMVKTGNST
HHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
GLALFSSTLKSDVE
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100