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The map label for this gene is tyrA [H]

Identifier: 15602529

GI number: 15602529

Start: 773366

End: 774490

Strand: Reverse

Name: tyrA [H]

Synonym: PM0664

Alternate gene names: 15602529

Gene position: 774490-773366 (Counterclockwise)

Preceding gene: 15602530

Following gene: 15602528

Centisome position: 34.31

GC content: 41.24

Gene sequence:

>1125_bases
GTGGATACGTTAAATAAGTTAAGAACACAGATTGATCAAGTTGATCGTCAGTTATTACAGCTTTTAGCACAGCGACTTGA
GTTAGTGAAACAAGTCGGTGAAGTCAAGCATCAACAAGGTCTGCCGATTTATGTGCCAGAACGTGAAGCGGAGATGCTCA
ACGCCCGCCGTGCGGAAGCTGAAACGTTAGGGGTATCTGCTGATTTAATTGAAGATGTATTACGTCGTATCATGCGAGAA
TCTTATGCGCGGGAAAACCAATTTGGTTTTAAAACCGTGAATCCGGCGATCAAAAAAATCGTGATCGTAGGTGGGGGAGG
GAAACTTGGTAGCTTGTTTGCACGTTATTTCACATTGTCTGGTTACTATGTTGAGATTTTAGAGCAACAGGATTGGCAAA
GTGCGGACAAGATTTTGAACGAAACAGATGTGATTGTTGTTTCGGTACCGATCGCCAAAACCGTCGAAACAATTAAACGT
TTGAAGCCTTATTTGACAGATAATATGCTGTTGGTGGATTTAACTTCAGTTAAGCGTGCACCATTACAAGCGATGTTAGA
CGTGCACGCTGGCGCGGTATTAGGTTTACATCCAATGTTTGGTCCGGATATCGCCAGCATGGCAAAACAAGTGATTGTAC
GCTGTGATGGTCGTTTTGAATCACGTTATCAATGGCTGATCACCCAAATACAAATTTGGGGGGCAAAATTCTACCAAGTT
GAGGCGACTGAACACGATCATAGTATGACGTATGTACAAGCGTTGCGACACTTTTCCACTTTTGCTAATGGCTTACATTT
ATCAAAACAACCGGTTCAATTAGCGAATTTATTGGCACTTTCTTCGCCAATTTATTGCTTAGAATTGGCGATGATTGGGC
GTTTATTTGCGCAAGATGCAGAACTTTATGCCGATATTATTTTAGATAAGCCTGAAAATCTCGCGGTCATTGAGAGTTTA
AAGCAAAGTTATGAAGAAAGTTTGGCATTTTTTACCCATGGTGATAAGCAGGCATTCATTGACAGCTTTGAACAAGTTAA
ACAATGGTTTGGTGAATACTCGGAGCAGTTTCTGAAAGAAAGTCGCCAGTTGCTCCAACAAGCAAATGATTATCGACAAA
TTTAA

Upstream 100 bases:

>100_bases
ATATGGGGTTTCGATTACGGATGCCTGTATTGATTGGCAGACGACAGAACAATTATTACGTGAAATGACGAGCGCATTGC
GCCAAAAATAAGGATGCAAC

Downstream 100 bases:

>100_bases
TGTCATAAGCACAAAAAGATGGGGAAACCCGTCTTTTTTTATGTTTTTTATTTATAAAAAACAAATGTTTAAGACGGTTT
TTATTTGGCGTAACGTGGAT

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MDTLNKLRTQIDQVDRQLLQLLAQRLELVKQVGEVKHQQGLPIYVPEREAEMLNARRAEAETLGVSADLIEDVLRRIMRE
SYARENQFGFKTVNPAIKKIVIVGGGGKLGSLFARYFTLSGYYVEILEQQDWQSADKILNETDVIVVSVPIAKTVETIKR
LKPYLTDNMLLVDLTSVKRAPLQAMLDVHAGAVLGLHPMFGPDIASMAKQVIVRCDGRFESRYQWLITQIQIWGAKFYQV
EATEHDHSMTYVQALRHFSTFANGLHLSKQPVQLANLLALSSPIYCLELAMIGRLFAQDAELYADIILDKPENLAVIESL
KQSYEESLAFFTHGDKQAFIDSFEQVKQWFGEYSEQFLKESRQLLQQANDYRQI

Sequences:

>Translated_374_residues
MDTLNKLRTQIDQVDRQLLQLLAQRLELVKQVGEVKHQQGLPIYVPEREAEMLNARRAEAETLGVSADLIEDVLRRIMRE
SYARENQFGFKTVNPAIKKIVIVGGGGKLGSLFARYFTLSGYYVEILEQQDWQSADKILNETDVIVVSVPIAKTVETIKR
LKPYLTDNMLLVDLTSVKRAPLQAMLDVHAGAVLGLHPMFGPDIASMAKQVIVRCDGRFESRYQWLITQIQIWGAKFYQV
EATEHDHSMTYVQALRHFSTFANGLHLSKQPVQLANLLALSSPIYCLELAMIGRLFAQDAELYADIILDKPENLAVIESL
KQSYEESLAFFTHGDKQAFIDSFEQVKQWFGEYSEQFLKESRQLLQQANDYRQI
>Mature_374_residues
MDTLNKLRTQIDQVDRQLLQLLAQRLELVKQVGEVKHQQGLPIYVPEREAEMLNARRAEAETLGVSADLIEDVLRRIMRE
SYARENQFGFKTVNPAIKKIVIVGGGGKLGSLFARYFTLSGYYVEILEQQDWQSADKILNETDVIVVSVPIAKTVETIKR
LKPYLTDNMLLVDLTSVKRAPLQAMLDVHAGAVLGLHPMFGPDIASMAKQVIVRCDGRFESRYQWLITQIQIWGAKFYQV
EATEHDHSMTYVQALRHFSTFANGLHLSKQPVQLANLLALSSPIYCLELAMIGRLFAQDAELYADIILDKPENLAVIESL
KQSYEESLAFFTHGDKQAFIDSFEQVKQWFGEYSEQFLKESRQLLQQANDYRQI

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=370, Percent_Identity=60.8108108108108, Blast_Score=467, Evalue=1e-133,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42687; Mature: 42687

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLNKLRTQIDQVDRQLLQLLAQRLELVKQVGEVKHQQGLPIYVPEREAEMLNARRAEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHH
ETLGVSADLIEDVLRRIMRESYARENQFGFKTVNPAIKKIVIVGGGGKLGSLFARYFTLS
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHC
GYYVEILEQQDWQSADKILNETDVIVVSVPIAKTVETIKRLKPYLTDNMLLVDLTSVKRA
CHHHHHHHHCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
PLQAMLDVHAGAVLGLHPMFGPDIASMAKQVIVRCDGRFESRYQWLITQIQIWGAKFYQV
HHHHHHHHHCCHHEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEE
EATEHDHSMTYVQALRHFSTFANGLHLSKQPVQLANLLALSSPIYCLELAMIGRLFAQDA
ECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ELYADIILDKPENLAVIESLKQSYEESLAFFTHGDKQAFIDSFEQVKQWFGEYSEQFLKE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRQLLQQANDYRQI
HHHHHHHHHHHCCC
>Mature Secondary Structure
MDTLNKLRTQIDQVDRQLLQLLAQRLELVKQVGEVKHQQGLPIYVPEREAEMLNARRAEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHH
ETLGVSADLIEDVLRRIMRESYARENQFGFKTVNPAIKKIVIVGGGGKLGSLFARYFTLS
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHC
GYYVEILEQQDWQSADKILNETDVIVVSVPIAKTVETIKRLKPYLTDNMLLVDLTSVKRA
CHHHHHHHHCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
PLQAMLDVHAGAVLGLHPMFGPDIASMAKQVIVRCDGRFESRYQWLITQIQIWGAKFYQV
HHHHHHHHHCCHHEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEE
EATEHDHSMTYVQALRHFSTFANGLHLSKQPVQLANLLALSSPIYCLELAMIGRLFAQDA
ECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ELYADIILDKPENLAVIESLKQSYEESLAFFTHGDKQAFIDSFEQVKQWFGEYSEQFLKE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRQLLQQANDYRQI
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]