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The map label for this gene is pyrD

Identifier: 15602482

GI number: 15602482

Start: 719204

End: 720223

Strand: Reverse

Name: pyrD

Synonym: PM0617

Alternate gene names: 15602482

Gene position: 720223-719204 (Counterclockwise)

Preceding gene: 15602483

Following gene: 15602481

Centisome position: 31.9

GC content: 42.25

Gene sequence:

>1020_bases
ATGTATGCATTAATCCGCAAAGCCCTTTTTTCCCTTGATGCTGAACAAGCACATGATCTCACCATTAAAACATTAAAAAC
GCTGGGGCGTTCCCCGTTCAATCCATTGCTAAAAACCTTGTTTGCTTGTCCGACGGGTAGCCCGAAGACAATCATGGGAC
TGCACTTTAAAAACCCAATTGGCTTGGCTGCTGGGGCAGATAAAAATGGCGAAGCGATTGAGGGTTTTGCAGCAATGGGA
TTTGGCTTTATCGAAGTGGGAACGGTGACGCCTTTGGCACAAGAGGGTAACCCGAAACCTCGTCAATTTCGCTTACCCGA
AGCTGAGGGGATTATTAATCGGAATGGTTTTAATAATTACGGCATTGATTATTTAATCGAAAATGTGAAACACGCTAACT
ATGACGGCATTTTAGGCATTAATATTGGCAAGAATACCTTTACGTCAGTAGAAAATGGCAAAGCCGATTACCTCATTTGC
TTAAATAAAGCCTATCACTATGCGGATTACATTACCATTAACATTTCATCACCTAACTCACCGGGCTTACGTCAATTACA
GTATGGTGAGGCGTTAGAGGATTTATTGCAAGGGGTGAAAGCGCGTCAAAAAGATTTAGCTGAGCAATATCAGAAATACG
TGCCTATTGCGGTTAAAATTGCGCCAGATCTCACAGAGGGTGAGGTCGTACAAATCGCTGATACATTACAACGTCACAAA
ATGGATGCCGTCATTGCGACCAATACCACGATTTCACGTGATACCGTAAGTGGCTTGCAAAATGCCGAACAACAAGGTGG
ACTTAGTGGCAAACCGTTACAACAAAAAAGCACAGAAATTATTGCAAGACTTCACCAAGAATTGAAAGGTCAAATTCCGA
TTATTGGTAGTGGAGGGATTGATAGTGTTGCCAATGCGCAAGAGAAAATCAAGGCGGGCGCAGAGTTGCTACAACTTTAT
TCCGGCTTAATTTATCACGGTCCACACTTAATTAAACAATTGGTTCAACAGATTAAATAG

Upstream 100 bases:

>100_bases
TGATGGCTCAAACAAAATCAATTTTTCATTACATTTTATGTTGAAAAGCGTATAATCCGGCAGATTTTCACAGTTAAACT
ATCCAGAGAGATAAACGAGT

Downstream 100 bases:

>100_bases
GGTAATGAAGATAAAGGGCGGATTCACATATCTGCCCTGATGCTTTCATCGTTTCCCACTTTTACAGGTTCAAATTAGGA
TAACAGATGACAACAATTTA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MYALIRKALFSLDAEQAHDLTIKTLKTLGRSPFNPLLKTLFACPTGSPKTIMGLHFKNPIGLAAGADKNGEAIEGFAAMG
FGFIEVGTVTPLAQEGNPKPRQFRLPEAEGIINRNGFNNYGIDYLIENVKHANYDGILGINIGKNTFTSVENGKADYLIC
LNKAYHYADYITINISSPNSPGLRQLQYGEALEDLLQGVKARQKDLAEQYQKYVPIAVKIAPDLTEGEVVQIADTLQRHK
MDAVIATNTTISRDTVSGLQNAEQQGGLSGKPLQQKSTEIIARLHQELKGQIPIIGSGGIDSVANAQEKIKAGAELLQLY
SGLIYHGPHLIKQLVQQIK

Sequences:

>Translated_339_residues
MYALIRKALFSLDAEQAHDLTIKTLKTLGRSPFNPLLKTLFACPTGSPKTIMGLHFKNPIGLAAGADKNGEAIEGFAAMG
FGFIEVGTVTPLAQEGNPKPRQFRLPEAEGIINRNGFNNYGIDYLIENVKHANYDGILGINIGKNTFTSVENGKADYLIC
LNKAYHYADYITINISSPNSPGLRQLQYGEALEDLLQGVKARQKDLAEQYQKYVPIAVKIAPDLTEGEVVQIADTLQRHK
MDAVIATNTTISRDTVSGLQNAEQQGGLSGKPLQQKSTEIIARLHQELKGQIPIIGSGGIDSVANAQEKIKAGAELLQLY
SGLIYHGPHLIKQLVQQIK
>Mature_339_residues
MYALIRKALFSLDAEQAHDLTIKTLKTLGRSPFNPLLKTLFACPTGSPKTIMGLHFKNPIGLAAGADKNGEAIEGFAAMG
FGFIEVGTVTPLAQEGNPKPRQFRLPEAEGIINRNGFNNYGIDYLIENVKHANYDGILGINIGKNTFTSVENGKADYLIC
LNKAYHYADYITINISSPNSPGLRQLQYGEALEDLLQGVKARQKDLAEQYQKYVPIAVKIAPDLTEGEVVQIADTLQRHK
MDAVIATNTTISRDTVSGLQNAEQQGGLSGKPLQQKSTEIIARLHQELKGQIPIIGSGGIDSVANAQEKIKAGAELLQLY
SGLIYHGPHLIKQLVQQIK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=338, Percent_Identity=41.4201183431953, Blast_Score=238, Evalue=6e-63,
Organism=Escherichia coli, GI1787177, Length=337, Percent_Identity=61.7210682492582, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17509475, Length=338, Percent_Identity=40.8284023668639, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI281361352, Length=291, Percent_Identity=45.7044673539519, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17137316, Length=291, Percent_Identity=45.7044673539519, Blast_Score=252, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PASMU (P57858)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245554.1
- ProteinModelPortal:   P57858
- SMR:   P57858
- GeneID:   1243964
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0617
- NMPDR:   fig|272843.1.peg.617
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- BioCyc:   PMUL272843:PM0617-MONOMER
- BRENDA:   1.3.3.1
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36920; Mature: 36920

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALIRKALFSLDAEQAHDLTIKTLKTLGRSPFNPLLKTLFACPTGSPKTIMGLHFKNPI
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCC
GLAAGADKNGEAIEGFAAMGFGFIEVGTVTPLAQEGNPKPRQFRLPEAEGIINRNGFNNY
CEECCCCCCCCHHHHHHHHCCCEEEECCCCCHHHCCCCCCCEEECCCCCCCEECCCCCCC
GIDYLIENVKHANYDGILGINIGKNTFTSVENGKADYLICLNKAYHYADYITINISSPNS
CHHHHHHHHCCCCCCCEEEEECCCCHHCCCCCCCCCEEEEECCCEEEEEEEEEEECCCCC
PGLRQLQYGEALEDLLQGVKARQKDLAEQYQKYVPIAVKIAPDLTEGEVVQIADTLQRHK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHH
MDAVIATNTTISRDTVSGLQNAEQQGGLSGKPLQQKSTEIIARLHQELKGQIPIIGSGGI
CCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCC
DSVANAQEKIKAGAELLQLYSGLIYHGPHLIKQLVQQIK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MYALIRKALFSLDAEQAHDLTIKTLKTLGRSPFNPLLKTLFACPTGSPKTIMGLHFKNPI
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCC
GLAAGADKNGEAIEGFAAMGFGFIEVGTVTPLAQEGNPKPRQFRLPEAEGIINRNGFNNY
CEECCCCCCCCHHHHHHHHCCCEEEECCCCCHHHCCCCCCCEEECCCCCCCEECCCCCCC
GIDYLIENVKHANYDGILGINIGKNTFTSVENGKADYLICLNKAYHYADYITINISSPNS
CHHHHHHHHCCCCCCCEEEEECCCCHHCCCCCCCCCEEEEECCCEEEEEEEEEEECCCCC
PGLRQLQYGEALEDLLQGVKARQKDLAEQYQKYVPIAVKIAPDLTEGEVVQIADTLQRHK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHH
MDAVIATNTTISRDTVSGLQNAEQQGGLSGKPLQQKSTEIIARLHQELKGQIPIIGSGGI
CCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCC
DSVANAQEKIKAGAELLQLYSGLIYHGPHLIKQLVQQIK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11248100