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The map label for this gene is thrS [H]

Identifier: 15602458

GI number: 15602458

Start: 687397

End: 689328

Strand: Direct

Name: thrS [H]

Synonym: PM0593

Alternate gene names: 15602458

Gene position: 687397-689328 (Clockwise)

Preceding gene: 15602456

Following gene: 15602459

Centisome position: 30.45

GC content: 42.96

Gene sequence:

>1932_bases
ATGCCAATTATTACTTTGCCTGACGGTTCACAGCGTCAGTTTGAACAACCTATTTCTGTGATGGATGTTGCTGCCAGTAT
TGGTGCGGGTCTAGCGAAGGCTTGTATTGCAGGTCGTGTTAATGGCGAGCGGAAAGATGCTTGCGATCTGATTACTGAAG
ACAGCAAACTAGAGATTATTACCGCAAAAGAGGAAGATGGTTTAGAAATTATTCGTCACTCTTGTGCGCACTTATTAGGT
CATGCCATTAAACAGCTATTCCCAAATGTAAAAATGGCGATTGGTCCAACTATCGACAAGGGTTTTTATTATGACGTGGA
TCTTGATCGCTCTTTAACCCAAGAGGATTTAGATGCACTTGAAAAACGTATGCTTGAACTGGCAAAAACCAACTATGATG
TGGTGAAAAAAGTGGTCAGCTGGCAAGAGGCCCGTGATACCTTTGAAGCCCGCGGCGAGCCATATAAAATGGCAATTTTA
GATGAAAACATCGATCGTTGCGATACGCCAGCACTTTATCATCACGAAGAATACGTTGATATGTGTCGTGGTCCACACGT
ACCTAATATGCGTTTTTGCCATCACTTTAAATTAATGAAAGTTGCTGGTGCATACTGGCGTGGTGACAGCAAAAATAAAA
TGTTACAACGTATCTACGGTACCGCGTGGGCAGATAAAAAACAATTAAGCGAATACTTAACTCGTTTAGAAGAAGCGGCA
AAACGTGACCACCGTAAAATTGGTAAAGCGTTAGATTTATATCATATGCAAGAAGAAGCACCGGGTATGGTGTTCTGGCA
CAATGACGGTTGGACAATTTTCCGTGAACTTGAAACCTTCGTGCGTACTAAATTAAAAGAATACGATTACCAAGAAGTAA
AAGGTCCATTTATGATGGATCGCGTATTATGGGAAAAAACAGGGCACTGGCAAAACTACGGTGATTTGATGTTCACCACT
CAATCAGAAAACCGTGAATATGCGATTAAACCGATGAACTGTCCGGGACACGTGCAAATCTTTAATCAAGGTTTAAAATC
CTATCGCGATCTACCAATTCGTATGGCGGAATTTGGTTCATGCCACCGTAACGAACCGTCAGGTTCATTGCATGGCTTAA
TGCGTGTACGTGGCTTCACCCAAGATGATGCGCATATTTTCTGTACGGAAGATCAAATTGAAAGTGAAGTAACGGCGTGT
ATCAAAATGGTTTACGACATTTACAGCACATTCGGTTTTGAAAACATTCAAGTGAAACTGTCAACCCGTCCGGAAAAACG
TATTGGTGCCGATGAGATGTGGGACAGAGCCGAAGCCGGTCTTGCTGCTGCACTGTCGCACAATGGTCTTGAATATGAAA
TTCAAGAAGGTGAGGGGGCGTTCTATGGTCCGAAAATTGAATTCGCATTACGCGACTGCTTAGATCGTGAATGGCAGTGC
GGAACTATTCAGTTAGACTTCGCCTTACCGGGTCGCCTCAATGCGTCTTATGTGGCAGAAGATAATGATCGCCGTACACC
TGTGATGATTCACCGTGCAATTTTAGGTTCTATCGAGCGTTTCATCGGAATTATCACCGAAGAATACGCCGGTTTCTTCC
CTGCATGGTTAGCGCCAACACAAGCGATCGTGATGAACATCACGGATTCACAATCTGACTATGTGCAAAAAGTGGTGAAA
ACGTTATCTGACGCAGGTTTACGTGTGAAATCTGATTTACGTAATGAAAAAATCGGTTTCAAAATTCGTGAACACACCTT
ACGTCGCGTACCATACATGTTAGTTTGTGGCGATAAAGAAATCGAAGCCGGTAAAGTAGCGGTGCGTACCCGTAAAGGTG
CCGACCTCGGTACATTCACCATTGAAGAATTTTTAGATATCTTGAAAAAACAAGTACGTTCTCGCGAACTGAAATTACTT
GGTGAAGAGTAG

Upstream 100 bases:

>100_bases
TATTCAGAGTAGGAATGAGTCTAAAGTGCGGTTTATTTTTGAAAAATTTTAGCAAAAACAAGTAACCTCTCGTATGGGTT
ACCACTGTAAAGGAAAACTT

Downstream 100 bases:

>100_bases
TTTCATCACTTATTAGTAAAACACCGTTTGTGTAAAGACAAGCGGTGTTTTTTTATGGGAAAAGATCTTATTCGACATAA
AGTGTCTTATGAAAGGTATA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 643; Mature: 642

Protein sequence:

>643_residues
MPIITLPDGSQRQFEQPISVMDVAASIGAGLAKACIAGRVNGERKDACDLITEDSKLEIITAKEEDGLEIIRHSCAHLLG
HAIKQLFPNVKMAIGPTIDKGFYYDVDLDRSLTQEDLDALEKRMLELAKTNYDVVKKVVSWQEARDTFEARGEPYKMAIL
DENIDRCDTPALYHHEEYVDMCRGPHVPNMRFCHHFKLMKVAGAYWRGDSKNKMLQRIYGTAWADKKQLSEYLTRLEEAA
KRDHRKIGKALDLYHMQEEAPGMVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMDRVLWEKTGHWQNYGDLMFTT
QSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTAC
IKMVYDIYSTFGFENIQVKLSTRPEKRIGADEMWDRAEAGLAAALSHNGLEYEIQEGEGAFYGPKIEFALRDCLDREWQC
GTIQLDFALPGRLNASYVAEDNDRRTPVMIHRAILGSIERFIGIITEEYAGFFPAWLAPTQAIVMNITDSQSDYVQKVVK
TLSDAGLRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKEIEAGKVAVRTRKGADLGTFTIEEFLDILKKQVRSRELKLL
GEE

Sequences:

>Translated_643_residues
MPIITLPDGSQRQFEQPISVMDVAASIGAGLAKACIAGRVNGERKDACDLITEDSKLEIITAKEEDGLEIIRHSCAHLLG
HAIKQLFPNVKMAIGPTIDKGFYYDVDLDRSLTQEDLDALEKRMLELAKTNYDVVKKVVSWQEARDTFEARGEPYKMAIL
DENIDRCDTPALYHHEEYVDMCRGPHVPNMRFCHHFKLMKVAGAYWRGDSKNKMLQRIYGTAWADKKQLSEYLTRLEEAA
KRDHRKIGKALDLYHMQEEAPGMVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMDRVLWEKTGHWQNYGDLMFTT
QSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTAC
IKMVYDIYSTFGFENIQVKLSTRPEKRIGADEMWDRAEAGLAAALSHNGLEYEIQEGEGAFYGPKIEFALRDCLDREWQC
GTIQLDFALPGRLNASYVAEDNDRRTPVMIHRAILGSIERFIGIITEEYAGFFPAWLAPTQAIVMNITDSQSDYVQKVVK
TLSDAGLRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKEIEAGKVAVRTRKGADLGTFTIEEFLDILKKQVRSRELKLL
GEE
>Mature_642_residues
PIITLPDGSQRQFEQPISVMDVAASIGAGLAKACIAGRVNGERKDACDLITEDSKLEIITAKEEDGLEIIRHSCAHLLGH
AIKQLFPNVKMAIGPTIDKGFYYDVDLDRSLTQEDLDALEKRMLELAKTNYDVVKKVVSWQEARDTFEARGEPYKMAILD
ENIDRCDTPALYHHEEYVDMCRGPHVPNMRFCHHFKLMKVAGAYWRGDSKNKMLQRIYGTAWADKKQLSEYLTRLEEAAK
RDHRKIGKALDLYHMQEEAPGMVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMDRVLWEKTGHWQNYGDLMFTTQ
SENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTACI
KMVYDIYSTFGFENIQVKLSTRPEKRIGADEMWDRAEAGLAAALSHNGLEYEIQEGEGAFYGPKIEFALRDCLDREWQCG
TIQLDFALPGRLNASYVAEDNDRRTPVMIHRAILGSIERFIGIITEEYAGFFPAWLAPTQAIVMNITDSQSDYVQKVVKT
LSDAGLRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKEIEAGKVAVRTRKGADLGTFTIEEFLDILKKQVRSRELKLLG
EE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=651, Percent_Identity=39.0168970814132, Blast_Score=464, Evalue=1e-130,
Organism=Homo sapiens, GI38570111, Length=618, Percent_Identity=39.9676375404531, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI20070344, Length=643, Percent_Identity=34.8367029548989, Blast_Score=382, Evalue=1e-106,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=79.4392523364486, Blast_Score=1102, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=198, Percent_Identity=25.7575757575758, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984184, Length=634, Percent_Identity=37.6971608832808, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71984192, Length=634, Percent_Identity=37.6971608832808, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6322112, Length=649, Percent_Identity=37.7503852080123, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322654, Length=395, Percent_Identity=37.7215189873418, Blast_Score=293, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24583842, Length=633, Percent_Identity=39.0205371248025, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI28574141, Length=633, Percent_Identity=39.0205371248025, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24583839, Length=633, Percent_Identity=39.0205371248025, Blast_Score=472, Evalue=1e-133,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73720; Mature: 73589

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIITLPDGSQRQFEQPISVMDVAASIGAGLAKACIAGRVNGERKDACDLITEDSKLEII
CCEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEE
TAKEEDGLEIIRHSCAHLLGHAIKQLFPNVKMAIGPTIDKGFYYDVDLDRSLTQEDLDAL
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHH
EKRMLELAKTNYDVVKKVVSWQEARDTFEARGEPYKMAILDENIDRCDTPALYHHEEYVD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHCCHHHHH
MCRGPHVPNMRFCHHFKLMKVAGAYWRGDSKNKMLQRIYGTAWADKKQLSEYLTRLEEAA
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KRDHRKIGKALDLYHMQEEAPGMVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMD
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHH
RVLWEKTGHWQNYGDLMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGS
HHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTACIKMVYDIYSTFGFENIQVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
STRPEKRIGADEMWDRAEAGLAAALSHNGLEYEIQEGEGAFYGPKIEFALRDCLDREWQC
ECCCCHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHCCCCCCC
GTIQLDFALPGRLNASYVAEDNDRRTPVMIHRAILGSIERFIGIITEEYAGFFPAWLAPT
CEEEEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
QAIVMNITDSQSDYVQKVVKTLSDAGLRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKE
EEEEEEECCCHHHHHHHHHHHHHHCCCEEHHHHCCCCCCCCHHHHHHHHCCEEEEECCCC
IEAGKVAVRTRKGADLGTFTIEEFLDILKKQVRSRELKLLGEE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PIITLPDGSQRQFEQPISVMDVAASIGAGLAKACIAGRVNGERKDACDLITEDSKLEII
CEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEE
TAKEEDGLEIIRHSCAHLLGHAIKQLFPNVKMAIGPTIDKGFYYDVDLDRSLTQEDLDAL
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHH
EKRMLELAKTNYDVVKKVVSWQEARDTFEARGEPYKMAILDENIDRCDTPALYHHEEYVD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHCCHHHHH
MCRGPHVPNMRFCHHFKLMKVAGAYWRGDSKNKMLQRIYGTAWADKKQLSEYLTRLEEAA
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KRDHRKIGKALDLYHMQEEAPGMVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMD
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHH
RVLWEKTGHWQNYGDLMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGS
HHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTACIKMVYDIYSTFGFENIQVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
STRPEKRIGADEMWDRAEAGLAAALSHNGLEYEIQEGEGAFYGPKIEFALRDCLDREWQC
ECCCCHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHCCCCCCC
GTIQLDFALPGRLNASYVAEDNDRRTPVMIHRAILGSIERFIGIITEEYAGFFPAWLAPT
CEEEEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
QAIVMNITDSQSDYVQKVVKTLSDAGLRVKSDLRNEKIGFKIREHTLRRVPYMLVCGDKE
EEEEEEECCCHHHHHHHHHHHHHHCCCEEHHHHCCCCCCCCHHHHHHHHCCEEEEECCCC
IEAGKVAVRTRKGADLGTFTIEEFLDILKKQVRSRELKLLGEE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA